The DOI matches its Crossref record; 53 of the 55 references it cites were found in a registry or an index.
Puberty-related influences on brain development
Abstract
Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“structurally, this brain area is among the last to reach adult-like cortical composition”
From Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking (2013) · cites this paper as Giedd, 2006
In the citing paper
“In humans, there are significant changes in gray matter volume in associative cortices around the time of puberty (Giedd et al., 2006; Peper et al., 2009b; Herting et al., 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Giedd et al., 2006
Citations
Cites
CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Strawn, L. G., Flegal, K. M., & Mei, Z. (2002) · Cited by 6,426
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604
Self-citationBrain development during childhood and adolescence: a longitudinal MRI study
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552
Self-citationCongenital adrenal hyperplasia due to 21-hydroxylase deficiency*
White, P. C., & Speiser, P. W. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.3.0398 · Cited by 1,432
HAMMER: hierarchical attribute matching mechanism for elastic registration
Shen, D. G., & Davatzikos, C. A. (2002) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2002.803111 · Cited by 1,089
Self-citationKlinefelter, H. F., Reifenstein, E. C., & Albright, F. (1942) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-2-11-615 · Cited by 1,069
Quantitative magnetic resonance imaging of human brain development: ages 4–18
Giedd, J. N., Snell, J. W., Lange, N., Rajapakse, J. C., Casey, B. J., Kozuch, P. L., Vaituzis, A. C., Vauss, Y. C., Hamburger, S. D., Kaysen, D., et al. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.4.551 · Cited by 1,024
Self-citationNew Insights into Neuron-Glia Communication
Fields, R. D., & Stevens, B. (2002) · Science · doi:10.1126/science.298.5593.556 · Cited by 975
The Brain Connection: The Corpus Callosum Is Larger in Left-Handers
Witelson, S. F. (1985) · Science · doi:10.1126/science.4023705 · Cited by 689
THOMPSON & Thompson genetics in medicine
Nussbaum, R. L., McInnes, R. R., & Willard, H. F. (2016) · Cited by 485
A Unified Statistical Approach to Deformation-Based Morphometry
Chung, M. K., Worsley, K. J., Paus, T., Cherif, C., Collins, D. L., Giedd, J. N., Rapoport, J. L., & Evans, A. C. (2001) · NeuroImage · doi:10.1006/nimg.2001.0862 · Cited by 414
Self-citationForms and measures of adult and developing human corpus callosum: Is there sexual dimorphism?
Clarke, S., Kraftsik, R., der Loos, H. V., & Innocenti, G. M. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902800205 · Cited by 264
Oligodendrocytes as providers of growth factors
Du, Y., & Dreyfus, C. F. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10245 · Cited by 255
Neuropsychological impairment in 42 adolescents with sex chromosome abnormalities
Bender, B. G., Linden, M. G., & Robinson, A. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320480312 · Cited by 219
Hemispheric function and collaboration in the child
Best, C. T. (1985) · Cited by 208
Aberrant recombination and the origin of Klinefelter syndrome
Thomas, N. S. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg028 · Cited by 206
Sexual dimorphism in the human corpus callosum: an extension and replication study.
