Cited by 393Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchNutritional Studies and Diet

The DOI matches its Crossref record; 163 of the 164 references it cites were found in a registry or an index.

Flavonols and cardiovascular disease

Perez-Vizcaino, Francisco, Duarte, Juan·2010·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2010.09.002

Open this paper in CoChat — free account

Abstract

Flavonols, and specially quercetin, are widely distributed in plants and are present in considerable amounts in fruits and vegetables. In addition to their anti-oxidant effect, flavonols interfere with a large number of biochemical signaling pathways and, therefore, physiological and pathological processes. There is solid evidence that, in vitro, quercetin and related flavonols exert endothelium-independent vasodilator effects, protective effect on nitric oxide and endothelial function under conditions of oxidative stress, platelet antiaggregant effects, inhibition of LDL oxidation, reduction of adhesion molecules and other inflammatory markers and prevention of neuronal oxidative and inflammatory damage. The metabolites of quercetin show partial protective effects on endothelial function and LDL oxidation. Quercetin produces undisputed antihypertensive and antiatherogenic effects, prevents endothelial dysfunction and protects the myocardium from ischemic damage. It has no clear effects on serum lipid profile and on insulin resistance. Human intervention trials with isolated flavonols demonstrate an antihypertensive effect. The meta-analysis of epidemiological studies show an inverse association between flavonol (together with flavone) intake and coronary heart disease and stroke. Therefore, although there is no solid proof yet, a substantial body of evidence suggests that quercetin may prevent the most common forms of cardiovascular disease contributing to the protective effects afforded by fruits and vegetables.

