Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

Michinaga, Shotaro; Koyama, Yutaka

doi:10.3390/ijms20030571

Cited by 263Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

Open access

Michinaga, Shotaro, Koyama, Yutaka·2019·International Journal of Molecular Sciences

DOI 10.3390/ijms20030571PMC PMC6387062

Open this paper in CoChat — free account Open PDF

Abstract

The blood-brain barrier (BBB) is a major functional barrier in the central nervous system (CNS), and inhibits the extravasation of intravascular contents and transports various essential nutrients between the blood and the brain. After brain damage by traumatic brain injury, cerebral ischemia and several other CNS disorders, the functions of the BBB are disrupted, resulting in severe secondary damage including brain edema and inflammatory injury. Therefore, BBB protection and recovery are considered novel therapeutic strategies for reducing brain damage. Emerging evidence suggests key roles of astrocyte-derived factors in BBB disruption and recovery after brain damage. The astrocyte-derived vascular permeability factors include vascular endothelial growth factors, matrix metalloproteinases, nitric oxide, glutamate and endothelin-1, which enhance BBB permeability leading to BBB disruption. By contrast, the astrocyte-derived protective factors include angiopoietin-1, sonic hedgehog, glial-derived neurotrophic factor, retinoic acid and insulin-like growth factor-1 and apolipoprotein E which attenuate BBB permeability resulting in recovery of BBB function. In this review, the roles of these astrocyte-derived factors in BBB function are summarized, and their significance as therapeutic targets for BBB protection and recovery after brain damage are discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms20030571

