The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance
Open accessAbstract
Antibiotics represent a frequently employed therapeutic modality for the management of bacterial infections across diverse domains, including human health, agriculture, livestock breeding, and fish farming. The efficacy of antibiotics relies on four distinct mechanisms of action, which are discussed in detail in this review, along with accompanying diagrammatic illustrations. Despite their effectiveness, antibiotic resistance has emerged as a significant challenge to treating bacterial infections. Bacteria have developed defense mechanisms against antibiotics, rendering them ineffective. This review delves into the specific mechanisms that bacteria have developed to resist antibiotics, with the help of diagrammatic illustrations. Antibiotic resistance can spread among bacteria through various routes, resulting in previously susceptible bacteria becoming antibiotic-resistant. Multiple factors contribute to the worsening crisis of antibiotic resistance, including human misuse of antibiotics. This review also emphasizes alternative solutions proposed to mitigate the exacerbation of antibiotic resistance.
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Cites
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
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Amino acids: Metabolism, functions, and nutrition
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A Deep Learning Approach to Antibiotic Discovery
Stokes, J. M., Yang, K., Swanson, K., Jin, W., Cubillos-Ruiz, A., Donghia, N. M., MacNair, C. R., French, S., Carfrae, L. A., Bloom-Ackermann, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.021 · Cited by 2,463
How antibiotics kill bacteria: from targets to networks
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Outer membrane permeability and antibiotic resistance
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Mechanisms of Antimicrobial Resistance in Bacteria
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Molecular mechanisms of antibiotic resistance revisited
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“Tetracycline, for instance, functions by hindering the binding of tRNA to the A-site of the ribosome, which ultimately impedes the process of protein synthesis (Brodersen et al., 2000).”
BackgroundBeneficial roles of feed additives as immunostimulants in aquaculture: a review
Dawood, M. A. O., Koshio, S., & Esteban, M. Á. (2018) · Reviews in Aquaculture · doi:10.1111/raq.12209 · Cited by 921
Metadata
- Authors
- Halawa, E. M., Fadel, M., Al-Rabia, M. W., Behairy, A., Nouh, N. A., Abdo, M., Olga, R., Fericean, L., Atwa, A. M., El-Nablaway, M., & Abdeen, A.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2024-01-12
- Volume
- 14
- Pages
- 1305294-1305294
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W4390816777
- Cited by
- 280
- References
- 80
- FWCI
- 29.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance. https://app.cochat.ai/papers/10.3389/fphar.2023.1305294
- The paper
- Halawa, E. M., Fadel, M., Al-Rabia, M. W., Behairy, A., Nouh, N. A., Abdo, M., Olga, R., Fericean, L., Atwa, A. M., El-Nablaway, M., & Abdeen, A. (2024). Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2023.1305294
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
