The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.
Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials
Abstract
Objective C-reactive protein (CRP), inflammatory cytokines, and adipokines contribute to atherosclerosis, insulin resistance, and development of late-onset complication in patients with type 2 diabetes. We performed a systematic review to assess effects of exercise interventions on inflammatory markers/cytokines and adipokines.Materials/methods We searched electronic databases (MEDLINE, EMBASE, and Cochrane Controlled Trials Registry) and reference lists in relevant papers for articles published in 1966-2013. We selected studies that evaluated the effects of exercise intervention on inflammatory markers/cytokines and adipokines in adult patients with type 2 diabetes. Weighted mean differences of exercise on outcomes were derived using fixed or random effect models; factors influencing heterogeneity were identified using meta-regression analysis.Results Fourteen randomized controlled trials (824 patients) were included in our meta-analysis. Exercise was associated with a significant in CRP=-0.66mg/l (95% CI, -1.09 to -0.23mg/l; -14% from baseline) and interleukin-6 (IL-6)=-0.88pg/ml (95% CI, -1.44 to -0.32pg/ml; -18% from baseline) but did not alter adiponectin or resistin levels; aerobic exercise program was associated with a significant change in leptin=-3.72ng/ml (95% CI, -6.26 to -1.18ng/ml; -24% from baseline). For IL-6, exercise was more effective in those with a longer duration in the program and larger number of sessions during study (p=0.001).Conclusions Exercise decreases inflammatory cytokine (CRP and IL-6) in patients with type 2 diabetes. Exercise could be a therapeutic option for improving abnormalities in inflammation levels in patients with diabetes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some have either shown a reduction in resistin levels [233] or no change [227] following aerobic or resistance exercise interventions.”
In the citing paper
“A meta-analysis focusing specifically on individuals with T2DM has also described decreased levels of IL-6 and CRP with aerobic exercise interventions [227], which emphasizes that the anti-inflammatory properties of exercise are strong regardless of preexisting metabolic status.”
In the citing paper
“Alternatively, the absolute change in levels of CRP or IL-6 with a healthy diet intervention (Neale et al, 2016), or aerobic exercise (Hayashino et al, 2014), is comparable to the absolute difference found in association with sleep disturbance.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Hayashino et al, 2014
Citations
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Cited by
Sorted by citations
Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915
Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309
Sleep and inflammation: partners in sickness and in health
Irwin, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0190-z · Cited by 1,138
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803
Stubbs, B., Vancampfort, D., Hallgren, M., Firth, J., Veronese, N., Solmi, M., Brand, S., Cordes, J., Malchow, B., Gerber, M., et al. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.07.004 · Cited by 697
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624
Implications of sleep disturbance and inflammation for Alzheimer's disease dementia
Irwin, M. R., & Vitiello, M. V. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30450-2 · Cited by 611
Fedewa, M. V., Hathaway, E. D., & Ward-Ritacco, C. L. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-095999 · Cited by 309
Stubbs, B., Vancampfort, D., Rosenbaum, S., Ward, P. B., Richards, J., Soundy, A., Veronese, N., Solmi, M., & Schuch, F. B. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.019 · Cited by 284
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278
Fried, E. I., von Stockert, S., Haslbeck, J. M. B., Lamers, F., Schoevers, R. A., & Penninx, B. W. J. H. (2019) · Psychological Medicine · doi:10.1017/s0033291719002770 · Cited by 260
Zheng, G., Qiu, P., Xia, R., Lin, H., Ye, B., Tao, J., & Chen, L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00098 · Cited by 242
Perry, B. D., Caldow, M. K., Brennan‐Speranza, T. C., Sbaraglia, M., Jerums, G., GARNHAM, A. P., Wong, C. Y., Levinger, P., Haq, M. A. U., Hare, D. L., et al. (2016) · PubMed · Cited by 239
Metsios, G. S., Moe, R. H., & Kitas, G. D. (2020) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2020.101504 · Cited by 255
Abdominal obesity and metabolic syndrome: exercise as medicine?
