Sarcopenia: origins and clinical relevance
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This presentation reflects on the origins of the term sarcopenia. The Greek roots of the word are sarx for flesh and penia for loss. The term actually describes important changes in body composition and related functions. Clearly defining sarcopenia will allow investigators to appropriately classify patients and examine underlying pathogenic mechanisms and will allow funding agencies to appropriately target research funds to a taxonomically distinct syndrome.
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Physical inactivity is probably the most important factor contributing to age-related loss of muscle mass and strength.
“Many factors contributing to age-related loss of muscle mass and strength have been suggested, with physical inactivity probably being the most important.3”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [3]
In 1988, Irwin Rosenberg first introduced the term "sarcopenia" to delineate the age-related deterioration of skeletal muscle mass and function.
“In 1988, Irwin Rosenberg first introduced the term “sarcopenia” to delineate the age-related deterioration of skeletal muscle mass and function.13”
From Imaging of Sarcopenia in Type 2 Diabetes Mellitus (2024) · cites this paper as [13]
Loss of muscle mass with progressing age is an inevitable aspect of the aging process.
“Loss of muscle mass with progressing age is an inevitable aspect of the aging process [5].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [5]
Aging is associated with a progressive decline in muscle mass and strength, a process known as sarcopenia.
“Skeletal muscle aging is associated with a progressive decline in muscle mass and function, a biological process known as sarcopenia (Rosenberg, 1997).”
From Effects of Aging and Caloric Restriction on Fiber Type Composition, Mitochondrial Morphology and Dynamics in Rat Oxidative and Glycolytic Muscles (2019) · cites this paper as Rosenberg, 1997
With increasing age, skeletal muscle becomes less responsive to anabolic stimuli such as resistance exercise and protein feeding.
“With increasing age, skeletal muscle becomes less responsive to anabolic stimuli, such as resistance exercise and protein feeding.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [6]
Reduced sensitivity to anabolic stimuli, termed anabolic resistance, is implicated in the etiology of sarcopenia.
“It is thought that this reduced sensitivity to anabolic stimuli, termed ”anabolic resistance”, is implicated in the etiology of sarcopenia, which is the gradual loss of muscle mass with age [2,3,4,5,6,7].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [6]
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- Authors
- Rosenberg, I. H.
- Affiliations
- Tufts University (US)
- Corresponding author
- Rosenberg, Irwin H.
- ORCID
- Rosenberg, Irwin H.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 127
- Issue
- 5
- Pages
- 990S-991S
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2137687978
- Cited by
- 2,399
- References
- 1
- Citations by year
- 2026: 123 · 2025: 194 · 2024: 214 · 2023: 210 · 2022: 247 · 2021: 215 · 2020: 189 · 2019: 132 · 2018: 143 · 2017: 132 · 2016: 96 · 2015: 103 · 2014: 81 · 2013: 61 · 2012: 57
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- sarcopenia, etymology, body composition, muscle mass loss, pathophysiological mechanisms, clinical classification, research funding
- MeSH terms
- Aged, Aging, Humans, Middle Aged, Muscular Atrophy, Muscle, Skeletal
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