Roles of Vpr and Vpx in modulating the virus-host cell relationship
Open accessAbstract
The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human immunodeficiency virus 1 (HIV-1) deploys its viral proteins Vpr and Vpx, to recruit DDB1 and CUL4-associated factor 1 (DCAF1) to target several different human proteins, including DNA repair proteins, for ubiquitylation.
“Human immunodeficiency virus 1 (HIV-1) deploys its viral proteins Vpr and Vpx, to recruit DDB1 and CUL4-associated factor 1 (DCAF1) to target several different human proteins, including DNA repair proteins, for ubiquitylation237,238.”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [237]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., & Spies, T. A. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 3,000 · see citing works
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works
The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection
Gartner, S., Markovits, P., Markovitz, D. M., Kaplan, M. H., Gallo, R. C., & Popovič, M. (1986) · Science · doi:10.1126/science.3014648 · Cited by 1,808 · see citing works
ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works
Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635 · see citing works
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
Gasser, S., Orsulic, S., Brown, E. J., & Raulet, D. H. (2005) · Nature · doi:10.1038/nature03884 · Cited by 1,308 · see citing works
Cosman, D. J., Müllberg, J., Sutherland, C. L., Chin, W. A., Armitage, R. J., Fanslow, W. C., Kubin, M. Z., & Chalupny, N. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00095-4 · Cited by 1,228 · see citing works
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142 · see citing works
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
Kokoszka, J. E., Waymire, K. G., Levy, S. E., Sligh, J. E., Cai, J., Jones, D. P., MacGregor, G. R., & Wallace, D. C. (2004) · Nature · doi:10.1038/nature02229 · Cited by 1,086 · see citing works
An Activating Immunoreceptor Complex Formed by NKG2D and DAP10
Wu, J., Song, Y., Bakker, A. B. H., Bauer, S., Spies, T. A., Lanier, L. L., & Phillips, J. H. (1999) · Science · doi:10.1126/science.285.5428.730 · Cited by 1,037 · see citing works
He, J., Choe, S., Walker, R., Marzio, P. D., Morgan, D. O., & Landau, N. R. (1995) · Journal of Virology · doi:10.1128/jvi.69.11.6705-6711.1995 · Cited by 905 · see citing works
Bryceson, Y. T., March, M., Ljunggren, H., & Long, E. O. (2005) · Blood · doi:10.1182/blood-2005-04-1351 · Cited by 863 · see citing works
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
Guerra, N., Tan, Y. X., Joncker, N. T., Choy, A., Gallardo, F., Xiong, N., Knoblaugh, S., Cado, D., Greenberg, N. R., & Raulet, D. H. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.016 · Cited by 850 · see citing works
A second lineage of mammalian major histocompatibility complex class I genes.
