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Anemia of Inflammation
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“Iron homeostasis in women is strongly influenced by both the phase of the menstrual cycle36 and the presence of systemic inflammation55.”
From Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase (2025) · cites this paper as [55]
In the citing paper
“available literature indicates that ERFE synthesis depends on erythropoietin activity, iron status, and erythropoietic intensity, acting as a hepcidin antagonist to increase iron availability16,55.”
From Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase (2025) · cites this paper as [55]
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Citations
Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 1×
“IL-6 increases JAK/Stat signaling [31, 32], which promotes phosphorylation of Stat3 and Stat3 binding to the Hepcidin promoter [30, 33].”
BackgroundHentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275
Identification of erythroferrone as an erythroid regulator of iron metabolism
Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics · doi:10.1038/ng.2996 · Cited by 1,127 · cited 1×
“On the other hand, iron deficiency or the acute onset of anemia stimulates release of the hormone, erythroferrone, by erythroid progenitors, and erythropoietin by the kidney [11, 27] Erythroferrone suppresses hepcidin expression to promote intestinal iron absorption and macrophage iron release, while erythropoietin st…”
BackgroundBone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623
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Cited by
Aschemeyer, S., Qiao, B., Stefanova, D., Valore, E. V., Sek, A. C., Ruwe, T. A., Vieth, K. R., Jung, G., Casu, C., Rivella, S., et al. (2018) · Blood · doi:10.1182/blood-2017-05-786590 · Cited by 325
Mydłowska, M., Kasperska, A., Cichoń-Woźniak, J., Dziewiecka, H., Ostapiuk-Karolczuk, J., & Skarpańska-Stejnborn, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-29551-9 · Cited by 2
Metadata
- Authors
- Fraenkel, P. G.
- Venue
- Medical Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 101
- Issue
- 2
- Pages
- 285-296
- ISSN
- 0025-7125
- Cited by
- 192
- References
- 25
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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