Holloway, R. L., & LACOSTE, M. C. D. (1986) · PubMed · Cited by 196
Klinefelter syndrome: Expanding the phenotype and identifying new research directions
Simpson, J. L., de la Cruz, F., Swerdloff, R. S., Samango‐Sprouse, C. A., Skakkebæk, N. E., Graham, J. M., Hassold, T. J., Aylstock, M., Meyer‐Bahlburg, H. F. L., Willard, H. F., et al. (2003) · Genetics in Medicine · doi:10.1097/01.gim.0000095626.54201.d0 · Cited by 184
Self-citationMEMORY IMPAIRMENT AFTER COMMISSUROTOMY IN MAN
Zaidel, D. W., & Sperry, R. W. (1974) · Brain · doi:10.1093/brain/97.1.263 · Cited by 180
No sex‐related differences in human corpus callosum based on magnetic resonance imagery
Oppenheim, J. S., Lee, B. C. P., Nass, R. D., & Gazzaniga, M. S. (1987) · Annals of Neurology · doi:10.1002/ana.410210615 · Cited by 166
Very High-Resolution Morphometry Using Mass-Preserving Deformations and HAMMER Elastic Registration
Shen, D. G., & Davatzikos, C. A. (2002) · NeuroImage · doi:10.1006/nimg.2002.1301 · Cited by 165
Self-citationGenetic counseling for sex chromosome abnormalities
Linden, M. G., Bender, B. G., & Robinson, A. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10391 · Cited by 159
Androgen Binding and Metabolism in the Cerebral Cortex of the Developing Rhesus Monkey*
Clark, A. S., MacLusky, N. J., & Goldman‐Rakic, P. S. (1988) · Endocrinology · doi:10.1210/endo-123-2-932 · Cited by 155
Neuropsychological profiles of adults with Klinefelter syndrome
Boone, K. B., Swerdloff, R. S., Miller, B. L., Geschwind, D. H., Razani, J., Lee, A., Gonzalo, I. T. G., Haddal, A., Rankin, K. P., Lu, P. H., et al. (2001) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617701744013 · Cited by 153
A developmental study of sex and age interactions in the human corpus callosum
Cowell, P. E., Allen, L. S., Zalatimo, N., & Denenberg, V. H. (1992) · Developmental Brain Research · doi:10.1016/0165-3806(92)90079-c · Cited by 152
Merke, D. P., Bornstein, S. R., Avila, N. A., & Chrousos, G. P. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-4-200202190-00012 · Cited by 147
Self-citationPsychosocial Adaptation of 39 Adolescents With Sex Chromosome Abnormalities
Bender, B. G., Harmon, R. J., Linden, M. G., & Robinson, A. (1995) · PEDIATRICS · doi:10.1542/peds.96.2.302 · Cited by 141
Brain morphology in Klinefelter syndrome
Patwardhan, A. J., D, S. E. M., Bender, B. G., Linden, M. G., & Reiss, A. L. (2000) · Neurology · doi:10.1212/wnl.54.12.2218 · Cited by 138
Variations in human corpus callosum do not predict gender: A study using magnetic resonance imaging.
Byne, W. M., Bleier, R., & Houston, L. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.2.222 · Cited by 123
The Brain Code: Mechanisms of Information Transfer and the Role of the Corpus Callosum
Cook, N. D. (1986) · Medical Entomology and Zoology · Cited by 119
Kilnefelter Syndrome and Its Variants: An Update and Review for the Primary Pediatrician
Visootsak, J., Aylstock, M., & Graham, J. M. (2001) · Clinical Pediatrics · doi:10.1177/000992280104001201 · Cited by 113
Morse, J. K., Scheff, S. W., & DeKosky, S. T. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90244-x · Cited by 112
Neuronal and glial cell biology Editorial overview
Kelly, R. B., & Reichardt, L. F. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90001-9 · Cited by 111
The commissural fibre connections of the primary somatic sensory cortex
Shanks, M. F., Röckel, A., & Powell, T. P. S. (1975) · Brain Research · doi:10.1016/0006-8993(75)90516-8 · Cited by 102
Variations in human corpus callosum do not predict gender: A study using magnetic resonance imaging.
Byne, W. M., Bleier, R., & Houston, L. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.2.222 · Cited by 102
Neuronal and glial cell biology
Barres, B. A., & Barde, Y. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00134-3 · Cited by 101
Sex differences in the fetal human corpus callosum.
LACOSTE, M. C. D., Rl, H., & Dj, W. (1986) · PubMed · Cited by 94
A Review of Klinefelter's Syndrome in Children and Adolescents
MANDOKI, M. W., Sumner, G., Hoffman, R. P., & Riconda, D. L. (1991) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199103000-00001 · Cited by 91
Failure to demonstrate sexual dimorphism of the corpus callosum in childhood.
