Serum Levels of CRP are Associated with Depression in a Middle-aged and Elderly Population with Diabetes Mellitus: A Diabetes Mellitus-Stratified Analysis in a Population-Based Study
Abstract
Background The direct relationship between inflammation and depression in patients with diabetes is still unclear. We examined the association between serum C-reactive protein (CRP) levels and the high prevalence of depression in populations (aged ≥49 years) with and without type 2 diabetes.Methods Cross-sectional and longitudinal data from 3895 participants obtained from The Irish Longitudinal Study on Ageing (TILDA) were analyzed to determine the association between serum CRP levels and depression, accounting for relevant confounding factors.Results Multivariable analyses showed a positive association between serum CRP and depression score, independent of age and gender, BMI, marital status, education, smoking status, alcohol drinking status, systolic BP, diastolic BP, physical activity, self-reported CVDs and laboratory measurements in subjects with diabetes mellitus (coefficient = 0.179, P<0.001) but not in subjects without diabetes mellitus (coefficient = 0.011, P = 0.495). Higher serum CRP levels were associated with an increased risk of depressive symptoms in subjects with diabetes mellitus (OR = 1.301, 95% CI 1.012-1.799, P = 0.011) but not in subjects without diabetes mellitus (OR = 1.004, 95% CI 0.992-1.013, P = 0.344) after adjusting for these same confounding factors. After a follow-up of 4 years, higher serum CRP levels were significantly associated with a higher possibility of depression events in subjects with diabetes mellitus.Limitations Time-varying confounding factors may interfere with our results.Conclusion We observed a significant positive association between serum CRP levels and the prevalence of depressive symptoms in a middle-aged and elderly population with diabetes after adjustment for a range of lifestyle factors.
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Individuals affected with autoimmune disorders are more likely to display comorbid depressive symptomatology.
“Accordingly, it has been well documented that individual affected with autoimmune disorders (e.g., rheumatoid arthritis, psoriasis, diabetes mellitus, chronic inflammatory bowel disease, and autoimmune thyroiditis) are more likely to display comorbid depressive symptomatology [17,18,19,20,21,22,23].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [21]
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- Authors
- Huang, Y., Su, Y., Chen, H., Liu, H., & Hu, J.
- Affiliations
- Second Affiliated Hospital of Nanchang University (CN)
- Corresponding author
- Huang, Ying
- Su, Yuhao
- Hu, Jinzhu
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 281
- Pages
- 351-357
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W3111493307
- Cited by
- 20
- References
- 36
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- C-reactive protein, depression, type 2 diabetes, inflammation, depressive symptoms, middle-aged and older adults, Irish Longitudinal Study on Ageing
- MeSH terms
- Aged, C-Reactive Protein, Cross-Sectional Studies, Depression, Diabetes Mellitus, Type 2, Humans, Longitudinal Studies, Middle Aged, Risk Factors
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