Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants
Open accessAbstract
The endoplasmic reticulum (ER) is a key compartment responsible for protein processing and folding, and it also participates in many signal transduction and metabolic processes. Reactive oxygen species (ROS) are important signaling messengers involved in the redox equilibrium and stress response. A number of abiotic and biotic stresses can trigger the accumulation of unfolded or misfolded proteins and lead to ER stress. In recent years, a number of studies have reported that redox metabolism and ROS are closely related to ER stress. ER stress can benefit ROS generation and even cause oxidative burden in plants, finally leading to oxidative stress depending on the degree of ER stress. Moreover, ER stress activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated ROS signaling, increases antioxidant defense mechanisms, and alters the glutathione (GSH) redox state. Meanwhile, the accumulation of ROS plays a special role in inducing the ER stress response. Given these factors, plants have evolved a series of complex regulatory mechanisms to interact with ROS in response to ER stress. In this review, we summarize the perceptions and responses of plant ER stress and oxidative protein folding in the ER. In addition, we analyze the production and signaling of ROS under ER stress in detail in order to provide a theoretical basis for reducing ER stress to improve the crop survival rate in agricultural applications.
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The endoplasmic reticulum is a complex dynamic structure with functions including calcium storage, lipid metabolism, and protein synthesis.
“The endoplasmic reticulum (ER) is a complex dynamic structure possessing many functions in the cell, the most important ones include calcium storage, lipid metabolism, and protein synthesis (Cao et al. 2022).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Cao et al. 2022
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Cao, J., Wang, C., Hao, N., Fujiwara, T., & Wu, T.
- Affiliations
- Ministry of Agriculture and Rural Affairs (CN)
- The University of Tokyo (JP)
- Corresponding author
- Wu, Tao
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2022-06-24
- Volume
- 11
- Issue
- 7
- Pages
- 1240
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC9311536
- OpenAlex
- W4283457327
- Cited by
- 58
- References
- 93
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 18 · 2023: 10 · 2022: 2
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31972429, 31972407, 2021JJ10032, 2022JJ40164, 21B0180)
- Hunan Provincial Natural Science Foundation of China (31972429, 31972407, 2021JJ10032, 2022JJ40164, 21B0180)
- Youth Project of the Educational Department of Hunan Province (31972429, 31972407, 2021JJ10032, 2022JJ40164, 21B0180)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- endoplasmic reticulum stress, reactive oxygen species, oxidative stress, oxidative protein folding, NADPH oxidase, antioxidant defense, glutathione redox state, unfolded protein response, abiotic stress, biotic stress, plant stress response, redox signaling
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