Cited by 244Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesPhysical Activity and Health

The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.

Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Hayashino, Yasuaki, Jackson, Jeffrey L., Hirata, Takumi, Fukumori, Norio, Nakamura, Fumiaki, Fukuhara, Shunichi, Tsujii, Satoru, Ishii, Hitoshi·2014·Metabolism

DOI 10.1016/j.metabol.2013.08.018

Open this paper in CoChat — free account

Abstract

Objective C-reactive protein (CRP), inflammatory cytokines, and adipokines contribute to atherosclerosis, insulin resistance, and development of late-onset complication in patients with type 2 diabetes. We performed a systematic review to assess effects of exercise interventions on inflammatory markers/cytokines and adipokines.Materials/methods We searched electronic databases (MEDLINE, EMBASE, and Cochrane Controlled Trials Registry) and reference lists in relevant papers for articles published in 1966-2013. We selected studies that evaluated the effects of exercise intervention on inflammatory markers/cytokines and adipokines in adult patients with type 2 diabetes. Weighted mean differences of exercise on outcomes were derived using fixed or random effect models; factors influencing heterogeneity were identified using meta-regression analysis.Results Fourteen randomized controlled trials (824 patients) were included in our meta-analysis. Exercise was associated with a significant in CRP=-0.66mg/l (95% CI, -1.09 to -0.23mg/l; -14% from baseline) and interleukin-6 (IL-6)=-0.88pg/ml (95% CI, -1.44 to -0.32pg/ml; -18% from baseline) but did not alter adiponectin or resistin levels; aerobic exercise program was associated with a significant change in leptin=-3.72ng/ml (95% CI, -6.26 to -1.18ng/ml; -24% from baseline). For IL-6, exercise was more effective in those with a longer duration in the program and larger number of sessions during study (p=0.001).Conclusions Exercise decreases inflammatory cytokine (CRP and IL-6) in patients with type 2 diabetes. Exercise could be a therapeutic option for improving abnormalities in inflammation levels in patients with diabetes.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2013.08.018

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Global Prevalence of Diabetes
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604

Flagged first, then by citations

Show all 53 references

2 of the 53 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 243

Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance
Lee-Ødegård, S., Olsén, T., Norheim, F., Drevon, C. A., & Birkeland, K. I. (2022) · Metabolites · doi:10.3390/metabo12030208 · Cited by 20
Psoriasis comorbidities in Germany: A population-based study on spatiotemporal variations
Augustin, J., Wolf, S., Stephan, B., Augustin, M., & Andrees, V. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265741 · Cited by 21
Effect of Low-Intensity, Kinect™-Based Kaimai-Style Qigong Exercise in Older Adults With Type 2 Diabetes
Cai, H., Li, G., Jiang, S., Yin, H., Liu, P., & Chen, L. (2019) · Journal of Gerontological Nursing · doi:10.3928/00989134-20190111-05 · Cited by 22
Diagnosis, Prevention, and Treatment of Cardiovascular Diseases in People With Type 2 Diabetes and Prediabetes ― A Consensus Statement Jointly From the Japanese Circulation Society and the Japan Diabetes Society ―
Araki, E., Tanaka, A., Inagaki, N., Ito, H., Ueki, K., Murohara, T., Imai, K., Sata, M., Sugiyama, T., Ishii, H., et al. (2020) · Circulation Journal · doi:10.1253/circj.cj-20-0865 · Cited by 24
Serum Levels of CRP are Associated with Depression in a Middle-aged and Elderly Population with Diabetes Mellitus: A Diabetes Mellitus-Stratified Analysis in a Population-Based Study
Huang, Y., Su, Y., Chen, H., Liu, H., & Hu, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.028 · Cited by 20
