Melatonin’s Potential Side Effects: It May Be in Your Genes
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Individuals with certain genotypes, such as polymorphisms in the melatonin receptor 1B (MTNR1B) gene, may require monitoring of hemoglobin A1C if they take supplemental melatonin.
“Those with certain genotypes, such as polymorphisms in the melatonin receptor 1B (MTNR1B) gene, may require monitoring of hemoglobin A1C if they take supplemental melatonin [275,276].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [275]
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Lyssenko, V., Nagorny, C. L. F., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.288 · Cited by 742 · see citing works
Safety of higher doses of melatonin in adults: A systematic review and meta-analysis
Menczel Schrire, Z., Phillips, C. L., Chapman, J. L., Duffy, S. L., Wong, G., D’Rozario, A. L., Comas, M., Raisin, I., Saini, B., Gordon, C. J., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12782 · Cited by 133 · see citing works
Trends in Use of Melatonin Supplements Among US Adults, 1999-2018
Li, J., Somers, V. K., Xu, H., Lopez-Jimenez, F., & Covassin, N. (2022) · JAMA · doi:10.1001/jama.2021.23652 · Cited by 97 · see citing works
Garaulet, M., Lopez-Minguez, J., Dashti, H. S., Vetter, C., Hernández-Martínez, A. M., Pérez-Ayala, M., Baraza, J. C., Wang, W., Florez, J. C., Scheer, F. A. J. L., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1314 · Cited by 77 · see citing works
Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank
Tan, X. W., Ciuculete, D. M., Schiöth, H. B., & Benedict, C. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12994 · Cited by 41 · see citing works
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Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
- Authors
- Benedict, C.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Benedict, Christian
- ORCID
- Benedict, Christian
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 97
- Issue
- 7
- Pages
- 1401
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W4283739726
- Cited by
- 4
- References
- 5
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk Fonden (NNF19OC0056777)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- melatonin, supplement use prevalence, genetic susceptibility, adverse effects, sleep aids, NHANES
- MeSH terms
- Humans, Melatonin
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