Bahram, S., Bresnahan, M., Geraghty, D. E., & Spies, T. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6259 · Cited by 784 · see citing works
Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery
Angers, S., Li, T., Yi, X., MacCoss, M. J., Moon, R. T., & Zheng, N. (2006) · Nature · doi:10.1038/nature05175 · Cited by 674 · see citing works
Activation, coactivation, and costimulation of resting human natural killer cells
Bryceson, Y. T., March, M., Ljunggren, H., & Long, E. O. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00457.x · Cited by 648 · see citing works
Jin, J., Arias, E. E., Chen, J., Harper, J. W., & Walter, J. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.08.010 · Cited by 632 · see citing works
UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex
Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.035 · Cited by 576 · see citing works
Role of the mitochondrial membrane permeability transition in cell death
Tsujimoto, Y., & Shimizu, S. (2006) · APOPTOSIS · doi:10.1007/s10495-006-0525-7 · Cited by 559 · see citing works
Macrophages as a Source of HIV During Opportunistic Infections
Orenstein, J. M., Fox, C. H., & Wahl, S. M. (1997) · Science · doi:10.1126/science.276.5320.1857 · Cited by 533 · see citing works
Jowett, J. B. M., Planelles, V., Poon, B., Shah, N. P., Chen, M. L., & Chen, I. S. (1995) · Journal of Virology · doi:10.1128/jvi.69.10.6304-6313.1995 · Cited by 523 · see citing works
Self-citationWang, H., Zhai, L., Xu, J., Joo, H.-Y., Jackson, S., Erdjument‐Bromage, H., Tempst, P., Xiong, Y., & Zhang, Y. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.035 · Cited by 520 · see citing works
Goh, W. C., Rogel, M. E., Kinsey, C. M., Michael, S. F., Fultz, P. N., Nowak, M. A., Hahn, B. H., & Emerman, M. (1998) · Nature Medicine · doi:10.1038/nm0198-065 · Cited by 518 · see citing works
Pende, D., Rivera, P., Marcenaro, S., Chang, C., Biassoni, R., Conte, R., Kubin, M. Z., Cosman, D. J., Ferrone, S., Moretta, L., et al. (2002) · PubMed · Cited by 500 · see citing works
Bryceson, Y. T., March, M., Barber, D. F., Ljunggren, H., & Long, E. O. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051143 · Cited by 494 · see citing works
Jacotot, E. D., Ravagnan, L., Loeffler, M. W., Ferri, K. F., Vieira, H. L. A., Zamzami, N., Costantini, P., Druillennec, S., Hoebeke, J., Briand, J. P., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.33 · Cited by 450 · see citing works
Houchins, J. P., Yabe, T., McSherry, C., & Bach, F. H. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.4.1017 · Cited by 446 · see citing works
Higa, L. A., Wu, M., Ye, T., Kobayashi, R., Sun, H., & Zhang, H. (2006) · Nature Cell Biology · doi:10.1038/ncb1490 · Cited by 414 · see citing works
Rogel, M. E., Wu, L. I., & Emerman, M. (1995) · Journal of Virology · doi:10.1128/jvi.69.2.882-888.1995 · Cited by 410 · see citing works
Re, F., Braaten, D. C., Franke, E. K., & Luban, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.11.6859-6864.1995 · Cited by 376 · see citing works
Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage
Hu, J., McCall, C. M., Ohta, T., & Xiong, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1172 · Cited by 349 · see citing works
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4–ROC1 ubiquitin ligasesPreprint
He, Y. J., McCall, C. M., Hu, J., Zeng, Y., & Xiong, Y. (2006) · Genes & Development · doi:10.1101/gad.1483206 · Cited by 331 · see citing works
Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint
Higa, L. A., Mihaylov, I. S., Banks, D. P., Zheng, J., & Zhang, H. (2003) · Nature Cell Biology · doi:10.1038/ncb1061 · Cited by 289 · see citing works
Bryceson, Y. T., Ljunggren, H., & Long, E. O. (2009) · Blood · doi:10.1182/blood-2009-01-201632 · Cited by 285 · see citing works
Rouzic, E. L., Belaïdouni, N., Estrabaud, E., Morel, M., Rain, J., Transy, C., & Margottin-Goguet, F. (2007) · Cell Cycle · doi:10.4161/cc.6.2.3732 · Cited by 267 · see citing works
Fletcher, T. M., Břicháček, B., Sharova, N., Newman, M. A., Stivahtis, G. L., Sharp, P. M., Emerman, M., Hahn, B. H., & Stevenson, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01003.x · Cited by 238 · see citing works
Evolution of the primate lentiviruses: evidence from vpx and vpr.
