Cited by 47NF-κB Signaling PathwaysAdipokines, Inflammation, and Metabolic DiseasesSignaling Pathways in Disease

Nuclear factor kappa B (NF-κB): A novel cause for diabetes, coronary artery disease and cancer initiation and promotion?

Rial, Nathaniel S., Choi, Kwan, Nguyen, Tam, Snyder, Branden, Slepian, Marvin J.·2012·Medical Hypotheses

Abstract

Obesity is a growing epidemic in the United States (US). Obesity has been recognized as a modifiable risk factor for many diverse diseases including diabetes, cardiovascular disease and cancer burden. Common contributors to obesity include a high fat diet, smoking and physical inactivity. Systemic effects of obesity include increased micro-inflammatory molecules such as nuclear factor kappa B (NF-κB) that influence the both endothelial and epithelial layers as well as the supportive stroma. An emerging risk factor for micro-inflammation also includes periodontal disease. These pro-inflammatory states are hypothesized to contribute to diabetes as well as cardiovascular disease and cancer through the direct activation of NF-κB. Therefore, a comprehensive health care strategy would include reduction of diabetes, cardiovascular and cancer risk through the decrease in micro-inflammation.

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Crossref · 10.1016/j.mehy.2011.09.034

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Authors
Rial, N. S., Choi, K., Nguyen, T., Snyder, B., & Slepian, M. J.
Affiliations
University of Arizona (US)
Corresponding author
Rial, Nathaniel S.
Venue
Medical Hypotheses
Publisher
Elsevier BV
Published
2012-01
Volume
78
Issue
1
Pages
29-32
ISSN
0306-9877 (ISSN-L)
OpenAlex
W2078422294
Cited by
47
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Medical Hypotheses (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
NF-κB, obesity, microinflammation, diabetes mellitus, coronary artery disease, tumor initiation, tumor promotion, periodontal disease, endothelial inflammation, cardiovascular disease
MeSH terms
Coronary Artery Disease, Diabetes Mellitus, Type 2, Humans, Inflammation, Models, Biological, Neoplasms, Obesity, Periodontal Diseases, Risk Factors, Body Mass Index, NF-kappa B

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