Regulation of G-protein coupled receptor signalling underpinning neurobiology of mood disorders and depression
Abstract
G-protein coupled receptors (GPCRs) have long been at the center of investigations of the neurobiology of depression and mood disorders. Different facets of GPCR signalling pathways, including those controlling monoaminergic and neuropeptidergic hormonal systems are believed to be dysregulated in major depressive and bipolar disorders. Although these receptors are key molecular targets for a variety of therapeutic agents and continue to be the focus of intense pharmaceutical development, the molecular mechanisms activated by these GPCRs and underpin the pathological basis of mood disorders remain poorly understood. This review will discuss some of the emerging regulatory mechanisms of GPCR signaling in the central nervous system (CNS) involving protein-protein interactions, downstream effectors and cross-talk with other signaling molecules and their potential involvement in the neurobiology of psychiatric disease.
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Confounders in terms of prevalent POTS co-morbidities (such as IBS or depression) were not controlled for in the study of serum activity against GPCRs.
“Confounders in terms of prevalent POTS co-morbidities (such as IBS or depression) which may have elicited their own bi-directional effects on immune responses (Canals et al., 2019”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Grammatopoulos, 2017
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Borroto-Escuela, D. O., Cuesta-Marti, C., Lopez-Salas, A., Chruścicka-Smaga, B., Crespo-Ramírez, M., Tesoro-Cruz, E., Palacios-Lagunas, D. A., Perez de la Mora, M., Schellekens, H., & Fuxe, K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1055344 · Cited by 38 · see citing works
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- Authors
- Grammatopoulos, D. K.
- Affiliations
- University of Warwick (GB)
- Corresponding author
- Grammatopoulos, Dimitris K
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 449
- Pages
- 82-89
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2588056878
- Cited by
- 26
- References
- 4
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- G protein-coupled receptors, mood disorders, depression, bipolar disorder, monoaminergic systems, protein-protein interaction, central nervous system
- MeSH terms
- Animals, Depression, Humans, Models, Biological, Neurosciences, Signal Transduction, Mood Disorders, Receptors, G-Protein-Coupled, Protein Multimerization
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