The DOI matches its Crossref record; 179 of the 180 references it cites were found in a registry or an index.
Sensory and sympathetic nervous system control of white adipose tissue lipolysis
Open accessAbstract
Circulating factors are typically invoked to explain bidirectional communication between the CNS and white adipose tissue (WAT). Thus, initiation of lipolysis has been relegated primarily to adrenal medullary secreted catecholamines and the inhibition of lipolysis primarily to pancreatic insulin, whereas signals of body fat levels to the brain have been ascribed to adipokines such as leptin. By contrast, evidence is given for bidirectional communication between brain and WAT occurring via the sympathetic nervous system (SNS) and sensory innervation of this tissue. Using retrograde transneuronal viral tract tracers, the SNS outflow from brain to WAT has been defined. Functionally, sympathetic denervation of WAT blocks lipolysis to a variety of lipolytic stimuli. Using anterograde transneuronal viral tract tracers, the sensory input from WAT to brain has been defined. Functionally, these WAT sensory nerves respond electrophysiologically to increases in WAT SNS drive suggesting a possible neural negative feedback loop to regulate lipolysis.
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“All these functions of the SNS are related to allocation of energy-rich fuels and calcium and phosphate to an activated immune system.”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [49]
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“Adipose tissue is richly innervated by both sympathetic and parasympathetic fibers, with the former driving lipolysis during fasting and cold exposure and the latter promoting lipid accumulation after feeding (Bartness et al., 2010a; Kreier et al., 2002).”
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Metadata
- Authors
- Bartness, T. J., Shrestha, Y. B., Vaughan, C. H., Schwartz, G. J., & Song, C. K.
- Affiliations
- Georgia State University (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Bartness, Timothy J.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 318
- Issue
- 1-2
- Pages
- 34-43
- ISSN
- 0303-7207 (ISSN-L)
- PMC
- PMC2826518
- OpenAlex
- W1990112639
- Cited by
- 289
- References
- 180
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 16 · 2023: 22 · 2022: 23 · 2021: 15 · 2020: 12 · 2019: 21 · 2018: 14 · 2017: 19 · 2016: 13 · 2015: 27 · 2014: 18 · 2013: 15 · 2012: 24
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK35254, R37DK035254)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- white adipose tissue, lipolysis, sympathetic nervous system, sensory innervation, sympathetic denervation, anterograde and retrograde tracing, catecholamines, insulin, leptin, adipokines
- MeSH terms
- Animals, Humans, Lipolysis, Sensory Receptor Cells, Sympathetic Nervous System, Adipose Tissue, White
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