Integrity signals

Registry

Crossref · 10.1016/j.mam.2010.09.002

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,589
Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
(2003) · The Lancet · doi:10.1016/s0140-6736(03)14739-3 · Cited by 2,402
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 1×
“However the quercetin metabolites, quercetin 30-sulfate, quercetin 3-glucuronide and 30-methylquercetin 3-glucuronide were almost without effect (Tribolo et al., 2008; Winterbone et al., 2009).”
Background
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms
Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652
Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine
Frankel, E. N., German, J. B., Kinsella, J. E., Parks, E. J., & Kanner, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)90206-v · Cited by 1,651
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Hollman, P. C. H., de Vries, J., van Leeuwen, S., Mengelers, M. J. B., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1276 · Cited by 956
Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke: The Zutphen Study
Keli, S., Hertog, M. G., Feskens, E., & Kromhout, D. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440060059007 · Cited by 914
SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881
Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and ?-cell damage in rat pancreas
COSKUN, O., Kanter, M., Korkmaz, A., & Öter, Ş. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2004.06.002 · Cited by 824
Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study
Keli, S. O. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.6.637 · Cited by 781
Business Information
Rodbard, H. W., Blonde, L., Ss, B., Brett, E. M., Cobin, R. H., Handelsman, Y., Hellman, R., Jellinger, P. S., Jovanovic, L. G., Levy, P., et al. (2007) · Endocrine Practice · doi:10.4158/ep.13.s1.1 · Cited by 694
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
Aviram, M., Rosenblat, M., Billecke, S. S., Erogul, J., Sorenson, R. C., Bisgaier, C. L., Newton, R. S., & Du, B. L. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00272-x · Cited by 596
Reduced Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice Following Consumption of Red Wine, or Its Polyphenols Quercetin or Catechin, Is Associated With Reduced Susceptibility of LDL to Oxidation and Aggregation
Hayek, T., Fuhrman, B., Vaya, J., Rosenblat, M., Belinky, P. A., Coleman, R., Elis, A., & Aviram, M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2744 · Cited by 552
Quercetin Reduces Blood Pressure in Hypertensive Subjects1,
Edwards, R. L., Lyon, T., Litwin, S. E., Rabovsky, A. B., Symons, J. D., & Jalili, T. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2405 · Cited by 551
Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179
Montagnani, M., Chen, H., Barr, V. A., & Quon, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103702200 · Cited by 541
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Ahn, J., Lee, H., Kim, S., Park, J., & Ha, T. Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.077 · Cited by 524
How should we assess the effects of exposure to dietary polyphenols in vitro?
Kroon, P. A., Clifford, M. N., Crozier, A., Day, A. J., Donovan, J. L., Manach, C., & Williamson, G. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.1.15 · Cited by 507
Comparative Evaluation of Quercetin, Isoquercetin and Rutin as Inhibitors of α-Glucosidase
Li, Y. Q., Zhou, F. C., Gao, F., Bian, J. S., & Shan, F. F. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903083h · Cited by 498
Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., & Galisteo, M. (2008) · Obesity · doi:10.1038/oby.2008.315 · Cited by 473
Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats
Duarte, J., Pérez‐Palencia, R., Vargas, F., Ocete, M. A., Pérez‐Vizcaíno, F., Zarzuelo, A., & Tamargo, J. L. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704064 · Cited by 464
Self-citation
Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
Zbarsky, V., Datla, K. P., Parkar, S., Rai, D. K., Aruoma, O. I., & Dexter, D. T. (2005) · Free Radical Research · doi:10.1080/10715760500233113 · Cited by 462
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids
Kwon, O., Eck, P., Chen, S., Corpe, C. P., Lee, J., Kruhlak, M. J., & Levine, M. N. (2006) · The FASEB Journal · doi:10.1096/fj.06-6620com · Cited by 450
Inhibition of Pro-inflammatory Markers in Primary Bone Marrow-Derived Mouse Macrophages by Naturally Occurring Flavonoids: Analysis of the Structure-Activity Relationship
Comalada, M., Ballester, I., Bailón, E., Sierra, S., Xaus, J., Gálvez, J., Medina, F. S. D., & Zarzuelo, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.016 · Cited by 440
Dietary Flavonoid Intake and Risk of Cardiovascular Disease in Postmenopausal Women
Yochum, L., Kushi, L. H., Meyer, K., & Folsom, A. R. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009738 · Cited by 436
On the mechanism of antithrombotic action of flavonoids
Gryglewski, R. J., Korbut, R., Robak, J., & Świȩs, J. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90288-7 · Cited by 418
Endothelium-dependent vasorelaxing activity of wine and other grape products
Fitzpatrick, D. F., HIRSCHFIELD, S. L., & Coffey, R. G. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.2.h774 · Cited by 414
Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis
Song, Y., Manson, J. E., Buring, J. E., Sesso, H. D., & Liu, S. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719488 · Cited by 389
The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies
Huxley, R., & Neil, H. A. W. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601624 · Cited by 386
Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
Loke, W. M., Hodgson, J. M., Proudfoot, J. M., McKinley, A. J., Puddey, I. B., & Croft, K. D. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1018 · Cited by 372
