The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration
Open accessAbstract
Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and play important roles during bone development and fracture healing by supplying oxygen, nutrients, and cells. However, despite the successful development of bone mimetic materials that can replace damaged bone from a structural point of view, most of the available bone biomaterials often do not induce sufficient formation of blood vessels and nerves. In part, this is due to the difficulty of integrating and regulating multiple tissue types within artificial materials, which causes a gap between native skeletal tissue. Therefore, understanding the anatomy and underlying interaction mechanisms of blood vessels and nerve fibers in skeletal tissue is important to develop biomaterials that can recapitulate its complex microenvironment. In this perspective, we highlight the structure and osteogenic functions of the vascular and nervous system in bone, in a coupled manner. In addition, we discuss important design criteria for engineering vascularized, innervated, and neurovascularized bone implant materials, as well as recent advances in the development of such biomaterials. We expect that bone implant materials with neurovascularized networks can more accurately mimic native skeletal tissue and improve the regeneration of bone tissue.
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Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
Normal Bone Anatomy and Physiology
Clarke, B. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04151206 · Cited by 2,192
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13145 · Cited by 2,155
Common mechanisms of nerve and blood vessel wiring
Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085
Zhang, Y., Xu, J., Ruan, Y. C., Yu, M. K., O'Laughlin, M., Wise, H., Chen, D., Tian, L., Shi, D., Wang, J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4162 · Cited by 1,051
The role of macrophage phenotype in vascularization of tissue engineering scaffolds
Spiller, K. L., Anfang, R. R., Spiller, K. J., Ng, J., Nakazawa, K. R., Daulton, J. W., & Vunjak-Novakovic, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.012 · Cited by 948
SELF-REGULATION OF GROWTH IN THREE DIMENSIONS
Folkman, J., & Hochberg, M. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.138.4.745 · Cited by 829
Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A., & Foord, S. M. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.233 · Cited by 804
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Recent advances in biomaterials for 3D scaffolds: A review
Nikolova, M. P., & Chavali, M. S. (2019) · Bioactive Materials · doi:10.1016/j.bioactmat.2019.10.005 · Cited by 907
Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering
Collins, M. N., Ren, G., Young, K., Pina, S., Reis, R. L., & Oliveira, J. M. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010609 · Cited by 867
Biodegradable magnesium-based implants in orthopedics-a general review and perspectives
Wang, J., Xu, J., Hopkins, C., Chow, D. H., & Qin, L. (2020) · Advanced Science · doi:10.1002/advs.201902443 · Cited by 574
Hallmarks of peripheral nerve function in bone regeneration
Tao, R., Mi, B., Hu, Y., Lin, S., Xiong, Y., Lu, X., Panayi, A. C., Li, G., & Liu, G. (2023) · Bone Research · doi:10.1038/s41413-022-00240-x · Cited by 110
Research progress in calcitonin gene-related peptide and bone repair
Wang, Q., Qin, H., Deng, J., Xu, H., Liu, S., Weng, J., & Zeng, H. (2023) · Biomolecules · doi:10.3390/biom13050838 · Cited by 58
Metadata
- Authors
- Marrella, A., Lee, T. Y., Lee, D. H., Karuthedom, S., Syla, D., Chawla, A., Khademhosseini, A., & Jang, H. L.
- Venue
- Materials Today
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 21
- Issue
- 4
- Pages
- 362-376
- ISSN
- 1369-7021 (ISSN-L)
- OpenAlex
- W2765826316
- Cited by
- 311
- References
- 12
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Marrella, A., Lee, T. Y., Lee, D. H., Karuthedom, S., Syla, D., Chawla, A., Khademhosseini, A., & Jang, H. L. (2018). Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration. Materials Today. https://doi.org/10.1016/j.mattod.2017.10.005
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