Paley, C. A., & Johnson, M. I. (2018) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-018-0097-1 · Cited by 202
Physical activity, exercise and rheumatoid arthritis: Effectiveness, mechanisms and implementation
Metsios, G. S., & Kitas, G. D. (2018) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.03.013 · Cited by 219
Acquarone, E., Monacelli, F., Borghi, R., Nencioni, A., & Odetti, P. R. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.01.004 · Cited by 199
Derosa, G., Maffioli, P., Simental‐Mendía, L. E., Bo, S., & Sahebkar, A. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.07.004 · Cited by 180
Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes
Belvederi Murri, M., Ekkekakis, P., Magagnoli, M., Zampogna, D., Cattedra, S., Capobianco, L., Serafini, G., Calcagno, P., Zanetidou, S., & Amore, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00762 · Cited by 163
Inflammatory Mechanisms in the Pathophysiology of Diabetic Peripheral Neuropathy (DN)—New Aspects
Baum, P., Toyka, K. V., Blüher, M., Kosacka, J., & Nowicki, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910835 · Cited by 167
Zimmer, P., Baumann, F. T., Oberste, M., Wright, P., Garthe, A., Schenk, A., Elter, T., Galvao, D. A., Bloch, W., Hübner, S. T., et al. (2016) · BioMed Research International · doi:10.1155/2016/1820954 · Cited by 125
Marson, E. C., Delevatti, R. S., Prado, A. K. G., Netto, N. D. S., & Kruel, L. F. M. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.10.020 · Cited by 164
Becic, T., Studenik, C., & Hoffmann, G. (2018) · Medical Sciences · doi:10.3390/medsci6040097 · Cited by 127
Hulett, N. A., Scalzo, R. L., & Reusch, J. E. B. (2022) · Nutrients · doi:10.3390/nu14030647 · Cited by 140
Yu, N., Ruan, Y., Gao, X., & Sun, J. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0042-121605 · Cited by 120
Adiponectin—Consideration for its Role in Skeletal Muscle Health
Krause, M. P., Milne, K. J., & Hawke, T. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071528 · Cited by 121
Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity
Wedell‐Neergaard, A., Krogh‐Madsen, R., Petersen, G. L., Hansen, Å. M., Pedersen, B. K., Lund, R., & Brüünsgaard, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194991 · Cited by 122
Influence of Acute and Chronic Exercise on Glucose Uptake
Röhling, M., Herder, C., Stemper, T., & Müssig, K. (2016) · Journal of Diabetes Research · doi:10.1155/2016/2868652 · Cited by 114
Khalafi, M., & Symonds, M. E. (2020) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13754 · Cited by 116
Schmidt, S., Monk, J. M., Robinson, L. E., & Mourtzakis, M. (2015) · Obesity Reviews · doi:10.1111/obr.12281 · Cited by 104
Molecular mechanisms by which aerobic exercise induces insulin sensitivity
Yaribeygi, H., Atkin, S. L., Simental‐Mendía, L. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28066 · Cited by 108
Inoue, A., Cheng, X. W., Huang, Z., Hu, L., Kikuchi, R., Jiang, H., Piao, L., Sasaki, T., Itakura, K., Wu, H., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12166 · Cited by 89
Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials
García‐Hermoso, A., Ceballos-Ceballos, R., Poblete-Aro, C., Hackney, A. C., Mota, J. A. P. S., & Ramírez‐Vélez, R. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.230 · Cited by 89
The role of exercise in the management of rheumatoid arthritis
Metsios, G. S., Stavropoulos‐Kalinoglou, A., & Kitas, G. D. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.1067606 · Cited by 96
García-Hermoso, A., Ramírez-Vélez, R., Díez, J., González, A., & Izquierdo, M. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.11.003 · Cited by 80
Paredes-Turrubiarte, G., González-Chávez, A., Pérez-Tamayo, R., Salazar-Vázquez, B. Y., Hernández, V. S., Garibay-Nieto, N., Fragoso, J. M., & Escobedo, G. (2015) · Clinical and Experimental Medicine · doi:10.1007/s10238-015-0347-4 · Cited by 79