The metabolic syndrome: role of skeletal muscle metabolism.
Stump, C. S., Henriksen, E. J., Wei, Y., & Sowers, J. R. (2006) · Annals of Medicine · doi:10.1080/07853890600888413 · Cited by 362
Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity
Fang, X., Gao, J., & Zhu, D. (2008) · Life Sciences · doi:10.1016/j.lfs.2007.12.021 · Cited by 349
Apical GLUT2
Kellett, G. L., & Brot‐Laroche, E. (2005) · Diabetes · doi:10.2337/diabetes.54.10.3056 · Cited by 348
Supplementation with Quercetin Markedly Increases Plasma Quercetin Concentration without Effect on Selected Risk Factors for Heart Disease in Healthy Subjects
Conquer, J. A., Maiani, G., Azzini, E., Raguzzini, A., & Holub, B. J. (1998) · Journal of Nutrition · doi:10.1093/jn/128.3.593 · Cited by 332
EDHF: an update
Félétou, M., & Vanhoutte, P. M. (2009) · Clinical Science · doi:10.1042/cs20090096 · Cited by 331
Quercetin Decreases Oxidative Stress, NF-κB Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats
Dias, A. S., Porawski, M., Alonso-Chamorro, M., Marroni, N. P., Collado, P. S., & González‐Gallego, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2299 · Cited by 322
Antihypertensive effects of the flavonoid quercetin
Pérez‐Vizcaíno, F., Duarte, J., Jiménez, R., Santos‐Buelga, C., & Osuna, A. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70008-8 · Cited by 317
Self-citation
Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats
Sánchez, M., Galisteo, M., Vera, R., Villar, I. C., Zarzuelo, A., Tamargo, J. L., Pérez‐Vizcaíno, F., & Duarte, J. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000198029.22472.d9 · Cited by 315
Self-citation
Vitamin P: Flavonols as Vitamins
Rusznyák, S., & Szent‐Györgyi, A. (1936) · Nature · doi:10.1038/138027a0 · Cited by 312
Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships
Duarte, J., Pérez‐Vizcaíno, F., Utrilla, P., Jiménez, J., Tamargo, J. L., & Zarzuelo, A. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90159-u · Cited by 309
Self-citation
Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries
Kawai, Y., Nishikawa, T., Shiba, Y., Saito, S., Murota, K., Shibata, N., Kobayashi, M., Kanayama, M., Uchida, K., & Terao, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706571200 · Cited by 302
Effect of AMPK activation on muscle glucose metabolism in conscious rats
Bergeron, R., Russell, R. R., Young, L. H., Ren, J., Marcucci, M., Lee, A., & Shulman, G. I. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e938 · Cited by 301
Pathophysiology of insulin resistance
Sesti, G. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.09.007 · Cited by 297
Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor
Huang, Y. ‐., Hwang, J. ‐., Lee, P.-P. H., Ke, F. ‐., Huang, J. ‐., Huang, C. ‐., Kandaswami, C. C., Middleton, E., & Lee, M. ‐. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702879 · Cited by 287
Moving together: K+ channel openersand ATP-sensitive K+ channels
Quast, U., & Cook, N. S. (1989) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(89)80003-3 · Cited by 284
Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E–Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction
Loke, W. M., Proudfoot, J. M., Hodgson, J. M., McKinley, A. J., Hime, N. J., Magat, M., Stocker, R., & Croft, K. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.199687 · Cited by 284
Natural Dietary Polyphenolic Compounds Cause Endothelium-Dependent Vasorelaxation in Rat Thoracic Aorta
Andriambeloson, E., Magnier, C., Haan-Archipoff, G., Lobstein, A., Anton, R., Beretz, A., Stoclet, J., & Andriantsitohaina, R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2324 · Cited by 284
Minireview: Recent Developments in the Regulation of Glucose Transporter-4 Traffic: New Signals, Locations, and Partners
Ishiki, M., & Klip, A. (2005) · Endocrinology · doi:10.1210/en.2005-0850 · Cited by 281
Hypoxia decreases insulin signaling pathways in adipocytes.
Regazzetti, C., Peraldi, P., Grémeaux, T., Najem-Lendom, R., Ben-Sahra, I., Cormont, M., Bost, F., Le Marchand-Brustel, Y., Tanti, J.-F., & Giorgetti-Peraldi, S. (2009) · Diabetes · doi:10.2337/db08-0457 · Cited by 281
Fruits, vegetables and coronary heart disease
Dauchet, L., Amouyel, P., & Dallongeville, J. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.131 · Cited by 270
Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study
Janssen, K., Mensink, R. P., Cox, F., Harryvan, J., Hovenier, R., Hollman, P. C. H., & Katan, M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.2.255 · Cited by 267
Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155
Boesch, C., Łoboda, A., Wagner, A. E., Stachurska, A., Józkowicz, A., Dulak, J., Döring, F., Wolffram, S., & Rimbach, G. H. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.02.008 · Cited by 263
Vasodilator effects of quercetin in isolated rat vascular smooth muscle
Duarte, J., Pérez‐Vizcaíno, F., Zarzuelo, A., Jiménez, J., & Tamargo, J. L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90968-n · Cited by 262
Self-citation
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta
Machha, A., Gilani, A. H., & Mustafa, M. R. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.06.039 · Cited by 262
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
Yang, J., Della‐Fera, M. A., Rayalam, S., Ambati, S., Hartzell, D. L., Park, H. J., & Baile, C. A. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.003 · Cited by 253
Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures
Mercer, L. D., Kelly, B. L., Horne, M. K., & Beart, P. M. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.09.018 · Cited by 241
Resveratrol and quercetin inhibit angiogenesis in vitro
Igura, K., Ohta, T., Kuroda, Y., & Kaji, K. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00443-8 · Cited by 227
Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids
Luo, H., Jiang, B., King, S. M., & Chen, Y. (2008) · Nutrition and Cancer · doi:10.1080/01635580802100851 · Cited by 225
SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., & Sunagawa, K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.166991 · Cited by 221
Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
Stewart, L. K., Soileau, J. L., Ribnicky, D., Wang, Z. Q., Raskin, I., Poulev, A., Majewski, M., Cefalu, W. T., & Gettys, T. W. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.003 · Cited by 220
Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes
Strobel, P., Allard, C., Pérez‐Acle, T., Calderón, R., Aldunate, R., & Leighton, F. (2005) · Biochemical Journal · doi:10.1042/bj20040703 · Cited by 219
Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols
Pérez‐Vizcaíno, F., Duarte, J., & Andriantsitohaina, R. (2006) · Free Radical Research · doi:10.1080/10715760600823128 · Cited by 218
Self-citation
Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea
Eid, H. M., Martineau, L. C., Saleem, A., Muhammad, A., Vallerand, D., Benhaddou-Andaloussi, A., Nistor, L., Afshar, A., Arnason, J. T., & Haddad, P. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900218 · Cited by 218
Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice
Kobori, M., Masumoto, S., Akimoto, Y., & Takahashi, Y. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800310 · Cited by 213
Modulation of interleukin-1β mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection
Sharma, V., Mishra, M., Ghosh, S., Tewari, R., Basu, A., Seth, P., & Sen, E. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.01.016 · Cited by 202
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells
Fryer, L. G. D., Foufelle, F., Barnes, K., Baldwin, S. A., Woods, A., & Carling, D. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630167 · Cited by 198
Micronised Purified Flavonoid Fraction
Lyseng-Williamson, K. A., & Perry, C. M. (2003) · Drugs · doi:10.2165/00003495-200363010-00005 · Cited by 197
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
Kobuchi, H., Roy, S., Sen, C. K., Nguyen, H. G., & Packer, L. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.3.c403 · Cited by 197
Serum Lipid and Blood Pressure Responses to Quercetin Vary in Overweight Patients by Apolipoprotein E Genotype
Egert, S., Boesch, C., Wolffram, S., Rimbach, G. H., & Müller, M. J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.117655 · Cited by 194
Endothelium-Independent Vasodilator Effects of the Flavonoid Quercetin and Its Methylated Metabolites in Rat Conductance and Resistance Arteries
Pérez‐Vizcaíno, F., Ibarra, M., Cogolludo, A. L., Duarte, J., Zaragozá‐Arnáez, F., Moreno, L., López‐López, G., & Tamargo, J. L. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.66 · Cited by 191
Self-citation
Tissue Distribution of Quercetin in Pigs after Long-Term Dietary Supplementation
Bieger, J., Cermak, R., Blank, R., de Boer, V. C. J., Hollman, P. C. H., Kamphues, J., & Wolffram, S. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1417 · Cited by 187
Altered body composition and metabolism in the male offspring of high fat–fed rats
Buckley, A., Keserü, B., BRIODY, J. N., Thompson, M., Ozanne, S. E., & Thompson, C. H. (2005) · Metabolism · doi:10.1016/j.metabol.2004.11.003 · Cited by 186
Cardiovascular endothelins: Essential regulators of cardiovascular homeostasis
Brünner, F., Brás‐Silva, C., Cerdeira, A. S., & Leite-Moreira, A. F. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.001 · Cited by 181
Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines
Nègre‐Salvayre, A., & Salvayre, R. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90002-x · Cited by 180
Quercetin from Shallots (Allium cepa L. var.aggregatum) Is More Bioavailable Than Its Glucosides , ,3
Wiczkowski, W., Romaszko, J., Buciński, A., Szawara‐Nowak, D., Honke, J., Zieliński, H., & Piskuła, M. K. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.885 · Cited by 176
Quercetin intake and the incidence of cerebrovascular disease
Knekt, P., Isotupa, S., Rissanen, H. A., Heliövaara, M., Järvinen, R., Häkkinen, S. H., Aromaa, A., & Reunanen, A. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600974 · Cited by 175
Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9
Moon, S., Cho, G.-O., Jung, S.-Y., Gal, S.-W., Kwon, T. K., Lee, Y., Madamanchi, N. R., & Kim, C. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00091-3 · Cited by 175
Endothelium‐derived factors and hyperpolarization of the carotid artery of the guinea‐pig
Corriu, C., Félétou, M., Canet, E., & Vanhoutte, P. M. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15765.x · Cited by 172
A flavonoid‐rich diet increases nitric oxide production in rat aorta
Benito, S., Lopez, D., Sáiz, M. P., Buxaderas, S., Sánchez, J., Puig‐Parellada, P., & Mitjavila, M. T. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704534 · Cited by 164
Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43
Pietsch, K., Saul, N., Menzel, R., Stürzenbaum, S. R., & Steinberg, C. E. W. (2008) · Biogerontology · doi:10.1007/s10522-008-9199-6 · Cited by 164
Cell culture protection andin vivo neuroprotective capacity of flavonoids
Dajas, F., Rivera, F., Blasina, F., Arredondo, F., Echeverry, C., Lafon-Hughes, L., Morquio, A., & Heinzen, H. (2003) · Neurotoxicity Research · doi:10.1007/bf03033172 · Cited by 163
Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
Suchankova, G., Nelson, L. E., Gerhart-Hines, Z., Kelly, M., Gauthier, M.-S., Saha, A. K., Ido, Y., Puigserver, P., & Ruderman, N. B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.130 · Cited by 162
Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion
SHUTENKO, Z., Henry, Y. A., Pinard, E., Seylaz, J., Potìer, P., Berthet, F.-X., Girard, P., & Sercombe, R. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00296-2 · Cited by 161
Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia
Cho, J.-Y., Kim, I.-S., Jang, Y., Kim, A.-R., & Lee, S. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.010 · Cited by 155