Comparing the Efficacy of Supervised and Unsupervised Exercise Training on Glycaemic Control in Type 2 Diabetes: A Systematic Review
Gajanand, T., Keating, S. E., Brown, W. J., Hordern, M., Fassett, R. G., & Coombes, J. S. (2019) · Current Diabetes Reviews · doi:10.2174/1573399815666190212120404 · Cited by 20
Comparison of the Effect of Endurance, Strength, and Endurance-Strength Training on Inflammatory Markers and Adipokines Levels in Overweight and Obese Adults: Systematic Review and Meta-Analysis of Randomised Trials
Makarewicz-Bukowska, A., Jamka, M., Geltz, J., Śmidowicz, A., Kokot, M., Kaczmarek, N., Mądry, E., & Walkowiak, J. (2022) · Healthcare · doi:10.3390/healthcare10061098 · Cited by 19
Comparative efficacy of different exercise types on inflammatory markers in women with overweight and obesity: A systematic review and network meta-analysis of randomized controlled trials
Tan, L., Yan, W., Zhang, B., Zhao, Z., Lipowski, M., & Ossowski, Z. M. (2024) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2024.03.007 · Cited by 21
Impact of aerobic exercise training during chemotherapy on cancer related cognitive impairments in patients suffering from acute myeloid leukemia or myelodysplastic syndrome — Study protocol of a randomized placebo-controlled trial
Zimmer, P., Oberste, M., Bloch, W., Schenk, A., Joisten, N., Hartig, P., Wolf, F., Baumann, F. T., Garthe, A., Hallek, M. J., et al. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.05.007 · Cited by 19
Impacts of Exercise Interventions on Inflammatory Markers and Vascular Adhesion Molecules in Patients With Heart Failure: A Meta-analysis of RCTs
Malandish, A., Karimi, A., Naderi, M., Ghadamyari, N., & Gulati, M. (2023) · CJC Open · doi:10.1016/j.cjco.2023.02.009 · Cited by 19
Exercise-Induced Alternations of Adiponectin, Interleukin-8 and Indicators of Carbohydrate Metabolism in Males with Metabolic Syndrome
Makiel, K., Suder, A., Targosz, A., Maciejczyk, M., & Haim, A. (2023) · Biomolecules · doi:10.3390/biom13050852 · Cited by 22
Cultivating a healthy neuro‐immune network: A health psychology approach
Bower, J. E., Kuhlman, K. R., Haydon, M. D., Boyle, C. C., & Radin, A. S. (2019) · Social and Personality Psychology Compass · doi:10.1111/spc3.12498 · Cited by 21
Effects of aerobic training with and without progression on blood pressure in patients with type 2 diabetes: A systematic review with meta-analyses and meta-regressions
Heberle, I., de Barcelos, G. T., Silveira, L. M. P., Costa, R. R., Gerage, A. M., & Delevatti, R. S. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108581 · Cited by 20
Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men
Gastebois, C., Villars, C., Drai, J., Canet‐Soulas, E., Blanc, S., Bergouignan, A., Lefai, É., & Simon, C. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3466-z · Cited by 17
Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society
the directors of the JCS, J., Araki, E., Tanaka, A., Inagaki, N., Ito, H., Ueki, K., Murohara, T., Imai, K., Sata, M., Sugiyama, T., et al. (2020) · Diabetology International · doi:10.1007/s13340-020-00471-5 · Cited by 16
Comparative Efficacy of Different Exercise Modes on Inflammatory Markers in Patients With Type 2 Diabetes Mellitus: A Systematic Review With Pairwise and Network Meta‐Analyses
Khalafi, M., Maleki, A. H., Symonds, M. E., Alamdari, K. A., Ehsanifar, M., & Rosenkranz, S. K. (2025) · Obesity Reviews · doi:10.1111/obr.13954 · Cited by 18
Using network analysis to examine links between individual depression symptoms, inflammatory markers, and covariatesPreprint
Fried, E. I., & Haslbeck, J. M. B. (2018) · doi:10.31234/osf.io/84ske · Cited by 17
Effect of aerobic exercise training on cardiometabolic risk factors among professional athletes in the heaviest-weight class
Guo, J., Lou, Y., Zhang, X., & Song, Y. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0071-y · Cited by 18
Type 2 diabetes mellitus risk and exercise: is resistin involved?