Khalafi, M., Malandish, A., & Rosenkranz, S. K. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111398 · Cited by 81
Farinha, J. B., Ramis, T. R., Vieira, A., Macedo, R. C. O., Rodrigues-Krause, J. D. C., Boeno, F. P., Schroeder, H. T., Muller, C. H. D. L., Boff, W., Krause, M. D. S., et al. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.09.008 · Cited by 80
Grosse, L., Carvalho, L. A., Wijkhuijs, A. J. M., Bellingrath, S., Ruland, T., Ambrée, O., Alferink, J., Ehring, T., Drexhage, H. A., & Arolt, V. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.004 · Cited by 71
Cronin, O., Keohane, D. M., Molloy, M. G., & Shanahan, F. (2017) · QJM · doi:10.1093/qjmed/hcx091 · Cited by 78
Irwin, M. R. (2022) · Temperature · doi:10.1080/23328940.2022.2109932 · Cited by 80
Bizjak, D. A., Brinkmann, C. K., Bloch, W., & Grau, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125206 · Cited by 67
Costa, R. R., Buttelli, A. C. K., Vieira, A., Coconcelli, L., Magalhães, R. D. L., Delevatti, R. S., & Kruel, L. F. M. (2019) · Journal of Physical Activity and Health · doi:10.1123/jpah.2018-0317 · Cited by 65
Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions
Guardia, L. D., & Codella, R. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.09.003 · Cited by 68
Metsios, G. S., Moe, R. H., van der Esch, M., Zanten, J. V., Fenton, S. A. M., Koutedakis, Y., Vitalis, P., Kennedy, N., Brodin, N., Boström, C., et al. (2019) · Rheumatology International · doi:10.1007/s00296-019-04483-6 · Cited by 68
Adiponectin Abates Atherosclerosis by Reducing Oxidative Stress
Yang, Y. (2014) · Medical Science Monitor · doi:10.12659/msm.892299 · Cited by 58
Papagianni, G., Panayiotou, C., Vardas, M., Balaskas, N., Antonopoulos, C., Tachmatzidis, D., Didangelos, T., Lambadiari, V., & Kadoglou, N. P. E. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156157 · Cited by 56
Zhu, J., Guo, B., Gan, X., Zhang, L., He, Y., Liu, B., Chen, X., Zhang, S., & Yu, H. (2017) · BMC Oral Health · doi:10.1186/s12903-017-0395-0 · Cited by 59
Role of exercise-induced hepatokines in metabolic disorders
Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54
Xing, H., Lu, J., Yoong, S. Q., Tan, Y. Q., Kusuyama, J., & Wu, X. V. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.01.055 · Cited by 53
Hayashino, Y., Mashitani, T., Tsujii, S., Ishii, H., & for the Diabetes Distress and Care Registry at Tenri Study Group (2014) · Diabetes Care · doi:10.2337/dc13-2312 · Cited by 53
Murri, M. B., Folesani, F., Zerbinati, L., Nanni, M. G., Ounalli, H., Caruso, R., & Grassi, L. G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155545 · Cited by 58
Chen, X., Sun, X., Wang, C., & He, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6660557 · Cited by 53
Miele, E. M., & Headley, S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0927-7 · Cited by 48
Kim, S.-D., & Yeun, Y.-R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063434 · Cited by 49
Delevatti, R. S., Bracht, C. G., Lisboa, S. D. C., Costa, R. R., Marson, E. C., Netto, N., & Kruel, L. F. M. (2019) · Sports Medicine - Open · doi:10.1186/s40798-019-0194-z · Cited by 46
Pearson, M. J., Mungovan, S. F., & Smart, N. A. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9677-0 · Cited by 48
Hejazi, K., Rahimi, G. R. M., & Rosenkranz, S. K. (2022) · Biological Research For Nursing · doi:10.1177/10998004221132841 · Cited by 47
Gestational diabetes mellitus: Multi-disciplinary treatment approaches
Kintiraki, E., & Goulis, D. G. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.025 · Cited by 50
Zimmer, P., Baumann, F. T., Oberste, M., Schmitt, J., Joisten, N., Hartig, P., Schenk, A., Kuhn, R., Bloch, W., & Reuss-Borst, M. A. (2017) · Integrative Cancer Therapies · doi:10.1177/1534735417713301 · Cited by 43