Polyphenols in Cerebral Ischemia: Novel Targets for Neuroprotection
Simonyi, Á., Wang, Q., Miller, R. L., Yusof, M., Shelat, P. B., Sun, A. Y., & Sun, G. Y. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:135 · Cited by 154
Correlation between antiangiogenic activity and antioxidant activity of various components from propolis
Ahn, M., Kunimasa, K., Kumazawa, S., Nakayama, T., Kaji, K., Uto, Y., Hori, H., Nagasawa, H., & Ohta, T. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800021 · Cited by 151
Dietary Flavonol Intake May Lower Stroke Risk in Men and Women ,
Hollman, P. C. H., Geelen, A., & Kromhout, D. (2010) · Journal of Nutrition · doi:10.3945/jn.109.116632 · Cited by 151
Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats
Duarte, J., Jiménez, R., O’Valle, F., Galisteo, M., Pérez‐Palencia, R., Vargas, F., Pérez‐Vizcaíno, F., Zarzuelo, A., & Tamargo, J. L. (2002) · Journal of Hypertension · doi:10.1097/00004872-200209000-00031 · Cited by 150
Self-citation
Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats
Annapurna, A., Challa, S. R., Akondi, B. R., & Rao, S. R. C. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp/61.10.0014 · Cited by 149
Quercetin Increases Oxidative Stress Resistance and Longevity in Saccharomyces cerevisiae
Belinha, I., Amorim, M. A., Rodrigues, P., de Freitas, V. A. P., Moradas‐Ferreira, P., Mateus, N. F. D. C. B., & Costa, V. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf063302e · Cited by 146
Dietary Wine Phenolics Catechin, Quercetin, and Resveratrol Efficiently Protect Hypercholesterolemic Hamsters against Aortic Fatty Streak Accumulation
Auger, C., Teissèdre, P., Gérain, P., Lequeux, N., Bornet, A., Serisier, S., Besançon, P., Caporiccio, B., Cristol, J., & Rouanet, J. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048177q · Cited by 144
Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC
Romero, M., Jiménez, R., Sánchez, M., López-Sepúlveda, R., Zarzuelo-Romero, M. J., O’Valle, F., Zarzuelo, A., Pérez‐Vizcaíno, F., & Duarte, J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.03.007 · Cited by 142
Self-citation
SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis
Ota, H., Eto, M., Ogawa, S., Iijima, K., Akishita, M., & Ouchi, Y. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.3525 · Cited by 140
Antihypertensive Effect of Quercetin in Rats Fed with a High-Fat High-Sucrose Diet
Yamamoto, Y., & Eriko, O. U. E. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.933 · Cited by 139
High–saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice
Liang, C., Decourcy, K. R., & Prater, M. R. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.015 · Cited by 136
Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells
Tribolo, S., Lodi, F., Connor, C., Suri, S., Wilson, V. G., Taylor, M. A., Needs, P. W., Kroon, P. A., & Hughes, D. A. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.07.040 · Cited by 131
Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: Structure-activity relationships
Beretz, A., Cazenave, J., & Anton, R. (1982) · Inflammation Research · doi:10.1007/bf01965408 · Cited by 129
Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C‐dependent NADPH oxidase activation: effect on platelet recruitment
Pignatelli, P., Santo, S. D., Buchetti, B., Sanguigni, V., Brunelli, A., & Violi, F. (2006) · The FASEB Journal · doi:10.1096/fj.05-5269com · Cited by 127
Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels
Khoo, N. K. H., White, C. R., Pozzo‐Miller, L. D., Zhou, F., Constance, C., Inoue, T., Patel, R. P., & Parks, D. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.022 · Cited by 123
Protective Effect of Flavonoids against Aging- and Lipopolysaccharide-Induced Cognitive Impairment in Mice
Patil, C. S., Singh, V. P., Satyanarayan, P. S. V., Jain, N., Singh, À., & Kulkarni, S. K. (2003) · Pharmacology · doi:10.1159/000072357 · Cited by 123
Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit
Kamada, C., da Silva, E. L., Ohnishi‐Kameyama, M., Moon, J., & Terao, J. (2005) · Free Radical Research · doi:10.1080/10715760400019638 · Cited by 123
Spontaneously Hypertensive Rats
Meneses, A., & Hong, E. (1998) · Hypertension · doi:10.1161/01.hyp.31.4.968 · Cited by 122
Intrauterine exposure to high saturated fat diet elevates risk of adult‐onset chronic diseases in C57BL/6 mice
Liang, C., Oest, M. E., & Prater, M. R. (2009) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20206 · Cited by 121
Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats
Annapurna, A., Reddy, C. S., Akondi, B. R., & Rao, S. R. C. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.10.0014 · Cited by 121
Effects of chronic quercetin treatment in experimental renovascular hypertension
Garc�a-Saura, M. F., Galisteo, M., Villar, I. C., Bermejo, A., Zarzuelo, A., Vargas, F., & Duarte, J. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-4503-0 · Cited by 120
Self-citation
Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells
Bast, A., Wolf, G., Oberbäumer, I., & Walther, R. (2002) · Diabetologia · doi:10.1007/s00125-002-0846-1 · Cited by 119
A structural basis for the inhibition of collagen‐stimulated platelet function by quercetin and structurally related flavonoids
Wright, B., Moraes, L. A., Kemp, C. F., Mullen, W., Crozier, A., Lovegrove, J. A., & Gibbins, J. M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00632.x · Cited by 118
Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway
Yoshizumi, M., Tsuchiya, K., Suzaki, Y., Kirima, K., Kyaw, M. H., Moon, J., Terao, J., & Tamaki, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00407-2 · Cited by 118
Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia
Kao, T.-K., Ou, Y., Raung, S., Lai, C.-Y., Liao, S., & Chen, C. (2010) · Life Sciences · doi:10.1016/j.lfs.2009.12.014 · Cited by 116
Quercetin and Isorhamnetin Prevent Endothelial Dysfunction, Superoxide Production, and Overexpression of p47phox Induced by Angiotensin II in Rat Aorta
