Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
Abstract
Recently, receptor protein tyrosine phosphatase-sigma (RPTPsigma) has been shown to inhibit axon regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS), central nervous system (CNS) neurons fail to regenerate their axons after injury or in disease. In order to assess the role of RPTPsigma in CNS regeneration, we used the retinocollicular system of adult mice lacking RPTPsigma to evaluate retinal ganglion cell (RGC) axon regrowth after optic nerve lesion. Quantitative analysis demonstrated a significant increase in the number of RGC axons that crossed the glial scar and extended distally in optic nerves from RPTPsigma (-/-) mice compared to wild-type littermate controls. Although we found that RPTPsigma is expressed by adult RGCs in wild-type mice, the retinas and optic nerves of adult RPTPsigma (-/-) mice showed no histological defects. Furthermore, the time-course of RGC death after nerve lesion was not different between knockout and wild-type animals. Thus, enhanced axon regrowth in the absence of RPTPsigma could not be attributed to developmental defects or increased neuronal survival. Finally, we show constitutively elevated activity of mitogen-activated protein kinase (MAPK) and Akt kinase in adult RPTPsigma (-/-) mice retinas, suggesting that these signaling pathways may contribute to promoting RGC axon regrowth following traumatic nerve injury. Our results support a model in which RPTPsigma inhibits axon regeneration in the adult injured CNS.
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RPTPσ binds with high affinity to neurocan and aggrecan and strongly inhibits axon outgrowth and regeneration.
“RPTPσ can bind with high affinity to neurocan and aggrecan and strongly inhibits axon outgrowth and regeneration (Sapieha et al., 2005;Shen et al., 2009;Fry et al., 2010;Lang et al., 2015).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Sapieha et al., 2005
Cites
Guide to the care and use of experimental animals
Olfert, E. D. (1993) · Cited by 3,176 · see citing works
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,090 · see citing works
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works
McKerracher, L. J., David, S., Jackson, D. L., Kottis, V., Dunn, R. J., & Braun, P. E. (1994) · Neuron · doi:10.1016/0896-6273(94)90247-x · Cited by 1,125 · see citing works
Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
Fournier, A. E., GrandPré, T., & Strittmatter, S. M. (2001) · Nature · doi:10.1038/35053072 · Cited by 1,083 · see citing works
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
Mukhopadhyay, G., Doherty, P., Walsh, F. S., Crocker, P. R., & Filbin, M. T. (1994) · Neuron · doi:10.1016/0896-6273(94)90042-6 · Cited by 1,061 · see citing works
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
Wang, K., Koprivica, V., Kim, J. A., Sivasankaran, R., Guo, Y., Neve, R. L., & He, Z. (2002) · Nature · doi:10.1038/nature00867 · Cited by 955 · see citing works
Caroni, P., & Schwab, M. E. (1988) · Neuron · doi:10.1016/0896-6273(88)90212-7 · Cited by 892 · see citing works
Caroni, P., & Schwab, M. E. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.4.1281 · Cited by 880 · see citing works
Mansour-Robaey, S., Clarke, D. B., Wang, Y. C., Bray, G. M., & Aguayo, A. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1632 · Cited by 731 · see citing works
Rho Signaling Pathway Targeted to Promote Spinal Cord Repair
Dergham, P., Ellezam, B., Essagian, C., Avedissian, H., Lubell, W. D., & McKerracher, L. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06570.2002 · Cited by 725 · see citing works
Huber, A. B., Kolodkin, A. L., Ginty, D. D., & Cloutier, J. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.010302.081139 · Cited by 720 · see citing works
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
Newsome, T. P., Åsling, B., & Dickson, B. J. (2000) · Development · doi:10.1242/dev.127.4.851 · Cited by 630 · see citing works
Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve
Leon, S. P., Yin, Y., Nguyen, J. T., Irwin, N., & Benowitz, L. I. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04615.2000 · Cited by 606 · see citing works
Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration
Lehmann, M., Fournier, A. E., Sellés-Navarro, I., Dergham, P., Sebök, Á., Leclerc, N. M., Tigyi, G., & McKerracher, L. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07537.1999 · Cited by 587 · see citing works
Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor
Liu, B. P., Fournier, A. E., GrandPré, T., & Strittmatter, S. M. (2002) · Science · doi:10.1126/science.1073031 · Cited by 578 · see citing works
Cai, D., Shen, Y.-J., de Bellard, M. E., Tang, S., & Filbin, M. T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80681-9 · Cited by 536 · see citing works
Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells
Goldberg, J. L., Klassen, M. P., Hua, Y., & Barres, B. A. (2002) · Science · doi:10.1126/science.1068428 · Cited by 488 · see citing works
Debant, A., Serra‐Pages, C., Seipel, K., O'Brien, S., Tang, M. H. Y., Park, S. H., & Streuli, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5466 · Cited by 467 · see citing works
S ELECTIVITY IN N EUROTROPHIN S IGNALING : Theme and Variations
Segal, R. A. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131421 · Cited by 447 · see citing works
The TrkB-Shc Site Signals Neuronal Survival and Local Axon Growth via MEK and PI3-Kinase
Atwal, J. K., Bernard Massie, B., Miller, F. D., & Kaplan, D. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00035-0 · Cited by 435 · see citing works
Evidence for an amacrine cell system in the ganglion cell layer of the rat retina
Perry, V. H. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90174-3 · Cited by 396 · see citing works
The Transmembrane Tyrosine Phosphatase DLAR Controls Motor Axon Guidance in Drosophila
Krueger, N. X., Vactor, D. V., Wan, H., Gelbart, W. M., Goodman, C. S., & Saito, H. (1996) · Cell · doi:10.1016/s0092-8674(00)81036-3 · Cited by 328 · see citing works
Raf and Akt Mediate Distinct Aspects of Sensory Axon Growth
Markus, A., Zhong, J., & Snider, W. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00752-3 · Cited by 327 · see citing works
Cai, D., Deng, K., Mellado, W., Lee, J.-H., Ratan, R. R., & Filbin, M. T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00826-7 · Cited by 313 · see citing works
Protein-tyrosine phosphatases: The other side of the coin
Hunter, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90496-0 · Cited by 306 · see citing works
Wills, Z. P., Bateman, J. R., Korey, C. A., Comer, A. R., & Vactor, D. V. (1999) · Neuron · doi:10.1016/s0896-6273(00)81091-0 · Cited by 293 · see citing works
Fischer, D., He, Z., & Benowitz, L. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5119-03.2004 · Cited by 277 · see citing works
Receptor Tyrosine Phosphatases Are Required for Motor Axon Guidance in the Drosophila Embryo
Desai, C. J., Gindhart, J. G., Goldstein, L. S. B., & Zinn, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81035-1 · Cited by 269 · see citing works
Oligodendrocyte‐myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth
Kottis, V., Thibault, P., Mikol, D. D., Xiao, Z., Zhang, R., Dergham, P., & Braun, P. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01146.x · Cited by 265 · see citing works
TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced DeathIn Vivo
Cheng, L., Sapieha, P. S., Kittlerová, P., Hauswirth, W. W., & Polo, A. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-03977.2002 · Cited by 255 · see citing works
Self-citationImpaired learning with enhanced hippocampal long‐term potentiation in PTPδ‐deficient mice
Uetani, N., Kato, K., Ogura, H., Mizuno, K., Kawano, K., Mikoshiba, K., Yakura, H., Asano, M., & Iwakura, Y. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2775 · Cited by 250 · see citing works
Self-citationBartsch, U., Bandtlow, C. E., Schnell, L., Bartsch, S., Spillmann, A. A., Rubin, B. P., Hillenbrand, R., Montag, D., & Schachner, M. (1995) · Neuron · doi:10.1016/0896-6273(95)90015-2 · Cited by 250 · see citing works
Different Signaling Pathways Mediate Regenerative versus Developmental Sensory Axon Growth
Liu, R., & Snider, W. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-j0003.2001 · Cited by 236 · see citing works
The Guanine Nucleotide Exchange Factor Trio Mediates Axonal Development in the Drosophila Embryo
Bateman, J. R., Shu, H., & Vactor, D. V. (2000) · Neuron · doi:10.1016/s0896-6273(00)81141-1 · Cited by 225 · see citing works
Receptor Protein Tyrosine Phosphatases in Nervous System Development
Johnson, K. G., & Vactor, D. V. (2003) · Physiological Reviews · doi:10.1152/physrev.00016.2002 · Cited by 224 · see citing works
Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice
Williams, R. W., Strom, R. C., Rice, D. S., & Goldowitz, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-22-07193.1996 · Cited by 209 · see citing works
Awasaki, T., Saito, M., Sone, M., Suzuki, E., Sakai, R., Ito, K., & Hama, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81143-5 · Cited by 206 · see citing works
Angelucci, A., Clascá, F., & Sur, M. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00155-7 · Cited by 205 · see citing works
Profilin and the Abl Tyrosine Kinase Are Required for Motor Axon Outgrowth in the Drosophila Embryo
Wills, Z. P., Marr, L., Zinn, K., Goodman, C. S., & Vactor, D. V. (1999) · Neuron · doi:10.1016/s0896-6273(00)81090-9 · Cited by 199 · see citing works
Brann, A. B., Scott, R., Neuberger, Y., Abulafia, D. P., Boldin, S. A., Fainzilber, M., & Futerman, A. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08199.1999 · Cited by 194 · see citing works
Distinct Neurite Outgrowth Signaling Pathways Converge on ERK Activation
Perron, J. C., & Bixby, J. L. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0753 · Cited by 167 · see citing works
Plunet, W. T., Kwon, B. K., & Tetzlaff, W. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10176 · Cited by 161 · see citing works
Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase σ
Elchebly, M., Wagner, J., Kennedy, T. E., Lanctôt, C., Michaliszyn, E., Itié, A., Drouin, J., & Tremblay, M. L. (1999) · Nature Genetics · doi:10.1038/6859 · Cited by 158 · see citing works
Self-citationRohrer, B., Korenbrot, J. I., LaVail, M. M., Reichardt, L. F., & Xu, B. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08919.1999 · Cited by 137 · see citing works
Retinal Axon Target Selection in Drosophila Is Regulated by a Receptor Protein Tyrosine Phosphatase
Garrity, P., Lee, C., Salecker, I., Robertson, H. C., Desai, C. J., Zinn, K., & Zipursky, S. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80730-8 · Cited by 136 · see citing works
Wallace, M. J., Batt, J. A. E., Fladd, C., Henderson, J. T., Skarnes, W. C., & Rotin, D. (1999) · Nature Genetics · doi:10.1038/6866 · Cited by 134 · see citing works
Retinal Ganglion Cell and Nonneuronal Cell Responses to a Microcrush Lesion of Adult Rat Optic Nerve
Sellés-Navarro, I., Ellezam, B., Fajardo, R., Latour, M., & McKerracher, L. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7573 · Cited by 130 · see citing works
Sapieha, P. S., Peltier, M., Rendahl, K. G., Manning, W. C., & Polo, A. D. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00228-8 · Cited by 128 · see citing works
Self-citationReceptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
Sun, Q., Bahri, S. M., Schmid, A. T., Chia, W. N., & Zinn, K. (2000) · Development · doi:10.1242/dev.127.4.801 · Cited by 116 · see citing works
Kokel, M., Borland, C. Z., DeLong, L., Horvitz, H. R., & Stern, M. (1998) · Genes & Development · doi:10.1101/gad.12.10.1425 · Cited by 103 · see citing works
A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system.
Yan, H., Grossman, A., Wang, H., D’Eustachio, P., Mossie, K. G., Musacchio, J. M., Silvennoinen, O., & Schlessinger, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74547-5 · Cited by 97 · see citing works
Thompson, K. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00120-9 · Cited by 93 · see citing works
Signaling mechanisms of the myelin inhibitors of axon regeneration
Yiu, G. C., & He, Z. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.09.006 · Cited by 91 · see citing works
McLean, J., Batt, J. A. E., Doering, L. C., Rotin, D., & Bain, J. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05481.2002 · Cited by 91 · see citing works
Xie, Y., Yeo, T. T. S., Zhang, C., Yang, T., Tisi, M. A., Massa, S. M., & Longo, F. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05130.2001 · Cited by 79 · see citing works
Mikkelsen, J. D. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90112-b · Cited by 76 · see citing works
The Receptor Tyrosine Phosphatase Crypα Promotes Intraretinal Axon Growth
Ledig, M. M., Haj, F. G., Bixby, J. L., Stoker, A. W., & Mueller, B. K. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.375 · Cited by 72 · see citing works
Receptor tyrosine phosphatases in axon growth and guidance
Stoker, A. W. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00179-3 · Cited by 69 · see citing works
Schaapveld, R. Q. J., Schepens, J. T. G., Bächner, D., Attema, J., Wieringa, B., Jap, P. H. K., & Hendriks, W. J. A. J. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00119-1 · Cited by 67 · see citing works
Edstrøm, A. C., & Ekström, P. A. R. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10686 · Cited by 62 · see citing works
Sörby, M., & Östman, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10963 · Cited by 59 · see citing works
Jallal, B., Schlessinger, J., & Ullrich, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42843-8 · Cited by 58 · see citing works
Gershon, T. R., Baker, M. W., Nitabach, M. N., & Macagno, E. R. (1998) · Development · doi:10.1242/dev.125.7.1183 · Cited by 57 · see citing works
Myelin inhibitors: does NO mean GO?
Raisman, G. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1328 · Cited by 52 · see citing works
Johnson, K. G., McKinnell, I. W., Stoker, A. W., & Holt, C. E. (2001) · Journal of Neurobiology · doi:10.1002/neu.1068 · Cited by 50 · see citing works
Earnest, D. J., Liang, F.-Q., DiGiorgio, S., Gallagher, M., Harvey, B. K., Earnest, B. J., & Seigel, G. M. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199904)39:1 · Cited by 49 · see citing works
Baker, M. W., & Macagno, E. R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00674-6 · Cited by 40 · see citing works
Wang, H., Yan, H., Canoll, P., Silvennoinen, O., Schlessinger, J., & Musacchio, J. M. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490410303 · Cited by 36 · see citing works
Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development
Fuchs, M., Wang, H., Ciossek, T., Chen, Z., & Ullrich, A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00179-2 · Cited by 34 · see citing works
Retinal projections in the cat: A cholera toxin B subunit study
Matteau, I., Boire, D., & Ptito, M. (2003) · Visual Neuroscience · doi:10.1017/s0952523803205022 · Cited by 33 · see citing works
The Expression of Receptor Tyrosine Phosphatases Is Responsive to Sciatic Nerve Crush
Haworth, K. E., Shiu, K., Stokes, A. J., Morris, R. J., & Stoker, A. W. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0707 · Cited by 27 · see citing works
Vaccination stimulates retinal ganglion cell regeneration in the adult optic nerve
Ellezam, B., Bertrand, J., Dergham, P., & McKerracher, L. J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00013-x · Cited by 26 · see citing works
Expression of CRYP-α, LAR, PTP-δ, and PTP-ρ in the developing Xenopus visual system
Johnson, K. G., & Holt, C. E. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00345-7 · Cited by 26 · see citing works
Putting the Brakes on Regeneration
McKerracher, L. J., & Ellezam, B. (2002) · Science · doi:10.1126/science.1073590 · Cited by 9 · see citing works
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Protein tyrosine phosphatases: from genes, to function, to disease
Tonks, N. K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2039 · Cited by 1,685 · see citing works
PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
Shen, Y., Tenney, A. P., Busch, S. A., Horn, K. P., Cuascut, F. X., Liu, K., He, Z., Silver, J., & Flanagan, J. G. (2009) · Science · doi:10.1126/science.1178310 · Cited by 682 · see citing works
Functional regeneration beyond the glial scar
Cregg, J. M., DePaul, M. A., Filous, A. R., Lang, B. T., Tran, A. P., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.024 · Cited by 664 · see citing works
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A., Koriyama, Y., Raiker, S. J., Askew, K. L., Wood, A., Geoffroy, C. G., Zheng, B., Liepmann, C. D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3070 · Cited by 449 · see citing works
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
Lang, B. T., Cregg, J. M., DePaul, M. A., Tran, A. P., Xu, K., Dyck, S. M., Madalena, K. M., Brown, B. P., Weng, Y.-L., Li, S., et al. (2015) · Nature · doi:10.1038/nature13974 · Cited by 465 · see citing works
Guidance Molecules in Axon RegenerationPreprint
Giger, R. J., Hollis, E. R., II, & Tuszynski, M. H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001867 · Cited by 344 · see citing works
“In the CNS, loss of RPTPs has been reported to promote axon regeneration in the injured optic nerve (Sapieha et al. 2005) and to markedly improve axon extension into the lesion 12 Cite this article as Cold Spring Harb Perspect Biol 2010;2:a001867 penumbra following dorsal column crush injury (Shen…”
BackgroundProteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
Coles, C. H., Shen, Y., Tenney, A. P., Siebold, C., Sutton, G. C., Lu, W., Gallagher, J. T., Jones, E. Y., Flanagan, J. G., & Aricescu, A. R. (2011) · Science · doi:10.1126/science.1200840 · Cited by 320 · see citing works
Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury
Yang, T., Dai, Y., Chen, G., & Cui, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00078 · Cited by 257 · see citing works
“…leukocyte common antigenrelated (LAR), protein tyrosine phosphatase σ (PTPσ) and nogo receptors 1, 2, and 3 (NgR), CSPGs adhere to and immobilize regenerating axons to function as inhibitory factors (Sapieha et al., 2005; Schwab and Strittmatter, 2014; Lang et al., 2015; Dyck et al., 2018, 2019).”
BackgroundDyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.006 · Cited by 189 · see citing works
Scar-mediated inhibition and CSPG receptors in the CNS
Sharma, K., Selzer, M. E., & Li, S. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.009 · Cited by 189 · see citing works
“Moreover, previous studies indicated enhanced regeneration of injured optic nerve and peripheral nerves in PTPσ knockout mice (Fry et al., 2010; McLean et al., 2002; Sapieha et al., 2005; Thompson et al., 2003).”
ResultExcitotoxic Death of Retinal NeuronsIn VivoOccurs via a Non-Cell-Autonomous Mechanism
Lebrun-Julien, F., Duplan, L., Pernet, V., Osswald, I. K., Sapieha, P. S., Bourgeois, P., Dickson, K. M., Bowie, D., Barker, P. A., & Polo, A. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0831-09.2009 · Cited by 182 · see citing works
“Fluorogold-positive retinal ganglion cells were counted in 12 retinal zones: three areas in each eye quadrant located at 0.5, 1.0, and 1.5 mm from the optic nerve head were examined (Sapieha et al., 2005), corresponding to a total area of 0.5 mm 2.”
BackgroundMethodInfluentialSelf-citationKwon, S., Woo, J., Kim, S., Kim, H., & Kim, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061127 · Cited by 163 · see citing works
Structural genomics of protein phosphatases
Almo, S. C., Bonanno, J. B., Sauder, J. M., Emtage, S., DiLorenzo, T. P., Malashkevich, V. N., Wasserman, S. R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., et al. (2007) · Journal of Structural and Functional Genomics · doi:10.1007/s10969-007-9036-1 · Cited by 158 · see citing works
Fry, E. J., Chagnon, M. J., López‐Vales, R., Tremblay, M. L., & David, S. (2010) · Glia · doi:10.1002/glia.20934 · Cited by 152 · see citing works
“, 2003) and also promotes limited regeneration in the optic nerve (Sapieha et al., 2005).”
BackgroundResultInfluentialSelf-citationA sulfated carbohydrate epitope inhibits axon regeneration after injury
Brown, J. M., Xia, J., Zhuang, B., Cho, K.-S., Rogers, C. J., Gama, C. I., Rawat, M., Tully, S. E., Uetani, N., Mason, D. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121318109 · Cited by 154 · see citing works
Self-citationPromoting optic nerve regeneration
Fischer, D., & Leibinger, M. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.005 · Cited by 151 · see citing works
“, 2009) and enhanced axonal regeneration beyond the glial scar in the optic nerve (Sapieha et al., 2005).”
BackgroundChondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ
Pendleton, J. C., Shamblott, M. J., Gary, D. S., Belegu, V., Hurtado, A., Malone, M. L., & McDonald, J. W. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.04.003 · Cited by 134 · see citing works
Mammalian Motoneuron Axon Targeting Requires Receptor Protein Tyrosine Phosphatases σ and δ
Uetani, N., Chagnon, M. J., Kennedy, T. E., Iwakura, Y., & Tremblay, M. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0386-06.2006 · Cited by 133 · see citing works
Self-citationOohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131 · see citing works
Lebrun-Julien, F., Bertrand, M. J. M., Backer, O. D., Stellwagen, D., Morales, C. R., Polo, A. D., & Barker, P. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909276107 · Cited by 122 · see citing works
“9% NaCl, which was applied to the superior colliculus as described (58).”
BackgroundKwon, B. K., & Tetzlaff, W. (2001) · Spine · doi:10.1097/00007632-200112151-00003 · Cited by 116 · see citing works
Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities
Hendriks, W. J. A. J., & Pulido, R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.022 · Cited by 113 · see citing works
Gene therapy and transplantation in CNS repair: The visual system
Harvey, A. R., Hu, Y. J., Leaver, S. G., Mellough, C., Park, K. K., Verhaagen, J., Plant, G. W., & Cui, Q. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.07.002 · Cited by 110 · see citing works
Young, W. (2014) · Cell Transplantation · doi:10.3727/096368914x678427 · Cited by 103 · see citing works
Molecular mechanisms of scar-sourced axon growth inhibitors
Ohtake, Y., & Li, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.08.064 · Cited by 102 · see citing works
“Consistently, PTPσ knockout mice exhibited enhanced regeneration of injured optic nerve and peripheral nerves after injury (Fry et al., 2010; McLean et al., 2002; Sapieha et al., 2005; Thompson et al., 2003).”
BackgroundInhibition of p75NTR in glia potentiates TrkA-mediated survival of injured retinal ganglion cells
Lebrun-Julien, F., Morquette, B., Douillette, A., Saragovi, H. U., & Polo, A. D. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.12.005 · Cited by 99 · see citing works
Lost in the jungle: new hurdles for optic nerve axon regeneration
Pernet, V., & Schwab, M. E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.05.002 · Cited by 89 · see citing works
Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury
Alizadeh, A., & Karimi‐Abdolrezaee, S. (2016) · The Journal of Physiology · doi:10.1113/jp270895 · Cited by 89 · see citing works
“…Ashii et al. 2012; Furusho et al. 2012), and lack of RPTP-σ or blockade of LAR has been shown to improve remyelination, axonal growth and functional recovery following SCI (McLean et al. 2002; Thompson et al. 2003; Sapeiha et al. 2005; Shen et al. 2009; Fry et al. 2010; Fisher et al. 2011) (Fig.”
BackgroundContributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer
Silver, D. J., & Silver, J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.016 · Cited by 84 · see citing works
Dyck, S. M., Alizadeh, A., Santhosh, K. T., Proulx, E. H., Wu, C., & Karimi‐Abdolrezaee, S. (2015) · Stem Cells · doi:10.1002/stem.1979 · Cited by 84 · see citing works
Protein tyrosine phosphatases: functional inferences from mouse models and human diseases
Hendriks, W. J. A. J., Elson, A., Harroch, S., & Stoker, A. W. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06249.x · Cited by 81 · see citing works
Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors
Sami, A., Selzer, M. E., & Li, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00174 · Cited by 74 · see citing works
Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury
van Niekerk, E. A., Tuszynski, M. H., Lu, P., & Dulin, J. N. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.053751 · Cited by 72 · see citing works
“One of these, receptor protein tyrosine phosphatase sigma (PTP ), has been successfully targeted in experimental studies to promote axon regeneration in the optic nerve (196) and the spinal cord (197, 198).”
BackgroundUetani, N., Bertozzi, K., Chagnon, M. J., Hendriks, W. J. A. J., Tremblay, M. L., & Bouchard, M. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37196 · Cited by 70 · see citing works
Self-citationExploring Optic Nerve Axon Regeneration
Li, H., Sun, Z.-L., Yang, X., Zhu, L., & Feng, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666161227150250 · Cited by 67 · see citing works
“Accordingly, neurons from PTPσ knockout mice displayed reduced sensitivity towards CSPGs in culture [102] and enhanced axonal regeneration beyond the glial scar in the ON [103].”
BackgroundMaintenance of Axo-Oligodendroglial Paranodal Junctions Requires DCC and Netrin-1
Jarjour, A. A., Bull, S.-J., Almasieh, M., Rajasekharan, S., Baker, K. A., Mui, J., Antel, J., Polo, A. D., & Kennedy, T. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3285-08.2008 · Cited by 69 · see citing works
“The needle tip was inserted into the superior (dorsal) hemisphere of the eye, at the level of the pars plana, at a 45° angle through the sclera into the vitreous body as described previously (Sapieha et al., 2005).”
MethodSelf-citationTwo PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons
Ohtake, Y., Wong, D., Abdul-Muneer, P. M., Selzer, M. E., & Li, S. (2016) · Scientific Reports · doi:10.1038/srep37152 · Cited by 59 · see citing works
“Deletion of PTP σ activates MAPK and Akt signals in adult mouse retinal cells 70 .”
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity
Horn, K. E., Xu, B., Gobert, D., Hamam, B. N., Thompson, K. M., Wu, C., Bouchard, J., Uetani, N., Racine, R. J., Tremblay, M. L., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07762.x · Cited by 56 · see citing works
Self-citationTanaka, T., Wakabayashi, T., Oizumi, H., NISHIO, S., Sato, T., Harada, A., Fujii, D., Matsuo, Y., Hashimoto, T., & Iwatsubo, T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2440-13.2014 · Cited by 56 · see citing works
Roberta, S., Fladd, C., & Rotin, D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00707-06 · Cited by 55 · see citing works
Tran, A. P., Warren, P. M., & Silver, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113276 · Cited by 53 · see citing works
LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain
Cornejo, F., Cortés, B. I., Findlay, G. M., & Cancino, G. I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.659951 · Cited by 53 · see citing works
“The same results were observed when axonal regeneration was evaluated after optic nerve injury, where the number of axons that cross the lesion site was higher in PTPRS deficient mice (Sapieha et al., 2005).”
ResultLebrun-Julien, F., & Suter, U. (2015) · ASN NEURO · doi:10.1177/1759091415593066 · Cited by 53 · see citing works
“9% NaCl, which was applied to both superior colliculi as described (Sapieha et al., 2005).”
MethodInfluentialFaux, C. H., Hawadle, M., Nixon, J., Wallace, A. S., Lee, S. M., Murray, S. S., & Stoker, A. W. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.06.008 · Cited by 43 · see citing works
LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin
Wang, F., Wolfson, S. N., Gharib, A., & Sagasti, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.01.040 · Cited by 42 · see citing works
Proteoglycans and axon guidance: a new relationship between old partners
Masu, M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13508 · Cited by 41 · see citing works
Dimerization of Protein Tyrosine Phosphatase σ Governs both Ligand Binding and Isoform Specificity
Lee, S. M., Faux, C. H., Nixon, J., Alete, D. E., Chilton, J. K., Hawadle, M., & Stoker, A. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00535-06 · Cited by 41 · see citing works
“Although the role of ligand interactions is currently unclear, it is likely that they influence the biological functions of this phosphatase (6, 15, 33, 42, 44, 46, 49, 56, 60).”
BackgroundStrategies to neutralize RhoA/ROCK pathway after spinal cord injury
Roy, A., Pathak, Z., & Kumar, H. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113794 · Cited by 39 · see citing works
Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems
Ohtake, Y., Saito, A., & Li, S. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.01.014 · Cited by 37 · see citing works
“Consistently, PTPσ knockout mice exhibited enhanced regeneration of optic nerve and peripheral nerve after injury (McLean et al., 2002; Sapieha et al., 2005; Thompson et al., 2003).”
InfluentialMolecular approaches for spinal cord injury treatment
Martinez, A. B., de Almeida, F. M., Marques, S. A., dos Santos, A. R., Prins, C. A., Cardoso, F. S. D. S., Heringer, L. D. S., & Mendonça, H. R. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.344830 · Cited by 36 · see citing works
“CSPG signals through different receptors, such as LAR, protein tyrosine phosphatase σ (PTPσ) and NgR 1, 2, and 3 (Sapieha et al., 2005; Schwab and Strittmatter, 2014; Lang et al., 2015; Dyck et al., 2018, 2019).”
BackgroundA New Role for RPTPσ in Spinal Cord Injury: Signaling Chondroitin Sulfate Proteoglycan Inhibition
Duan, Y., & Giger, R. J. (2010) · Science Signaling · doi:10.1126/scisignal.3110pe6 · Cited by 34 · see citing works
Mechanisms of PTPσ-Mediated Presynaptic Differentiation
Bomkamp, C., Padmanabhan, N., Karimi, B., Ge, Y., Chao, J. T., Loewen, C. J. R., Siddiqui, T. J., & Craig, A. M. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00017 · Cited by 31 · see citing works
“This is exemplified by the first discovered and best known pair of synaptic organizing proteins, the postsynaptic neuroligins (Scheiffele et al., 2000) and the presynaptic neurexins (Graf et al., 2004).”
BackgroundNeuroprotection and regeneration in glaucoma.
Levin, L. A. (2005) · PubMed · doi:10.1016/j.ohc.2005.07.001 · Cited by 30 · see citing works
“For example, upregulation of cAMP allows regeneration of spinal cord [54,55] and retinal ganglion cell [56] axons, and mice lacking receptor protein tyrosine phosphatase sigma have increased retinal ganglion cell axon regeneration past a glial scar [57].”
RPTPs in axons, synapses and neurology
Stoker, A. W. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.006 · Cited by 28 · see citing works
Chagnon, M. J., Wu, C., Nakazawa, T., Yamamoto, T. S., Noda, M., Blanchetot, C., & Tremblay, M. L. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.06.001 · Cited by 28 · see citing works
Self-citationMurphy, J. A., Franklin, T. B., Rafuse, V. F., & Clarke, D. B. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.07.006 · Cited by 28 · see citing works
Murchie, R., Guo, C., Persaud, A. K., Muise, A. M., & Rotin, D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315017111 · Cited by 27 · see citing works
Protein Tyrosine Phosphatase σ in Proteoglycan-Mediated Neural Regeneration Regulation
Chien, P. N., & Ryu, S. E. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8346-x · Cited by 25 · see citing works
“However, the similar lesion or injury in PTPσ knockout mice does not show the inhibition, resulting in the regeneration of long distance axons [36–39] (Fig.”
Joly, S., & Pernet, V. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13701 · Cited by 25 · see citing works
Self-citationGupta, R. K., Saha, P., Sen, T., & Sen, N. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.02.015 · Cited by 22 · see citing works
Liu, H., Xu, H., Yu, T., Yao, J., Zhao, C., & Yin, Z. Q. (2013) · Current Eye Research · doi:10.3109/02713683.2013.803287 · Cited by 22 · see citing works
“It is abundantly expressed in both the developing and mature mammalian nervous systems,(16) acting to inhibit axon growth and slow axon regeneration.(14,17)”
BackgroundNB‐3 signaling mediates the cross‐talk between post‐traumatic spinal axons and scar‐forming cells
Huang, Z., Gao, Y., Sun, Y., Zhang, C., Yin, Y., Shimoda, Y., Watanabe, K., & Liu, Y. (2016) · The EMBO Journal · doi:10.15252/embj.201593460 · Cited by 22 · see citing works
“Loss of PTP r enhances regeneration in sciatic, facial, optic, and corticospinal axons after injury (McLean et al , 2002; Thompson et al , 2003; Sapieha et al , 2005; Shen et al , 2009; Fry et al , 2010), although the mechanism remains unclear.”
Martin, K. R., Narang, P., Xu, Y., Kauffman, A. L., Petit, J. L., Xu, H. E., Meurice, N., & MacKeigan, J. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050217 · Cited by 20 · see citing works
Shiga, Y., Olguin, A. G. R., Hajji, S. E., Belforte, N., Quintero, H., Dotigny, F., Alarcón-Martínez, L., Krishnaswamy, A., & Polo, A. D. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101839 · Cited by 19 · see citing works
Traffic lights for axon growth: proteoglycans and their neuronal receptors
Shen, Y. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.128236 · Cited by 19 · see citing works
“…are now increasingly recognized as key regulators of post-injury axonal plasticity (Xie et al., 2001; McLean et al., 2002; Thompson, 2003; Van der Zee et al., 2003; Sapieha et al., 2005; Shen et al., 2009; Fry et al., 2010; Fisher et al., 2011; Takahashi et al., 2012; Gardner and Habecker, 2013).”
BackgroundResultInfluentialNiknam, P., Raoufy, M. R., Fathollahi, Y., & Javan, M. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103391 · Cited by 20 · see citing works
Small Molecules Targeting PTPσ–Trk Interactions Promote Sympathetic Nerve Regeneration
Blake, M. R., Gardner, R. T., Jin, H., Staffenson, M. A., Rueb, N. J., Barrios, A. M., Dudley, G. B., Cohen, M. S., & Habecker, B. A. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00854 · Cited by 17 · see citing works
Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery
Martin, K. R., Narang, P., Medina‐Franco, J. L., Meurice, N., & MacKeigan, J. P. (2013) · Methods · doi:10.1016/j.ymeth.2013.08.013 · Cited by 17 · see citing works
Joly, S., Dalkara, D., & Pernet, V. (2017) · Neural Plasticity · doi:10.1155/2017/6818970 · Cited by 17 · see citing works
Self-citationPark, H., Chien, P. N., & Ryu, S. E. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.08.081 · Cited by 15 · see citing works
Murphy, J. A., Hartwick, A. T. E., Rutishauser, U. S., & Clarke, D. B. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2334 · Cited by 14 · see citing works
Zhang, Q., Li, Y., & Zhuo, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02781-y · Cited by 13 · see citing works
“Initially, genetic deletion of PTPσ was found to diminish neuronal sensitivity toward CSPGs and comprehensively enabled regenerative RGC axons to penetrate the glial scar at the lesion sites [120, 130].”
BackgroundAstrogliosis and Axonal Regeneration
Sharma, K., Zhang, G., & Li, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00011-2 · Cited by 12 · see citing works
Wu, C., Hardy, S., Aubry, I., Landry, M., Haggarty, A., Saragovi, H. U., & Tremblay, M. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178489 · Cited by 11 · see citing works
Self-citationLiu, Z.-G., Zhou, L.-Y., Yong-quan, S., Ma, Y., Liu, C.-M., & Zhang, B.-Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2024.1526973 · Cited by 10 · see citing works
Santhanam, A., Liang, S., Chen, D.-Y., Chen, G., & Meng, T. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08696.x · Cited by 9 · see citing works
Sethi, J., Zhao, B., Cuvillier‐Hot, V., Boidin‐Wichlacz, C., Salzet, M., Macagno, E. R., & Baker, M. W. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.002 · Cited by 9 · see citing works
“In contrast, RPTPσ, which closely resembles LAR, has been shown to slow axon regeneration after peripheral nerve injury and to inhibit axon regeneration following facial and optic nerve crush (Thompson et al., 2003; Sapieha et al., 2005).”
BackgroundRodemer, W., Zhang, G., Sinitsa, I., Hu, J., Jin, L., Li, S., & Selzer, M. E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00061 · Cited by 9 · see citing works
“For example, following optic nerve crush, PTPσ deletion reportedly improved axon regeneration but did not prevent retinal ganglion cell death (Sapieha et al., 2005).”
BackgroundERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells
Avilés, E. C., Wang, S. K., Patel, S., Cordero, S., Shi, S., Lin, L., Kefalov, V. J., Goodrich, L. V., Cepko, C. L., & Xue, Y. (2025) · The Journal of General Physiology · doi:10.1085/jgp.202413642 · Cited by 9 · see citing works
“This might also explain why Ptprs mutants have no obvious changes in retinal lamination (Sapieha et al., 2005).”
Hou, L., Wang, J., Zhou, Y., Li, J., Zang, Y., & Li, J. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr095 · Cited by 8 · see citing works
Berillo, O., Huo, K.-G., Richer, C., Fraulob-Aquino, J. C., Briet, M. B., Lipman, M. L., Sinnett, D., Paradis, P., & Schiffrin, E. L. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003160 · Cited by 9 · see citing works
Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension
Lee, H. S., Ku, B., Park, T. H., Park, H., Choi, J., Chang, K., Kim, C., Ryu, S. E., & Kim, S. J. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.11.026 · Cited by 8 · see citing works
Awakening the stalled axon — Surprises in CSPG gradients
Lee, S. J., Kalinski, A. L., & Twiss, J. L. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.025 · Cited by 6 · see citing works
Rodriguez, L., Joly, S., Mdzomba, J. B., & Pernet, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114100 · Cited by 6 · see citing works
“The rate of surviving RGCs reported in the present study is in agreement with previous studies [14].”
BackgroundResultSelf-citationMajd, S., Smardencas, A., Parish, C. L., & Drago, J. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0435-0 · Cited by 5 · see citing works
“Injury to adult brain neurons often results in cell death as mature neurons lack the capacity for self-repair [1–3].”
BackgroundLiu, X., Duan, H., Gao, L., Yuan, L., Hao, P., Zhao, W., Gao, Y., Huang, Z., Wang, X., Zhou, W., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2756-9 · Cited by 4 · see citing works
“…these measures cannot rebuild the visual pathway and restore visual functions (Fischer et al., 2004; Gaub et al., 2011; Leon et al., 2000; Lu et al., 2020; Moore et al., 2009; Park et al., 2008; Sapieha et al., 2005; So and Aguayo, 1985; Sun et al., 2011; Yin et al., 2003; You et al., 2016).”
Wang, R., Li, T., Diao, S., & Chen, C. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114564 · Cited by 4 · see citing works
Brahimi, F., Galán, A., Jmaeff, S., Barcelona, P. F., Jay, N. D., Dejgaard, K., Young, J. C., Kleinman, C. L., Thomas, D. Y., & Saragovi, H. U. (2020) · iScience · doi:10.1016/j.isci.2020.101447 · Cited by 4 · see citing works
“It is also noteworthy that, unrelated to TrkC activity, PTPsigma also regulates axonal growth after injury and inhibits axon regeneration (Sapieha et al., 2005; Thompson et al., 2003).”
BackgroundDickendesher, T. L., Duan, Y., & Giger, R. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00004-1 · Cited by 4 · see citing works
Chondroitin Sulfates in Axon Regeneration and Plasticity
Kwok, J. C. F., Tan, C. L., Wang, D., Heller, J. P., & Fawcett, J. W. (2011) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.23.201 · Cited by 3 · see citing works
Park, H., Lee, H. S., Ku, B., & Kim, S. J. (2013) · Medicinal Chemistry Research · doi:10.1007/s00044-013-0713-2 · Cited by 2 · see citing works
“In this regard, a line of experimental evidence indicated the involvement of PTPr in mediating the inhibitory role of CSPG in neural regeneration (Shen et al., 2009; Sapieha et al., 2005; McLean et al., 2002).”
BackgroundNeuroprotection and Neurorepair
Levin, L. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-7020-5193-7.00061-3 · Cited by 1 · see citing works
CNS Disease and Regeneration: When Growing Is Not Enough
Belin, S., & Nawabi, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11529-6 · Cited by 1 · see citing works
Unblocking axonal regeneration
Fulmer, T. (2009) · Science-Business eXchange · doi:10.1038/scibx.2009.1588 · Cited by 1 · see citing works
Genetic analysis of latrophilin in the toxicity of combined latrotoxins for C elegans.
Adenle, A. A. (2010) · Nottingham ePrints (University of Nottingham)
Neural repair: basic cellular and molecular processes
Selzer, M. E., Clarke, S., Cohen, L. G., Kwakkel, G., & Miller, R. H. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995583.020
Axonguidance during development and regeneration
Moore, S. W., & Kennedy, T. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995583.023
Self-citationProtein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem
Self-Renewal, C., & Quarmyne, M. (2015)
Spinal Cord and Peripheral Nerve Regeneration Current Research and Future Possibilities
Young, W., & Kaplan, H. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-41406-5_27
Glypican-1 modulates CSPG inhibition on growing axons
Kim, B. (2015) · TSpace (University of Toronto)
- Authors
- Sapieha, P. S., Duplan, L., Uetani, N., Joly, S., Tremblay, M. L., Kennedy, T. E., & Di Polo, A.
- Affiliations
- Université de Montréal (CA)
- McGill University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 28
- Issue
- 4
- Pages
- 625-635
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2092811972
- Cited by
- 106
- References
- 76
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 15 · 2013: 6 · 2012: 10
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- axon regeneration, optic nerve injury, retinal ganglion cells, glial scar, mitogen-activated protein kinase, Akt kinase, knockout mice
- MeSH terms
- Animals, Axons, Female, Mice, Inbred BALB C, Nerve Regeneration, Neural Inhibition, Retinal Ganglion Cells, Protein Tyrosine Phosphatases, Mice, Knockout, Optic Nerve Injuries, Mice, Receptor-Like Protein Tyrosine Phosphatases, Class 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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