Physical capability markers used to define sarcopenia and their association with cardiovascular and respiratory outcomes and all-cause mortality: A prospective study from UK Biobank
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Introduction It is unclear what combinations of physical capability markers used to define sarcopenia have the strongest associations with health outcomes.Aim To compare the associations between different combinations of physical capability markers of sarcopenia with cardiovascular and respiratory outcomes and all-cause mortality.Study design 469,830 UK Biobank participants were included in this prospective study. Four groups were derived based on combinations of three physical capability markers used to define sarcopenia or severe sarcopenia: gait speed, grip strength and muscle mass. Outcomes studied were all-cause mortality, as well as incidence and mortality from cardiovascular disease (CVD), respiratory disease and chronic obstructive pulmonary disease (COPD).Results All combinations of physical capability markers used to define sarcopenia or severe sarcopenia identified individuals at increased risk of respiratory disease and all-cause mortality. However, the definition most strongly associated with a wide range of adverse health outcomes was the combination of slow gait speed plus low muscle mass, followed by severe sarcopenia, and the combination of slow gait speed plus low grip strength. The current definition of sarcopenia (low grip strength plus low muscle mass) had the weakest associations with all-cause (HR: 1.35 [95% CI: 1.07 to 1.71]) and respiratory mortality (HR: 1.88 [95% CI: 1.15 to 3.10]), as well as respiratory disease (HR: 1.38 [95% CI: 1.11 to 1.73]) and COPD incidence (HR: 2.08 [95% CI: 1.14 to 3.79]).Conclusions Associations of sarcopenia with adverse outcomes were strongest when sarcopenia was defined as slow gait speed plus low muscle mass, followed by severe sarcopenia, suggesting that this combination of physical capability markers should be still considered in the diagnosis of sarcopenia.
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The adverse effects of sarcopenia on quality of life, health care demand, morbidity, and mortality can affect both middle-aged and older-aged adults.
“Therefore, the adverse effects of sarcopenia on quality of life, health care demand, morbidity, and mortality can affect both middle‐aged and older‐aged adults. 1 , 2 , 6”
From Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis (2022) · cites this paper as [6]
Sarcopenia is a progressive and complex disease associated with a higher burden of morbidity and mortality.
“Sarcopenia is a progressive and complex disease associated with a higher burden of morbidity and mortality. 1 , 2 , 6”
From Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis (2022) · cites this paper as [6]
Previous research has demonstrated a higher risk of adverse health outcome in middle-aged individuals with sarcopenia.
“previous research has demonstrated a higher risk of adverse health outcome in middle‐aged individuals with sarcopenia, 6”
From Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis (2022) · cites this paper as [6]
A previous work demonstrated that the combination of slow gait speed and low grip strength, followed by severe sarcopenia, had the highest risk effect over all-cause mortality, cardiovascular disease, and respiratory disease.
“a previous work demonstrated that the combination of slow gait speed and low grip strength, followed by severe sarcopenia, had the highest risk effect over all‐cause mortality, cardiovascular disease, and respiratory disease, 6”
From Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis (2022) · cites this paper as [6]
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Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis
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- Authors
- Petermann-Rocha, F., Ho, F. K., Welsh, P., Mackay, D., Brown, R., Gill, J. M. R., Sattar, N., Gray, S. R., Pell, J. P., & Celis-Morales, C. A.
- Affiliations
- University of Glasgow (GB)
- Universidad Mayor (CL)
- Corresponding author
- Celis-Morales, Carlos A
- ORCID
- Venue
- Maturitas
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 138
- Pages
- 69-75
- ISSN
- 0378-5122 (ISSN-L)
- OpenAlex
- W3022567055
- Cited by
- 52
- References
- 31
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 5 · 2020: 2
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.gla.ac.uk
- Licence
- Locations
- Maturitas (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- Funders
- Medical Research Council, Department of Health, Scottish Government
- Northwest Regional Development Agency
- Welsh Assembly Government
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, walking speed, grip strength, muscle mass, severe sarcopenia, cardiovascular mortality, respiratory mortality, chronic obstructive pulmonary disease, all-cause mortality, sarcopenia definitions, UK Biobank
- MeSH terms
- Walking Speed, Aged, Cardiovascular Diseases, Female, United Kingdom, Humans, Male, Middle Aged, Mortality, Prospective Studies, Respiratory Tract Diseases, Muscle, Skeletal, Hand Strength, Sarcopenia
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