Sánchez, M., Lodi, F., Vera, R., Villar, I. C., Cogolludo, A. L., Jiménez, R., Moreno, L., Romero, M., Tamargo, J. L., Pérez‐Vizcaíno, F., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.910 · Cited by 116
Self-citation
Flavonoid inhibition of the human neutrophil NADPH-oxidase
Tauber, A. I., Fay, J. R., & Marletta, M. A. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90194-1 · Cited by 115
Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta
Lodi, F., Jiménez, R., Moreno, L., Kroon, P. A., Needs, P. W., Hughes, D. A., Santos‐Buelga, C., Paramás, A. M. G., Cogolludo, A. L., López-Sepúlveda, R., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.007 · Cited by 115
Self-citation
Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells
Nomura, M., Takahashi, T., Nagata, N., Tsutsumi, K., Kobayashi, S., Akiba, T., Yokogawa, K., Moritani, S., & Miyamoto, K. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1403 · Cited by 111
Quercetin-Supplemented Diets Lower Blood Pressure and Attenuate Cardiac Hypertrophy in Rats With Aortic Constriction
Jalili, T., Carlstrom, J., Kim, S. Y., Freeman, D. J., Jin, H., Wu, T., Litwin, S. E., & Symons, J. D. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000211746.78454.50 · Cited by 111
Quercetin Modulates NF-κ B and AP-1/JNK Pathways to Induce Cell Death in Human Hepatoma Cells
Granado‐Serrano, A. B., Martín, M. Á., Bravo, L., Goya, L., & Ramos, S. (2010) · Nutrition and Cancer · doi:10.1080/01635580903441196 · Cited by 107
Relationship Between Blood Pressure, Plasma Insulin ana Triglyceride Concentration, and Insulin Action in Spontaneous Hypertensive and Wistar-Kyoto Rats
Reaven, G. M., & Chang, H. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.1.34 · Cited by 103
Quercetin, kaempferol and biapigenin fromhypericum perforatum are neuroprotective against excitotoxic insults
Silva, B., Oliveira, P. J., Dias, A. C. P., & Malva, J. O. (2008) · Neurotoxicity Research · doi:10.1007/bf03033510 · Cited by 101
Nitric Oxide (NO) Scavenging and NO Protecting Effects of Quercetin and Their Biological Significance in Vascular Smooth Muscle
López‐López, G., Moreno, L., Cogolludo, A. L., Galisteo, M., Ibarra, M., Duarte, J., Lodi, F., Tamargo, J. L., & Pérez‐Vizcaíno, F. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.851 · Cited by 97
Self-citation
The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation
Cogolludo, A. L., Frazziano, G., Briones, A. M., Cobeño, L., Moreno, L., Lodi, F., Salaíces, M., Tamargo, J. L., & Pérez‐Vizcaíno, F. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.008 · Cited by 96
Nitric Oxide Formation and Corresponding Relaxation of Porcine Coronary Arteries Induced by Plant Phenols: Essential Structural Features
Taubert, D., Berkels, R., Klaus, W., & Roesen, R. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200211000-00008 · Cited by 95
Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin
Brookes, P. S., Digerness, S. B., Parks, D. A., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00839-0 · Cited by 93
Flavonoid modulation of human neutrophil function
Busse, W. W., Kopp, D. E., & Middleton, E. (1984) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(84)90450-0 · Cited by 93
Chronic Treatment with Flavonoids Prevents Endothelial Dysfunction in Spontaneously Hypertensive Rat Aorta
Machha, A., & Mustafa, M. R. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000162769.83324.c1 · Cited by 91
The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells
Pérez‐Vizcaíno, F., Bishop-Bailley, D., Lodi, F., Duarte, J., Cogolludo, A. L., Moreno, L., Boscá, L., Mitchell, J. A., & Warner, T. D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.198 · Cited by 80
Self-citation
Quercetin Inhibits eNOS, Microtubule Polymerization, and Mitotic Progression in Bovine Aortic Endothelial Cells
Jackson, S. J. T., & Venema, R. C. (2006) · Journal of Nutrition · doi:10.1093/jn/136.5.1178 · Cited by 78
The Antihypertensive Effects of Quercetin in a Salt-sensitive Model of Hypertension
Mackraj, I., Govender, T., & Ramesar, S. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318162011f · Cited by 76
Endothelial no release caused by red wine polyphenols.
Stoclet, J. C., Kleschyov, A. L., Andriambeloson, E., Diebolt, M., & Andriantsitohaina, R. (1999) · PubMed · Cited by 75
Effect of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats
Machha, A., Achike, F. I., Mustafa, A. M., & Mustafa, M. R. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.11.004 · Cited by 75
Effects of Quercetin on Gene and Protein Expression of NOX and NOS after Myocardial Ischemia and Reperfusion in Rabbit
Wan, L. L., Xia, J., Ye, D., Liu, J., Chen, J., & Wang, G. (2009) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2009.00071.x · Cited by 71
Pretreatment with Natural Flavones and Neuronal Cell Survival after Oxidative Stress: A Structure−Activity Relationship Study
Echeverry, C., Arredondo, F., Abin‐Carriquiry, J. A., Midiwo, J. O., Ochieng, C. O., Kerubo, L., & Dajas, F. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902951v · Cited by 69
Quercetin Exhibits a Specific Fluorescence in Cellular Milieu: A Valuable Tool for the Study of Its Intracellular Distribution
Nifli, A., Theodoropoulos, P. A., Munier, S., Castagnino, C., Roussakis, E., Katerinopoulos, H. E., Vercauteren, J., & Castanas, E. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0632637 · Cited by 68
Quercetin and its major metabolites selectively modulate cyclic GMP‐dependent relaxations and associated tolerance in pig isolated coronary artery
Suri, S., Liu, X.-H., Rayment, S. J., Hughes, D., Kroon, P. A., Needs, P. W., Taylor, M. A., Tribolo, S., & Wilson, V. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00556.x · Cited by 67
Quercetin up-regulates paraoxonase 1 gene expression with concomitant protection against LDL oxidation
