A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates

Cooke, Keegan S.; Hinkle, Beth; Salimi-Moosavi, Hossein; Foltz, Ian; King, Chadwick; Rathanaswami, Palaniswami; Winters, Aaron; Steavenson, Shirley; Begley, C. Glenn; Molineux, Graham; Sasu, Barbra J.

doi:10.1182/blood-2013-06-505792

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates

Key Points Fully human anti-hepcidin Abs have been generated for use as a potential therapeutic to treat AI. The mechanism of action was shown to be due to an increase in available serum iron leading to enhanced red cell hemoglobinization.