Khalafi, M., Symonds, M. E., & Akbari, A. M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1873732 · Cited by 46
Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
Reddy, I., Yadav, Y., & Dey, C. S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01272-x · Cited by 46
Exercise Therapy for Patients With Type 2 Diabetes: A Narrative Review
Yanai, H., Adachi, H., Masui, Y., Katsuyama, H., Kawaguchi, A., Hakoshima, M., Waragai, Y., Harigae, T., Hamasaki, H., & Sako, A. (2018) · Journal of Clinical Medicine Research · doi:10.14740/jocmr3382w · Cited by 45
Jabardo-Camprubí, G., Roca, R. D., Sitjà‐Rabert, M., Milà, R., & Roig, J. B. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112786 · Cited by 40
Exercise and its role in gestational diabetes mellitus
Wang, C., Guelfi, K. J., & Yang, H. (2016) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2016.11.006 · Cited by 39
Miller, E. G., Sethi, P., Nowson, C. A., Dunstan, D. W., & Daly, R. M. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3657-2 · Cited by 39
García‐Hermoso, A., Sánchez‐López, M., Escalante, Y., Saavedra, J. M., & Martínez‐Vizcaíno, V. (2015) · Pediatric Research · doi:10.1038/pr.2015.274 · Cited by 38
Khalafi, M., Maleki, A. H., Symonds, M. E., Sakhaei, M. H., Rosenkranz, S. K., Ehsanifar, M., Korivi, M., & Liu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1288537 · Cited by 37
Physical exercise and epigenetic adaptations of the cardiovascular system
Zimmer, P., & Bloch, W. (2015) · Herz · doi:10.1007/s00059-015-4213-7 · Cited by 37
Inverse association of resistin with physical activity in the general population
Marcelino-Rodríguez, I., González, D. A., Alemán-Sánchez, J. J., Díaz, B. B., Pérez, M. D. C. R., Gannar, F., Coello, S. D., Fernández, F. J. C., & de León, A. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182493 · Cited by 35
Fernández‐Rodríguez, R., Monedero-Carrasco, S., Bizzozero‐Peroni, B., Garrido‐Miguel, M., Mesas, A. E., & Martínez‐Vizcaíno, V. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0007 · Cited by 41
Exercise Training: The Holistic Approach in Cardiovascular Prevention
Giallauria, F., Strisciuglio, T., Cuomo, G., Lorenzo, A. D., D’Angelo, A., Volpicelli, M., Izzo, R., Manzi, M. V., Barbato, E., & Morisco, C. (2021) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-021-00482-6 · Cited by 36
Coelho‐Júnior, H. J., Gambassi, B. B., Diniz, T. A., Fernandes, I. M. D. C., Caperuto, É. C., Uchida, M. C., Lira, F. S., & Rodrigues, B. (2016) · Mediators of Inflammation · doi:10.1155/2016/3957958 · Cited by 37
Hepatokines as a Molecular Transducer of Exercise
Seo, D. Y., Park, S.-H., Marquez, J. C., Kwak, H., Kim, T. N., Bae, J. H., Koh, J., & Han, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030385 · Cited by 37
Gu, Y., Dennis, S. M., Kiernan, M. C., & Harmer, A. R. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3099 · Cited by 35
Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target
Milani, I., Codini, M., Guarisco, G., Chinucci, M., Gaita, C., Leonetti, F., & Capoccia, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910795 · Cited by 40
Tayebi, S. M., Poorhabibi, H., Heidary, D., Amini, M. A., & Sadeghi, A. (2025) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-025-01279-z · Cited by 41
Spartano, N. L., Stevenson, M., Xanthakis, V., Larson, M. G., Andersson, C., Murabito, J. M., & Vasan, R. S. (2017) · Clinical Obesity · doi:10.1111/cob.12177 · Cited by 32
How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging
Shin, Y.-A. (2019) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2019.28.2.92 · Cited by 33
Ding, Y., & Xu, X. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1932279 · Cited by 30
Hejazi, K., & Wong, A. (2022) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.22.14103-4 · Cited by 36
Association between metabolic syndrome and age-related cataract.