Cites

190 of 190 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reactive astrocytes are a major source of various vascular permeability factors.
“Reactive astrocytes are a major source of various vascular permeability factors [44–47].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [46]
Section 3.1 (page unavailable) reports that reactive astrocytes produce VEGF and release MMP-2 and MMP-9, factors associated with blood–brain barrier disruption. It does not establish that astrocytes are a major source relative to other cells; the section notes that VEGF and MMPs are also produced by other CNS cell types. (LLM, conf=0.83)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARα Activation
Hou, X., & Pei, F. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0522-y · Cited by 33 · see citing works
Retracted
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459 · see citing works
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060 · see citing works
Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
Asahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004 · see citing works
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., et al. (2011) · Science · doi:10.1126/science.1206936 · Cited by 845 · see citing works
Crosstalk of tight junction components with signaling pathways
González-Mariscal, L., Tapia, R., & Chamorro, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.018 · Cited by 759 · see citing works
Astrocyte roles in traumatic brain injury
Burda, J. E., Bernstein, A. M., & Sofroniew, M. V. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.020 · Cited by 758 · see citing works
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease
Argaw, A. T., Asp, L., Zhang, J., Navrazhina, K., Pham, T., Mariani, J. N., Mahase, S., Dutta, D. J., Seto, J., Kramer, E. G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60842 · Cited by 733 · see citing works
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
Argaw, A. T., Gurfein, B. T., Zhang, Y., Zameer, A., & John, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808698106 · Cited by 666 · see citing works
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation
Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654 · see citing works
Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
van de Haar, H. J., Burgmans, S., Jansen, J. F. A., van Osch, M. J. P., van Buchem, M. A., Muller, M., Hofman, P. A. M., Verhey, F. R. J., & Backes, W. H. (2016) · Radiology · doi:10.1148/radiol.2016152244 · Cited by 601 · see citing works
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works
SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier
Lee, S., Kim, W. J., Choi, Y. K., Song, H. S., Son, M. J., Gelman, I. H., Kim, Y.-J., & Kim, K. (2003) · Nature Medicine · doi:10.1038/nm889 · Cited by 473 · see citing works
Absence of Glial Fibrillary Acidic Protein and Vimentin Prevents Hypertrophy of Astrocytic Processes and Improves Post-Traumatic Regeneration
Wilhelmsson, U., Li, L., Pekna, M., Berthold, C.-H., Blom, S., Eliasson, C., Renner, O., Bushong, E., Ellisman, M., Morgan, T. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0820-04.2004 · Cited by 455 · see citing works
Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease
Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409 · see citing works
Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism
Yin, K.-J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F.-F., Turk, J., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2085-06.2006 · Cited by 381 · see citing works
Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression
Kim, I., Moon, S.-O., Park, S. K., Chae, S., & Koh, G. Y. (2001) · Circulation Research · doi:10.1161/hh1801.097034 · Cited by 368 · see citing works
The Role of Astrocytes in Multiple Sclerosis
Ponath, G. D., Park, C., & Pitt, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00217 · Cited by 356 · see citing works
Inflammatory cell trafficking across the blood–brain barrier: chemokine regulation and in vitro models
Takeshita, Y., & Ransohoff, R. M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01127.x · Cited by 327 · see citing works
Astrocyte reactivity and astrogliosis after spinal cord injury
Okada, S., Hara, M., Kobayakawa, K., Matsumoto, Y., & Nakashima, Y. (2018) · Neuroscience Research · doi:10.1016/j.neures.2017.10.004 · Cited by 313 · see citing works
Factors controlling permeability of the blood–brain barrier
Almutairi, M. M., Chen, G., Xu, Y. G., Chang, Y., & Shi, H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2050-8 · Cited by 308 · see citing works
Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke
Zacharek, A., Chen, J., Li, A., Cui, X., Li, Y., Roberts, C., Feng, Y., Gao, Q., & Chopp, M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600475 · Cited by 297 · see citing works
Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes
Wang, Y., Jin, S., Sonobe, Y., Cheng, Y., Horiuchi, H., Parajuli, B., Kawanokuchi, J., Mizuno, T., Takeuchi, H., & Suzumura, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110024 · Cited by 286 · see citing works
Neuron–glia crosstalk gets serious: role in pain hypersensitivity
Ren, K., & Dubner, R. A. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32830edbdf · Cited by 271 · see citing works
Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans
Hay, J. R., Johnson, V. E., Young, A. M. H., Smith, D. H., & Stewart, W. B., Jr. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000261 · Cited by 265 · see citing works
Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging
Wrigley, S., Arafa, D., & Tropea, D. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00014 · Cited by 263 · see citing works
Caveolin‐1 regulates nitric oxide‐mediated matrix metalloproteinases activity and blood–brain barrier permeability in focal cerebral ischemia and reperfusion injury
Gu, Y., Zheng, G., Xu, M., Li, Y., Chen, X., Zhu, W., Tong, Y., Chung, S. K., Liu, K. J., & Shen, J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07542.x · Cited by 251 · see citing works
Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor
Pan, Y., Liang, H., Liu, H., Li, D., Chen, X., Li, L., Zhang, C., & Zen, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301790 · Cited by 238 · see citing works
Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI
Cramer, S. P., Simonsen, H., Frederiksen, J. L., Rostrup, E., & Larsson, H. B. W. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.12.001 · Cited by 232 · see citing works
Astrocyte activation and reactive gliosis—A new target in stroke?
Pekny, M., Wilhelmsson, U., Tatlisumak, T., & Pekna, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.021 · Cited by 231 · see citing works
MicroRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury
Bhalala, O. G., Pan, L., Sahni, V., McGuire, T. L., Gruner, K., Tourtellotte, W. G., & Kessler, J. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3860-12.2012 · Cited by 220 · see citing works
Sonic hedgehog signalling pathway: a complex network
Choudhry, Z., Rikani, A. A., Choudhry, A. M., Tariq, S., Zakaria, F., Asghar, M. W., Sarfraz, M., Haider, K., Shafiq, A. A., & Mobassarah, N. J. (2014) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.210109 · Cited by 207 · see citing works
Astrocyte-derived endothelin-1 inhibits remyelination through notch activation
Hammond, T. R., Gadea, A., Dupree, J., Kerninon, C., Nait-Oumesmar, B., Aguirre, A., & Gallo, V. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.015 · Cited by 206 · see citing works
Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery
Vazana, U., Veksler, R., Pell, G. S., Prager, O., Fassler, M., Chassidim, Y., Roth, Y., Shahar, H., Zangen, A., Raccah, R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-16.2016 · Cited by 205 · see citing works
PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms
Yi, J., Park, S. W., Brooks, N. P., Lang, B. T., & Vemuganti, R. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.074 · Cited by 204 · see citing works
Retinoic Acid Induces Blood–Brain Barrier Development
Mizee, M. R., Wooldrik, D., Lakeman, K. A. M., van het Hof, B., Drexhage, J. A. R., Geerts, D., Bugiani, M., Aronica, E., Mebius, R. E., Prat, A., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1338-12.2013 · Cited by 203 · cited 2× · see citing works
“During BBB differentiation, the inhibition of RAR activation caused leakage of serum proteins into the developing brain, and reduced the expression of BBB determinants [118].”
Background
Sonic Hedgehog Pathway Activation Is Induced by Acute Brain Injury and Regulated by Injury-Related Inflammation
Amankulor, N. M., Hambardzumyan, D., Pyonteck, S. M., Becher, O. J., Joyce, J. A., & Holland, E. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2500-09.2009 · Cited by 200 · see citing works
Astrocyte-Derived Monocyte-Chemoattractant Protein-1 Directs the Transmigration of Leukocytes Across a Model of the Human Blood-Brain Barrier
Weiss, J. M., Downie, S. A., Lyman, W. D., & Berman, J. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6896 · Cited by 186 · see citing works
Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions
Chapouly, C., Argaw, A. T., Horng, S. H., Castro, K., Zhang, J., Asp, L., Loo, H., Laitman, B. M., Mariani, J. N., Farber, R. S., et al. (2015) · Brain · doi:10.1093/brain/awv077 · Cited by 184 · see citing works
Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER Signaling on Astrocytes But Not through ER Signaling on Astrocytes or Neurons
Spence, R. D., Wisdom, A. J., Cao, Y., Hill, H., Mongerson, C. R., Stapornkul, B., Itoh, N., Sofroniew, M. V., & Voskuhl, R. R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0886-13.2013 · Cited by 183 · see citing works
Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head
Liu, B., & Neufeld, A. H. (2000) · Glia · doi:10.1002/(sici)1098-1136(200004)30:2 · Cited by 177 · see citing works
Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor
Sharp, C. D., Hines, I. N., Houghton, J., Warren, A., Jackson, T. H., Jawahar, A., Nanda, A., Elrod, J. W., Long, A. C., Chi, A., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00520.2003 · Cited by 175 · see citing works
Nitric oxide induces and inhibits apoptosis through different pathways
Shen, Y. H., Wang, X. L., & Wilcken, D. E. L. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00844-8 · Cited by 171 · see citing works
Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice
Kenne, E. M., Erlandsson, A., Lindbom, L., Hillered, L., & Clausen, F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-17 · Cited by 169 · see citing works
MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain
Zeng, L., He, X., Wang, Y., Tang, Y., Zheng, C., Cai, H., Liu, J., Wang, Y., Fu, Y., & Yang, G. (2013) · Gene Therapy · doi:10.1038/gt.2013.55 · Cited by 168 · see citing works
MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3
Zheng, X., Chopp, M., Lü, Y., Buller, B., & Jiang, F. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.10.026 · Cited by 168 · see citing works
The NMDA and AMPA/KA Receptors are Involved in Glutamate-Induced Alterations of Occludin Expression and Phosphorylation in Brain Endothelial Cells
Andras, I. E., Deli, M. A., Veszelka, S., Hayashi, K., Hennig, B., & Toborek, M. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600445 · Cited by 167 · see citing works
Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood–Brain Barrier Permeability During Early Reperfusion in Stroke
Zhang, S., An, Q., Wang, T., Gao, S., & Zhou, G. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.035 · Cited by 167 · see citing works
Disruptions of occludin and claudin‐5 in brain endothelial cells in vitro and in brains of mice with acute liver failure†
Chen, F., Ohashi, N., Li, W., Eckman, C. B., & Nguyen, J. H. (2009) · Hepatology · doi:10.1002/hep.23203 · Cited by 165 · see citing works
Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice
Zhang, Z. G., Zhang, L., Croll, S. D., & Chopp, M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00175-6 · Cited by 160 · see citing works
ELEVATION OF MATRIX METALLOPROTEINASES 3 AND 9 IN CEREBROSPINAL FLUID AND BLOOD IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY
Grossetete, M., Phelps, J., Arko, L., Yonas, H., & Rosenberg, G. A. (2009) · Neurosurgery · doi:10.1227/01.neu.0000351768.11363.48 · Cited by 149 · see citing works
Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells
McCarron, R. M., Wang, L., Stanimirovic, D. B., & Spatz, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90432-k · Cited by 145 · see citing works
MMP-Mediated Disruption of Claudin-5 in the Blood–Brain Barrier of Rat Brain After Cerebral Ischemia
Yang, Y. R., & Rosenberg, G. A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-185-7_24 · Cited by 144 · see citing works
Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier
Shimizu, F., Sano, Y., Saito, K., Abe, M., Maeda, T., Haruki, H., & Kanda, T. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0626-8 · Cited by 144 · see citing works
How Endothelial Cells Regulate Transmigration of Leukocytes in the Inflammatory Response
Müller, W. A. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.033 · Cited by 143 · see citing works
Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia
Ouyang, Y., Xu, L., Lu, Y., Sun, X., Yue, S., Xiong, X., & Giffard, R. G. (2013) · Glia · doi:10.1002/glia.22556 · Cited by 139 · see citing works
Astrocyte-Derived Transforming Growth Factor-β Mediates the Neuroprotective Effects of 17β-Estradiol: Involvement of Nonclassical Genomic Signaling Pathways
Dhandapani, K. M., Wade, F. M., Mahesh, V. B., & Brann, D. W. (2005) · Endocrinology · doi:10.1210/en.2005-0014 · Cited by 139 · see citing works
MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3965-12.2013 · Cited by 138 · see citing works
Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat
Williams, A. J., Wei, H. H., Dave, J. R., & Tortella, F. C. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-17 · Cited by 137 · see citing works
Delayed Inhibition of VEGF Signaling after Stroke Attenuates Blood–Brain Barrier Breakdown and Improves Functional Recovery in a Comorbidity-Dependent Manner
Reeson, P. L., Tennant, K. A., Gerrow, K., Wang, J., Novak, S. W., Thompson, K., Lockhart, K.-L., Holmes, A. S., Nahirney, P. C., & Brown, C. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2810-14.2015 · Cited by 136 · see citing works
Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β
Morikawa, M., Fryer, J. D., Sullivan, P. M., Christopher, E., Schindler, S. E., Demattos, R. B., Odell, M., Fagan, A. M., Lashuel, H. A., Walz, T., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.11.005 · Cited by 136 · see citing works
Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury
Main, B. S., Villapol, S., Sloley, S. S., Barton, D. J., Parsadanian, M., Iweka, C. A., Stefos, K. A., McCann, M. S., Washington, P. M., Rodriguez, O. C., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0249-5 · Cited by 136 · see citing works
Endothelin-1 Overexpression Leads to Further Water Accumulation and Brain Edema after Middle Cerebral Artery Occlusion via Aquaporin 4 Expression in Astrocytic End-Feet
Lo, A., Chen, A. Y. S., Hung, V., Yaw, L. P., Fung, M. K. L., Ho, M. C., Tsang, M. C. S., Chung, S. S., & Chung, S. K. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600108 · Cited by 134 · see citing works
Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy
Harting, M. T., Jiménez, F., Adams, S. D., Mercer, D., & Cox, C. S. (2008) · Surgery · doi:10.1016/j.surg.2008.05.017 · Cited by 130 · see citing works
Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients
Rhind, S. G., Crnko, N. T., BAKER, A. J., Morrison, L. J., Shek, P. N., Scarpelini, S., & Rizoli, S. B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-5 · Cited by 129 · see citing works
Protective Effect of Endothelin Type A Receptor Antagonist on Brain Edema and Injury After Transient Middle Cerebral Artery Occlusion in Rats
Matsuo, Y., Mihara, S., Ninomiya, M., & Fujimoto, M. (2001) · Stroke · doi:10.1161/hs0901.94259 · Cited by 128 · see citing works
Induction of Caspase-Mediated Cell Death by Matrix Metalloproteinases in Cerebral Endothelial Cells after Hypoxia—Reoxygenation
Lee, S.-R., & Lo, E. H. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000122747.72175.47 · Cited by 127 · see citing works
Activated/effector CD4+ T cells exacerbate acute damage in the central nervous system following traumatic injury.
Fee, D. B., Crumbaugh, A., Jacques, T. J., Herdrich, B. H., Sewell, D. L., Auerbach, D., Piaskowski, S. M., Hart, M., Sandor, M., & Fabry, Z. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00008-0 · Cited by 127 · see citing works
CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson’s disease
Chung, Y. C., Shin, W.-H., Baek, J. Y., Cho, E. J., Baik, H. H., Kim, S. R., Won, S.-Y., & Jin, B. K. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.100 · Cited by 126 · see citing works
Astrocyte-derived retinoic acid: a novel regulator of blood–brain barrier function in multiple sclerosis
Mizee, M. R., Nijland, P. G., van der Pol, S. M. A., Drexhage, J., Hof, B. V. H., Mebius, R. E., van der Valk, P., van Horssen, J., Reijerkerk, A., & de Vries, H. E. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1335-6 · Cited by 124 · see citing works
Signals for the induction of nitric oxide synthase in astrocytes
Saha, R. N., & Pahan, K. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.007 · Cited by 123 · see citing works
MicroRNA-29b is a Therapeutic Target in Cerebral Ischemia Associated with Aquaporin 4
Wang, Y., Huang, J., Ma, Y., Tang, G., Liu, Y., Chen, X., Zhang, Z., Zeng, L., Wang, Y., Ouyang, Y.-B., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.156 · Cited by 121 · see citing works
Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study
Matsuo, R., Ago, T., Kamouchi, M., Kuroda, J., Kuwashiro, T., Hata, J., Sugimori, H., Fukuda, K., Gotoh, S., Makihara, N., et al. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-32 · Cited by 116 · see citing works
Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS
Rogers, S. D., Peters, C. M., Pomonis, J. D., Hagiwara, H., Ghilardi, J. R., & Mantyh, P. W. (2002) · Glia · doi:10.1002/glia.10173 · Cited by 109 · see citing works
Induction of Blood‐Brain Barrier Endothelial Cell Differentiation a
Risau, W. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb15630.x · Cited by 106 · see citing works
Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators
Acaz‐Fonseca, E., Sánchez‐González, R., Azcoitia, Í., Arévalo, M., & García‐Segura, L. M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.009 · Cited by 104 · see citing works
Notch1–STAT3–ETB R signaling axis controls reactive astrocyte proliferation after brain injury
LeComte, M. D., Shimada, I. S., Sherwin, C., & Spees, J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501029112 · Cited by 103 · see citing works
17β-Estradiol attenuates blood–brain barrier disruption induced by cerebral ischemia–reperfusion injury in female rats
Liu, R., Wen, Y., Perez, E., Wang, X., Day, A. L., Simpkins, J. W., & Yang, S.-H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.048 · Cited by 103 · see citing works
Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage
Xia, Y., He, Q., Li, Y., Chen, S., Huang, M., Wang, Y., Gao, Y., Huang, Y., Wang, M., Mao, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068891 · Cited by 101 · see citing works
Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs
Zhang, H.-T., Zhang, P., Gao, Y., Li, C.-L., Wang, H.-J., Chen, L.-C., Feng, Y., Li, R.-Y., Li, Y.-L., & Jiang, C.-L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5974 · Cited by 101 · see citing works
Vascular Endothelial Growth Factors Enhance the Permeability of the Mouse Blood-brain Barrier
Jiang, S., Xia, R., Jiang, Y., Wang, L., & Gao, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086407 · Cited by 100 · see citing works
Endocannabinoids modulate human blood–brain barrier permeability in vitro
Hind, W. H., Tufarelli, C., Neophytou, M., Anderson, S., England, T. J., & O’Sullivan, S. E. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13106 · Cited by 99 · see citing works
Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice
Madathil, S. K., Carlson, S. W., Brelsfoard, J., Ye, P., D’Ercole, A. J., & Saatman, K. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067204 · Cited by 99 · see citing works
Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., et al. (2017) · Glia · doi:10.1002/glia.23232 · Cited by 98 · see citing works
Endocannabinoid Degradation Inhibition Improves Neurobehavioral Function, Blood–Brain Barrier Integrity, and Neuroinflammation following Mild Traumatic Brain Injury
Katz, P. S., Sulzer, J. K., Impastato, R. A., Teng, S. X., Rogers, E., & Molina, P. E. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3508 · Cited by 97 · see citing works
The Role of MicroRNA in Traumatic Brain Injury
Pan, Y., Sun, Z.-L., & Feng, D. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.046 · Cited by 95 · see citing works
MicroRNA‐145 as one negative regulator of astrogliosis
Wang, C., Yang, S., & Tzeng, S. (2014) · Glia · doi:10.1002/glia.22743 · Cited by 93 · see citing works
Differentiation of blood-brain barrier endothelial cells.
Risau, W., Esser, S., & Engelhardt, B. (1998) · PubMed · Cited by 91 · see citing works
MicroRNA‐150 regulates blood‐brain barrier permeability via Tie‐2 after permanent middle cerebral artery occlusion in rats
Fang, Z. H., He, Q., Li, Q., Chen, X., Baral, S., Jin, H., Zhu, Y., Li, M., Xia, Y., Mao, L., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201500126 · Cited by 91 · see citing works
Role of spermine in amyloid ?-peptide-associated free radical-induced neurotoxicity
Yatin, S. M., Yatin, M., Varadarajan, S., Ain, K. B., & Butterfield, D. A. (2001) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20010301)63:5 · Cited by 89 · see citing works
Estradiol Regulates Angiopoietin-1 mRNA Expression Through Estrogen Receptor-α in a Rodent Experimental Stroke Model
Ardelt, A. A., McCullough, L. D., Korach, K. S., Wang, M. M., Munzenmaier, D. H., & Hurn, P. D. (2005) · Stroke · doi:10.1161/01.str.0000153795.38388.72 · Cited by 87 · see citing works
Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers
Pitt, J. E., Wilcox, K. C., Tortelli, V., Diniz, L. P., Oliveira, M. S., Dobbins, C., Yu, X., Nandamuri, S., Gomes, F. C. A., DiNunno, N., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0416 · Cited by 86 · see citing works
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis
Brilha, S., Ong, C. W. M., Weksler, B. B., Romero, N., Couraud, P., & Friedland, J. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-16250-3 · Cited by 86 · see citing works
MicroRNA‐149–5p regulates blood–brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes
Wan, Y., Jin, H., Zhu, Y., Fang, Z. H., Mao, L., He, Q., Xia, Y., Li, M., Li, Y., Chen, X., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201701121r · Cited by 86 · see citing works
Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells.
Gille, J., Paxton, L. L. L., Lawley, T. J., Caughman, S. W., & Swerlick, R. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119184 · Cited by 85 · see citing works
Blood–brain barrier leakage increases with small vessel disease in acute ischemic stroke
Arba, F., Leigh, R. J., Inzitari, D., Warach, S. J., Luby, M. L., Lees, K. R., Albers, G. W., Davis, S. M., Donnan, G. A., Fisher, M., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004677 · Cited by 82 · see citing works
Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling
Muñoz, M. F., Puebla, M., & Figueroa, X. F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00059 · Cited by 81 · see citing works
Astrocyte-Derived Sonic Hedgehog Contributes to Angiogenesis in Brain Microvascular Endothelial Cells via RhoA/ROCK Pathway After Oxygen–Glucose Deprivation
He, Q., Xia, Y., Chen, S.-C., Wang, Y., Huang, M., Huang, Y., Li, J., Li, Y., Gao, Y., Mao, L., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8396-8 · Cited by 81 · see citing works
GDNF is Involved in the Barrier-Inducing Effect of Enteric Glial Cells on Intestinal Epithelial Cells Under Acute Ischemia Reperfusion Stimulation
