Skeletal muscle atrogenes: From rodent models to human pathologies

Identification of ubiquitin ligases required for skeletal muscle atrophy.

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Fiber Types in Mammalian Skeletal Muscles

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

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Skeletal muscle: A brief review of structure and function

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Cancer-associated cachexia

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Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

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Cancer cachexia: understanding the molecular basis

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Mechanisms regulating skeletal muscle growth and atrophy

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Proteasomal and Autophagic Degradation Systems

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Proteolysis: from the lysosome to ubiquitin and the proteasome

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Muscle wasting in disease: molecular mechanisms and promising therapies

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A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

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PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

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Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

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Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

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Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

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The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle

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Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

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Muscle type and fiber type specificity in muscle wasting

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IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1

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TNF‐α acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle

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Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

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Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

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Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

Furuyama, T., Nakazawa, T., Nakano, I., et al. (2000) · Biochemical Journal · doi:10.1042/bj3490629 · Cited by 505 · see citing works

BMP signaling controls muscle mass

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Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL −/− Renal Cancer

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Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

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Mitochondrial quality control and muscle mass maintenance.

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Selective accumulation of MyoD and Myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones

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Degradation of MyoD Mediated by the SCF (MAFbx) Ubiquitin Ligase

Tintignac, L. A. J., Lagirand-Cantaloube, J., Batonnet‐Pichon, S., Sirri, V., Leibovitch, M.-P., & Leibovitch, S. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411346200 · Cited by 406 · see citing works

Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass

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Akt signalling through GSK‐3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy

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Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I

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Patterns of gene expression in atrophying skeletal muscles: response to food deprivation

Jagoe, R. T., Lecker, S. H., Gomes, M., & Goldberg, A. L. (2002) · The FASEB Journal · doi:10.1096/fj.02-0312com · Cited by 344 · see citing works

The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse

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Recruitment of a 19 <i>S</i> Proteasome Subcomplex to an Activated Promoter

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FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

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The initiation factor eIF3‐f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy

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Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

Furuyama, T., Kitayama, K., Yamashita, H., & Mori, N. (2003) · Biochemical Journal · doi:10.1042/bj20030022 · Cited by 326 · see citing works

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

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Regulation of Muscle Protein Degradation

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Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

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Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy

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Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

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The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity

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Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma.

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Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures

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Coordinate activation of lysosomal, Ca2+-activated and ATP-ubiquitin-dependent proteinases in the unweighted rat soleus muscle

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Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3

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Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle

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The 19S Regulatory Particle of the Proteasome Is Required for Efficient Transcription Elongation by RNA Polymerase II

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Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

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Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

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Toll‐like receptor 4 mediates lipopolysaccharide‐induced muscle catabolism <i>via</i> coordinate activation of ubiquitin‐proteasome and autophagy‐lysosome pathways

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The ubiquitin–proteasome system and skeletal muscle wasting

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Neuromuscular electrical stimulation prevents muscle disuse atrophy during leg immobilization in humans

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Muscle Atrophy and Hypertrophy Signaling in Patients with Chronic Obstructive Pulmonary Disease

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Lysosomal proteolysis in skeletal muscle

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miR-29b contributes to multiple types of muscle atrophy

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Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

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Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

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Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

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Effects of spaceflight on murine skeletal muscle gene expression

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Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

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Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

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Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

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PGC1‐α over‐expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice

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Structural Biology of the Proteasome

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Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle

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Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

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Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97

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Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats.

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The 26 S Proteasome: From Basic Mechanisms to Drug Targeting

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Skeletal muscle gene expression in space-flown rats

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Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle

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SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

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FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.

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Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice

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Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle

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Translational Suppression of Atrophic Regulators by MicroRNA-23a Integrates Resistance to Skeletal Muscle Atrophy

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Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis

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The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer

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Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease

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