Gong, M., Garige, M., Varatharajalu, R., Marmillot, P., Gottipati, C. S., Leckey, L. C., & Lakshman, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.015 · Cited by 65
Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat
Aoi, W., Niisato, N., Miyazaki, H., & Marunaka, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.150 · Cited by 64
[The efficacy of quercetin in alloxan diabetes].
Нуралиев, Ю. Н., & Avezov, G. A. (1993) · PubMed · Cited by 62
Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells
Winterbone, M. S., Tribolo, S., Needs, P. W., Kroon, P. A., & Hughes, D. A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.04.040 · Cited by 59
Effects of the Flavonoid Quercetin and its Methylated Metabolite Isorhamnetin in Isolated Arteries from Spontaneously Hypertensive Rats
Ibarra, M., Moreno, L., Vera, R., Cogolludo, A. L., Duarte, J., Tamargo, J. L., & Pérez‐Vizcaíno, F. (2003) · Planta Medica · doi:10.1055/s-2003-45144 · Cited by 58
Self-citation
Cardiovascular Effects of Isorhamnetin and Quercetin in Isolated Rat and Porcine Vascular Smooth Muscle and Isolated Rat Atria
Ibarra, M., Pérez‐Vizcaíno, F., Cogolludo, A. L., Duarte, J., Zaragozá‐Arnáez, F., López‐López, J. G., & Tamargo, J. L. (2002) · Planta Medica · doi:10.1055/s-2002-26752 · Cited by 58
Self-citation
Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells
Khan, N. Q., Lees, D. M., Douthwaite, J. A., CARRIER, M. J., & Corder, R. (2002) · Clinical Science · doi:10.1042/cs103s072s · Cited by 58
Role of superoxide dismutase in in vivo and in vitro nitrate tolerance
Münzel, T. F., Hink, U., Yigit, H., Macharzina, R. R., Harrison, D. G., & Mülsch, A. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702622 · Cited by 57
Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats
Rivera, F., Costa, G., Abin, A., Urbanavicius, J., Arruti, C., Casanova, G., & Dajas, F. (2008) · Neurotoxicity Research · doi:10.1007/bf03033562 · Cited by 57
Effects of Quercetin Treatment on Vascular Function in Deoxycorticosterone Acetate-Salt Hypertensive Rats. Comparative Study with Verapamil
Galisteo, M., Garcia-Saura, M. F., Jiménez, R., Villar, I. C., Wangensteen, R., Zarzuelo, A., Vargas, F., & Duarte, J. (2004) · Planta Medica · doi:10.1055/s-2004-818945 · Cited by 56
Self-citation
Vasorelaxant Effects of the Bioflavonoid Chrysin in Isolated Rat Aorta
Duarte, J., Jiménez, R., Villar, I. C., Pérez‐Vizcaíno, F., Jiménez, J., & Tamargo, J. L. (2001) · Planta Medica · doi:10.1055/s-2001-16492 · Cited by 55
Self-citation
Pretreatment with a combination of quercetin and α-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats
Punithavathi, V. R., & Prince, P. S. M. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.11.021 · Cited by 52
Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice
Motoyama, K., Koyama, H., Moriwaki, M., Emura, K., Okuyama, S., Sato, E. F., Inoue, M., Shioi, A., & Nishizawà, Y. (2008) · Nutrition · doi:10.1016/j.nut.2008.08.013 · Cited by 51
A Quercetin Supplemented Diet Does Not Prevent Cardiovascular Complications in Spontaneously Hypertensive Rats1
Carlstrom, J., Symons, J. D., Wu, T., Bruno, R. S., Litwin, S. E., & Jalili, T. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.628 · Cited by 51
Type 5 phosphodiesterase inhibition by sildenafil abrogates acute smoking-induced endothelial dysfunction
Vlachopoulos, C. V., Tsekoura, D., Alexopoulos, N. A., Panagiotakos, D. B., Aznaouridis, K., & Stefanadis, C. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.06.027 · Cited by 50
Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture
Zhao, X., Gu, Z., Attele, A. S., & Yuan, C. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(99)00055-0 · Cited by 50
Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats
Romero, M., Jiménez, R., Hurtado, B., Moreno, J. M., Rodríguez‐Gómez, I., López-Sepúlveda, R., Zarzuelo, A., Pérez‐Vizcaíno, F., Tamargo, J. L., Vargas, F., et al. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.11.006 · Cited by 38
Self-citation
Involvement of thromboxane A2 in the endothelium‐dependent contractions induced by myricetin in rat isolated aorta
Jiménez, R., Andriambeloson, E., Duarte, J., Andriantsitohaina, R., Jiménez, J., Pérez‐Vizcaíno, F., Zarzuelo, A., & Tamargo, J. L. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702694 · Cited by 30
Self-citation
Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation.
Lee-Hilz, Y. Y., Stolaki, M., van Berkel, W. V., Aarts, J., & Rietjens, I. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.02.010 · Cited by 28
Glucuronidated Metabolites of the Flavonoid Quercetin do not Auto-Oxidise, do not Generate Free Radicals and do not Decrease Nitric Oxide Bioavailability
Lodi, F., Jiménez, R., Menéndez, C., Needs, P. W., Duarte, J., & Pérez‐Vizcaíno, F. (2008) · Planta Medica · doi:10.1055/s-2008-1074525 · Cited by 25
Self-citation
Quercetin is bioavailable from a single ingestion of grape juice
Dávalos, A., Castilla, P., Gómez‐Cordovés, C., & Bartolomé, B. (2006) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480600858662 · Cited by 23
Term "Vitamin P" Recommended to be Discontinued
Vickery, H. B., Nelson, E. M., Almquist, H. J., & Elvehjem, C. A. (1950) · Science · doi:10.1126/science.112.2917.628 · Cited by 21
Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum
Jurkovičová, D., Kopáček, J., Štefánik, P., Kubovčáková, L., Zahradníková, A., Zahradníková, A., Pastoreková, S., & Križanová, O. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0214-6 · Cited by 20
Inhibition of the different cyclic nucleotide phosphodiesterase isoforms separated from rat brain by flavonoid compounds.
Picq, M., Dubois, M., Prigent, A., Némoz, G., & Pachéco, H. (1989) · PubMed · Cited by 11
Term "Vitamin P" Recommended to be Discontinued
Vickery, H. B., Nelson, E. M., Almquist, H. J., & Elvehjem, C. A. (1950) · Science · doi:10.1126/science.112.2917.628.a · Cited by 5

