Induced expression of polysialic acid in the spinal cord promotes regeneration of sensory axons
Abstract
After spinal cord injury axonal regeneration is prevented by glial scar formation. In this study we examined whether induced expression of polysialic acid (PSA) in the lesion site would render the glial scar permissive to axonal regeneration after dorsal column transection. PSA was induced by lentiviral vector-mediated expression of polysialyltransferase (LV/PST). PSA expression increased astrocyte infiltration and permitted the penetration of regenerating axons across the caudal border of the lesion and into the lesion cavity. In LV/PST-injected animals with a peripheral nerve-conditioning lesion, 20 times more axons grew into the lesion cavity than those LV/GFP-injected plus conditioning lesion, and some axons grew across the cavity and extended to the rostral cord, while in LV/GFP group most ascending axons terminated at the caudal border of the lesion. Our result suggests that induced expression of PSA can provide a favorable environment for axonal regeneration.
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The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.
“The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”
From Biological roles of glycans (2017) · cites this paper as [547]
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- Authors
- Zhang, Y., Ghadiri-Sani, M., Zhang, X., Richardson, P. M., Yeh, J., & Bo, X.
- Affiliations
- University of London (GB)
- Corresponding author
- Zhang, Yi
- Bo, Xuenong
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 35
- Issue
- 1
- Pages
- 109-119
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2077439657
- Cited by
- 49
- References
- 53
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- polysialic acid, spinal cord injury, axon regeneration, sensory axons, glial scar, polysialyltransferase, lentiviral vectors
- MeSH terms
- Animals, Astrocytes, Axons, Genetic Vectors, Gliosis, Male, Nerve Regeneration, Neurons, Afferent, Sialic Acids, Sialyltransferases, Spinal Cord, Spinal Cord Injuries, Genetic Therapy, Lentivirus, Rats, Wistar, DNA, Complementary, Green Fluorescent Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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