Xiao, W., Wang, W., Chen, W., Sun, L., Li, X., Zhang, C., & Yang, H. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8730-9 · Cited by 81 · see citing works
17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen–glucose deprivation/reperfusion
Guo, J., DUCKLES, S. P., Weiss, J. H., Li, X., & Krause, D. N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.005 · Cited by 80 · see citing works
Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat
Yang, S., Chen, Y., Deng, X., Jiang, W., Li, B., Fu, Z., Du, M.-X., & Ding, R. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9990-y · Cited by 76 · see citing works
Absence of Glial α-Dystrobrevin Causes Abnormalities of the Blood-Brain Barrier and Progressive Brain Edema
Lien, C. F., Mohanta, S. K., Frontczak‐Baniewicz, M., Swinny, J. D., Zabłocka, B., & Górecki, D. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400044 · Cited by 76 · see citing works
TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage in animal models
Min, H., Hong, J., Cho, I.-H., Jang, Y. H., Lee, H., Kim, D., Yu, S.-W., Lee, S., & Lee, S. J. (2015) · Molecular Brain · doi:10.1186/s13041-015-0116-z · Cited by 76 · see citing works
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury
Ma, Q., Dasgupta, C., Li, Y., Huang, L., & Zhang, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071356 · Cited by 76 · see citing works
Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma
Lee, K. S., Jin, S. M., Kim, H. J., & Lee, Y. C. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1501 · Cited by 74 · see citing works
Astrocyte-derived growth factors and estrogen neuroprotection: Role of transforming growth factor-α in estrogen-induced upregulation of glutamate transporters in astrocytes
Karki, P., Smith, K., Johnson, J., & Lee, E. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.010 · Cited by 73 · see citing works
Astrocytes drive cortical vasodilatory signaling by activating endothelial NMDA receptors
Lu, L., Hogan-Cann, A. D., Globa, A. K., Lü, P., Nagy, J. I., Bamji, S. X., & Anderson, C. M. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17734100 · Cited by 72 · see citing works
Gonadal hormones and the control of reactive gliosis
Arévalo, M., Santos‐Galindo, M., Acaz‐Fonseca, E., Azcoitia, Í., & García‐Segura, L. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.021 · Cited by 71 · see citing works
Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy
Sison, S. L., Patitucci, T. N., Seminary, E. R., Villalón, E., Lorson, C. L., & Ebert, A. D. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx230 · Cited by 71 · see citing works
Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
Kozela, E., Juknat, A., & Vogel, Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081669 · Cited by 70 · see citing works
MicroRNA‐130a regulates cerebral ischemia–induced blood–brain barrier permeability by targeting Homeobox A5
Wang, Y., Wang, M., Xia, Y., Gao, Y., Zhu, Y., Chen, S., Mao, L., He, Q., Yue, Z., & Hu, B. (2017) · The FASEB Journal · doi:10.1096/fj.201700139rrr · Cited by 70 · see citing works
Functional requirement of dicer1 and miR‐17‐5p in reactive astrocyte proliferation after spinal cord injury in the mouse
Hong, P., Jiang, M. H., & Li, H. (2014) · Glia · doi:10.1002/glia.22725 · Cited by 69 · see citing works
Endothelin-1 Is Increased in Cerebrospinal Fluid and Associated with Unfavorable Outcomes in Children after Severe Traumatic Brain Injury
Salonia, R., Empey, P. E., Poloyac, S. M., Wisniewski, S. R., Klamerus, M. M., Ozawa, H., Wagner, A. K., Ruppel, R. A., Bell, M. J., Feldman, K., et al. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1402 · Cited by 69 · see citing works
ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury
Teng, Z., Guo, Z., Zhong, J., Cheng, C., Huang, Z., Wu, Y., Tang, S., Luo, C., Peng, X., Wu, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06932-3 · Cited by 68 · see citing works
Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury
Cao, F., Jiang, Y., Wu, Y., Zhong, J., Liu, J., Qin, X., Chen, L., Vitek, M. P., Li, F., Xu, L., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.3887 · Cited by 66 · see citing works
17β-Estradiol Ameliorates Tight Junction Disruption via Repression of MMP Transcription
Na, W., Lee, J. Y., Kim, W., Yune, T. Y., & Ju, B. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1124 · Cited by 65 · see citing works
Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging
Rodriguez-Perez, A. I., Borrajo, A., Díaz-Ruiz, C., Garrido‐Gil, P., & Labandeira-García, J. L. (2016) · Oncotarget · doi:10.18632/oncotarget.9174 · Cited by 65 · see citing works
Up-regulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis
Fernández-Trapero, M., Espejo‐Porras, F., Rodríguez‐Cueto, C., Coates, J. R., Pérez-Díaz, C., de Lago, E., & Fernández‐Ruíz, J. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.028373 · Cited by 65 · see citing works
Retinoic acid ameliorates blood–brain barrier disruption following ischemic stroke in rats
Kong, L., Wang, Y., Wang, X., Wang, X., Zhao, Y., Wang, L., & Chen, Z.-Y. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.014 · Cited by 64 · see citing works
Recombinant Human Angiopoietin-1 Ameliorates the Expressions of ZO-1, Occludin, VE-cadherin, and PKCα Signaling after Focal Cerebral Ischemia/Reperfusion in Rats
Yu, H., Wang, P., An, P., & Xue, Y. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9584-5 · Cited by 64 · see citing works
Reactive Astrocytes as Drug Target in Alzheimer’s Disease
Assefa, B. T., Gebre, A. K., & Altaye, B. M. (2018) · BioMed Research International · doi:10.1155/2018/4160247 · Cited by 64 · see citing works
Status Epilepticus Induces Vasogenic Edema via Tumor Necrosis Factor-α/ Endothelin-1-Mediated Two Different Pathways
Kim, J., Ryu, H. J., & Kang, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074458 · Cited by 63 · see citing works
Vascular Endothelial Growth Factor Is Increased in Cerebrospinal Fluid after Traumatic Brain Injury in Infants and Children
Shore, P. M., Jackson, E. K., Wisniewski, S. R., Clark, R. S. B., Adelson, P. D., & Kochanek, P. M. (2004) · Neurosurgery · doi:10.1227/01.neu.0000108642.88724.db · Cited by 61 · see citing works
Expression of GFRα-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB
Utsumi, H., Chiba, H., Kamimura, Y., Osanai, M., Igarashi, Y., Tobioka, H., Mori, M., & Sawada, N. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.2.c361 · Cited by 61 · see citing works
Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats
Jiang, L., Pan, C., Wang, C., Liu, B., Han, Y., Hu, L., Liu, L., Yang, Y., Qu, J., & Liu, W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0947-x · Cited by 61 · see citing works
Angiopoietin/Tie2 Axis Regulates the Age-at-Injury Cerebrovascular Response to Traumatic Brain Injury
Brickler, T., Hazy, A., Correa, F. G., Dai, R., Kowalski, E., Dickerson, R., Chen, J., Wang, X., Morton, P. D., Whittington, A. R., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0914-18.2018 · Cited by 61 · see citing works
Role of Nitric Oxide Synthases in Early Blood-Brain Barrier Disruption following Transient Focal Cerebral Ischemia
Jiang, Z., Li, C., Arrick, D. M., Yang, S., Baluna, A. E., & Sun, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093134 · Cited by 60 · see citing works
Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes
Korotkov, A., Broekaart, D. W. M., van Scheppingen, J., Anink, J. J., Baayen, J. C., Idema, S., Gorter, J. A., Aronica, E., & van Vliet, E. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1245-y · Cited by 60 · see citing works
Expression of Receptors for Glial Cell Line-derived Neurotrophic Factor (GDNF) and Neurturin in the Inner Blood-retinal Barrier of Rats.
Igarashi, Y., Chiba, H., Utsumi, H., Miyajima, H., Ishizaki, T., Gotoh, T., Kuwahara, K., Tobioka, H., Satoh, M., Mori, M., et al. (2000) · Cell Structure and Function · doi:10.1247/csf.25.237 · Cited by 59 · see citing works
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
Elsayed, M., & Magistretti, P. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00468 · Cited by 59 · see citing works
Sources of endothelin-1 in hippocampus and cortex following traumatic brain injury
Petrov, T., Steiner, J. H., Braun, B., & Rafols, J. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00345-7 · Cited by 57 · see citing works
ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status epilepticus
Kim, J. Y., Ko, A.-R., Hyun, H.-W., & Kang, T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.065 · Cited by 55 · see citing works
Astrocyte‐specific insulin‐like growth factor‐1 gene transfer in aging female rats improves stroke outcomes
Okoreeh, A. K., Bake, S., & Sohrabji, F. (2017) · Glia · doi:10.1002/glia.23142 · Cited by 55 · see citing works
CB1 receptor activation induces intracellular Ca2+ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes
Hegyi, Z., Oláh, T., Kőszeghy, Á., Piscitelli, F., Holló, K., Pál, B. Z., Csernoch, L. J., Marzo, V. D., & Antal, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28763-6 · Cited by 55 · see citing works
Contribution of estrogen receptors alpha and beta in the brain response to traumatic brain injury
Zahediasl, S., Khaksari, M., khachki, A. S., Shahrokhi, N., & Nourizade, S. (2013) · Journal of neurosurgery · doi:10.3171/2013.4.jns121636 · Cited by 54 · see citing works
MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis
Fan, Y.-C., Mei, P.-J., Chen, C., Miao, F., Zhang, H., & Li, Z.-L. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1223-2 · Cited by 53 · see citing works
A strocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis
Eilam, R., Segal, M., Malach, R., Sela, M., Arnon, R., & Aharoni, R. (2018) · Glia · doi:10.1002/glia.23304 · Cited by 53 · see citing works
MiR-21 involve in ERK-mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia
Deng, X., Zhong, Y., Gu, L.-Z., Shen, W., & Guo, J. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.02.007 · Cited by 52 · see citing works
Brain endothelial barrier passage by monocytes is controlled by the endothelin system
Reijerkerk, A., Lakeman, K. A. M., Drexhage, J., Hof, B. V. H., van Wijck, Y., van der Pol, S. M. A., Kooij, G., Geerts, D., & de Vries, H. E. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07393.x · Cited by 52 · see citing works
Differential Expression of Sonic Hedgehog Immunoreactivity During Lesion Evolution in Autoimmune Encephalomyelitis
Seifert‐Held, T., Bauer, J., Weissert, R., Fazekas, F., & Storch, M. K. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.5.404 · Cited by 52 · see citing works
Delayed Administration of BQ788, an ET B Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood–Brain Barrier Function and a Reduction of Cerebral Edema in Mice
Michinaga, S., Kimura, A., Hatanaka, S., Minami, S., Asano, A., Ikushima, Y., Matsui, S., Toriyama, Y., Fujii, M., & Kōyama, Y. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5421 · Cited by 52 · see citing works
Self-citation
MiR‐150 Regulates Poststroke Cerebral Angiogenesis via Vascular Endothelial Growth Factor in Rats
He, Q., Li, Q., Jin, H., Fang, Z. H., Baral, S., Zhu, Y., Xia, Y., Mao, L., Chen, X., & Hu, B. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12525 · Cited by 51 · see citing works
Selective Astrocytic Endothelin-1 Overexpression Contributes to Dementia Associated with Ischemic Stroke by Exaggerating Astrocyte-Derived Amyloid Secretion
Hung, V., Yeung, P. K. K., Lai, A. K. W., Ho, M. C., Lo, A., Chan, K. C., Wu, E. X., Chung, S. S., Cheung, C. W., & Chung, S. K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.109 · Cited by 49 · see citing works
Sonic Hedgehog (Shh) Regulates the Expression of Angiogenic Growth Factors in Oxygen–Glucose-Deprived Astrocytes by Mediating the Nuclear Receptor NR2F2
Li, Y., Xia, Y., Wang, Y., Mao, L., Gao, Y., He, Q., Huang, M., Chen, S., & Hu, B. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8395-9 · Cited by 49 · see citing works
Endothelins reciprocally regulate VEGF‐A and angiopoietin‐1 production in cultured rat astrocytes: Implications on astrocytic proliferation
Kōyama, Y., Maebara, Y., Hayashi, M., Nagae, R., Tokuyama, S., & Michinaga, S. (2012) · Glia · doi:10.1002/glia.22411 · Cited by 49 · see citing works
