Cited by 26HIV Research and TreatmentVirus-based gene therapy researchT-cell and Retrovirus Studies

Roles of Vpr and Vpx in modulating the virus-host cell relationship

Open access
Planelles, Vicente, Barker, Edward·2010·Molecular Aspects of Medicine

Abstract

The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.mam.2010.05.002

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Human immunodeficiency virus 1 (HIV-1) deploys its viral proteins Vpr and Vpx, to recruit DDB1 and CUL4-associated factor 1 (DCAF1) to target several different human proteins, including DNA repair proteins, for ubiquitylation.

    “Human immunodeficiency virus 1 (HIV-1) deploys its viral proteins Vpr and Vpx, to recruit DDB1 and CUL4-associated factor 1 (DCAF1) to target several different human proteins, including DNA repair proteins, for ubiquitylation237,238.”

    From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [237]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 98 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Planelles, V., & Barker, E.
Affiliations
  • University of Utah (US)
  • Rush University Medical Center (US)
Corresponding author
Planelles, Vicente
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
2010-10
Volume
31
Issue
5
Pages
398-406
ISSN
0098-2997 (ISSN-L)
OpenAlex
W1967347754
Cited by
26
References
98
Citations by year
2025: 3 · 2024: 1 · 2022: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 3 · 2012: 3
FWCI
0.31
Type
journal article
Language
en
Open access
Locations
  • Molecular Aspects of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI087508, AI 52809, R56AI049057, AI 49057, R01AI049057, R03AI052809, AI56923, R21AI056923, R01AI065361)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
Vpr, Vpx, HIV-1, simian immunodeficiency virus, human immunodeficiency virus, viral replication, host cell modulation, host-virus interaction, small open reading frames
MeSH terms
Cell Cycle, DNA Damage, Humans, Simian Immunodeficiency Virus, Apoptosis, vpr Gene Products, Human Immunodeficiency Virus, Viral Regulatory and Accessory Proteins, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review