The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
ROS signaling and ER stress in cardiovascular disease
Open accessAbstract
The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the extracellular space, including hormones and cytokines, as well as cell surface receptors and other proteins which interact with the environment. Accordingly, this organelle controls essentially all vital links to a cell’s external milieu, responding to systemic metabolic, inflammatory, endocrine, and mechanical stimuli. The central role the ER plays in meeting protein synthetic and quality control requirements in the face of such demands is matched by an extensive and versatile ER stress response signaling network. ROS mediate several critical aspects of this response. Nox4, an ER resident capable of producing ROS, acts as a proximal signaling intermediate to transduce ER stress-related conditions to the unfolded protein response, a homeostatic corrective mechanism. However, chronic ER stress caused by unrelenting internal or external demands produces a secondary rise in ROS, generally resulting in cell death. Sorting out the involvement of ROS at different levels of the ER stress response in specific cell types is key to understanding the molecular basis for chronic diseases such as atherosclerosis, hypertension, and diabetes. Here, we provide an overview of ER stress signaling with an emphasis on the role of ROS.
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Cites
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“While the source of ROS in this circumstance is unclear, catalase targeted to mitochondria afford protection from insulin resistance, consistent with this organelle being an important source of ROS as is the case with other causes of prolonged ER stress (Houstis et al. 2006).”
BackgroundÖzcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413
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Cited by
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Ren, J., Bi, Y., Sowers, J. R., Hetz, C., & Zhang, Y. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00511-w · Cited by 708
Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants
Cao, J., Wang, C., Hao, N., Fujiwara, T., & Wu, T. (2022) · Antioxidants · doi:10.3390/antiox11071240 · Cited by 58
Metadata
- Authors
- Ochoa, C. D., Wu, R. F., & Terada, L. S.
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 63
- Pages
- 18-29
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2790375319
- Cited by
- 325
- References
- 116
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ochoa, C. D., Wu, R. F., & Terada, L. S. (2018). ROS signaling and ER stress in cardiovascular disease. Molecular Aspects of Medicine. https://doi.org/10.1016/j.mam.2018.03.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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