Self-citation
Insulin-Like Growth Factor (IGF)-I Modulates Endothelial Blood-Brain Barrier Function in Ischemic Middle-Aged Female Rats
Bake, S., Okoreeh, A. K., Alaniz, R. C., & Sohrabji, F. (2015) · Endocrinology · doi:10.1210/en.2015-1840 · Cited by 49 · see citing works
Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling
Wu, L., Ye, Z., Pan, Y., Li, X., Fu, X., Zhang, B., Li, Y., Lin, W., Li, X., & Gao, Q. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.05.029 · Cited by 49 · see citing works
High Serum Levels of Growth Factors Are Associated with Good Outcome in Intracerebral Hemorrhage
Sobrino, T., Arias, S., Rodríguez‐González, R., Brea, D., Silva, Y., de la Ossa, N. P., Agulla, J., Blanco, M., Pumar, J. M., Serena, J. L., et al. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.182 · Cited by 47 · see citing works
Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α
Stary, C. M., Xu, L., Li, L., Sun, X., Ouyang, Y.-B., Xiong, X., Zhao, J., & Giffard, R. G. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.05.004 · Cited by 47 · see citing works
Glial Cell Line-Derived Neurotrophic Factor (GDNF) Promotes Angiogenesis through the Demethylation of the Fibromodulin (FMOD) Promoter in Glioblastoma
Chen, M., Ba, H., Lü, C., Dai, J., & Sun, J. F. (2018) · Medical Science Monitor · doi:10.12659/msm.911669 · Cited by 47 · see citing works
A cannabinoid receptor 2 agonist reduces blood–brain barrier damage via induction of MKP-1 after intracerebral hemorrhage in rats
Li, L., Yun, D., Zhang, Y., Tao, Y., Tan, Q., Qiao, F., Luo, B., Liu, Y., Fan, R., Xian, J., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2018.06.006 · Cited by 45 · see citing works
Enhanced Astrocytic Nitric Oxide Production and Neuronal Modifications in the Neocortex of a NOS2 Mutant Mouse
Buskila, Y., Abu‐Ghanem, Y., Levi, Y., Moran, A., Grauer, E., & Amitai, Y. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000843 · Cited by 44 · see citing works
Morphogens and blood-brain barrier function in health and disease
Wevers, N. R., & de Vries, H. E. (2015) · Tissue Barriers · doi:10.1080/21688370.2015.1090524 · Cited by 42 · see citing works
MiR-155 targets PTCH1 to mediate endothelial progenitor cell dysfunction caused by high glucose
Gao, J., Zhao, G., Li, W., Zhang, J., Che, Y., Song, M., Gao, S., Zeng, B., & Wang, Y. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.03.012 · Cited by 41 · see citing works
Insulin-like Growth Factor (IGF)-1 treatment stabilizes the microvascular cytoskeleton under ischemic conditions
Bake, S., Okoreeh, A. K., Khosravian, H., & Sohrabji, F. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.09.016 · Cited by 41 · see citing works
Highly Enhanced Permeability of Blood‐Brain Barrier Induced by Repeated Administration of Endothelin‐1 in Dogs and Rats
Narushima, I., Kita, T., Kubo, K., Yonetani, Y., Momochi, C., Yoshikawa, I., Ohno, N., & Nakashima, T. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.920104.x · Cited by 40 · see citing works
Idazoxan reduces blood–brain barrier damage during experimental autoimmune encephalomyelitis in mouse
Wang, X., Fang, H.-L., Chen, Y., Liang, S.-S., Zhu, Z.-G., Zeng, Q., Li, J., Xu, H., Shao, B., He, J., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.04.034 · Cited by 39 · see citing works
Vascular expression of angiopoietin1, α5β1 integrin and tight junction proteins is tightly regulated during vascular remodeling in the post-ischemic brain
Sun, J., Yu, L., Huang, S.-K., Lai, X., Milner, R., & Li, L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.040 · Cited by 38 · see citing works
Angiopoietin-1 Mimetic Peptide Promotes Neuroprotection after Stroke in Type 1 Diabetic Rats
Venkat, P., Yan, T., Chopp, M., Zacharek, A., Ning, R., Slyke, P. V., Dumont, D., Landschoot‐Ward, J., Liang, L., & Chen, J. (2018) · Cell Transplantation · doi:10.1177/0963689718791568 · Cited by 38 · see citing works
Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia
Meng, Z., Li, M., He, Q., Jiang, S. S., Zhang, X., Xiao, J.-F., & Bai, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.036 · Cited by 37 · see citing works
ApoE-Deficient Promotes Blood–Brain Barrier Disruption in Experimental Autoimmune Encephalomyelitis via Alteration of MMP-9
Zheng, M., Wei, J., Tang, Y., Yang, C., Wei, Y., Yin, X., & Liu, Q. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0291-x · Cited by 37 · see citing works
Inhibition of calcium/calmodulin‐dependent protein kinase kinase (Ca MKK ) exacerbates impairment of endothelial cell and blood–brain barrier after stroke
Sun, P., Bu, F., Min, J., Munshi, Y., Howe, M. D., Liu, L., Koellhoffer, E. C., Li, Q., McCullough, L. D., & Li, J. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14223 · Cited by 37 · see citing works
Changes in the gene expression of estrogen receptors involved in the protective effect of estrogen in rat׳s trumatic brain injury
Khaksari, M., Hajializadeh, Z., Shahrokhi, N., & Esmaeili‐Mahani, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.05.017 · Cited by 36 · see citing works
Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage
Yeung, P. K. K., Shen, J., Chung, S. S., & Chung, S. K. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-131 · Cited by 36 · see citing works
Inhibition of Transient Receptor Potential Vanilloid 1 Attenuates Blood–Brain Barrier Disruption after Traumatic Brain Injury in Mice
Yang, D., Yao, J., Liu, Y., Xu, Z., Yuan, F., Wang, M.-L., Geng, Z., & Tian, H. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5942 · Cited by 36 · see citing works
Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1
Ito, J., Nagayasu, Y., Miura, Y., Yokoyama, S., & Michikawa, M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.037 · Cited by 33 · see citing works
Effects of blockade of ionotropic glutamate receptors on blood–brain barrier disruption in focal cerebral ischemia
Liu, X., Hunter, C., Weiss, H. R., & CHI, O. Z. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0241-5 · Cited by 32 · see citing works
Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence
Golledge, J., Clancy, P., Maguire, J. M., Lincz, L. F., Koblar, S. A., McEvoy, M., Attia, J., Levi, C. R., Sturm, J. W., Almeida, O. P., et al. (2014) · Stroke · doi:10.1161/strokeaha.113.004339 · Cited by 30 · see citing works
Pretreatment with 17β-Estradiol Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Disruption in Aged Rats: Involvement of Antioxidant Signaling
Xiao, H., Deng, M., Yang, B., Hu, Z.-P., & Tang, J. (2017) · Neuroendocrinology · doi:10.1159/000455866 · Cited by 30 · see citing works
MicroRNA-711–Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death
Sabirzhanov, B. E., Faden, A. I., Aubrecht, T. G., Henry, R. J., Glaser, E. P., & Stoica, B. A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5572 · Cited by 29 · see citing works
Endothelin-1 is over-expressed in amyotrophic lateral sclerosis and induces motor neuron cell death
Ranno, E., D’Antoni, S., Spatuzza, M., Berretta, A., Laureanti, F., Bonaccorso, C. M., Pellitteri, R., Longone, P., Spalloni, A., Iyer, A. M., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.002 · Cited by 28 · see citing works
Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage
Chiu, C., Yao, N.-W., Guo, J., Shen, C., Lee, H., Chiu, Y.-P., Ji, H.-R., Chen, X., Chen, C., & Chang, C. (2017) · Oncotarget · doi:10.18632/oncotarget.22022 · Cited by 28 · see citing works
Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function
Drannik, A. G., Martin, J., Peterson, R., Ma, X., Jiang, F., & Turnbull, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171668 · Cited by 27 · see citing works
Estrogen regulates the expression of Ndrg2 in astrocytes
Ma, Y., Qin, P., Feng, D., Li, Y., Zhang, L., Liu, Z., Yin, A., Tang, W.-H., Dong, H., Meng, L., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.036 · Cited by 25 · see citing works
The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes
Guo, M., Meng, J., Lǐ, Y., Yu, J., Liu, C., Ling, F., Yang, W., Li, J., Feng, Q., Xiao, B., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.05.034 · Cited by 25 · see citing works
Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells
Zhu, S., Luo, M., Peng, W., Li, Q.-X., Feng, Z.-Y., Li, Z., Wang, M.-X., Feng, X., Liu, F., & Huang, J. (2014) · Rheumatology · doi:10.1093/rheumatology/keu421 · Cited by 25 · see citing works
Intracerebroventricular Administration of an Endothelin ETB–Receptor Agonist Increases Expression of Matrix Metalloproteinase-2 and -9 in Rat Brain
Kōyama, Y., & Tanaka, K. (2010) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10195fp · Cited by 24 · see citing works
Effects of Angiopoietin-1 on Hemorrhagic Transformation and Cerebral Edema after Tissue Plasminogen Activator Treatment for Ischemic Stroke in Rats
Kawamura, K., Takahashi, T., Kanazawa, M., Igarashi, H., Nakada, T., Nishizawa, M., & Shimohata, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098639 · Cited by 23 · see citing works
Protective effects of vascular endothelial growth factor in cultured brain endothelial cells against hypoglycemia
Zhao, F. L., Deng, J., Yu, X., Li, D., Shi, H., & Zhao, Y. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9659-z · Cited by 23 · see citing works
Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., & Luo, G. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9513 · Cited by 22 · see citing works
MMP-9 expression and activity is concurrent with endothelial cell apoptosis in the basilar artery after subarachnoid hemorrhaging in rats
Guo, Z., Xu, L., Wang, X., & Sun, X. (2015) · Neurological Sciences · doi:10.1007/s10072-015-2092-6 · Cited by 21 · see citing works
MicroRNA‐31 is required for astrocyte specification
Meares, G. P., Rajbhandari, R., Gerigk, M., Tien, C., Chang, C., Fehling, S. C., Rowse, A. L., Mulhern, K. C., Nair, S., Gray, G. K., et al. (2018) · Glia · doi:10.1002/glia.23296 · Cited by 21 · see citing works
Angiopoietin-1 Protects the Endothelial Cells Against Advanced Glycation End Product Injury by Strengthening Cell Junctions and Inhibiting Cell Apoptosis
Zhao, J., Chen, L., Shu, B., Tang, J., Zhang, L., Xie, J., Liu, X., Xu, Y., & Qi, S. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24920 · Cited by 20 · see citing works
Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease
Miyazaki, I., & Asanuma, M. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666170710163731 · Cited by 20 · see citing works
Matrix metalloproteinase-9 in the ventricular cerebrospinal ﬂuid correlated with the prognosis of traumatic brain injury
Liu, C.-L., Chen, S. C.-C., Lee, H.-C., & Cho, D. (2013) · Turkish Neurosurgery · doi:10.5137/1019-5149.jtn.8551-13.0 · Cited by 19 · see citing works
Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.
Meng, X.-D., Wei, D., Li, J., Kang, J., Wu, C., Ma, L., Yang, F., Zhu, G., Ou-Yang, T.-P., Liu, Y., et al. (2014) · PubMed Central · Cited by 16 · see citing works
Angiopoietin-1 and Angiopoietin-2 Expression Imbalance Influence in Early Period After Subarachnoid Hemorrhage
Gu, H., Fei, Z., Wang, Y., Yang, J., Zhao, C., Cai, Y., & Zhong, X. (2016) · International Neurourology Journal · doi:10.5213/inj.1632692.346 · Cited by 16 · see citing works
Molecular Changes Associated with the Protective Effects of Angiopoietin-1 During Blood-Brain Barrier Breakdown Post-Injury
Nag, S., Manias, J. L., Kapadia, A. N., & Stewart, D. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9973-4 · Cited by 15 · see citing works
Delayed Progression of Edema Formation Around a Hematoma Expressing High Levels of VEGF and MMP-9 in a Patient With Traumatic Brain Injury: Case Report
Hirose, T., Matsumoto, N., Tasaki, O., Nakamura, H., Akagaki, F., & Shimazu, T. (2013) · Neurologia medico-chirurgica · doi:10.2176/nmc.cr2012-0342 · Cited by 12 · see citing works
Abstract WP254: Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase (CaMKK) Exacerbates Endothelial Cell Impairment After Cerebral Ischemia
Sun, P., Liu, L., Koellhoffer, E. C., McCullough, L. D., & Li, J. (2018) · Stroke · doi:10.1161/str.49.suppl_1.wp254 · Cited by 1 · see citing works

