Cited by 149Advanced Glycation End Products researchChronic Kidney Disease and DiabetesAdipokines, Inflammation, and Metabolic Diseases

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Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects

Yamagishi, Sho-ichi, Adachi, Hisashi, Nakamura, Kazuo, Matsui, Takanori, Jinnouchi, Yuko, Takenaka, Katsuhiko, Takeuchi, Masayoshi, Enomoto, Mika, Furuki, Kumiko, Hino, Asuka, Shigeto, Yoshiyuki, Imaizumi, Tsutomu·2006·Metabolism

DOI 10.1016/j.metabol.2006.05.007

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Abstract

The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis is implicated in diabetic vascular complications. Administration of soluble form of RAGE (sRAGE) to mice has been shown to block the AGE-elicited tissue damage by acting as a decoy. These observations suggest that endogenous sRAGE may capture and eliminate circulating AGEs and decrease its serum levels. However, because AGEs up-regulate tissue RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, sRAGE may be positively, rather than inversely, associated with circulating AGEs by reflecting tissue RAGE expression. In this study, we investigated the association of sRAGE with serum levels of AGEs in humans. Data for fasting serum sRAGE and AGE levels of 184 nondiabetic subjects were obtained from a general population in Japan. We also measured body mass index (BMI), waist circumference, blood pressure, and blood biochemistries in this population. Uni- and multivariate analyses were applied for the determinants of serum sRAGE levels. The average sRAGE levels were 0.40 +/- 0.17 ng/mL in males and 0.43 +/- 0.14 ng/mL in females, respectively. In the univariate analysis, BMI (P < .05, inversely), waist circumference (P < .05, inversely), AGEs (P < .05), and alcohol intake (P < .05, inversely) were significantly associated with sRAGE levels. After performing multivariate analyses, BMI (P < .05, inversely) and AGEs (P < .05) still remained significant independently. The present study is the first demonstration that serum sRAGE levels were positively associated with circulating AGEs in the nondiabetic general population. Endogenous sRAGE levels are elevated in parallel with serum AGE levels.

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Authors: Yamagishi, S.-I., Adachi, H., Nakamura, K., Matsui, T., Jinnouchi, Y., Takenaka, K., Takeuchi, M., Enomoto, M., Furuki, K., Hino, A., Shigeto, Y., & Imaizumi, T.
Affiliations: Kurume University (JP)
Hokuriku University (JP)
Corresponding author: Yamagishi, Sho-ichi
ORCID: Yamagishi, Sho-ichi
Adachi, Hisashi
Matsui, Takanori
Takeuchi, Masayoshi
Enomoto, Mika
Venue: Metabolism
Publisher: Elsevier BV
Published: 2006-09
Volume: 55
Issue: 9
Pages: 1227-1231
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2006.05.007
OpenAlex: W2042667331
Cited by: 148
References: 33
Citations by year: 2026: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 1 · 2017: 5 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
FWCI: 9.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Kimura Memorial Heart Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: advanced glycation end products, soluble receptor for advanced glycation end products, non-diabetic patients, body mass index, waist circumference, alcohol consumption, diabetic vascular complications, AGE-RAGE axis
MeSH terms: Receptor for Advanced Glycation End Products, Aged, Alcohol Drinking, Analysis of Variance, Blood Chemical Analysis, Blood Pressure, Female, Humans, Japan, Male, Middle Aged, Receptors, Immunologic, Solubility, Body Mass Index, Glycation End Products, Advanced, Body Size

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Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects

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