CoChat
Sign Up
Cited by 47

Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α

Stary, Creed M., Xu, Lijun, Li, Le, Sun, Xiaoyun, Ouyang, Yi-Bing, Xiong, Xiaoxing, Zhao, Jing, Giffard, Rona G.·2017·Molecular and Cellular Neuroscience
DOI 10.1016/j.mcn.2017.05.004PMC PMC5561665
Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.mcn.2017.05.004

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In AD-related contexts, miR-181a is downregulated in astrocytes, where it normally prevents excessive GFAP/S100B reactivity and supports balanced survival signaling.

    “In AD-related contexts, miR-181a is downregulated in astrocytes, where it normally prevents excessive GFAP/S100B reactivity and supports balanced survival signaling (Hutchison et al., 2013; Stary et al., 2017).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Stary et al., 2017

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 57

  1. Alkayed NJ Harukuni I Kimes AS London ED Traystman RJ Hurn PD 1998 Gender-linked brain injury in experimental stroke Stroke 29 159 65 discussion 166 9445346
  2. Arimoto JM Wong A Rozovsky I Lin SW Morgan TE Finch CE 2013 Age increase of estrogen receptor-alpha (ERalpha) in cortical astrocytes impairs neurotrophic support in male and female rats Endocrinology 154 2101 2113 23515288 PMC3740484
  3. Bondar G Kuo J Hamid N Micevych P 2009 Estradiol-induced estrogen receptor-alpha trafficking J Neurosci 29 15323 15330 19955385 PMC2836237
  4. Carswell HV Macrae IM Gallagher L Harrop E Horsburgh KJ 2004 Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia Am J Physiol Heart Circ Physiol 287 H1501 4 15155257
  5. Cimarosti H Jones NM O’Shea RD Pow DV Salbego C Beart PM 2005 Hypoxic preconditioning in neonatal rat brain involves regulation of excitatory amino acid transporter 2 and estrogen receptor alpha Neurosci Lett 385 52 57 15927375
  6. Coleman KM Dutertre M El-Gharbawy A Rowan BG Weigel NL Smith CL 2003 Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s) J Biol Chem 278 12834 12845 12566449
  7. Dai X Chen L Sokabe M 2007 Neurosteroid estradiol rescues ischemia-induced deficit in the long-term potentiation of rat hippocampal CA1 neurons Neuropharmacology 52 1124 1138 17258238
  8. Dhandapani KM Wade FM Mahesh VB Brann DW 2005 Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways Endocrinology 146 2749 2759 15746252
  9. Dubal DB Kashon ML Pettigrew LC Ren JM Finklestein SP Rau SW Wise PM 1998 Estradiol protects against ischemic injury J Cereb Blood Flow Metab 18 1253 1258 9809515
  10. Dubal DB Zhu H Yu J Rau SW Shughrue PJ Merchenthaler I Kindy MS Wise PM 2001 Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury Proc Natl Acad Sci U S A 98 1952 1957 11172057 PMC29363
  11. Dugan LL Bruno VM Amagasu SM Giffard RG 1995 Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity J Neurosci 15 4545 4555 7540679 PMC6577706
  12. Galbiati M Martini L Melcangi RC 2002 Oestrogens, via transforming growth factor alpha, modulate basic fibroblast growth factor synthesis in hypothalamic astrocytes: in vitro observations J Neuroendocrinol 14 829 835 12372008
  13. Gao L Wang G Liu W Kinser H Franco HL Mendelson CR 2016 Reciprocal Feedback between miR-181a and E2/ERalpha in Myometrium Enhances Inflammation Leading to Labor J Clin Endocrinol Metab jc20162078 PMC5052345 27459534
  14. Garcia-Ovejero D Veiga S Garcia-Segura LM Doncarlos LL 2002 Glial expression of estrogen and androgen receptors after rat brain injury J Comp Neurol 450 256 271 12209854
  15. Greenham LW Greenham V 1977 Sexing mouse pups Lab Anim 11 181 184 886831
  16. Gulinello M Lebesgue D Jover-Mengual T Zukin RS Etgen AM 2006 Acute and chronic estradiol treatments reduce memory deficits induced by transient global ischemia in female rats Horm Behav 49 246 260 16125703 PMC4169120