Cobbold, C. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.18.08258-0 · Cited by 22
The Impact of Different Intensities of Physical Activity on Serum Urate and Gout: A Mendelian Randomization Study
Yang, T., Bi, S., Zhang, X. Y., Yin, M., Feng, S., & Li, H. (2024) · Metabolites · doi:10.3390/metabo14010066 · Cited by 15
Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs
Wu, H., Guo, Y., Pu, Y., & Tang, Z. (2021) · Bioscience Reports · doi:10.1042/bsr20192668 · Cited by 14
Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet
de Sousa, M. V., Fukui, R. T., Dagogo-Jack, S. E., Krustrup, P., Zouhal, H., & da Silva, M. E. R. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112618 · Cited by 15
Muscle LIM protein promotes expression of the acetylcholine receptor ?-subunit gene cooperatively with the myogenin-E12 complex
Lü, P., Taylor, M., Jia, H., & Ni, J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4213-x · Cited by 14
The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses
Khalafi, M., Maleki, A. H., Mojtahedi, S., Ehsanifar, M., Rosenkranz, S. K., Symonds, M. E., Tarashi, M. S., Fatolahi, S., & Fernández, M. L. (2025) · Nutrients · doi:10.3390/nu17152388 · Cited by 15
Translating Physical Activity Evidence to Hospital Settings
Tucker, S., & Carr, L. J. (2016) · Clinical Nurse Specialist · doi:10.1097/nur.0000000000000212 · Cited by 14
Exercise Improves Insulin Sensitivity in the Absence of Changes in Cytokines
Verheggen, R. J. H. M., Poelkens, F., Roerink, S. H. P. P., Ramakers, R. E. F. S., Catoire, M., Hermus, A. R., Thijssen, D. H. J., & Hopman, M. T. E. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001035 · Cited by 15
Comparison of control fasting plasma glucose of exercise-only versus exercise-diet among a pre-diabetic population: a meta-analysis
Zheng, L., Wu, J., Wang, G., Persuitte, G. M., Ma, Y., Zou, L., Zhang, L., Zhao, M., Wang, J., Lan, Q., et al. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.128 · Cited by 13
The effects of extracellular vesicles and their cargo on metabolism and its adaptation to physical exercise in insulin resistance and type 2 diabetes
Mastrototaro, L., & Roden, M. (2023) · PROTEOMICS · doi:10.1002/pmic.202300078 · Cited by 13
Evaluation of Systemic Medications Associated With Surgically Treated Cataract Among US Adults
Deng, R., Zhu, Z., Han, X., Shang, X., He, M., Xu, G., Chen, Z., & Fan, H. (2023) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2023.01.005 · Cited by 12
Lifestyle modification in the management of insulin resistance states in overweight/obesity: the role of exercise training
Thaane, T., Motala, A. A., & McKune, A. J. (2019) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/16089677.2019.1608054 · Cited by 15
Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins
Lin, X., Qu, J., Yin, L., Wang, R., & Wang, X. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159409 · Cited by 14
The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
Memelink, R. G., Njemini, R., Kuil, M. J. J. D. B., Wopereis, S., den Bosch, J. D. V., Schoufour, J. D., Tieland, M., Weijs, P. J. M., & Bautmans, I. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112410 · Cited by 13
Type of Physical Training and Selected Aspects of Psychological Functioning of Women with Obesity: A Randomised Trial
Bąk‐Sosnowska, M., Gruszczyńska, M., Skrypnik, D., Grzegorczyn, S. M., Karolkiewicz, J., Ratajczak, M., Mądry, E., Walkowiak, J., & Bogdański, P. (2021) · Nutrients · doi:10.3390/nu13082555 · Cited by 11
The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials
Lin, H., Hu, M., Yan, Y., & Zhang, H. (2017) · Sport Sciences for Health · doi:10.1007/s11332-017-0358-5 · Cited by 11
Exercise and Dietary Restriction for Promotion of Neurohealth Benefits
Archer, T., & Garcia, D. (2015) · Health · doi:10.4236/health.2015.71016 · Cited by 10
Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats
Chen, Z., Sun, H., Wang, J., Ni, L.-S., Gu, X., Ge, S., Chen, Q., Mu, L., & Cheng, X. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej16-0458 · Cited by 10
Körperliche Aktivität und Sport bei Typ-2-Diabetes
Niess, A. M., & Thiel, A. (2017) · Diabetologie und Stoffwechsel · doi:10.1055/s-0042-121407 · Cited by 9
Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients
Shimoda, M., Kaneto, H., Yoshioka, H., Okauchi, S., Hirukawa, H., Kimura, T., Kanda‐Kimura, Y., Kohara, K., Kamei, S., Kawasaki, F., et al. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12388 · Cited by 10
Genetically predicted physical activity is associated with lower serum urate concentrations
Guan, Y., Wei, J., Meng, L., Li, Y., Wang, T., Chen, D., & Qian, Q. (2022) · Genes & Genomics · doi:10.1007/s13258-022-01239-8 · Cited by 11
Strategies and methods for the correction of obesity and associated cardiovascular risk
Kuznetsova, Т. Y., Druzhilov, М. A., Chumakova, G. A., & Veselovskaya, N. G. (2019) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2019-4-61-67 · Cited by 10
Molecular mechanisms underlying the beneficial effects of exercise and dietary interventions in the prevention of cardiometabolic diseases
Forte, M., Rodolico, D., Ameri, P., Catalucci, D., Chimenti, C., Crotti, L., Schirone, L., Pingitore, A., Torella, D., Iacovone, G., et al. (2022) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001397 · Cited by 10
Effects of aerobic exercise performed during pregnancy on hypertension and gestational diabetes: a systematic review and meta-analysis
Zhang, J., Wang, H., & Xin-Xu, W. A. N. G. (2023) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.23.14578-6 · Cited by 15
Physical activity initiated by employer induces improvements in a novel set of biomarkers of inflammation: an 8-week follow-up study
Lunde, L.-K., Skare, Ø., Aass, H. C. D., Mamen, A., Einarsdóttir, E., Ulvestad, B., & Skogstad, M. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3533-5 · Cited by 9
The relationship between the level of exercise and hemoglobin A1c in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Igarashi, Y., Akazawa, N., & Maeda, S. (2021) · Endocrine · doi:10.1007/s12020-021-02817-8 · Cited by 10
Effect of Exercise Instructions With Ambulatory Accelerometer in Japanese Patients With Type 2 Diabetes: a Randomized Control Trial
Matsushita, J., Okada, H., Okada, Y., Sekiyama, T., Iida, H., Shindo, A., Murata, H., & Fukui, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.949762 · Cited by 8
Tailored Interventions for Supporting Physical Activity Participation in People with Arthritis and Related Conditions: a Systematic Review
Ma, J. K., Ramachandran, S., Sandhu, A., Tsui, K., Hoens, A. M., Hu, D., & LI, L. C. (2022) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-022-00194-5 · Cited by 8
Physical Activity Is Associated with the Incidence of Depression in United States Adults from the NHANES 2013–18: A Cross-Sectional Study
Pereira-Payo, D., Mendoza-Muñoz, M., Denche-Zamorano, Á. M., la Osa, A. R.-D., Moreno-Quintanilla, M., & Pastor-Cisneros, R. (2024) · Healthcare · doi:10.3390/healthcare12050552 · Cited by 8
Unveiling the role of exercise training in targeting the inflammatory paradigm of heart failure with preserved ejection fraction: a narrative review
Jaconiano, E., & Moreira‐Gonçalves, D. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10138-1 · Cited by 8
Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-Ι diabetic rats
Rezaee, N., Rahmani‐Nia, F., Delfan, M., & Ghahremani, R. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119973 · Cited by 8
The Effects of 12-Week Traditional Thai Exercise (Ruesi Dadton) on Glycemic Control and Inflammatory Markers in Prediabetes: A Randomized Controlled Trial
Sawangwong, P., Tungsukruthai, S., Nootim, P., Sriyakul, K., Phetkate, P., Pawa, K. K., & Tungsukruthai, P. (2023) · Life · doi:10.3390/life13112166 · Cited by 7
Salivary concentrations of IL-8 and IL-1ra after HIIT and MICT in young, healthy adults: A randomized exercise study.