Tristem, M., Marshall, C., Karpas, A., & Hill, F. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05419.x · Cited by 238 · see citing works
Vieira, H. L. A., Haouzi, D., Hamel, C. E., Jacotot, E. D., Belzacq, A.-S., Brenner, C., & Kroemer, G. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400778 · Cited by 229 · see citing works
Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle
Hrecka, K., Gierszewska, M., Srivastava, S., Kozaczkiewicz, L., Swanson, S. K., Florens, L. A., Washburn, M. P., & Skowroński, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702102104 · Cited by 227 · see citing works
Srivastava, S., Swanson, S. K., Manel, N., Florens, L., Washburn, M. P., & Skowronski, J. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000059 · Cited by 209 · see citing works
Goujon, C., Rivière, L., Jarrosson, L., Bernaud, J., Rigal, D., Darlix, J., & Cimarelli, A. (2007) · Retrovirology · doi:10.1186/1742-4690-4-2 · Cited by 205 · see citing works
The DNA damage response: sensing and signaling
McGowan, C. H., & Russell, P. R. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.005 · Cited by 202 · see citing works
Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R
Roshal, M., Kim, B., Zhu, Y., Nghiem, P., & Planelles, V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303948200 · Cited by 200 · see citing works
Self-citationThe Role of Monocytes and Macrophages in the Pathogenesis of HIV-1 Infection
Kedzierska, K., & Crowe, S. M. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023368935 · Cited by 198 · see citing works
Vpr-induced cell cycle arrest is conserved among primate lentiviruses
Planelles, V., Jowett, J. B. M., Li, Q. X., Xie, Y., Hahn, B. H., & Chen, I. S. (1996) · Journal of Virology · doi:10.1128/jvi.70.4.2516-2524.1996 · Cited by 195 · see citing works
Self-citationWard, J. P., Bonaparte, M. I., Sacks, J., Guterman, J., Fogli, M., Mavilio, D., & Barker, E. (2007) · Blood · doi:10.1182/blood-2006-06-028175 · Cited by 190 · see citing works
Self-citationHIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase
Belzile, J.-P., Duisit, G., Rougeau, N., Mercier, J., Finzi, A., & Cohen, É. A. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030085 · Cited by 189 · see citing works
Primate Lentiviral Vpx Commandeers DDB1 to Counteract a Macrophage Restriction
Sharova, N., Wu, Y., Zhu, X., Stránská, R., Kaushik, R., Sharkey, M. E., & Stevenson, M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000057 · Cited by 188 · see citing works
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
Schröfelbauer, B., Hakata, Y., & Landau, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610167104 · Cited by 187 · see citing works
The Vpr protein from HIV-1: distinct roles along the viral life cycle
Rouzic, E. L., & Bénichou, S. (2005) · Retrovirology · doi:10.1186/1742-4690-2-11 · Cited by 187 · see citing works
Mahalingam, S., Ayyavoo, V., Patel, M., Kieber‐Emmons, T., & Weiner, D. B. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6339-6347.1997 · Cited by 179 · see citing works
Mutational analysis of the human immunodeficiency virus vpr open reading frame
Ogawa, K., Shibata, R., Kiyomasu, T., Higuchi, I., Kishida, Y., Ishimoto, A., & Adachi, A. (1989) · Journal of Virology · doi:10.1128/jvi.63.9.4110-4114.1989 · Cited by 177 · see citing works
Cerboni, C., Neri, F., Casartelli, N., Zingoni, A., Cosman, D. J., Rossi, P., Santoni, A., & Doria, M. (2006) · Journal of General Virology · doi:10.1099/vir.0.82125-0 · Cited by 177 · see citing works
NMR Structure of the HIV-1 Regulatory Protein VPR
Morellet, N., Bouaziz, S., Petitjean, P., & Roques, B. P. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00060-3 · Cited by 172 · see citing works
