Advanced protein glycosylation in diabetes and aging

Brownlee, M.D, Michael

doi:10.1146/annurev.med.46.1.223

Cited by 1,312Advanced Glycation End Products researchChronic Kidney Disease and DiabetesGlycosylation and Glycoproteins Research

Advanced protein glycosylation in diabetes and aging

Brownlee, M.D, Michael·1995·Annual Review of Medicine

DOI 10.1146/annurev.med.46.1.223

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Abstract

Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.

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In a small controlled study, eight subjects aged 55-75 consuming 700 mg/d arachidonic acid for 12 weeks showed no effect on plasma sVCAM-1, sICAM-1 or sE-selectin concentrations.
“In another small, but controlled, study, eight subjects aged 55 -75 years consumed capsules providing 700 mg/d of arachidonic acid for 12 weeks (605) ; there was no effect on plasma sVCAM-1, sICAM-1 or sE-selectin concentrations.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [605]
In healthy older adults, supplementation with 0.7 g/d DHA for 12 weeks did not affect sICAM-1, sVCAM-1, or sE-selectin.
“DHA: ¼ sICAM-1, sVCAM-1, sE-selectin”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [605]
In healthy older adults, supplementation with 1 g/d EPA and DHA for 12 weeks inversely affected sVCAM-1.
“# sVCAM-1”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [605]

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Authors: Brownlee, M. D.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Brownlee, M.D, Michael
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 1995-02
Volume: 46
Issue: 1
Pages: 223-234
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev.med.46.1.223
OpenAlex: W2120833123
Cited by: 1,312
References: 80
Citations by year: 2026: 21 · 2025: 25 · 2024: 22 · 2023: 37 · 2022: 28 · 2021: 49 · 2020: 33 · 2019: 46 · 2018: 44 · 2017: 58 · 2016: 52 · 2015: 68 · 2014: 67 · 2013: 54 · 2012: 54
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords: advanced glycation end products, diabetes mellitus, aging, AGE receptor, extracellular matrix, reactive oxygen species, cytokines, diabetes complications, diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, AGE formation inhibition
MeSH terms: Receptor for Advanced Glycation End Products, Aged, Alzheimer Disease, Animals, Diabetes Mellitus, Humans, Receptors, Immunologic, Cytokines, Extracellular Matrix Proteins, Cellular Senescence, Glycation End Products, Advanced, Reactive Oxygen Species

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Advanced protein glycosylation in diabetes and aging

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