Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female rats
Abstract
Effects of estrogen on thermoregulatory vasomotion and heat-escape behavior were investigated in ovariectomized female rats supplemented with estrogen (replaced estrogen rats) or control saline (low estrogen rats). First, we measured tail temperature of freely moving rats at ambient temperatures (T(a)) between 13 and 31 degrees C. Tail temperature of the low estrogen rats was higher than that of the replaced estrogen rats at T(a) between 19 and 25 degrees C, indicating that the low estrogen rats exhibit more skin vasodilation than the replaced estrogen rats. There was no significant difference in oxygen consumption and core temperature between the two groups. Second, we analyzed heat-escape behaviors in a hot chamber where rats could obtain cold air by moving in and out of a reward area. The low estrogen rats kept T(a) at a lower level than did the replaced estrogen rats. These results imply that the lack of estrogen facilitates heat dissipation both by skin vasodilation and by heat-escape behavior. Ovariectomized rats may mimic climacteric hot flushes not only for autonomic skin vasomotor activity but also for thermoregulatory behavior.
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Core temperature has been reported to be increased, decreased, or unaffected by estrogen treatment of ovariectomized rats.
“Core temperature has been reported to be increased (Hosono et al., 1997a; Marrone et al., 1976), decreased (Wilkinson et al., 1980) or unaffected by estrogen treatment of ovariectomized rats (Hosono et al., 2001; Laudenslager et al., 1980; Williams et al., 2010).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Hosono et al., 2001
Cites
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- Authors
- Hosono, T., Chen, X.-M., Miyatsuji, A., Yoda, T., Yoshida, K., Yanase-Fujiwara, M., & Kanosue, K.
- Affiliations
- The University of Osaka (JP)
- Nara Women's University (JP)
- Department of Physiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Yamadaoka 1 – 7, Suita, Osaka, 565-0871, and
- Department of Human Behavior Science, Nara Women's University, Kitauoyahigashimachi, Nara, 630-8506, Japan
- ORCID
- Kanosue, Kazuyuki
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2001-05-01
- Volume
- 280
- Issue
- 5
- Pages
- R1341-R1347
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2241249302
- Cited by
- 32
- References
- 26
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- estrogen, thermoregulation, ovariectomy, estrogen replacement therapy, cutaneous vasodilation, tail temperature, hot flashes, climacteric, female rats, heat dissipation
- MeSH terms
- Animals, Body Temperature Regulation, Climacteric, Drug Implants, Escape Reaction, Estradiol, Female, Hot Temperature, Motor Activity, Ovariectomy, Reward, Skin, Skin Temperature, Tail, Vasodilation, Estrogen Replacement Therapy, Rats, Wistar, Models, Animal, Rats
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