Bell, A. D., & Variend, S. (1985) · PubMed · Cited by 89
Automated morphometric study of brain variation in XXY males
Shen, D. G., Liu, D., Liu, H., CLASEN, L. S., Giedd, J. N., & Davatzikos, C. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.018 · Cited by 86
Self-citationThe brain code: Mechanisms of information transfer and the role of the corpus callosum
Bradshaw, J. L. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90124-2 · Cited by 86
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Flier, J. S., Underhill, L. H., Cutler, G. B., & Laue, L. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012273232605 · Cited by 82
COGNITIVE FUNCTION IN CONGENITAL ADRENAL HYPERPLASIA
Berenbaum, S. A. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(08)70025-2 · Cited by 71
The Controversy About a Sexual Dimorphism of the Human Corpus Callosum
Weis, S., Weber, G., Wenger, E., & Kimbacher, M. (1989) · International Journal of Neuroscience · doi:10.3109/00207458908987430 · Cited by 62
Taurodontism in 47,XXY Males: An Effect of the Extra X Chromosome on Root Development
Varrela, J., & Alvesalo, L. J. (1988) · Journal of Dental Research · doi:10.1177/00220345880670021401 · Cited by 55
Cognitive and behavioral factors in the learning disabilities of 47,XXY and 47,XYY boys.
Walzer, S., Bashir, A. S., & Silbert, A. (1990) · PubMed · Cited by 51
Samango‐Sprouse, C. A., & Rogol, A. D. (2002) · Infants & Young Children · doi:10.1097/00001163-200207000-00004 · Cited by 40
Self-citationLevin, M. G., & Mercola, M. A. (1998) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1998)23:3 · Cited by 35
Automatic detection of intracranial contours in MR images
Zijdenbos, A. P., Dawant, B. M., & Margolin, R. A. (1994) · Computerized Medical Imaging and Graphics · doi:10.1016/0895-6111(94)90057-4 · Cited by 35
Fields, R. D., Eshete, F., Dudek, S. M., Ozsarac, N., & Stevens, B. (2001) · Novartis Foundation symposium · doi:10.1002/0470846674.ch13 · Cited by 32
The human corpus callosum and the controversy about a sexual dimorphism
Weis, S., Weber, G., Wenger, E., & Kimbacher, M. (1988) · Psychobiology · doi:10.3758/bf03327338 · Cited by 30
Giedd (1996) · doi:10.1002/(sici)1096-9861(19960304)366:2
Self-citation
Research works printed but not linked: 2
- Berlucchi, 1981, Interhemispheric asymmetries in visual discrimination: a neurophysiological hypothesis, Doc. Opthal. Proc. Ser., 30, 87
- Samango-Sprouse, 2001, The neurocognitive profile of the young child with XXY, Eur. J. Hum. Gen., 9, 193
Cited by
Sorted by citations
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123
Self-citationPhillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.65 · Cited by 1,383
Stress, sensitive periods and maturational events in adolescent depression
Andersen, S. L., & Teicher, M. H. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.004 · Cited by 1,005
Sex differences in impulsivity: A meta-analysis.
Cross, C. P., Copping, L. T., & Campbell, A. (2011) · Psychological Bulletin · doi:10.1037/a0021591 · Cited by 866
Culture, Mind, and the Brain: Current Evidence and Future Directions
Kitayama, S., & Üskül, A. K. (2010) · Annual Review of Psychology · doi:10.1146/annurev-psych-120709-145357 · Cited by 751
Metadata
- Authors
- Giedd, J. N., Clasen, L. S., Lenroot, R., Greenstein, D., Wallace, G. L., Ordaz, S., Molloy, E. A., Blumenthal, J. D., Tossell, J. W., Stayer, C., Samango-Sprouse, C. A., Shen, D., Davatzikos, C., Merke, D., & Chrousos, G. P.
- Affiliations
- National Institutes of Health (US)
- University of Pennsylvania (US)
- Corresponding author
- Giedd, Jay N.
- ORCID
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 254-255
- Pages
- 154-162
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2122741903
- Cited by
- 300
- References
- 55
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 45 · 2017: 6 · 2016: 21 · 2015: 11 · 2014: 23 · 2013: 28 · 2012: 20
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- puberty, brain development, brain morphometry, gray matter thickness, sex differences, congenital adrenal hyperplasia, amygdala volume, Klinefelter syndrome, sex chromosome aneuploidy, neuroimaging
- MeSH terms
- Adolescent, Adrenal Hyperplasia, Congenital, Adult, Amygdala, Brain, Child, Child, Preschool, Female, Hippocampus, Humans, Klinefelter Syndrome, Male, Organ Size, Puberty
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
