The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Inflammatory markers and the risk of Alzheimer disease: The Framingham Study
Abstract
OBJECTIVE: To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD). METHODS: We followed 691 cognitively intact community-dwelling participants (mean age 79 years, 62% women) and related PBMC cytokine production (tertiles of spontaneous production of interleukin 1 [IL-1], IL-1 receptor antagonist, and tumor necrosis factor alpha [TNF-alpha]) and serum C-reactive protein and interleukin 6 (IL-6) to the risk of incident AD. RESULTS: Adjusting for clinical covariates, individuals in the top two tertiles (T2 and T3) of PBMC production of IL-1 or the top tertile (T3) of PBMC production of TNF-alpha were at increased risk of developing AD (multivariable-adjusted hazard ratio [HR] for IL-1 T2 = 2.84, 95% CI 1.09 to 7.43; p = 0.03 and T3 = 2.61, 95% CI 0.96 to 7.07; p = 0.06; for TNF-alpha, adjusted HR for T2 = 1.30, 95% CI 0.53 to 3.17; p = 0.57 and T3 = 2.59, 95% CI 1.09 to 6.12; p = 0.031]) compared with those in the lowest tertile (T1). INTERPRETATION: Higher spontaneous production of interleukin 1 or tumor necrosis factor alpha by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals. These data strengthen the evidence for a pathophysiologic role of inflammation in the development of clinical AD.
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“For example, increased number of monocytes, neutrophils, and elevated levels of circulating cytokines have been consistently reported in elderly individuals (Leng et al, 2005;Roubenoff et al, 1998;Tan et al, 2007).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Tan et al, 2007
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Immune modulation of learning, memory, neural plasticity and neurogenesis
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Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
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Proinflammatory Cytokines, Aging, and Age-Related Diseases
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Neuroinflammation: The role and consequences
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Metadata
- Authors
- Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., & Seshadri, S.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Neurology
- Published
- 2007-05-29
- Volume
- 68
- Issue
- 22
- Pages
- 1902-1908
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2106118263
- Cited by
- 440
- References
- 43
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 21 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 22 · 2019: 20 · 2018: 25 · 2017: 34 · 2016: 26 · 2015: 22 · 2014: 34 · 2013: 28 · 2012: 35
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Institute on Aging (5R01 AG 16495, R01AG016495, 5-R01-AG-08122, P30AG013846, R01AG008122, P30-AG13846))
- National Heart, Lung, and Blood Institute (N01‐HC25195)
- National Institute of Neurological Disorders and Stroke (5-R01-NS-17950, R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, inflammatory markers, serum cytokines, peripheral blood mononuclear cells, interleukin-1, TNF-α, interleukin-1 receptor antagonist, C-reactive protein, interleukin-6, inflammation, dementia risk, older adults
- MeSH terms
- Aged, Alzheimer Disease, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Interleukin-1, Leukocytes, Mononuclear, Male, Neuropsychological Tests, Risk Factors, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Immunoprecipitation, Interleukin 1 Receptor Antagonist Protein
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