O'Neill, C., O’Rourke, N., Jeffrey, M., Green-Johnson, J., & Dogra, S. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155965 · Cited by 7
Bewegung als Neuromodulator: Wie körperliche Aktivität die Physiologie der adoleszenten Depression reguliert
Wunram, H. L., Kasparbauer, A., Oberste, M., & Bender, S. (2023) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000954 · Cited by 7
Effects of an adapted cardiac rehabilitation programme on arterial stiffness in patients with type 2 diabetes without cardiac disease diagnosis
Brozic, A., Marzolini, S., & Goodman, J. M. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164116679078 · Cited by 7
Comparison of the Effects of Aerobic Exercise on Pulmonary Function and Levels of Inflammatory Mediators in Men With Type 2 Diabetes
Saki, H., Shahrokhian, S., Taeid, V., Amani, M., Talebifard, H., & Delaramnasab, M. (2017) · International journal of basic science in medicine · doi:10.15171/ijbsm.2017.18 · Cited by 7
Exercise and Inflammation
Kandola, A. A., & Brendon, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-71229-7_26 · Cited by 7
Exercise Training Protocols to Improve Obesity, Glucose Homeostasis, and Subclinical Inflammation
Diniz, T. A., Antunes, B. M., Little, J. P., Lira, F. S., & Neto, J. C. R. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1558-4_7 · Cited by 7
Körperliche Aktivität, Sport und Bewegungstherapie bei (morbider) Adipositas
Graf, C., & Ferrari, N. (2015) · Der Diabetologe · doi:10.1007/s11428-015-0001-5 · Cited by 7
Hypoxic compound exercise improves cardiac function in Drosophila high fructose diet via KHK
Ping, X., Li, Q., Ding, M., Yu, Z., Yi, Q., Li, Y., Gu, W., Zhang, P., Zhang, Z., & Zheng, L. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.02.005 · Cited by 6
Effects of concurrent exercise training on body composition, systemic inflammation, and components of metabolic syndrome in inactive academics: a randomised controlled trial
Higham, S. M., Mendham, A. E., Rosenbaum, S., Allen, N. G., Smith, G., Stadnyk, A. M. J., & Duffield, R. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05108-w · Cited by 7
Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer
Huang, S., Zhan, Y., Jeon, S., Bruner, D. W., Miller, A. H., Felger, J. C., Wommack, E. C., Saba, N. F., Higgins, K. A., Irwin, M. L., et al. (2023) · Head & Neck · doi:10.1002/hed.27420 · Cited by 6
High-Intensity Interval Training Versus Moderate Intensity Combined Training (Resistance and Aerobic) for Improving Insulin-Related Adipokines in Type 2 Diabetic Women
Banitalebi, E., Faramarzi, M., & Nasiri, S. (2018) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms.68793 · Cited by 6
Role of Exercise-induced Adiponectin Activation on Obese and Diabetic Individuals
Lim, K., & Kim, K.-J. (2020) · Exercise Science · doi:10.15857/ksep.2020.29.3.208 · Cited by 6
Lifestyle Behaviors, Perceived Stress, and Inflammation of Individuals With Chronic Graft-Versus-Host Disease
Kelly, D. L., Lyon, D., Periera, D., GARVAN, C. W., & Wingard, J. R. (2016) · Cancer Nursing · doi:10.1097/ncc.0000000000000453 · Cited by 6
Using network analysis to examine links between individual depression symptoms, inflammatory markers, and covariatesPreprint
Fried, E. I., & Haslbeck, J. M. B. (2019) · doi:10.31234/osf.io/5mvz4 · Cited by 6
The intensity of exercise and inflammation markers in women with overweight & obesity: a systematic review and network meta-analysis
Tan, L., Huang, D., Liu, B., Ossowski, Z. M., Wang, N., & Yan, W. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01777-7 · Cited by 10
