Myostatin Up-Regulation Is Associated with the Skeletal Muscle Response to Hypoxic Stimuli
Open accessAbstract
Myostatin and hypoxia signalling pathways are able to induce skeletal muscle atrophy, but whether a relationship between these two pathways exists is currently unknown. Here, we tested the hypothesis that a potential mechanism for hypoxia effect on skeletal muscle may be through regulation of myostatin. We reported an induction of myostatin expression in muscles of rats exposed to chronic hypoxia. Interestingly, we also demonstrated increased skeletal muscle myostatin protein expression in skeletal muscle of hypoxemic patients with severe chronic obstructive pulmonary disease (COPD). Parallel studies in human skeletal muscle cell cultures showed that induction of myostatin expression in myotubes treated with hypoxia-mimicking agent such as cobalt chloride (CoCl(2)) is associated with myotube atrophy. Furthermore, we demonstrated that inhibition of myostatin by means of genetic deletion of myostatin or treatment with blocking antimyostatin antibodies inhibits the CoCl(2)-induced atrophy in muscle cells. Finally, addition of recombinant myostatin restored the CoCl(2)-induced atrophy in myostatin deficient myotubes. These results strongly suggest that myostatin can play an essential role in the adaptation of skeletal muscle to hypoxic environment.
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Hypoxia was found to increase myostatin expression in a rat model.
“hypoxia was found to increase myostatin (a negative regulator of muscle mass) expression in a rat model [72].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [72]
Myostatin expression is increased in the quadriceps of COPD patients, possibly related to hypoxia.
“Its expression is increased in the quadriceps of COPD patients [176], possibly related to hypoxia [72].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [72]
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Signaling pathways controlling skeletal muscle mass
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“Its expression is increased in the quadriceps of COPD patients [176], possibly related to hypoxia [72].”
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- Authors
- Hayot, M., Rodriguez, J., Vernus, B., Carnac, G., Jean, E., Allen, D., Goret, L., Obert, P., Candau, R., & Bonnieu, A.
- Affiliations
- Inserm (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- University of Colorado Boulder (US)
- Université d'Avignon et des Pays de Vaucluse (FR)
- Corresponding author
- Bonnieu, Anne
- ORCID
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 332
- Issue
- 1-2
- Pages
- 38-47
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2039328837
- Cited by
- 98
- References
- 9
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Institut National de la Recherche Agronomique (INRA)
- fédération ANTADIR (Association Nationale pour le Traitement à Domicile, l’Innovation et la Recherche)
- Centre Hospitalier Universitaire de Montpellier
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
- Keywords
- myostatin, hypoxia, skeletal muscle atrophy, chronic obstructive pulmonary disease, cobalt chloride, myotubes, hypoxia signaling
- MeSH terms
- Adult, Aged, Animals, Hypoxia, Body Weight, Cells, Cultured, Cobalt, Humans, Male, Middle Aged, Muscle Proteins, Muscular Atrophy, Recombinant Proteins, Signal Transduction, Up-Regulation, Antimutagenic Agents, Rats, Wistar, Mice, Knockout, Muscle, Skeletal, Pulmonary Disease, Chronic Obstructive, SKP Cullin F-Box Protein Ligases, Mice, Rats, Myostatin
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