Rat tail skin temperature regulation by estrogen, phytoestrogens and tamoxifen
Abstract
Objective Develop a rat model for the evaluation of estrogenic agents on estrogen deficiency-induced changes in thermoregulation.Methods OVX rats are impaired in thermoregulation which manifests itself as an elevation in basal tail skin temperature (TST) and are less able to respond to temperature changes than intact rats.Results Administration of estrogen subcutaneously to estrogen-depleted rats either as depot formulation, biodegradable pellets, or daily injections, suppressed the increased TST. OVX rats maintained on a diet devoid of phytoestrogens had a higher TST by several degrees than OVX rats fed normal chow, offering greater ability to test estrogenic agents on thermoregulation. Depletion of estrogen in intact rats via chronic administration of leuprolide acetate, a GnRH agonist, also increased TST, which was in turn suppressed by estrogen. In intact rats, tamoxifen exhibited estrogen antagonistic activity elevating TST, while in OVX rats, tamoxifen acted as an agonist by suppressing TST.Conclusion OVX rats kept on a diet devoid of phytoestrogens are a sensitive model for estrogen-dependent thermoregulation.
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Tail skin temperature is increased by ovariectomy and reduced by estrogen treatment of ovariectomized rats.
“Tail skin temperature is increased by ovariectomy (Berendsen et al., 2001; Kobayashi et al., 1995; Opas et al., 2004) and reduced by estrogen treatment of ovariectomized rats (Berendsen et al., 2001; Bowe et al., 2006; Dacks and Rance, 2010; Hosono et al., 2001; Kobayashi et al., 1995).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Opas et al., 2004
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- Authors
- Opas, E. E., Jane Rutledge, S., Vogel, R. L., Rodan, G. A., & Schmidt, A.
- Corresponding author
- Schmidt, Azriel
- Venue
- Maturitas
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 48
- Issue
- 4
- Pages
- 463-471
- ISSN
- 0378-5122 (ISSN-L)
- OpenAlex
- W2028187381
- Cited by
- 25
- References
- 25
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Maturitas (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- thermoregulation, tail skin temperature, estrogen, phytoestrogens, tamoxifen, ovariectomy, estrogen deficiency, leuprolide, GnRH agonist, estrogen antagonism, rat model
- MeSH terms
- Animals, Estrogen Antagonists, Estrogens, Female, Ovariectomy, Skin Temperature, Tail, Tamoxifen, Time Factors, Rats, Sprague-Dawley, Models, Animal, Phytoestrogens, Rats
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