Richard, J., Sindhu, S. T. A. K., Pham, T. N. Q., Belzile, J.-P., & Cohen, É. A. (2009) · Blood · doi:10.1182/blood-2009-08-237370 · Cited by 162 · see citing works
Hattori, N., Michaels, F. H., Fargnoli, K., Marcon, L., Gallo, R. C., & Franchini, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.8080 · Cited by 161 · see citing works
Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis through Caspase Activation
Stewart, S. A., Poon, B., Song, J. Y., & Chen, I. S. Y. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3105-3111.2000 · Cited by 161 · see citing works
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
DeHart, J. L., Zimmerman, E. S., Ardon, O., Monteiro-Filho, C. M., Argañaraz, E. R., & Planelles, V. (2007) · Virology Journal · doi:10.1186/1743-422x-4-57 · Cited by 152 · see citing works
Self-citationWen, X., Duus, K., Friedrich, T. D., & de Noronha, C. M. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703955200 · Cited by 150 · see citing works
HIV-1 Vpr Induces Apoptosis through Caspase 9 in T Cells and Peripheral Blood Mononuclear Cells
Muthumani, K., Hwang, D. S., Desai, B. M., Zhang, D., Dayes, N. S., Green, D. R., & Weiner, D. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205313200 · Cited by 149 · see citing works
Human Immunodeficiency Virus: The Eighth Gene
Wong‐Staal, F., Chanda, P. K., & Ghrayeb, J. (1987) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1987.3.33 · Cited by 144 · see citing works
Ward, J. P., Davis, Z., DeHart, J. L., Zimmerman, E. S., Bosque, A., Brunetta, E., Mavilio, D., Planelles, V., & Barker, E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000613 · Cited by 141 · see citing works
Self-citationDDB1 and Cul4A Are Required for Human Immunodeficiency Virus Type 1 Vpr-Induced G 2 Arrest
Tan, L., Ehrlich, E. S., & Yu, X.-F. (2007) · Journal of Virology · doi:10.1128/jvi.01380-07 · Cited by 130 · see citing works
Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.
Zhao, L. J., Mukherjee, S., & Narayan, O. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40719-8 · Cited by 129 · see citing works
Yu, X. F., Yu, Q., Essex, M., & Lee, T. H. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.5088-5091.1991 · Cited by 120 · see citing works
Higa, L. A., Yang, X., Zheng, J., Banks, D. P., Wu, M., Ghosh, P., Sun, H., & Zhang, H. (2005) · Cell Cycle · doi:10.4161/cc.5.1.2266 · Cited by 118 · see citing works
Guyader, M., Emerman, M., Montagnier, L., & Peden, K. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03488.x · Cited by 118 · see citing works
HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT
Andersen, J. L., DeHart, J. L., Zimmerman, E. S., Ardon, O., Kim, B., Jacquot, G., Bénichou, S., & Planelles, V. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020127 · Cited by 116 · see citing works
Self-citationHrimech, M., Yao, X., Bachand, F., Rougeau, N., & Cohen, É. A. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.4101-4109.1999 · Cited by 115 · see citing works
Fogli, M., Mavilio, D., Brunetta, E., Varchetta, S., Ata, K., Roby, G. A., Kovacs, C. M., Follmann, D. A., Pende, D., Ward, J. P., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000101 · Cited by 114 · see citing works
Self-citationScheerens, H., Hessel, E. M., Malefyt, R. D. W., Leach, M. W., & Rennick, D. M. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200105)31:5 · Cited by 104 · see citing works
Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress InVitro and In Vivo
