Cited by 315Pancreatic function and diabetesDiabetes Treatment and ManagementNeuropeptides and Animal Physiology

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Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells

Lee, Young-Sun, Jun, Hee-Sook·2014·Metabolism

DOI 10.1016/j.metabol.2013.09.010

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Abstract

Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin secretion from pancreatic beta-cells in a glucose-dependent manner. In addition, GLP-1 slows gastric emptying, suppresses appetite, reduces plasma glucagon, and stimulates glucose disposal, which are beneficial for glucose homeostasis. Therefore, incretin-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase IV, an enzyme which inactivates GLP-1, have been developed for treatment of diabetes. This review outlines our knowledge of the actions of GLP-1 on insulin secretion and biosynthesis, beta-cell proliferation and regeneration, and protection against beta-cell damage, as well as the involvement of recently discovered signaling pathways of GLP-1 action, mainly focusing on pancreatic beta-cells.

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Global Prevalence of Diabetes
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
The mechanism of pancreatic secretion
Bayliss, W. M., & Starling, E. H. (1902) · The Journal of Physiology · doi:10.1113/jphysiol.1902.sp000920 · Cited by 1,274
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
Xu, G., Stoffers, D. A., Habener, J. F., & Bonner-Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2270 · Cited by 1,209
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 2×
“[12] Jang HJ, Kokrashvili Z, Theodorakis MJ, et al.”
Background
Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
Elashoff, M., Matveyenko, A. V., Gier, B., Elashoff, R., & Butler, P. C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.018 · Cited by 944
Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans
Ørskov, C., Rabenhøj, L., Wettergren, A., Kofod, H., & Holst, J. J. (1994) · Diabetes · doi:10.2337/diab.43.4.535 · Cited by 916
Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.
Thorens, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8641 · Cited by 906
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene
Scrocchi, L. A., Brown, T. J., Maclusky, N., Brubaker, P. L., Auerbach, A. B., Joyner, A. L., & Drucker, D. J. (1996) · Nature Medicine · doi:10.1038/nm1196-1254 · Cited by 793
Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets
Farilla, L., Bulotta, A., Hirshberg, B., Li Calzi, S., Khoury, N., Noushmehr, H., Bertolotto, C., Di Mario, U., Harlan, D. M., & Perfetti, R. (2003) · Endocrinology · doi:10.1210/en.2003-0323 · Cited by 664 · cited 1×
“[53] Farilla L, Bulotta A, Hirshberg B, et al.”
Background
Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor
Thorens, B., Porret, A., Bühler, L. H., Deng, S., Morel, P., & Widmann, C. (1993) · Diabetes · doi:10.2337/diab.42.11.1678 · Cited by 555
Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
Farilla, L., Hui, H., Bertolotto, C., Kang, E., Bulotta, A., Di Mario, U., & Perfetti, R. (2002) · Endocrinology · doi:10.1210/en.2002-220405 · Cited by 502
Role of the Vagus Nerve in Mediating Proximal Nutrient-Induced Glucagon-Like Peptide-1 Secretion
Rocca, A. S., & Brubaker, P. L. (1999) · Endocrinology · doi:10.1210/endo.140.4.6643 · Cited by 475
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
Butler, A. E., Campbell-Thompson, M., Gurlo, T., Dawson, D. W., Atkinson, M., & Butler, P. C. (2013) · Diabetes · doi:10.2337/db12-1686 · Cited by 457
Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats
Perfetti, R., Zhou, J., Doyle, M. E., & Egan, J. M. (2000) · Endocrinology · doi:10.1210/endo.141.12.7806 · Cited by 448
Glucagon-Like Peptide 1 Induces Pancreatic β-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor
Buteau, J., Foisy, S., Joly, E., & Prentki, M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.124 · Cited by 411
A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line
Gribble, F. M., Williams, L., Simpson, A. K., & Reimann, F. M. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1147 · Cited by 400
Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs
de Rooij, J., Rehmann, H., van Triest, M. H., Cool, R. H., Wittinghofer, A., & Bos, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001113200 · Cited by 398
Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age
Tourrel‐Cuzin, C., Bailbé, D., Meile, M.-J., Kergoat, M., & Portha, B. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1562 · Cited by 365
A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence
Brown, J. C., & Dryburgh, J. R. (1971) · Canadian Journal of Biochemistry · doi:10.1139/o71-122 · Cited by 345
Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation
Liu, Z., & Habener, J. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706105200 · Cited by 327
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.
Zhou, J., Wang, X., Piñeyro, M. A., & Egan, J. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2358 · Cited by 319
Glucagon-Like Peptide-1 Inhibits Apoptosis of Insulin-Secreting Cells via a Cyclic 5′-Adenosine Monophosphate-Dependent Protein Kinase A- and a Phosphatidylinositol 3-Kinase-Dependent Pathway
Hui, H., Nourparvar, A., Zhao, X., & Perfetti, R. (2003) · Endocrinology · doi:10.1210/en.2002-220897 · Cited by 307
Modulation of taste sensitivity by GLP‐1 signaling
Shin, Y., Martin, B., Golden, E., Dotson, C. D., Maudsley, S. R., Kim, W., Jang, H.-J., Mattson, M. P., Drucker, D. J., Egan, J. M., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05397.x · Cited by 295
Glucagon gene expression in vertebrate brain.
Drucker, D. J., & Asa, S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68261-4 · Cited by 264
β-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1
Li, Y., Cao, X., Li, L., Brubaker, P. L., Edlund, H., & Drucker, D. J. (2005) · Diabetes · doi:10.2337/diabetes.54.2.482 · Cited by 256
Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12D Mouse Model
Gier, B., Matveyenko, A. V., Kirakossian, D., Dawson, D., Dry, S. M., & Butler, P. C. (2012) · Diabetes · doi:10.2337/db11-1109 · Cited by 255
Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation
Buteau, J., Foisy, S., Rhodes, C. J., Carpenter, L., Biden, T. J., & Prentki, M. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2237 · Cited by 252
Expression and Functional Activity of Glucagon, Glucagon-Like Peptide I, and Glucose-Dependent Insulinotropic Peptide Receptors in Rat Pancreatic Islet Cells
Moens, K., Heimberg, H., Flamez, D., Huypens, P., Quartier, E., Ling, Z., Pipeleers, D., Gremlich, S., Thorens, B., & Schuit, F. (1996) · Diabetes · doi:10.2337/diab.45.2.257 · Cited by 250
Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes
Matveyenko, A. V., Dry, S., Cox, H. I., Moshtaghian, A., Gurlo, T., Galasso, R., Butler, A. E., & Butler, P. C. (2009) · Diabetes · doi:10.2337/db09-0058 · Cited by 244
Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes
Bunck, M. C., Cornér, A., Eliasson, B., Heine, R. J., Shaginian, R. M., Taskinen, M.-R., Smith, U., Yki-Järvinen, H., & Diamant, M. (2011) · Diabetes Care · doi:10.2337/dc11-0291 · Cited by 240
Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells
Hui, H., Wright, C. V. E., & Perfetti, R. (2001) · Diabetes · doi:10.2337/diabetes.50.4.785 · Cited by 224
Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
Cunha, D. A., Ladrière, L., Ortis, F., Igoillo‐Esteve, M., Gurzov, E. N., Lupi, R., Marchetti, P., Eizirik, D. L., & Cnop, M. (2009) · Diabetes · doi:10.2337/db09-0685 · Cited by 222
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
Wang, Q., Li, L., Xu, E., Wong, V. S. C., Rhodes, C. J., & Brubaker, P. L. (2004) · Diabetologia · doi:10.1007/s00125-004-1327-5 · Cited by 209
Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic β Cell Growth and Function
Park, S., Dong, X. C., Fisher, T. L., Dunn, S., Omer, A., Weir, G. C., & White, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508307200 · Cited by 209
GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells
Quoyer, J., Longuet, C., Broca, C., Linck, N., Costes, S., Varin, E. M., Bockaert, J., Bertrand, G., & Dalle, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067207 · Cited by 195
Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?
Whalley, N., Pritchard, L. E., Smith, D. M., & White, A. E. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0094 · Cited by 188
A meta-analysis of serious adverse events reported with exenatide and liraglutide: Acute pancreatitis and cancer
Alves, C., Batel-Marques, F., & Macedo, A. F. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.09.008 · Cited by 186
