Topical application/formulation of probiotics: Will it be a novel treatment approach for diabetic foot ulcer?
Abstract
Treatment of chronic conditions like diabetic foot ulcer (DFU) is challenging due to increased susceptibility for infection and delayed wound healing. Complexity of existing therapy, adverse effects and microbial resistance emphasizes the need of an alternative approach for the management of DFU. The increasing body of evidence associated with probiotic application in diverse disease states merits its use in wound healing and infection too. Different probiotic strains have shown their efficacy in various infections like gut infections, oral infections and urogenital infections. Experimental studies have demonstrated probiotics' ability for gastric ulcer healing. Underlying mechanism of the above therapeutic effects of probiotics involves modulation of local and systemic immunity. The hypothesis is based on the concept that mechanism of anti-infective and ulcer healing action of probiotics will be similar in peripheral wounds and ulcers as on any other part of the body. This paper focuses on the hypothesis that topical applications/formulation of probiotics may be effective for the treatment of diabetic foot ulcers.
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Topical probiotics secrete antimicrobial substances (hydrogen peroxide and bacteriocin) that inhibit the growth of pathogenic microorganisms and prevent wound infection.
“As an effective treatment for wounds, they are recognized as topical probiotics because they secrete antimicrobial substances (i.e., hydrogen peroxide [98] and bacteriocin [99]), which inhibit the growth of pathogenic microorganisms and prevent wound infection.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [98]
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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Evaluation of the Role of Probiotics As a New Strategy to Eliminate Microbial Toxins: A Review
Ghadaksaz, A., Nodoushan, S. M., Sedighian, H., Behzadi, E., & Fooladi, A. A. I. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09893-2 · Cited by 20 · see citing works
- Authors
- Sonal Sekhar, M., Unnikrishnan, M. K., Vijayanarayana, K., Rodrigues, G. S., & Mukhopadhyay, C.
- Affiliations
- Manipal Academy of Higher Education (IN)
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 82
- Issue
- 1
- Pages
- 86-88
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W1998603962
- Cited by
- 52
- References
- 12
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- diabetic foot ulcer, topical probiotics, probiotic formulation, wound healing, infection, immunomodulation, probiotic strains, gastric ulcer healing, complementary and alternative medicine
- MeSH terms
- Administration, Topical, Humans, Models, Biological, Diabetic Foot, Probiotics
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