High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes
Abstract
Accumulation of advanced glycation end products in vessel walls may increase arterial stiffness and/or thickness, contributing to a high incidence of cardiovascular disease (CVD) in patients with diabetes. We investigated whether serum concentrations of pentosidine, a well-defined advanced glycation end product, are associated with arterial stiffness or thickness in patients with type 2 diabetes. Pentosidine was measured in sera from 98 patients with type 2 diabetes and 61 age-matched control subjects by a competitive enzyme-linked immunosorbent assay. Arterial stiffness was evaluated by heart-brachial and brachial-ankle pulse wave velocities (PWVs) measured using an automatic device. Arterial thickness was determined ultrasonographically as carotid intima-media wall thickness (IMT). Serum concentrations of pentosidine were significantly higher in patients with diabetes than in control subjects (64.4 +/- 21.0 vs 22.8 +/- 7.0 microg/L; P < .0001). In patients with diabetes, serum pentosidine correlated positively with heart-brachial PWV (r = 0.304; P < .01) but not with brachial-ankle PWV. Serum pentosidine also correlated positively with carotid IMT in patients with diabetes (r = 0.300; P < .01). Serum pentosidine concentrations were significantly higher in patients with diabetes with CVD than in those without (72.3 +/- 23.7 vs 62.3 +/- 19.8 microg/L; P = .0453). By multivariate analysis, only age (partial coefficient = 0.308; P < .05) and serum creatinine (partial coefficien…
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Previous investigations using ELISA or HPLC revealed higher serum pentosidine levels in diabetes patients compared to healthy controls.
“previous investigations, using ELISA or HPLC techniques, revealing higher serum pentosidine levels in diabetes patients compared to healthy controls [166,167]”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [166]
Cites
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Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?
Vlassara, H., & Uribarri, J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0453-1 · Cited by 594 · see citing works
Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases
Kehm, R., Baldensperger, T., Raupbach, J., & Höhn, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101901 · Cited by 348 · see citing works
“The latter finding is in contrast to previous investigations, using ELISA or HPLC techniques, revealing higher serum pentosidine levels in diabetes patients compared to healthy controls [166,167].”
ResultFishman, S. L., Sonmez, H., Basman, C., Singh, V., & Poretsky, L. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0060-3 · Cited by 330 · see citing works
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SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory
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- Authors
- Yoshida, N., Okumura, K.-I., & Aso, Y.
- Affiliations
- Dokkyo University (JP)
- Corresponding author
- Aso, Yoshimasa
- ORCID
- Aso, Yoshimasa
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 54
- Issue
- 3
- Pages
- 345-350
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2012070284
- Cited by
- 138
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 13 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- pentosidine, advanced glycation end products, type 2 diabetes, arterial stiffness, carotid intima-media thickness, pulse wave velocity, cardiovascular disease, serum biomarkers, renal function
- MeSH terms
- Aged, Analysis of Variance, Arginine, Arteries, Biomechanical Phenomena, Brachial Artery, Cardiovascular Diseases, Carotid Arteries, Diabetes Mellitus, Type 2, Female, Humans, Lysine, Male, Middle Aged, Pulse, Ultrasonography, Linear Models, Glycation End Products, Advanced, Tunica Intima, Tunica Media
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