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Cell separation by non-inertial force fields in microfluidic systems
Open accessAbstract
Cell and microparticle separation in microfluidic systems has recently gained significant attention in sample preparations for biological and chemical studies. Microfluidic separation is typically achieved by applying differential forces on the target particles to guide them into different paths. This paper reviews basic concepts and novel designs of such microfluidic separators with emphasis on the use of non-inertial force fields, including dielectrophoretic force, optical gradient force, magnetic force, and acoustic primary radiation force. Comparisons of separation performances with discussions on physiological effects and instrumentation issues toward point-of-care devices are provided as references for choosing appropriate separation methods for various applications.
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Jones, T. B. (1995) · doi:10.1017/cbo9780511574498 · Cited by 2,786
Cited by
Label-free cell separation and sorting in microfluidic systems
Gossett, D. R., Weaver, W. M., Mach, A. J., Hur, S. C., Tse, H. T. K., Lee, W., Amini, H., & Di Carlo, D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3721-9 · Cited by 930
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Lab on a chip for continuous-flow magnetic cell separation
Hejazian, M., Li, W., & Nguyen, N.-T. (2015) · Lab on a Chip · doi:10.1039/c4lc01422g · Cited by 347
Continuous scalable blood filtration device using inertial microfluidics
Mach, A. J., & Di Carlo, D. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22833 · Cited by 334
Metadata
- Authors
- Tsutsui, H., & Ho, C.-M.
- Venue
- Mechanics Research Communications
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 36
- Issue
- 1
- Pages
- 92-103
- ISSN
- 0093-6413 (ISSN-L)
- OpenAlex
- W2159266794
- Cited by
- 190
- References
- 1
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- green
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