Minocycline May Be Useful to Prevent/Treat Postoperative Cognitive Decline in Elderly Patients
Abstract
Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and pathophysiological mechanisms of this surgical complication remain elusive. Therefore, developing strategies for preventing or treating POCD is still challenging. However, increasing evidence suggests that central and systemic inflammation triggered by surgery likely plays a fundamental role in POCD developing and progression. Minocycline, a tetracycline derivative with anti-inflammatory properties, has been shown to be effective in treating neuroinflammatory related conditions or neurodegenerative diseases such as AD, Parkinson's disease, Huntington's disease. Considering that inflammation may be a potential factor of POCD and minocycline is effective in improving cognitive dysfunction induced by inflammation, we hypothesize that minocycline may be useful to treat/prevent the POCD development after surgery in elderly patients.
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Minocycline efficiently crosses the BBB.
“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [254]
Minocycline is considered neuroprotective for a variety of neurological conditions, including PD.
“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [254]
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- Authors
- Fan, L., Wang, T.-L., Xu, Y. C., Ma, Y. H., & Ye, W. G.
- Affiliations
- Capital Medical University (CN)
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 76
- Issue
- 5
- Pages
- 733-736
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2082551985
- Cited by
- 19
- References
- 37
- Citations by year
- 2024: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- minocycline, postoperative cognitive dysfunction, elderly patients, cardiac surgery, neuroinflammation, Alzheimer's disease, anti-inflammatory therapy, cognitive decline prevention, neurodegenerative diseases
- MeSH terms
- Aged, Anti-Inflammatory Agents, Anti-Bacterial Agents, Brain Diseases, Cognition Disorders, Humans, Inflammation, Minocycline, Models, Theoretical, Postoperative Complications, Tetracycline, Treatment Outcome, Sepsis, Neurodegenerative Diseases
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