The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Biofilms: Understanding the structure and contribution towards bacterial resistance in antibiotics
Open accessAbstract
The biofilm is a bacterial colony wrapped in an auto-produced polymer matrix of polysaccharides, proteins, and DNA. Bacterial biofilms cause persistent infections because they are more resistant to antibiotics, disinfectants, and the immune system of the body. Other significant biofilm characteristics are a gradient of oxygen and nutrition from the top layer to the bottom layer of biofilms. Lower bacterial cell metabolic activity and longer doubling rates are linked to the gradients; these are the quiescent cells responsible for some of the resistance to antibiotics. Biofilms may be avoided and cured with vigorous antibiotic prophylaxis or treatment early on and with continuous suppressive medication. This review discusses the development of antibiotic resistance and tolerance in bacteria due to biofilm formation, the tolerance mechanisms, and the development of persistent cells that induce antibiotic resistance in bacteria. Recent strategies to combat antibiotic resistance are also discussed.
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Cites
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Cited by
Halawa, E. M., Fadel, M., Al-Rabia, M. W., Behairy, A., Nouh, N. A., Abdo, M., Olga, R., Fericean, L., Atwa, A. M., El-Nablaway, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1305294 · Cited by 280
Tang, Y., Deng, H., Xu, Z., Yu, Z., Xiang, Y., Wen, Z., Han, S., Chen, Z., & Hou, T. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04104-2 · Cited by 4
Metadata
- Authors
- Shree, P., Singh, C. K., Sodhi, K. K., Surya, J. N., & Singh, D. K.
- Venue
- Medicine in Microecology
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 16
- Pages
- 100084
- ISSN
- 2590-0978 (ISSN-L)
- OpenAlex
- W4378832553
- Cited by
- 396
- References
- 139
- FWCI
- 29.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shree, P., Singh, C. K., Sodhi, K. K., Surya, J. N., & Singh, D. K. (2023). Biofilms: Understanding the structure and contribution towards bacterial resistance in antibiotics. Medicine in Microecology. https://doi.org/10.1016/j.medmic.2023.100084
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
