The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Emerging roles of ECM remodeling processes in cancer
Abstract
Extracellular matrix (ECM) plays a central and dynamic role in the creation of tumor microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of ECM buildup and proteolysis in cancer niche formation. Dysregulated ECM remodeling by cancer cells facilitate irreversible proteolysis and crosslinking, which in turn influence cell signaling, micro environmental cues, angiogenesis and tissue biomechanics. Further, we introduce the emerging roles of cancer microbiome in aberrant tumor ECM remodeling and membrane bound nano-sized vesicles called exosomes in creation of distant pre-metastatic niches. A detailed molecular and biophysical understanding of the ECM morphologies and its components such as key enzymes, structural and signaling molecules is critical in successfully finding the next generation of therapeutic and diagnostic targets in cancer.
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1 retracted
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Cited by
Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373
Engineering extracellular matrix to improve drug delivery for cancer therapy
He, X., Yang, Y., Li, L., Zhang, P., Guo, H., Liu, N., Yang, X., & Xu, F. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.06.029 · Cited by 54
Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression
Moreira, A. M., Ferreira, R. M., Carneiro, P., Figueiredo, J., Osório, H., Barbosa, J., Preto, J., Pinto-do-Ó, P., Carneiro, F., & Seruca, R. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.818552 · Cited by 21
Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance
Ding, X., Liang, Y., Zhou, S., Wu, Y., Sałata, P., Mikolajczk-Martinez, A., Khosrawipour, V., & Zhang, Z. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113786 · Cited by 20
Metadata
- Authors
- Mohan, V., Das, A., & Sagi, I.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 62
- Pages
- 192-200
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W2973152655
- Cited by
- 334
- References
- 165
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