Flagged first, then by citations

2 of the 192 references couldn’t be matched to a known paper.

Sorted by citations

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
Takata, F., Nakagawa, S., Matsumoto, J., & Dohgu, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.661838 · Cited by 651 · see citing works
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
Inoue, Y., Shue, F., Bu, G., & Kanekiyo, T. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00640-5 · Cited by 356 · see citing works
Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury
Cash, A., & Theus, M. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093344 · Cited by 324 · see citing works
Blood-Brain Barrier Overview: Structural and Functional Correlation
Alahmari, A. (2021) · Neural Plasticity · doi:10.1155/2021/6564585 · Cited by 299 · see citing works
Factors influencing the blood-brain barrier permeability
Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147937 · Cited by 291 · see citing works
Astrocyte Endfeet in Brain Function and Pathology: Open Questions
Díaz-Castro, B., Robel, S., & Mishra, A. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091922-031205 · Cited by 238 · see citing works
Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
Archie, S. R., Shoyaib, A. A., & Cucullo, L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111779 · Cited by 232 · see citing works
Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
Zhou, Y., Shao, A., Yao, Y., Tu, S., Deng, Y., & Zhang, J. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00549-2 · Cited by 206 · see citing works
APOE4 derived from astrocytes leads to blood–brain barrier impairment
Jackson, R. J., Meltzer, J. C., Nguyen, H., Commins, C., Bennett, R. E., Hudry, E., & Hyman, B. T. (2022) · Brain · doi:10.1093/brain/awab478 · Cited by 205 · see citing works
Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases
Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00557-1 · Cited by 201 · see citing works
Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke
Song, S., Huang, H., Guan, X., Fiesler, V. M., Bhuiyan, M. I. H., Liu, R., Jalali, S., Hasan, M. N., Tai, A., Chattopadhyay, A., et al. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101963 · Cited by 144 · see citing works
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke
Zhang, Q., Liu, C., Shi, R., Zhou, S., Shan, H., Deng, L., Chen, T., Guo, Y., Zhang, Z., Yang, G., et al. (2022) · Aging and Disease · doi:10.14336/ad.2021.1029 · Cited by 138 · see citing works
The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target
Okada, T., Suzuki, H., Travis, Z. D., & Zhang, J. H. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528143301 · Cited by 137 · see citing works
The blood–brain barriers: novel nanocarriers for central nervous system diseases
Liu, J., Wang, T., Dong, J., & Lu, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03247-8 · Cited by 133 · see citing works
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127 · see citing works
The Role of Astrocytes in the Neurorepair Process
Chiareli, R. A., Carvalho, G. A., Marques, B. L., Mota, L. S., Oliveira‐Lima, O. C., Gomes, R. M., Birbrair, A., Gomez, R. S., Simão, F., Klempin, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665795 · Cited by 126 · see citing works
Astrocytic <scp>VEGFA</scp> : An essential mediator in blood–brain‐barrier disruption in Parkinson's disease
Lan, G., Wang, P., Chan, R. B., Liu, Z., Yu, Z., Liu, X., Yang, Y., & Zhang, J. (2022) · Glia · doi:10.1002/glia.24109 · Cited by 122 · see citing works
Neuroinflammation and peripheral immunity: Focus on ischemic stroke
Wang, H., Zhang, S., Xie, L., Zhe, Z., & Yan, F. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110332 · Cited by 121 · see citing works
Mercury-induced toxicity: Mechanisms, molecular pathways, and gene regulation
Kang, B., Wang, J., Guo, S., & Yang, L. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173577 · Cited by 114 · see citing works
Improving CNS Delivery to Brain Metastases by Blood–Tumor Barrier Disruption
Sprowls, S. A., Arsiwala, T. A., Bumgarner, J. R., Shah, N., Lateef, S. S., Kielkowski, B. N., & Lockman, P. R. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.06.003 · Cited by 112 · see citing works
Reactive Astrocytes in Central Nervous System Injury: Subgroup and Potential Therapy
Yu, G., Zhang, Y., & Ning, B. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.792764 · Cited by 106 · see citing works
Blood-brain barrier disruption: a culprit of cognitive decline?
Che, J., Sun, Y., Deng, Y., & Zhang, J. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00563-3 · Cited by 103 · see citing works
Astrocyte-Mediated Neuroinflammation in Neurological Conditions
Zhao, Y., Huang, Y., Cao, Y., & Yang, J. H. (2024) · Biomolecules · doi:10.3390/biom14101204 · Cited by 100 · see citing works
Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Peng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02543-6 · Cited by 95 · see citing works
Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury
Hernández, I. H., Villa-González, M., Martín-López, G., Soto, M. S., & Pérez-Álvarez, M. J. (2021) · Cells · doi:10.3390/cells10071639 · Cited by 94 · see citing works
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke
Spitzer, D. E., Guérit, S., Pütz, T., Khel, M. I., Armbrust, M., Dunst, M., Macas, J., Zinke, J., Devraj, G., Jia, X., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02452-1 · Cited by 91 · see citing works
The Underlying Neurobiological Mechanisms of Psychosis: Focus on Neurotransmission Dysregulation, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction
Rawani, N. S., Chan, A. W., Dursun, S. M., & Baker, G. B. (2024) · Antioxidants · doi:10.3390/antiox13060709 · Cited by 90 · see citing works
Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells
Wu, Y., Sonninen, T.-M., Peltonen, S., Koıstınaho, J., & Lehtonen, Š. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147710 · Cited by 88 · see citing works
Therapeutic role of targeting mTOR signaling and neuroinflammation in epilepsy
Hodges, S. L., & Lugo, J. N. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106282 · Cited by 87 · see citing works
Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia
Abrahamson, E. E., & Ikonomović, M. D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113257 · Cited by 87 · see citing works
Blood–Brain Barrier Dysfunction and Astrocyte Senescence as Reciprocal Drivers of Neuropathology in Aging
Preininger, M. K., & Kaufer, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116217 · Cited by 83 · see citing works
Ischemia Reperfusion Injury Induced Blood Brain Barrier Dysfunction and the Involved Molecular Mechanism
Guo, X., Liu, R., Jia, M., Wang, Q., & Wu, J. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03923-x · Cited by 79 · see citing works
Effects of propofol on ischemia-reperfusion and traumatic brain injury
Hausburg, M. A., Banton, K. L., Roman, P. E., Salgado, F., Baek, P., Waxman, M., Tanner, A. H., Yoder, J., & Bar‐Or, D. (2019) · Journal of Critical Care · doi:10.1016/j.jcrc.2019.12.021 · Cited by 77 · see citing works
Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer’s disease
Yue, Q., & Hoi, M. P. M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.367832 · Cited by 77 · see citing works
Effect of Systemic Inflammation in the CNS: A Silent History of Neuronal Damage
Solano, M. V. M., Lara, C. S., Sánchez-Garibay, C., Soto-Rojas, L. O., Escobedo-Ávila, I., Tena‐Suck, M. L., Ortiz-Butrón, R., Choreño-Parra, J. A., Romero‐López, J. P., & Meléndez-Camargo, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511902 · Cited by 77 · see citing works
Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease
Pistono, C., Bister, N., Stanová, I., & Malm, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.623771 · Cited by 75 · see citing works
Neurocognitive impacts of arbovirus infections
Clé, M., Eldin, P., Briant, L., Lannuzel, A., Simonin, Y., Van de Perre, P., Cabié, A., & Salinas, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01904-3 · Cited by 67 · see citing works
Microglia Regulate Neuronal Circuits in Homeostatic and High-Fat Diet-Induced Inflammatory Conditions
Wang, X., & Li, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.722028 · Cited by 67 · see citing works
Astrocytes in functional recovery following central nervous system injuries
Alhadidi, Q., Bahader, G. A., Arvola, O., Kitchen, P., Shah, Z. A., & Salman, M. M. (2023) · The Journal of Physiology · doi:10.1113/jp284197 · Cited by 64 · see citing works
Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology
Derouiche, A., & Geiger, K. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153776 · Cited by 63 · see citing works
Glycometabolic Reprogramming of Microglia in Neurodegenerative Diseases: Insights from Neuroinflammation
Huang, Q., Wang, Y., Chen, S., & Liang, F. (2023) · Aging and disease · doi:10.14336/ad.2023.0807 · Cited by 62 · see citing works
The Blood–Brain Barrier—A Key Player in Multiple Sclerosis Disease Mechanisms
Schreiner, T. G., Romanescu, C., & Popescu, B. O. (2022) · Biomolecules · doi:10.3390/biom12040538 · Cited by 61 · see citing works
Inflammatory Pathogenesis of Post-stroke Depression
Feng, X., Ma, X., Li, J., Zhou, Q., Liu, Y., Song, J., Liu, J., Situ, Q., Wang, L., Zhang, J., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0203 · Cited by 61 · see citing works
Immune‐mediated disruption of the blood–brain barrier after intracerebral hemorrhage: Insights and potential therapeutic targets
Jia, P., Peng, Q., Fan, X., Zhang, Y., Xu, H., Li, J., Sonita, H., Liu, S., Le, A. C. T., Hu, Q., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14853 · Cited by 59 · see citing works
Blast-induced temporal alterations in blood–brain barrier properties in a rodent model
Kawoos, U., Abutarboush, R., Gu, M., Chen, Y., Statz, J. K., Goodrich, S. Y., & Ahlers, S. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-84730-8 · Cited by 58 · see citing works
Neurotoxicity and the Global Worst Pollutants: Astroglial Involvement in Arsenic, Lead, and Mercury Intoxication
Arrifano, G. D. P., Lopez, M. E. C., Lopes-Araújo, A., Santos-Sacramento, L., Barthelemy, J. L., Leal-Nazaré, C. G., de Freitas, L. G. D. R., & Augusto‐Oliveira, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03725-7 · Cited by 57 · see citing works
Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer’s Disease
Borsom, E. M., Lee, K., & Cope, E. K. (2020) · Brain Sciences · doi:10.3390/brainsci10110814 · Cited by 54 · see citing works
Targetability of the neurovascular unit in inflammatory diseases of the central nervous system
Smith, B. C., Tinkey, R. A., Shaw, B. C., & Williams, J. L. (2022) · Immunological Reviews · doi:10.1111/imr.13121 · Cited by 53 · see citing works
Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes
Feng, X.-F., Li, M., Lin, Z., Li, M.-Z., Lu, Y., Zhuang, Y., Lei, J., Wang, L., & Zhao, H. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1125412 · Cited by 53 · see citing works
Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology
Muñoz‐Ballester, C., & Robel, S. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1622 · Cited by 53 · see citing works
Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation
Ye, Q., Jo, J.-Y., Wang, C., Oh, H., Zhan, J., Choy, T. J., Kim, K. I., D’Alessandro, A., Reshetnyak, Y. K., Jung, S. Y., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114193 · Cited by 53 · see citing works
