Nuclear factor kappa B (NF-κB): A novel cause for diabetes, coronary artery disease and cancer initiation and promotion?
Abstract
Obesity is a growing epidemic in the United States (US). Obesity has been recognized as a modifiable risk factor for many diverse diseases including diabetes, cardiovascular disease and cancer burden. Common contributors to obesity include a high fat diet, smoking and physical inactivity. Systemic effects of obesity include increased micro-inflammatory molecules such as nuclear factor kappa B (NF-κB) that influence the both endothelial and epithelial layers as well as the supportive stroma. An emerging risk factor for micro-inflammation also includes periodontal disease. These pro-inflammatory states are hypothesized to contribute to diabetes as well as cardiovascular disease and cancer through the direct activation of NF-κB. Therefore, a comprehensive health care strategy would include reduction of diabetes, cardiovascular and cancer risk through the decrease in micro-inflammation.
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NF-κB pathway activation is a key event in inflammatory disease development, and blocking it can slow disease progression.
“Mounting evidence suggests that activation of NF-κB pathway is a major underlying event for the development of inflammatory diseases and its inhibition can decrease the disease progression [51–53].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [51]
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- Authors
- Rial, N. S., Choi, K., Nguyen, T., Snyder, B., & Slepian, M. J.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Rial, Nathaniel S.
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 78
- Issue
- 1
- Pages
- 29-32
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2078422294
- Cited by
- 47
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB, obesity, microinflammation, diabetes mellitus, coronary artery disease, tumor initiation, tumor promotion, periodontal disease, endothelial inflammation, cardiovascular disease
- MeSH terms
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Humans, Inflammation, Models, Biological, Neoplasms, Obesity, Periodontal Diseases, Risk Factors, Body Mass Index, NF-kappa B
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