The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vitamin D and intestinal calcium absorption
Open accessAbstract
The principal function of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. Calcium is absorbed by both an active transcellular pathway, which is energy dependent, and by a passive paracellular pathway through tight junctions. 1,25Dihydroxyvitamin D3 (1,25(OH)2D3) the hormonally active form of vitamin D, through its genomic actions, is the major stimulator of active intestinal calcium absorption which involves calcium influx, translocation of calcium through the interior of the enterocyte and basolateral extrusion of calcium by the intestinal plasma membrane pump. This article reviews recent studies that have challenged the traditional model of vitamin D mediated transcellular calcium absorption and the crucial role of specific calcium transport proteins in intestinal calcium absorption. There is also increasing evidence that 1,25(OH)2D3 can enhance paracellular calcium diffusion. The influence of estrogen, prolactin, glucocorticoids and aging on intestinal calcium absorption and the role of the distal intestine in vitamin D mediated intestinal calcium absorption are also discussed.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Cited by
Vitamin D-effects on skeletal and extraskeletal health and the need for supplementation
Wacker, M., & Holick, M. (2013) · Nutrients · doi:10.3390/nu5010111 · Cited by 733
Calcium intake, calcium homeostasis and health
Pu, F., Chen, N., & Xue, S. (2016) · Food Science and Human Wellness · doi:10.1016/j.fshw.2016.01.001 · Cited by 173
The role of vitamin D and vitamin D binding protein in chronic liver diseases
Pop, T. L., Sîrbe, C., Benţa, G., Mititelu, A., & Grama, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810705 · Cited by 105
“Vitamin D is a fat-soluble vitamin that has a major role in phospho-calcium metabolism, maintaining normal calcium levels and bone health development [1,2].”
BackgroundUnraveling female reproductive senescence to enhance healthy longevity
Dong, L., Teh, D. B. L., Kennedy, B. K., & Huang, Z. (2023) · Cell Research · doi:10.1038/s41422-022-00718-7 · Cited by 101
“Calcium makes up the major component in bone that provides strength and structure,(94) and the absorption of calcium from the gut is very much reliant on the availability of vitamin D in the body.(95) Aging is related to an increase in the production of vitamin D(96) but malabsorption of calcium, which has a compoundi…”
BackgroundPostpartum depression and vitamin D: a systematic review
Amini, S., Jafarirad, S., & Amani, R. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1423276 · Cited by 72
Metadata
- Authors
- Christakos, S., Dhawan, P., Porta, A., Mady, L. J., & Seth, T.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 347
- Issue
- 1-2
- Pages
- 25-29
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2025386062
- Cited by
- 341
- References
- 1
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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