A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit
Chen, S., Nazeri, A., Baek, H., Ye, D., Yang, Y., Yuan, J., Rubin, J. B., & Chen, H. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211046129 · Cited by 50 · see citing works
Ammonia-Induced Glial-Inflammaging
Bobermin, L. D., Roppa, R. H. A., Gonçalves, C., & Quincozes‐Santos, A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01985-4 · Cited by 50 · see citing works
Modulation of neuroinflammation by cysteinyl leukotriene 1 and 2 receptors: implications for cerebral ischemia and neurodegenerative diseases
Wang, Y., Yang, Y., Zhang, S., Li, C.-T., & Zhang, L. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.013 · Cited by 49 · see citing works
The Neuroprotective Role of Reactive Astrocytes after Central Nervous System Injury
Boghdadi, A. G., Teo, L., & Bourne, J. A. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6938 · Cited by 49 · see citing works
Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity
Xing, G., Zhao, T., Zhang, X., He, L., Li, X., Cui, P., Li, M., Li, D., Zhang, N., & Jiang, W. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.575690 · Cited by 48 · see citing works
Review of Design Considerations for Brain-on-a-Chip Models
Cameron, T., Bennet, T. J., Rowe, E. M., Anwer, M., Wellington, C. L., & Cheung, K. C. (2021) · Micromachines · doi:10.3390/mi12040441 · Cited by 48 · see citing works
Epigenetics in blood–brain barrier disruption
Ihezie, S. A., Mathew, I. E., McBride, D. W., Dienel, A., Blackburn, S., & Pandit, P. K. T. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00250-7 · Cited by 47 · see citing works
Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer’s Disease
Huang, W., Xia, Q., Zheng, F., Zhao, X. L., Ge, F., Xiao, J., Liu, Z., Shen, Y., Ye, K., Wang, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221064 · Cited by 46 · see citing works
Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment
Schepers, M., Tiane, A., Paes, D., Sanchez, S., Rombaut, B., Piccart, E., Rutten, B. P. F., Brône, B., Hellings, N., Prickaerts, J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01727 · Cited by 45 · see citing works
White matter and neurological disorders
Bae, H., Kim, T. K., Suk, H. Y., Jung, S., & Jo, D. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01270-x · Cited by 45 · see citing works
Non-coding RNAs: the extensive and interactive regulators of the blood-brain barrier permeability
Yang, R., Xu, B., Yang, B., Fu, J., Chen, H., & Wang, X. (2021) · RNA Biology · doi:10.1080/15476286.2021.1950465 · Cited by 45 · see citing works
Astrocytic p75NTR expression provoked by ischemic stroke exacerbates the blood–brain barrier disruption
Qin, X., Wang, J., Chen, S., Liu, G., Wu, C., Lv, Q., He, X., Bai, X., Huang, W., & Liao, H. (2022) · Glia · doi:10.1002/glia.24146 · Cited by 45 · see citing works
The Cerebral Effect of Ammonia in Brain Aging: Blood–Brain Barrier Breakdown, Mitochondrial Dysfunction, and Neuroinflammation
Jo, D., Kim, B. C., Cho, K. A., & Song, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132773 · Cited by 44 · see citing works
Astrocytes and Inflammatory T Helper Cells: A Dangerous Liaison in Multiple Sclerosis
Kunkl, M., Amormino, C., Tedeschi, V., Fiorillo, M. T., & Tuosto, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.824411 · Cited by 43 · see citing works
Clearance Systems in the Brain, From Structure to Function
Liu, J., Guo, Y., Zhang, C., Zeng, Y., Luo, Y., & Wang, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.729706 · Cited by 42 · see citing works
Aloin Protects Against Blood–Brain Barrier Damage After Traumatic Brain Injury in Mice
Yao, J., Yang, D., Wang, W., Yuan, F., Chen, H., Ding, J., Geng, Z., & Tian, H. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00471-0 · Cited by 42 · see citing works
Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/β-catenin axis
Hou, Y., Xie, Y., Liu, X., Chen, Y., Zhou, F., & Yang, B. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00510-2 · Cited by 41 · see citing works
Endothelin ETB Receptor-Mediated Astrocytic Activation: Pathological Roles in Brain Disorders
Kōyama, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094333 · Cited by 41 · see citing works
Blood-brain barrier pathology in cerebral small vessel disease
Jia, R., Guardia, G. S., & Kiliaan, A. J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385864 · Cited by 40 · see citing works
A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
Wasielewska, J. M., Chaves, J. C. S., Johnston, R. L., Milton, L. A., Hernández, D., Chen, L., Song, J. H., Lee, W., Leinenga, G., Nisbet, R. M., et al. (2022) · Theranostics · doi:10.7150/thno.72685 · Cited by 40 · see citing works
Blood-Brain Barrier Disruption: A Common Driver of Central Nervous System Diseases
Segura‐Collar, B., Mata-Martínez, P., Hernández‐Laín, A., Sánchez‐Gómez, P., & Gargini, R. (2021) · The Neuroscientist · doi:10.1177/1073858420985838 · Cited by 38 · see citing works
Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice
Liu, N., Jiang, Y., Chung, J. Y., Li, Y., Yu, Z., Kim, J. W., Lok, J. M., Whalen, M. J., & Wang, X. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246125 · Cited by 37 · see citing works
Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells
Janowska, J., Gargaś, J., Ziemka‐Nałęcz, M., Zalewska, T., & Sypecka, J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02015-z · Cited by 37 · see citing works
Inflammation: A Mediator Between Hypertension and Neurodegenerative Diseases
Youwakim, J., & Girouard, H. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpab094 · Cited by 37 · see citing works
Advancements in modelling human blood brain-barrier on a chip
Guarino, V., Zizzari, A. T., Bianco, M., Gigli, G., Moroni, L., & Arima, V. (2023) · Biofabrication · doi:10.1088/1758-5090/acb571 · Cited by 37 · see citing works
Blood–Brain Barrier Dysfunction and the Potential Mechanisms in Chronic Cerebral Hypoperfusion Induced Cognitive Impairment
Xu, W., Bai, Q., Dong, Q., Guo, M., & Cui, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.870674 · Cited by 36 · see citing works
The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells
Hourfar, H., Aliakbari, F., Aqdam, S. R., Nayeri, Z., Bardania, H., Otzen, D. E., & Morshedi, D. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.134 · Cited by 36 · see citing works
Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System
Meneghini, V., Peviani, M., Luciani, M., Zambonini, G., & Gritti, A. (2021) · Frontiers in Genome Editing · doi:10.3389/fgeed.2021.644319 · Cited by 36 · see citing works
Astrocytes in the Traumatic Brain Injury: the Good and the Bad
Yuan, M., & Wu, H. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113943 · Cited by 36 · see citing works
Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury
Zhou, Y., Chen, Q., Wang, Y., Wu, H., Xu, W., Pan, Y., Gao, S., Dong, X., Zhang, J. H., & Shao, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00581 · Cited by 35 · see citing works
Innate Immune Signaling and Role of Glial Cells in Herpes Simplex Virus- and Rabies Virus-Induced Encephalitis
Feige, L., Zaeck, L. M., Sehl‐Ewert, J., Finke, S., & Bourhy, H. (2021) · Viruses · doi:10.3390/v13122364 · Cited by 35 · see citing works
Hemorrhagic stroke-induced subtype of inflammatory reactive astrocytes disrupts blood-brain barrier
Liu, C., Guo, Y., Deng, S., Zhou, S., Wu, S., Chen, T., Shi, X., Mamtilahun, M., Xu, T., Liu, Z., et al. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241235008 · Cited by 34 · see citing works
Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke
Zhang, S., Shang, D., Shi, H., Teng, W., & Li, T. X. (2021) · European Neurology · doi:10.1159/000517378 · Cited by 33 · see citing works
Central Nervous System Pericytes Contribute to Health and Disease
Girolamo, F., Errede, M., Bizzoca, A., Virgintino, D., & Ribatti, D. (2022) · Cells · doi:10.3390/cells11101707 · Cited by 32 · see citing works
Revisiting Astrocytic Roles in Methylmercury Intoxication
Arrifano, G. D. P., Augusto‐Oliveira, M., Monteiro, J. R. S., Macchi, B. D. M., Lima, R. R., Sunol, C. E., do Nascimento, J. L. M., & Lopez, M. E. C. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02420-y · Cited by 31 · see citing works
Brain metastases in patients with oncogenic-driven non-small cell lung cancer: Pros and cons for early radiotherapy
Lee, J., & Ahn, M. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102291 · Cited by 31 · see citing works
Pre-Treatment with Laminarin Protects Hippocampal CA1 Pyramidal Neurons and Attenuates Reactive Gliosis Following Transient Forebrain Ischemia in Gerbils
Lee, T.-K., Ahn, J. H., Park, C. W., Kim, B., Park, Y. E., Lee, J., Park, J. H., Yang, G. E., Shin, M. C., Cho, J. H., et al. (2020) · Marine Drugs · doi:10.3390/md18010052 · Cited by 31 · see citing works
The role of integrins in brain health and neurodegenerative diseases
Cui, Y., Rõlova, T., & Fagerholm, S. C. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151441 · Cited by 30 · see citing works
Cognitive decline in heart failure: Biomolecular mechanisms and benefits of exercise
Maroofi, A., Moro, T., Agrimi, J., & Safari, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166511 · Cited by 30 · see citing works
CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke
Zhou, S., Liu, C., Wang, J., Ye, J., Lian, Q., Gan, L., Deng, S., Xu, T., Guo, Y., Li, W., et al. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231214838 · Cited by 30 · see citing works
CNS Drug Delivery in Stroke: Improving Therapeutic Translation From the Bench to the Bedside
Ronaldson, P. T., Williams, E. I., Betterton, R. D., Stanton, J. A., Nilles, K. L., & Davis, T. P. (2023) · Stroke · doi:10.1161/strokeaha.123.043764 · Cited by 29 · see citing works
Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer’s Disease and Vascular Dementia
Liu, R., Collier, J. M., Abdul‐Rahman, N., Capuk, O., Zhang, Z., & Begum, G. (2024) · Aging and Disease · doi:10.14336/ad.2023.1201 · Cited by 29 · see citing works
Understanding the Blood-Brain Barrier: From Physiology to Pathology
Garcia-Gallardo, A., & Campbell, M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_1 · Cited by 29 · see citing works
Not Just a Bystander: The Emerging Role of Astrocytes and Research Tools in Studying Cognitive Dysfunctions in Schizophrenia
Chang, C., Luo, D.-Z., Pei, J.-C., Kuo, M., Hsieh, Y., & Lai, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105343 · Cited by 29 · see citing works
Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research
Sood, A., Kumar, A., Dev, A., Gupta, V. K., & Han, S. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050993 · Cited by 28 · see citing works
Reactive astrocytes associated with prion disease impair the blood brain barrier
Kushwaha, R., Li, Y., Makarava, N., Pandit, N. P., Molesworth, K., Birukov, K. G., & Baskakov, I. V. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106264 · Cited by 28 · see citing works
A guide for blood–brain barrier models
Soliman, Y., Al‐khodor, J., Koken, G. Y., & Mustafaoğlu, N. (2024) · FEBS Letters · doi:10.1002/1873-3468.15053 · Cited by 27 · see citing works
Role of mitochondria transmission in ischemic stroke: Friend or foe?
Yang, L., Wei, X., Liao, Z., Chen, B., Zeng, G., & Mei, Z. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103868 · Cited by 27 · see citing works
Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective
Nishihara, H., & Engelhardt, B. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_407 · Cited by 27 · see citing works

Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability
(2024) · Vitamins and Hormones · doi:10.1016/bs.vh.2024.04.006 · Cited by 13 · see citing works
Self-citation
Protection of the Blood–Brain Barrier as a Therapeutic Strategy for Brain Damage
Michinaga, S., & Kōyama, Y. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00991 · Cited by 35 · see citing works
Self-citation
Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
Cabezas, R., Ávila, M. F., González, J., El-Bachá, R. D. S., Báez-Jurado, E., García‐Segura, L. M., Jurado-Coronel, J. C., Capani, F., Cardona‐Gómez, G. P., & Barreto, G. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00211 · Cited by 453 · see citing works
Mechanisms of Astrocyte Action in the Blood Brain Barrier: From Structural Support to Dynamic Regulation
Feng, D. N., Wang, L. N., Hu, A. N., & Zhang, S. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin45223 · Cited by 11 · see citing works
In Search of the Astrocytic Factor(s) Modulating Blood–Brain Barrier Functions in Brain Capillary Endothelial Cells In Vitro
Haseloff, R. F., Blasig, I. E., Bauer, H., & Bauer, H. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1375-x · Cited by 301 · see citing works

Authors: Michinaga, S., & Koyama, Y.
Affiliations: Osaka Ohtani University (JP)
Laboratory of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyama-Kita Higashinada, Kobe 668-8558, Japan
ORCID: Michinaga, Shotaro
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2019-01-29
Volume: 20
Issue: 3
Pages: 571
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms20030571
PMC: PMC6387062
OpenAlex: W2912925231
Cited by: 263
References: 192
Citations by year: 2026: 30 · 2025: 21 · 2024: 38 · 2023: 44 · 2022: 43 · 2021: 48 · 2020: 28 · 2019: 11
FWCI: 3.38
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Japan Society for the Promotion of Science (16K18890, 18K06695)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: blood-brain barrier, astrocytes, blood-brain barrier permeability, brain damage, traumatic brain injury, cerebral ischemia, vascular endothelial growth factor, matrix metalloproteinases, nitric oxide, endothelin-1, glutamate, angiopoietin-1, Sonic hedgehog, glial cell line-derived neurotrophic factor, retinoic acid, insulin-like growth factor I, apolipoprotein E, cerebral edema, neuroinflammation
MeSH terms: Animals, Astrocytes, Blood-Brain Barrier, Brain Injuries, Humans, Tight Junctions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks