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Cited by 28Bone Tissue Engineering MaterialsHydrogels: synthesis, properties, applicationsWound Healing and Treatments

Engineering mussel-inspired multifunctional nanocomposite hydrogels to orchestrate osteoimmune microenvironment and promote bone healing

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Wu, Minhao, Wang, Ye, Liu, Huifan, Chen, Feixiang, Zhang, Yufeng, Wu, Ping, Deng, Zhouming, Cai, Lin·2023·Materials & Design
DOI 10.1016/j.matdes.2023.111705
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Abstract

The reconstruction of large bone defects by bioactive materials without exogenous cells, cytokines or growth factors remains a substantial clinical challenge. Herein, we present the rational design of injectable and adhesive (GMAD/LP) hydrogels composed of gelatin-methacryloyl (GelMA), dopamine-grafted alginate (AD), and polydopamine-functionalized Laponite ([email protected]) nanosheets that can act as osteoimmune regulators to engineer the pro-regenerative microenvironment for personalized bone regeneration. The as-fabricated GMAD/LP hydrogel with excellent tissue adhesion, self-healing, injectability, and improved mechanical strength can fill irregular bone defects in a minimally invasive manner. Moreover, the hydrogel exhibited outstanding osteogenic potential and osteoimmunomodulatory functions in vitro, significantly promoting the adhesion, proliferation, spreading, and osteogenic differentiation of bone mesenchymal stem cells (BMSCs), which was further augmented by hydrogel-induced macrophage M2-phenotype polarization and effective M2 macrophage-BMSC crosstalk. In vivo experiments in a cranial defect model demonstrated that the GMAD/LP hydrogel induced a reparative microenvironment similar to that in normal cranium, as characterized by an increased percentage of anti-inflammatory M2 macrophages and endogenous stem cells and high-level neovascularization, consequently accelerating bone healing. This strategy not only achieves a bioactive hydrogel for bone defect reconst…

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  • The fascinating properties of mussel-inspired injectable hydrogels benefit their application in numerous biomedical fields, such as wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, and biological coatings.

    “Their fascinating properties benefit their application in numerous biomedical fields, such as wound closure and healing [36,37], hemostasis [38,39], bone repair [40,41], drug delivery [42,43], smart sensors [44], biological coatings [45], etc. (Figure 2).”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [40]

  • GMAD/LP hydrogel exhibits high tissue adhesiveness, robust mechanical strength, injectability, and self-healing abilities.

    “The GMAD/LP hydrogel exhibited high tissue adhesiveness, robust mechanical strength, injectability, and self-healing abilities.”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [40]

  • GMAD/LP hydrogel can serve as an osteoimmune regulator to promote bone regeneration.

    “It can serve as an osteoimmune regulator to promote bone regeneration [40].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [40]

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Authors
Wu, M., Wang, Y., Liu, H., Chen, F., Zhang, Y., Wu, P., Deng, Z., & Cai, L.
Affiliations
  • Zhongnan Hospital of Wuhan University (CN)
  • Ezhou Central Hospital (CN)
  • Wuhan University (CN)
  • Second Hospital of Tianjin Medical University (CN)
  • Huazhong University of Science and Technology (CN)
Corresponding author
  • Deng, Zhouming
  • Cai, Lin
ORCID
Venue
Materials & Design
Publisher
Elsevier BV
Published
2023-03
Volume
227
Pages
111705
ISSN
0264-1275 (ISSN-L)
DOI
10.1016/j.matdes.2023.111705
OpenAlex
W4319311040
Cited by
28
References
0
Citations by year
2026: 5 · 2025: 9 · 2024: 9 · 2023: 5
FWCI
2.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Materials & Design (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
mussel-inspired hydrogel, nanocomposite hydrogels, bone regeneration, bone defects, osteoimmunomodulation, macrophage M2 polarization, bone mesenchymal stem cells, gelatin methacryloyl, cranial defects, self-healing hydrogels, neovascularization

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