A single-set functional training program increases muscle power, improves functional fitness, and reduces pro-inflammatory cytokines in postmenopausal women: A randomized clinical trial
Rocha, J. N. D. S., Vasconcelos, A. B. S., Aragão-Santos, J. C., de Resende–Neto, A. G., Monteiro, M. R. P., Nogueira, A. C., Pantoja-Cardoso, A., Corrêa, C. B., de Moura, T. R., & Silva‐Grigoletto, M. E. D. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1054424 · Cited by 5
Metabolic and inflammatory health in SARS-CoV-2 and the potential role for habitual exercise in reducing disease severity
Marino, F. E., Vargas, N. T., Skein, M., & Hartmann, T. E. (2021) · Inflammation Research · doi:10.1007/s00011-021-01517-3 · Cited by 6
Recommendations of the Schizophrenia Expert Center network for adequate physical activity in real-world schizophrenia (FACE-SZ)
de Verville, P. L. S., Stubbs, B., Etchecopar‐Etchart, D., Godin, O., Andrieu-Haller, C., Berna, F. S., Aouizerate, B., Capdevielle, D., Chéreau, I., Clauss, J. M. E., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01384-x · Cited by 5
Single and Joined Behaviour of Circulating Biomarkers and Metabolic Parameters in High-Fit and Low-Fit Healthy Females
Janssen, J. J. E., Lagerwaard, B., Nieuwenhuizen, A. G., Escoté, X., Canela-Canela, N., Bas-Prior, J. M. D., de Boer, V. C. J., & Keijer, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044202 · Cited by 5
The effect of acute step-aerobic exercise on adiponectin and leptin levels in premenopausal women
Sarı, İ., HABİPOĞLU, S., Seydel, G. Ş., Erşan, S., & Güntürk, İ. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.11297-0 · Cited by 5
Effect of online aerobic exercise training in patients with bipolar depression: Protocol of a randomized clinical trial
Wang, X., Luo, H., Zhang, Y., Mao, M., Lu, Y., Zhang, Z., Jiang, C., & Luo, Q. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1011978 · Cited by 6
Effect of Concurrent Exercise Training on Stress, Depression and Anxiety in Inactive Academics: Secondary Analysis of a Randomized Controlled Trial
Higham, S. M., Mendham, A. E., Rosenbaum, S., Allen, N. G., Smith, G., & Duffield, R. (2025) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2025.2461322 · Cited by 4
Rheumatoid Arthritis
Dimitroulas, T., Sandoo, A., Skeoch, S., O’Sullivan, M., Yessirkepov, M., Ayvazyan, L., Gasparyan, A. Y., Metsios, G. S., & Kitas, G. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803267-1.00006-5 · Cited by 4
Sportmedizinische Grundlagen: Immunologische Beanspruchung durch körperliche Belastung
Puta, C., & Gabriel, H. H. W. (2021) · Springer eBooks · doi:10.1007/978-3-662-53386-4_20-1 · Cited by 3
Comparing the prolonged effect of interval versus continuous aerobic exercise on blood inflammatory marker of Visfatin level and body mass index of sedentary overweigh/fat female college students
Moravveji, A., Sayyah, M., Shamsnia, E., & Vakili, Z. (2019) · AIMS Public Health · doi:10.3934/publichealth.2019.4.568 · Cited by 4
Implementing Follow‐Along Physical Activity Videos with People Living With Chronic Conditions: A Feasibility Study
Tucker, S., Abbott, L., Anderson, R. E., Eppen, K., Laroche, H. H., Paelmo, E., & Lanningham‐Foster, L. (2019) · Worldviews on Evidence-Based Nursing · doi:10.1111/wvn.12392 · Cited by 3
ATHLETIC PERFORMANCE ENHANCING ACE, ACTN3, AMPD1 GENETIC MARKERS, FITNESS CHARACTERISTICS, C-REACTIVE PROTEIN AND URIC ACID OF CRICKET, NETBALL, RUGBY AND SOCCER PLAYERS: A REVIEW