  17. Ivanova T Karolczak M Beyer C 2001 Estrogen stimulates the mitogen-activated protein kinase pathway in midbrain astroglia Brain Res 889 264 269 11166717
  18. Kalaitzidis D Gilmore TD 2005 Transcription factor cross-talk: the estrogen receptor and NF-kappaB Trends Endocrinol Metab 16 46 52 15734144
  19. Kastrati I Canestrari E Frasor J 2015 PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres Oncogene 34 2309 2316 24954507 PMC4275416
  20. Kuo J Hamid N Bondar G Prossnitz ER Micevych P 2010 Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes J Neurosci 30 12950 12957 20881113 PMC2957903
  21. Lee ES Sidoryk M Jiang H Yin Z Aschner M 2009 Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes J Neurochem 110 530 544 19453300 PMC3920654
  22. Li X Blizzard KK Zeng Z DeVries AC Hurn PD McCullough LD 2004 Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender Exp Neurol 187 94 104 15081592
  23. Liao S Chen W Kuo J Chen C 2001 Association of serum estrogen level and ischemic neuroprotection in female rats Neurosci Lett 297 159 162 11137752
  24. Liu Y Zhao Z Yang F Gao Y Song J Wan Y 2013 microRNA-181a is involved in insulin-like growth factor-1-mediated regulation of the transcription factor CREB1 J Neurochem 126 771 780 23865718
  25. Livak KJ Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method Methods 25 402 408 11846609
  26. Lu A Ran RQ Clark J Reilly M Nee A Sharp FR 2002 17-beta-estradiol induces heat shock proteins in brain arteries and potentiates ischemic heat shock protein induction in glia and neurons J Cereb Blood Flow Metab 22 183 195 11823716
  27. Maillot G Lacroix-Triki M Pierredon S Gratadou L Schmidt S Bénès V Roché H Dalenc F Auboeuf D Millevoi S Vagner S 2009 Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth Cancer Res 69 8332 8340 19826037
  28. Manwani B Bentivegna K Benashski SE Venna VR Xu Y Arnold AP McCullough LD 2015 Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement J Cereb Blood Flow Metab 35 221 229 25388681 PMC4426738
  29. Manwani B Friedler B Verma R Venna VR McCullough LD Liu F 2014 Perfusion of ischemic brain in young and aged animals: a laser speckle flowmetry study Stroke 45 571 578 24357659 PMC3946827
  30. McCarthy JB Barker-Gibb AL Alves SE Milner TA 2002 TrkA immunoreactive astrocytes in dendritic fields of the hippocampal formation across estrous Glia 38 36 44 11921202
  31. McCullough LD Blizzard K Simpson ER Oz OK Hurn PD 2003 Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection J Neurosci 23 8701 8705 14507969 PMC6740420
  32. Melcangi RC Magnaghi V Galbiati M Martini L 2001 Formation and effects of neuroactive steroids in the central and peripheral nervous system Int Rev Neurobiol 46 145 176 11599299
  33. Miller NR Jover T Cohen HW Zukin RS Etgen AM 2005 Estrogen can act via estrogen receptor alpha and beta to protect hippocampal neurons against global ischemia-induced cell death Endocrinology 146 3070 3079 15817665
  34. Moon JM Xu L Giffard RG 2013 Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss J Cereb Blood Flow Metab 33 1976 1982 24002437 PMC3851907
  35. Mozaffarian D Benjamin EJ Go AS Arnett DK Blaha MJ Cushman M de Ferranti S Despres JP Fullerton HJ Howard VJ Huffman MD Judd SE Kissela BM Lackland DT Lichtman JH Lisabeth LD Liu S Mackey RH Matchar DB McGuire DK Mohler ER Moy CS Muntner P Mussolino ME Nasir K Neumar RW Nichol G Palaniappan L Pandey DK Reeves MJ Rodriguez CJ Sorlie PD Stein J Towfighi A Turan TN Virani SS Willey JZ Woo D Yeh RW Turner MB 2015 Heart disease and stroke statistics--2015 update: a report from the American Heart Association Circulation 131 e29 322 25520374
  36. Ouyang YB Lu Y Yue S Xu LJ Xiong XX White RE Sun X Giffard RG 2012 miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo Neurobiol Dis 45 555 563 21983159 PMC3251314
