The DOI matches its Crossref record; 163 of the 164 references it cites were found in a registry or an index.
Flavonols and cardiovascular disease
Abstract
Flavonols, and specially quercetin, are widely distributed in plants and are present in considerable amounts in fruits and vegetables. In addition to their anti-oxidant effect, flavonols interfere with a large number of biochemical signaling pathways and, therefore, physiological and pathological processes. There is solid evidence that, in vitro, quercetin and related flavonols exert endothelium-independent vasodilator effects, protective effect on nitric oxide and endothelial function under conditions of oxidative stress, platelet antiaggregant effects, inhibition of LDL oxidation, reduction of adhesion molecules and other inflammatory markers and prevention of neuronal oxidative and inflammatory damage. The metabolites of quercetin show partial protective effects on endothelial function and LDL oxidation. Quercetin produces undisputed antihypertensive and antiatherogenic effects, prevents endothelial dysfunction and protects the myocardium from ischemic damage. It has no clear effects on serum lipid profile and on insulin resistance. Human intervention trials with isolated flavonols demonstrate an antihypertensive effect. The meta-analysis of epidemiological studies show an inverse association between flavonol (together with flavone) intake and coronary heart disease and stroke. Therefore, although there is no solid proof yet, a substantial body of evidence suggests that quercetin may prevent the most common forms of cardiovascular disease contributing to the protective effects afforded by fruits and vegetables.
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“The results of our 7 d study, the 10 d study described above (20) and a 15 d study by Vanhatalo et al. (34) suggest that HN vegetables do not induce tolerance, which is a potential advantage over the therapeutic use of organic nitrates (26) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [34]
In the citing paper
“Some observational studies evaluating total or selected dietary flavonoids observe lower risk of cardiometabolic events;299, 300 no long-term clinical trials have been performed.”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [299]
Citations
Cites
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Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
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“However the quercetin metabolites, quercetin 30-sulfate, quercetin 3-glucuronide and 30-methylquercetin 3-glucuronide were almost without effect (Tribolo et al., 2008; Winterbone et al., 2009).”
BackgroundKim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652
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1 of the 164 references couldn’t be matched to a known paper.
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Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
RETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D’Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 743
RetractedBioactive compounds in banana and their associated health benefits – A review
Singh, B., Singh, J. P., Kaur, A., & Singh, N. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.03.033 · Cited by 531
Therapeutic potential of quercetin as a cardiovascular agent
Patel, R. V., Mistry, B. M., Shinde, S. K., Syed, R., Singh, V., & Shin, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.06.053 · Cited by 506
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396
“Indeed, a range of pharmacological effects have been demonstrated for different phenolic compounds—especially flavonoids—through in vitro, ex vivo and animal assays [8, 9].”
Background
Metadata
- Authors
- Perez-Vizcaino, F., & Duarte, J.
- Affiliations
- Universidad de Granada (ES)
- ORCID
- Duarte, Juan
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 31
- Issue
- 6
- Pages
- 478-494
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2088383365
- Cited by
- 393
- References
- 164
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 23 · 2023: 21 · 2022: 33 · 2021: 26 · 2020: 18 · 2019: 20 · 2018: 29 · 2017: 16 · 2016: 32 · 2015: 34 · 2014: 30 · 2013: 30 · 2012: 31
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Spanish Ministerio de Ciencia y Tecnología (AGL2007-66108, SAF2008-03948, Red HERACLES RD06/0009)
- Junta de Andalucía (P06-CTS-01555)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- flavonols, quercetin, cardiovascular disease, endothelial function, nitric oxide, oxidative stress, platelet aggregation, LDL oxidation, inflammation, antihypertensive effect, atherosclerosis, coronary artery disease, stroke, flavonoid metabolites, fruits and vegetables, antioxidant activity
- MeSH terms
- Animals, Antioxidants, Cardiovascular Diseases, Endothelium, Vascular, Humans, Muscle, Smooth, Vascular, Quercetin, Oxidative Stress, Flavonols
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