Mugandani, S. (2019) · Journal of Applied Sports Sciences · doi:10.37393/jass.2019.01.13 · Cited by 3
Breastfeeding and Maternal Age-related Cataract
Park, S., & Choi, N. (2018) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2018.05.017 · Cited by 3
Comparative analysis of dietary and physical activity behavior between prediabetic and normoglycemic populations
Lin, J., Liu, S., Gao, L., Guo, X., & Hu, X. (2025) · BMC Public Health · doi:10.1186/s12889-025-24790-x · Cited by 2
A Conceptual Digital Health Framework for Longevity Optimization: Inflammation-Centered Approach Integrating Microbiome and Lifestyle Data—A Review and Proposed Platform
Adibi, S. (2026) · Nutrients · doi:10.3390/nu18020231 · Cited by 2
Comparative effects of different exercise types on inflammatory markers in type 2 diabetes mellitus patients with overweight and obesity: a systematic review and network meta-analysis
Dong, M., Zhang, X., & Lu, S. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-026-02193-2 · Cited by 3
Obesity and Non-Alcoholic Fatty Liver - Therapies in Ayurvedic Medicines
Menashi, S., Cohen, L., & Neuman, M. G. (2018) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.1801002 · Cited by 2
Effects of 16 weeks’ combined exercise on insulin resistance, inflammatory markers, oxidative stress, and leukocyte telomere length in elderly women with type 2 DM
Lee, T.-H., Jung, W., Cho, H., & Lee, M.-G. (2019) · Korean Journal of Sport Science · doi:10.24985/kjss.2019.30.3.470 · Cited by 2
The association between physical activity, low-grade inflammation, and labour market attachment among people with multimorbidity: A cross-sectional study from the Lolland-Falster Health Study, Denmark
Poulsen, V. R., Fischer, L. K., Aadahl, M., Mortensen, O. S., Skou, S. T., Jørgensen, L. B., Jepsen, R., Møller, A., Petersen, T. L., Brønd, J. C., et al. (2023) · Journal of Multimorbidity and Comorbidity · doi:10.1177/26335565231195510 · Cited by 2
Association between physical activity and the prevalence of gout among patients with type 2 diabetes mellitus and hyperuricemia: a two-center population-based cross-sectional study
Cai, N., Chen, M., Wu, L., Feng, P., Ye, X., Liu, Q., Zhu, X., Lu, C., Zheng, Q., & Wang, Y. (2024) · Clinical Rheumatology · doi:10.1007/s10067-024-07081-5 · Cited by 2
The Influence of Physical Activity on the Level of Chronic Inflammation in Health and in Noninfectious Diseases
Pahomov, N. V., Kostunina, D. S., & Artemenkov, A. A. (2024) · Human Physiology · doi:10.1134/s0362119723600595 · Cited by 2
Chronic Medical Conditions
Chou, C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-47904-2.00028-3 · Cited by 2
Physical Activity Levels and Cardiometabolic Risks in Obese African American Adults: A Pilot Intervention Study
Zhou, Y., Buchowski, M. S., Akatue, R. A., Wu, J., Liu, J., & Hargreaves, M. K. (2018) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2018.0077 · Cited by 2
Entorno inflamatorio diferencial en pacientes con osteoporosis y diabetes mellitus tipo 2
Muñoz‐Torres, M., Carazo, Á., Jiménez-López, J. C., Avilés-Pérez, M., Díaz-Arco, S., Alonso, S. L., Lima‐Cabello, E., Ramírez, J. D. D. A., Reyes‐García, R., & Morales, S. (2022) · Revista de Osteoporosis y Metabolismo Mineral · doi:10.4321/s1889-836x2022000100004 · Cited by 2
The effect of 17β-estradiol plus norethisterone acetate on blood pressure and inflammation markers: A meta-analysis of randomized controlled trials
Liu, H. S., Zhan, J., He, J., Zhong, L., Yang, J. B., Dai, Q., & Zhang, X. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.04.004 · Cited by 2