Zimmerman, E. S., Sherman, M. P., Blackett, J. L., Neidleman, J. A., Kreis, C., Mundt, P., Williams, S. A., Warmerdam, M. T., Kahn, J. O., Hecht, F. M., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01212-06 · Cited by 102 · see citing works
Self-citationRetraction Notice:Pathogenesis of Macrophage Tropic HIV-1
Gorry, P. R., Churchill, M. J., Crowe, S. M., Cunningham, A. L., & Gabuzda, D. H. (2005) · Current HIV Research · doi:10.2174/1570162052772951 · Cited by 102 · see citing works
Schüler, W., Wecker, K., de ROCQUIGNY, H., Baudat, Y., Sire, J., & Roques, B. P. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2381 · Cited by 100 · see citing works
Ghorpade, A., Nukuna, A., Che, M., Haggerty, S., Persidsky, Y., Carter, E., Carhart, L., Shafer, L. R., & Gendelman, H. E. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3340-3350.1998 · Cited by 100 · see citing works
Gene acquisition in HIV and SIV
Sharp, P. M., Bailes, E., Stevenson, M., Emerman, M., & Hahn, B. H. (1996) · Nature · doi:10.1038/383586a0 · Cited by 98 · see citing works
Kaushik, R., Zhu, X., Stránská, R., Wu, Y., & Stevenson, M. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.022 · Cited by 95 · see citing works
Schwartz, S., Felber, B. K., & Pavlakis, G. N. (1991) · Virology · doi:10.1016/0042-6822(91)90996-o · Cited by 92 · see citing works
Jacquot, G., Rouzic, E. L., David, A., Mazzolini, J., Bouchet, J., Bouaziz, S., Niedergang, F., Pancino, G., & Bénichou, S. (2007) · Retrovirology · doi:10.1186/1742-4690-4-84 · Cited by 89 · see citing works
HIV-1 Vpr Displays Natural Protein-Transducing Properties: Implications for Viral Pathogenesis
Sherman, M. P., Schubert, U., Williams, S. A., de Noronha, C. M. C., Kreisberg, J. F., Henklein, P., & Greene, W. C. (2002) · Virology · doi:10.1006/viro.2002.1576 · Cited by 89 · see citing works
Zhu, Y., Gelbard, H. A., Roshal, M., Pursell, S., Jamieson, B. D., & Planelles, V. (2001) · Journal of Virology · doi:10.1128/jvi.75.8.3791-3801.2001 · Cited by 86 · see citing works
Self-citationFujita, M., Otsuka, M., Miyoshi, M., Khamsri, B., Nomaguchi, M., & Adachi, A. (2008) · Journal of Virology · doi:10.1128/jvi.01003-07 · Cited by 84 · see citing works
Poon, B., Jowett, J. B. M., Stewart, S. A., Armstrong, R. W., Rishton, G. M., & Chen, I. S. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.3961-3971.1997 · Cited by 79 · see citing works
Roles of p53 and Caspases in the Induction of Cell Cycle Arrest and Apoptosis by HIV-1 vpr
Shostak, L. D., Ludlow, J. W., Fisk, J., Pursell, S., Rimel, B. J., Nguyen, D. X., Rosenblatt, J. D., & Planelles, V. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4568 · Cited by 69 · see citing works
Self-citationVprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation
Huang, J., & Chen, J. (2008) · Oncogene · doi:10.1038/onc.2008.44 · Cited by 68 · see citing works
Pancio, H. A., Heyden, N. V., & Ratner, L. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.6162-6167.2000 · Cited by 68 · see citing works
Tungaturthi, P. K., Sawaya, B. E., SINGH, S. P., Tomkowicz, B. E., Ayyavoo, V., Khalili, K., Collman, R. G., Amini, S., & Srinivasan, A. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00328-1 · Cited by 65 · see citing works
Kichler, A., Pagès, J., Leborgne, C., Druillennec, S., Lenoir, C., Coulaud, D., Delain, E., Cam, É. L., Roques, B. P., & Danos, O. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5424-5431.2000 · Cited by 63 · see citing works
ATR and GADD45α mediate HIV-1 Vpr-induced apoptosis
Andersen, J. L., Zimmerman, E. S., DeHart, J. L., Murala, S., Ardon, O., Blackett, J. L., Chen, J., & Planelles, V. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401565 · Cited by 58 · see citing works
Self-citationCoeytaux, E., Coulaud, D., Cam, É. L., Danos, O., & Kichler, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300248200 · Cited by 57 · see citing works
Fritz, J. V., Didier, P., Clamme, J., Schaub, E., Muriaux, D. M., Cabanne, C., Morellet, N., Bouaziz, S., Darlix, J., Mély, Y., et al. (2008) · Retrovirology · doi:10.1186/1742-4690-5-87 · Cited by 52 · see citing works
Human Immunodeficiency Virus Type 1 Vpr Links Proteasomal Degradation and Checkpoint Activation
DeHart, J. L., & Planelles, V. (2007) · Journal of Virology · doi:10.1128/jvi.01628-07 · Cited by 49 · see citing works
Self-citationBelzile, J.-P., Richard, J., Rougeau, N., Xiao, Y., & Cohen, É. A. (2010) · Journal of Virology · doi:10.1128/jvi.02590-09 · Cited by 49 · see citing works
Wang, L., Mukherjee, S., Narayan, O., & Zhao, L. J. (1996) · Gene · doi:10.1016/0378-1119(96)00312-5 · Cited by 40 · see citing works
Yuan, H., Xie, Y., & Chen, I. S. Y. (2003) · Journal of Virology · doi:10.1128/jvi.77.3.2063-2070.2003 · Cited by 40 · see citing works
Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?
Jonjić, S., Polić, B., & Krmpotić, A. (2008) · European Journal of Immunology · doi:10.1002/eji.200838823 · Cited by 38 · see citing works
Vpr and Its Interactions with Cellular Proteins
Planelles, V., & Bénichou, S. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-02175-6_9 · Cited by 38 · see citing works
Self-citation
Flagged first, then by citations
1 of the 98 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
PROTAC targeted protein degraders: the past is prologue
Békés, M., Langley, D. R., & Crews, C. M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00371-6 · Cited by 3,395 · see citing works
HIV accessory proteins versus host restriction factors
Strebel, K. (2013) · Current Opinion in Virology · doi:10.1016/j.coviro.2013.08.004 · Cited by 133 · see citing works
Tao, Y., Remillard, D., Vinogradova, E. V., Yokoyama, M., Banchenko, S., Schwefel, D., Melillo, B. N., Schreiber, S. L., Zhang, X., & Cravatt, B. F. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c08964 · Cited by 125 · see citing works
Sharma, A., Yılmaz, A., Marsh, K., Cochrane, A., & Boris‐Lawrie, K. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002612 · Cited by 93 · see citing works
Abreu, C. M., Veenhuis, R. T., Avalos, C. R., Graham, S., Queen, S. E., Shirk, E. N., Bullock, B. T., Li, M., Pate, K. A. M., Beck, S. E., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00065-19 · Cited by 68 · see citing works
Evasion from NK cell-mediated immune responses by HIV-1
Jost, S., & Altfeld, M. A. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.05.001 · Cited by 63 · see citing works
HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus
Guerrero, S. X., Batisse, J., Libre, C., Bernacchi, S., Marquet, R., & Paillart, J. (2015) · Viruses · doi:10.3390/v7010199 · Cited by 61 · see citing works
Götz, N., Sauter, D., Usmani, S. M., Fritz, J. V., Goffinet, C., Heigele, A., Geyer, M., Bibollet‐Ruche, F., Learn, G. H., Fackler, O., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.07.008 · Cited by 35 · see citing works
Maudet, C., Sourisce, A., Dragin, L., Lahouassa, H., Rain, J., Bouaziz, S., Ramírez, B. C., & Margottin-Goguet, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077320 · Cited by 34 · see citing works
Viral proteins and Src family kinases: Mechanisms of pathogenicity from a “liaison dangereuse”
Pagano, M. A. (2013) · World Journal of Virology · doi:10.5501/wjv.v2.i2.71 · Cited by 27 · see citing works
HIV-1 Gag: An Emerging Target for Antiretroviral Therapy
Tedbury, P. R., & Freed, E. O. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_436 · Cited by 25 · see citing works
Mechanisms of Immune Evasion in HIV-1: The Role of Virus-Host Protein Interactions
Mouzakis, A., Petrakis, V., Tryfonopoulou, E., Panopoulou, M. I., Panagopoulos, P., & Chlichlia, K. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050367 · Cited by 23 · see citing works
Nomaguchi, M., Doi, N., Fujiwara, S., & Adachi, A. (2011) · InTech eBooks · doi:10.5772/23624 · Cited by 11 · see citing works
CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X
Dobransky, A., Root, M., Hafner, N., Marcum, M., & Sharifi, H. J. (2024) · Viruses · doi:10.3390/v16081313 · Cited by 9 · see citing works
Primate and feline lentiviruses in current intrinsic immunity research: The cat is back
Poeschla, E. M. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.06.014 · Cited by 7 · see citing works
Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
Plitnik, T., Sharkey, M. E., Mahboubi, B., Kim, B., & Stevenson, M. (2018) · Pathogens and Immunity · doi:10.20411/pai.v3i2.263 · Cited by 7 · see citing works
Damage control: how HIV survives the editor APOBEC3G
Croxford, J. L., & Gasser, S. (2011) · Nature Immunology · doi:10.1038/ni.2115 · Cited by 6 · see citing works
Applications and limitations of the passenger hypothesis for HIV reservoir persistence and cure
Schiffer, J. T., Mudd, J. C., Antar, A. A. R., Spivak, A. M., & Reeves, D. B. (2025) · Journal of Virology · doi:10.1128/jvi.00714-25 · Cited by 4 · see citing works
Lentiviral Vpx induces alteration of mammalian cell nuclear envelope integrity
Singh, S. P., Raja, S., & Mahalingam, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.018 · Cited by 3 · see citing works
Transcriptomic Analysis Reveals Key Pathways Influenced by HIV-2 Vpx
Szojka, Z. I., Kunkli, B., Kiarie, I. W., Linkner, T. R., Al-Muffti, A. S., Ahmad, H., Benkő, S., Jansson, M., Tőzsér, J., & Mahdi, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083460 · Cited by 1 · see citing works
de Meireles, C. A. B. (2016) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Interactions Between HIV-2 and Host Restriction Factors
Simpson, S., & Jallow, S. (2015) · Springer eBooks · doi:10.1007/978-1-4614-9610-6_41-1
Interactions Between HIV-2 and Host Restriction Factors
Simpson, S., & Jallow, S. (2016) · Springer eBooks · doi:10.1007/978-1-4614-9610-6_41-2
Interactions Between HIV-2 and Host Restriction Factors
Simpson, S., & Jallow, S. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7101-5_41
HIV-2 infection in human primary macrophages
Gea‐Mallorquí, E. (2017) · doi:10.70675/69e93c68z9afez4049zb135z99055e99e275
- Authors
- Planelles, V., & Barker, E.
- Affiliations
- University of Utah (US)
- Rush University Medical Center (US)
- Corresponding author
- Planelles, Vicente
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 31
- Issue
- 5
- Pages
- 398-406
- ISSN
- 0098-2997 (ISSN-L)
- PMC
- PMC2967654
- OpenAlex
- W1967347754
- Cited by
- 26
- References
- 98
- Citations by year
- 2025: 3 · 2024: 1 · 2022: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 3 · 2012: 3
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI087508, AI 52809, R56AI049057, AI 49057, R01AI049057, R03AI052809, AI56923, R21AI056923, R01AI065361)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- Vpr, Vpx, HIV-1, simian immunodeficiency virus, human immunodeficiency virus, viral replication, host cell modulation, host-virus interaction, small open reading frames
- MeSH terms
- Cell Cycle, DNA Damage, Humans, Simian Immunodeficiency Virus, Apoptosis, vpr Gene Products, Human Immunodeficiency Virus, Viral Regulatory and Accessory Proteins, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review