Park, S., & Lee, E. H. (2015) · Europe PMC (PubMed Central) · doi:10.3980/j.issn.2222-3959.2015.04.29 · Cited by 31
Liu, M., Lin, X., & Wang, X. (2018) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2017-0431 · Cited by 31
Effects of walking on low-grade inflammation and their implications for Type 2 Diabetes
Morettini, M., Storm, F. A., Sacchetti, M., Cappozzo, A., & Mazzà, C. (2015) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2015.06.012 · Cited by 30
Nguyen, C. L., Pham, N. M., Lee, A. H., Nguyen, P. T. H., Chu, T. K., Ha, A. V. V., Duong, D. V., Duong, T. H., & Binns, C. W. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1174-3 · Cited by 29
Tan, L., Yan, W., Yang, W., Kamionka, A., Lipowski, M., Zhao, Z., & Zhao, G. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112310 · Cited by 31
Saghebjoo, M., Nezamdoost, Z., Ahmadabadi, F., Saffari, I., & Hamidi, A. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.12.008 · Cited by 28
Lin, X., Yang, Y., Qu, J., & Wang, X. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0344-9 · Cited by 28
The Effects of Exercise on Appetite in Older Adults: A Systematic Review and Meta-Analysis
Hübner, S., Boron, J. B., & Koehler, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.734267 · Cited by 28
Liao, P., Lin, Z.-Y., Huang, J.-C., & Hsu, K. (2015) · Medicine · doi:10.1097/md.0000000000000554 · Cited by 27
Thompson, G., Davison, G. W., Crawford, J., & Hughes, C. (2020) · Journal of Sports Sciences · doi:10.1080/02640414.2020.1735684 · Cited by 27
Malandish, A., & Gulati, M. (2023) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2023.101234 · Cited by 26
Schmunk, L. J., Call, T. P., McCartney, D. L., Javaid, H., Hastings, W. J., Jovičević, V., Kojadinović, D., Tomkinson, N., Zlamalova, E., McGee, K. C., et al. (2025) · Aging Cell · doi:10.1111/acel.14444 · Cited by 25
Khalafi, M., Alamdari, K. A., Symonds, M. E., Rohani, H., & Sakhaei, M. H. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2064424 · Cited by 26
Ghanizadeh, A. J., Singh, A., Berk, M., & Nami, M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1019866 · Cited by 24
Yang, Q., Shao, D., Li, J., Yang, C., Fan, M.-H., & Cao, F. (2019) · Biological Research For Nursing · doi:10.1177/1099800419894641 · Cited by 26
Darbandi, M., Rezaeian, S., Dianatinasab, M., Yaghoobi, H., Soltani, M., Etemad, K., Valadbeigi, T., Taherpour, N., & Hajipour, M. (2020) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2021.62.4.1788 · Cited by 25
El-Kader, S. M. A., & Al-Shreef, F. M. (2018) · African Health Sciences · doi:10.4314/ahs.v18i1.15 · Cited by 24
Moori, M. H., Nosratabadi, S., Yazdi, N., Kasraei, R., Senjedary, Z. A., & Hatami, R. (2023) · International Journal of Clinical Practice · doi:10.1155/2023/3924018 · Cited by 22
Hu, H., Yuan, G., Wang, X., Jin, S. Y., Gao, Z., Zhou, T., Yin, W., Cai, R., Ye, X., & Wang, Z. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0191 · Cited by 23
Metadata
- Authors
- Hayashino, Y., Jackson, J. L., Hirata, T., Fukumori, N., Nakamura, F., Fukuhara, S., Tsujii, S., & Ishii, H.
- Affiliations
- Kyoto University (JP)
- Milwaukee VA Medical Center (US)
- Tenri Hospital (JP)
- ORCID
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 63
- Issue
- 3
- Pages
- 431-440
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2143812909
- Cited by
- 244
- References
- 53
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 11 · 2023: 28 · 2022: 29 · 2021: 20 · 2020: 15 · 2019: 34 · 2018: 22 · 2017: 21 · 2016: 20 · 2015: 18 · 2014: 5
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- physical activity, type 2 diabetes, C-reactive protein, interleukin-6, adipokines, leptin, adiponectin, resistin, inflammation, aerobic exercise, insulin resistance
- MeSH terms
- C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Male, Middle Aged, Biomarkers, Exercise, Interleukin-6, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