Chronic Medical Conditions:
Whiteson, J. H., Cohen, J. M., & Prilik, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-62539-5.00028-x · Cited by 2
The Role of Physical Counselling in Patients with Type 2 Diabetes Mellitus: A Systematic Review
Carraro, E., Roppolo, M., Bonetta, S., & Gilli, G. (2015) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2015.52012 · Cited by 1
Efeitos do Exercício Físico na Resposta da Interleucina-6 Durante o Tratamento da Síndrome Metabólica
Callegari, I. O. M., & Oliveira, A. G. (2022) · Saúde e Desenvolvimento Humano · doi:10.18316/sdh.v10i3.9029 · Cited by 1
Integrative Therapies in Metabolic Syndrome
Lucius, K. (2024) · Integrative and Complementary Therapies · doi:10.1089/ict.2024.88345.kl · Cited by 1
The effects of pulmonary rehabilitation on inflammatory biomarkers in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
Farley, C., LeBouedec, M. A., Oliveira, A., Goldstein, R. S., Nair, P. K., Brooks, D., & Newman, A. N. L. (2025) · Canadian Journal of Respiratory Critical Care and Sleep Medicine · doi:10.1080/24745332.2025.2491522 · Cited by 1
Effects of a home-based low-to-moderate-intensity dance exercise program on glycemic control and quality of life in elderly patients with type 2 diabetes: a single-arm, intervention study
Ujiie, A., Hara, K., Kubo, M., Yamauchi, M., Tsuchiya, T., Takebayashi, K., Maruyama, Y., & Hashimoto, K. (2025) · Diabetology International · doi:10.1007/s13340-025-00854-6 · Cited by 1
Effects of Resistance Training on Serum Inflammatory Markers and CatSper 1-4 Protein Expression in Testis of OLETF Rats
Lee, M., Park, S.-H., & Yoon, J.-H. (2017) · Exercise Science · doi:10.15857/ksep.2017.26.3.204 · Cited by 1
Effects of Single Bout and Short Term Aerobic Exercise on C-Reactive Protein in Type-2 Diabetes Patients: A Pilot Study
Ezema, C. I., Nweke, M., Amarachukwu, C., Obiekwe, C., Okafor, C. I., Esom, I. E. A., & Ukwuoma, M. (2020) · Ghana Journal of Science · doi:10.4314/gjs.v61i1.3 · Cited by 1
Stress, aging, and inflammation
Matovic, S., Rummel, C. D., Feldotto, M., & Gouin, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-817558-3.00004-4 · Cited by 1
Effect of aerobic training on baroreflex sensitivity, heart rate recovery, and heart rate variability in type 2 diabetes: a systematic review
Parveen, S., Azharuddin, M., & Noohu, M. M. (2023) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-023-01292-3 · Cited by 1

Authors: Hayashino, Y., Jackson, J. L., Hirata, T., Fukumori, N., Nakamura, F., Fukuhara, S., Tsujii, S., & Ishii, H.
Affiliations: Kyoto University (JP)
Milwaukee VA Medical Center (US)
Tenri Hospital (JP)
ORCID: Hayashino, Yasuaki
Jackson, Jeffrey L.
Hirata, Takumi
Nakamura, Fumiaki
Fukuhara, Shunichi
Tsujii, Satoru
Ishii, Hitoshi
Venue: Metabolism
Publisher: Elsevier BV
Published: 2014-03
Volume: 63
Issue: 3
Pages: 431-440
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2013.08.018
OpenAlex: W2143812909
Cited by: 244
References: 53
Citations by year: 2026: 6 · 2025: 14 · 2024: 11 · 2023: 28 · 2022: 29 · 2021: 20 · 2020: 15 · 2019: 34 · 2018: 22 · 2017: 21 · 2016: 20 · 2015: 18 · 2014: 5
FWCI: 1.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: physical activity, type 2 diabetes, C-reactive protein, interleukin-6, adipokines, leptin, adiponectin, resistin, inflammation, aerobic exercise, insulin resistance
MeSH terms: C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Male, Middle Aged, Biomarkers, Exercise, Interleukin-6, Adipokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks