The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Rapid continuous 3D printing of customizable peripheral nerve guidance conduits
Open accessAbstract
Engineered nerve guidance conduits (NGCs) have been demonstrated for repairing peripheral nerve injuries. However, there remains a need for an advanced biofabrication system to build NGCs with complex architectures, tunable material properties, and customizable geometrical control. Here, a rapid continuous 3D-printing platform was developed to print customizable NGCs with unprecedented resolution, speed, flexibility, and scalability. A variety of NGC designs varying in complexity and size were created including a life-size biomimetic branched human facial NGC. In vivo implantation of NGCs with microchannels into complete sciatic nerve transections of mouse models demonstrated the effective directional guidance of regenerating sciatic nerves via branching into the microchannels and extending toward the distal end of the injury site. Histological staining and immunostaining further confirmed the progressive directional nerve regeneration and branching behavior across the entire NGC length. Observational and functional tests, including the von Frey threshold test and thermal test, showed promising recovery of motor function and sensation in the ipsilateral limbs grafted with the 3D-printed NGCs.
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Cited by
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Arif, Z. U., Khalid, M. Y., Noroozi, R., Sadeghianmaryan, A., Jalalvand, M., & Hossain, M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.140 · Cited by 395
Huang, L., Lu, T.-Y., Berman, E., Park, A., Ercegovac, K., Schimelman, J., & Chen, S. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103203
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Metadata
- Authors
- Zhu, W., Tringale, K. R., Woller, S. A., You, S., Johnson, S., Shen, H., Schimelman, J., Whitney, M., Steinauer, J., Xu, W., Yaksh, T. L., Nguyen, Q. T., & Chen, S.
- Venue
- Materials Today
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 21
- Issue
- 9
- Pages
- 951-959
- ISSN
- 1369-7021 (ISSN-L)
- OpenAlex
- W2801289614
- Cited by
- 253
- References
- 41
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
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