Flagged first, then by citations

1 of the 164 references couldn’t be matched to a known paper.

Sorted by citations

Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
RETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D’Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 743
Retracted
Bioactive compounds in banana and their associated health benefits – A review
Singh, B., Singh, J. P., Kaur, A., & Singh, N. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.03.033 · Cited by 531
Therapeutic potential of quercetin as a cardiovascular agent
Patel, R. V., Mistry, B. M., Shinde, S. K., Syed, R., Singh, V., & Shin, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.06.053 · Cited by 506
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396
“Indeed, a range of pharmacological effects have been demonstrated for different phenolic compounds—especially flavonoids—through in vitro, ex vivo and animal assays [8, 9].”
Background

See all 393

Authors: Perez-Vizcaino, F., & Duarte, J.
Affiliations: Universidad de Granada (ES)
ORCID: Duarte, Juan
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2010-12
Volume: 31
Issue: 6
Pages: 478-494
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2010.09.002
OpenAlex: W2088383365
Cited by: 393
References: 164
Citations by year: 2026: 11 · 2025: 23 · 2024: 23 · 2023: 21 · 2022: 33 · 2021: 26 · 2020: 18 · 2019: 20 · 2018: 29 · 2017: 16 · 2016: 32 · 2015: 34 · 2014: 30 · 2013: 30 · 2012: 31
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Spanish Ministerio de Ciencia y Tecnología (AGL2007-66108, SAF2008-03948, Red HERACLES RD06/0009)
Junta de Andalucía (P06-CTS-01555)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: flavonols, quercetin, cardiovascular disease, endothelial function, nitric oxide, oxidative stress, platelet aggregation, LDL oxidation, inflammation, antihypertensive effect, atherosclerosis, coronary artery disease, stroke, flavonoid metabolites, fruits and vegetables, antioxidant activity
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Endothelium, Vascular, Humans, Muscle, Smooth, Vascular, Quercetin, Oxidative Stress, Flavonols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Flavonols and cardiovascular disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks