Use of polysialic acid in repair of the central nervous system
Open accessAbstract
Polysialic acid (PSA), a large cell-surface carbohydrate that regulates cell interactions, is used during vertebrate development to promote precursor cell migration and axon path-finding. The induction of PSA expression in damaged adult CNS tissues could help them to rebuild by creating conditions permissive for architectural remodeling. This possibility has been explored in two contexts, the regeneration of axons and the recruitment of endogenous neural precursors to a lesion. Glial scars that form at CNS injury sites block axon regeneration. It has been found that transfection of scar astrocytes by a viral vector encoding polysialyltransferase leads to sustained expression of high levels of PSA. With this treatment, a substantial portion of severed corticospinal tract axon processes were able to grow through a spinal injury site. In the studies of precursor cell migration to a cortical lesion, it was found that induced PSA expression in a path extending from the subventricular zone to a lesion near the cortical surface increased recruitment of BrdU/nestin-positive cells along the path and into the injury site. These displaced precursors were able to differentiate in a regionally appropriate manner. These findings suggest that induced PSA expression can be used as a strategy for promoting tissue repair involving both replacement of cells and rebuilding of neural connections.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.
“The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”
From Biological roles of glycans (2017) · cites this paper as [546]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Degeneration and Regeneration of the Nervous System.
(1929) · JAMA · doi:10.1001/jama.1929.02710220063037 · Cited by 2,920 · see citing works
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799 · see citing works
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357 · see citing works
David, S., & Aguayo, A. J. (1981) · Science · doi:10.1126/science.6171034 · Cited by 1,698 · see citing works
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,478 · see citing works
Induction of neurogenesis in the neocortex of adult mice
Magavi, S. S. P., Leavitt, B. R., & Macklis, J. D. (2000) · Nature · doi:10.1038/35016083 · Cited by 1,217 · see citing works
Caroni, P., & Schwab, M. E. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.4.1281 · Cited by 880 · see citing works
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873 · see citing works
Schwab, M. E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.004 · Cited by 613 · see citing works
Moon, L. D. F., Asher, R. A., Rhodes, K. E., & Fawcett, J. W. (2001) · Nature Neuroscience · doi:10.1038/87415 · Cited by 563 · see citing works
Tomasiewicz, H. G., Ono, K., Yee, D., Thompson, C., Goridis, C., Rutishauser, U. S., & Magnuson, T. (1993) · Neuron · doi:10.1016/0896-6273(93)90228-j · Cited by 475 · see citing works
Self-citationPicard-Riéra, N., Decker, L., Delarasse, C., Goude, K., Nait‐Oumesmar, B., Liblau, R., Pham-Dinh, D., & Evercooren, A. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192314199 · Cited by 469 · see citing works
Ono, K., Tomasiewicz, H. G., Magnuson, T., & Rutishauser, U. S. (1994) · Neuron · doi:10.1016/0896-6273(94)90028-0 · Cited by 414 · see citing works
Self-citationHu, H., Tomasiewicz, H. G., Magnuson, T., & Rutishauser, U. S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80094-x · Cited by 361 · see citing works
Self-citationAxonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice
Goldshmit, Y., Galea, M. P., Wise, G. E., Bartlett, P. F., & Turnley, A. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2981-04.2004 · Cited by 318 · see citing works
Polysialic acid as a regulator of intramuscular nerve branching during embryonic development
Landmesser, L. T., Dahm, L. M., Tang, J., & Rutishauser, U. S. (1990) · Neuron · doi:10.1016/0896-6273(90)90193-j · Cited by 317 · see citing works
Self-citationHolland, E. C., & VARMUS, H. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1218 · Cited by 305 · see citing works
Delayed Systemic Nogo-66 Receptor Antagonist Promotes Recovery from Spinal Cord Injury
Li, S., & Strittmatter, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04219.2003 · Cited by 305 · see citing works
NCAM Is Essential for Axonal Growth and Fasciculation in the Hippocampus
Cremer, H., Chazal, G., Goridis, C., & Represa, A. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0588 · Cited by 294 · see citing works
Seki, T., & Arai, Y. (1991) · Anatomy and Embryology · doi:10.1007/bf00957900 · Cited by 264 · see citing works
Seki, T., & Rutishauser, U. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03757.1998 · Cited by 262 · see citing works
Self-citationPolysialic acid regulates growth cone behavior during sorting of motor axons in the plexus region
Tang, J., Rutishauser, U. S., & Landmesser, L. T. (1994) · Neuron · doi:10.1016/0896-6273(94)90356-5 · Cited by 257 · see citing works
Self-citationPolysialic acid influences specific pathfinding by avian motoneurons
Tang, J., Landmesser, L. T., & Rutishauser, U. S. (1992) · Neuron · doi:10.1016/0896-6273(92)90125-w · Cited by 238 · see citing works
Self-citationJohnson, C. P., Fujimoto, I., Rutishauser, U. S., & Leckband, D. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410216200 · Cited by 220 · see citing works
Self-citationRoles, regulation, and mechanism of polysialic acid function during neural development
Brusés, J. L., & Rutishauser, U. S. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01293-7 · Cited by 207 · see citing works
Self-citationYoung, J. A. T., Bates, P. F., & VARMUS, H. E. (1993) · Journal of Virology · doi:10.1128/jvi.67.4.1811-1816.1993 · Cited by 207 · see citing works
The persistent expression of a highly polysialylated NCAM in the dentate gyrus of the adult rat
Seki, T., & Arai, Y. (1991) · Neuroscience Research · doi:10.1016/s0168-0102(09)80003-5 · Cited by 194 · see citing works
Camand, E., Morel, M., Faissner, A., Sotelo, C., & Dusart, I. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03558.x · Cited by 154 · see citing works
Regulation of Cell Adhesion by Polysialic Acid
Fujimoto, I., Brusés, J. L., & Rutishauser, U. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104525200 · Cited by 146 · see citing works
Self-citationDoyle, E., Nolan, P. M., Bell, R., & Regan, C. M. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310315 · Cited by 139 · see citing works
Franz, C. K., Rutishauser, U. S., & Rafuse, V. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4880-04.2005 · Cited by 130 · see citing works
Self-citationYoshida, K., Rutishauser, U. S., Crandall, J. E., & Schwarting, G. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00794.1999 · Cited by 118 · see citing works
Self-citationFredette, B. J., Rutishauser, U. S., & Landmesser, L. T. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1867 · Cited by 111 · see citing works
Self-citationRole of Neural Cell Adhesion Molecule and Polysialic Acid in Mouse Circadian Clock Function
Shen, H., Watanabe, M., Tomasiewicz, H. G., Rutishauser, U. S., Magnuson, T., & Glass, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05221.1997 · Cited by 111 · see citing works
Self-citationPetridis, A. K., El Maarouf, A., & Rutishauser, U. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20094 · Cited by 95 · see citing works
Self-citationDaston, M. M., Bastmeyer, M., Rutishauser, U. S., & O’Leary, D. D. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05488.1996 · Cited by 86 · see citing works
Self-citationDevelopment of an Avian Leukosis-Sarcoma Virus Subgroup A Pseudotyped Lentiviral Vector
Lewis, B. C., Chinnasamy, N., Morgan, R. A., & VARMUS, H. E. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.9339-9344.2001 · Cited by 83 · see citing works
Kiss, J. Z., Wang, C., & Rougon, G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90299-u · Cited by 76 · see citing works
Genetic Basis for Resistance to Parathyroid Hormone
Levine, M. A., Germain‐Lee, E. L., & de Beur, S. M. J. (2003) · Hormone Research in Paediatrics · doi:10.1159/000074508 · Cited by 63 · see citing works
Maarouf, A. E., & Rutishauser, U. S. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10635 · Cited by 55 · see citing works
Self-citationHonig, M. G., & Rutishauser, U. S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0118 · Cited by 47 · see citing works
Self-citationGlass, J. D., Lee, W., Shen, H., et al. (2008) · Neuroendocrinology · doi:10.1159/000126723 · Cited by 40 · see citing works
CNS regeneration: clinical possibility or basic science fantasy?
Batchelor, P., & Howells, D. W. (2003) · Journal of Clinical Neuroscience · doi:10.1016/s0967-5868(03)00004-3 · Cited by 33 · see citing works
Bellairs, R., Lear, P., Yamada, K. M., et al. (1995) · Developmental Dynamics · doi:10.1002/aja.1002020403 · Cited by 21 · see citing works
Canger, A. K. (2003) · Glycobiology · doi:10.1093/glycob/cwh014 · Cited by 18 · see citing works
Polysialic acid in adult brain plasticity
Maarouf, A. E., & Rutishauser, U. S. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198525387.003.0002 · Cited by 6 · see citing works
Self-citationS�nchez, M. M., Young, L. J., Plotsky, P. M., & Insel, T. R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990607)408:3
Rinaman (1998) · doi:10.1002/(sici)1096-9861(19980914)399:1
Flagged first, then by citations
Research works printed but not linked: 3
- [24]El Maarouf A, Rutishauser U. In: Neuroglycobiology. Fukuda M, Rutishauser U, Schnaar RL, editors. London: Oxford Univ Press; 2005. p. 39. [Google Scholar]
- [30]Aubert I, Ridet JL, Schachner M, Rougon G, Gage FH. J Comp Neurol. 1998;399:1–19. [PubMed] [Google Scholar]
- [31]Dusart I, Morel MP, Wehrle R, Sotelo C. J Comp Neurol. 1999;408:399–418. [PubMed] [Google Scholar]
Cited by
Sorted by citations
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“The "plasticity" resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546) (547) (548) (549) (550) (551) (552) (553) (554) .”
BackgroundSchnaar, R. L., Gerardy-Schahn, R., & Hildebrandt, H. (2014) · Physiological Reviews · doi:10.1152/physrev.00033.2013 · Cited by 745 · see citing works
Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
Rutishauser, U. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2285 · Cited by 584 · see citing works
Self-citationKataria, H., Wadhwa, R., Kaul, S. C., & Kaur, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037080 · Cited by 77 · see citing works
Battista, D., & Rutishauser, U. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4382-09.2010 · Cited by 60 · see citing works
Self-citationInduced expression of polysialic acid in the spinal cord promotes regeneration of sensory axons
Zhang, Y., Ghadiri-Sani, M., Zhang, X., Richardson, P. M., Yeh, J., & Bo, X. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.011 · Cited by 49 · see citing works
De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20 · see citing works
“In fact, due to both bulk and negative charges, hyaluronan and polysialic acid can inhibit cell–cell adhesion and cell–matrix interaction [37,38].”
Background
- Authors
- El Maarouf, A., Petridis, A. K., & Rutishauser, U.
- Affiliations
- Laboratory of Cellular and Developmental Neuroscience, Department of Cell Biology, Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, New York, NY 10021
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Rutishauser, Urs
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-11-07
- Volume
- 103
- Issue
- 45
- Pages
- 16989-16994
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1636566
- OpenAlex
- W2054293861
- Cited by
- 150
- References
- 48
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 10 · 2013: 5 · 2012: 14
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- National Cancer Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- polysialic acid, central nervous system repair, axon regeneration, corticospinal tract, spinal cord injury, glial scar, polysialyltransferase, subventricular zone, cortical lesions, nestin, bromodeoxyuridine, neural tissue regeneration
- MeSH terms
- Animals, Astrocytes, Axons, Brain Injuries, Cell Movement, Central Nervous System, Male, Mice, Transgenic, Nerve Regeneration, Recombinant Proteins, Sialic Acids, Sialyltransferases, Stem Cells, Transfection, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