  37. Ouyang YB Stary CM Yang GY Giffard R 2013 microRNAs: innovative targets for cerebral ischemia and stroke Curr Drug Targets 14 90 101 23170800 PMC3673881
  38. Ouyang YB Voloboueva LA Xu LJ Giffard RG 2007 Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia J Neurosci 27 4253 4260 17442809 PMC3140959
  39. Papadopoulos MC Koumenis IL Yuan TY Giffard RG 1998a Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses Neuroscience 82 915 925 9483545
  40. Papadopoulos MC Koumenis IL Yuan TY Giffard RG 1998b Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses Neuroscience 82 915 925 9483545
  41. Pawlak J Brito V Kuppers E Beyer C 2005 Regulation of glutamate transporter GLAST and GLT-1 expression in astrocytes by estrogen Brain Res Mol Brain Res 138 1 7 15896872
  42. Petrea RE Beiser AS Seshadri S Kelly-Hayes M Kase CS Wolf PA 2009 Gender differences in stroke incidence and poststroke disability in the Framingham heart study Stroke 40 1032 1037 19211484 PMC2676725
  43. Ritzel RM Capozzi LA McCullough LD 2013 Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke Horm Behav 63 238 253 22561337 PMC3426619
  44. Rusa R Alkayed NJ Crain BJ Traystman RJ Kimes AS London ED Klaus JA Hurn PD 1999 17beta-estradiol reduces stroke injury in estrogen-deficient female animals Stroke 30 1665 1670 10436119
  45. Sampei K Goto S Alkayed NJ Crain BJ Korach KS Traystman RJ Demas GE Nelson RJ Hurn PD 2000 Stroke in estrogen receptor-alpha-deficient mice Stroke 31 738 43 discussion 744 10700513
  46. Selvamani A Williams MH Miranda RC Sohrabji F 2014 Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model Clin Sci (Lond) 127 77 89 24428837 PMC4386587
  47. Simpkins JW Rajakumar G Zhang YQ Simpkins CE Greenwald D Yu CJ Bodor N Day AL 1997 Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat J Neurosurg 87 724 730 9347981
  48. Sisk CL Meek LR 2001 Sexual and reproductive behaviors Curr Protoc Neurosci Chapter 8 Unit 8.2 18428542
  49. Stary CM Sun X Ouyang Y Li L Giffard RG 2016 miR-29a differentially regulates cell survival in astrocytes from cornu ammonis 1 and dentate gyrus by targeting VDAC1 Mitochondrion 30 248 254 27553862 PMC6082172
  50. Su L Liu R Cheng W Zhu M Li X Zhao S Yu M 2014 Expression patterns of microRNAs in porcine endometrium and their potential roles in embryo implantation and placentation PLoS One 9 e87867 24505325 PMC3914855
  51. Towfighi A Saver JL Engelhardt R Ovbiagele B 2007 A midlife stroke surge among women in the United States Neurology 69 1898 1904 17581944
  52. Xiong X Barreto GE Xu L Ouyang YB Xie X Giffard RG 2011 Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia Stroke 42 2026 2032 21597016 PMC3128567
  53. Xiong X Xu L Wei L White RE Ouyang YB Giffard RG 2015 IL-4 Is Required for Sex Differences in Vulnerability to Focal Ischemia in Mice Stroke 46 2271 2276 26130091 PMC4519392
  54. Xu L Emery JF Ouyang YB Voloboueva LA Giffard RG 2010 Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia Glia 58 1042 1049 20235222 PMC3108566
  55. Yang G Chan PH Chen J Carlson E Chen SF Weinstein P Epstein CJ Kamii H 1994 Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia Stroke 25 165 170 8266365
  56. Yu L Moore AB Castro L Gao X Huynh HL Klippel M Flagler ND Lu Y Kissling GE Dixon D 2012 Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells J Signal Transduct 2012 204236 23094148 PMC3474284
  57. Zhang QG Raz L Wang R Han D De Sevilla L Yang F Vadlamudi RK Brann DW 2009 Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation J Neurosci 29 13823 13836 19889994 PMC2807671

Cited by

Sorted by citations

Authors
Stary, C. M., Xu, L., Li, L., Sun, X., Ouyang, Y.-B., Xiong, X., Zhao, J., & Giffard, R. G.
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2017-07
Volume
82
Pages
118-125
ISSN
1044-7431
DOI
10.1016/j.mcn.2017.05.004
PMC
PMC5561665
Cited by
47
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review