Reduction of the Incretin Effect in Rats by the Glucagon-Like Peptide 1 Receptor Antagonist Exendin (9–39) Amide
Kolligs, F. T., Fehmann, H.-C., Göke, R., & Göke, B. (1995) · Diabetes · doi:10.2337/diab.44.1.16 · Cited by 185
Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
Suarez‐Pinzon, W. L., Power, R. F., Yan, Y., Wasserfall, C. H., Atkinson, M. A., & Rabinovitch, A. (2008) · Diabetes · doi:10.2337/db08-0688 · Cited by 184
Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes
Meier, J. J., Lin, J. C., Butler, A. E., Galasso, R., Martinez, D. S., & Butler, P. C. (2006) · Diabetologia · doi:10.1007/s00125-006-0308-2 · Cited by 181
Insulinotropic Glucagon-Like Peptide I Receptor Expression in Glucagon-Producing α-Cells of the Rat Endocrine Pancreas
Heller, R. S., Kieffer, T. J., & Habener, J. F. (1997) · Diabetes · doi:10.2337/diab.46.5.785 · Cited by 179
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic β-cell mass
Buteau, J., Spatz, M. L., & Accili, D. (2006) · Diabetes · doi:10.2337/db05-0825 · Cited by 178
Role of Endogenous Glucagon-Like Peptide-1 in Islet Regeneration After Partial Pancreatectomy
León, D. D. D., Deng, S., Madani, R., Ahima, R. S., Drucker, D. J., & Stoffers, D. A. (2003) · Diabetes · doi:10.2337/diabetes.52.2.365 · Cited by 173
Exendin-4 Improves Reversal of Diabetes in NOD Mice Treated with Anti-CD3 Monoclonal Antibody by Enhancing Recovery of β-Cells
Sherry, N. A., Chen, W., Kushner, J. A., Glandt, M., Tang, Q., Tsai, S., Santamaria, P., Bluestone, J. A., Brillantes, A.-M. B., & Herold, K. C. (2007) · Endocrinology · doi:10.1210/en.2007-0358 · Cited by 169
Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats
Nie, Y., Nakashima, M., Brubaker, P. L., Li, Q., Perfetti, R., Jansen, E., Zambre, Y., PIPELEERS, D. G., & Friedman, T. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7456 · Cited by 168
Cure of Overt Diabetes in NOD Mice by Transient Treatment With Anti-Lymphocyte Serum and Exendin-4
Ogawa, N., List, J. F., Habener, J. F., & Maki, T. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1700 · Cited by 155
Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway
Ferdaoussi, M., Abdelli, S., Yang, J.-Y., Cornu, M., Niederhäuser, G., Favre, D., Widmann, C., Regazzi, R., Thorens, B., Waeber, G., et al. (2008) · Diabetes · doi:10.2337/db07-1214 · Cited by 153
Stimulation of pancreatic β-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, J. H., & Møldrup, A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06160 · Cited by 148
Self-citation
Regulation of glucagon secretion by incretins
Holst, J. J., Christensen, M., Lund, A., de Heer, J., Svendsen, B., Kielgast, U. L., & Knop, F. K. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01452.x · Cited by 143
Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation
Scopsi, L., Gullo, M., Rilke, F. O., Martin, S., & Steiner, D. F. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829629 · Cited by 141
Effects of exenatide alone and in combination with daclizumab on β-cell function in long-standing type 1 diabetes
Rother, K. I., Spain, L. M., Wesley, R. A., Digon, B. J., Baron, A., Chen, K., Nelson, P., Dosch, H.-M., Palmer, J. P., Brooks-Worrell, B., et al. (2009) · Diabetes Care · doi:10.2337/dc09-0773 · Cited by 133
Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.
Skoglund, G., Hussain, M. A., & Holz, G. G. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1156 · Cited by 131
The Human GLP-1 Analog Liraglutide and the Pancreas
Nyborg, N. C. B., Mølck, A.-M., Madsen, L. W., & Bjerre Knudsen, L. (2012) · Diabetes · doi:10.2337/db11-0936 · Cited by 125
Glucagon-Like Peptide I and Glucose-Dependent Insulinotropic Polypeptide Stimulate Ca2+-Induced Secretion in Rat α-Cells by a Protein Kinase A–Mediated Mechanism
Ding, W., Renström, E., Rorsman, P., Buschard, K., & Gromada, J. (1997) · Diabetes · doi:10.2337/diab.46.5.792 · Cited by 120
Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.
Scrocchi, L. A., Marshall, B. A., Cook, S., Brubaker, P. L., & Drucker, D. J. (1998) · Diabetes · doi:10.2337/diabetes.47.4.632 · Cited by 117
NFAT Regulates Insulin Gene Promoter Activity in Response to Synergistic Pathways Induced by Glucose and Glucagon-Like Peptide-1
Lawrence, M. C., Bhatt, H. S., & Easom, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.3.691 · Cited by 115
Ontogeny of Regeneration of β-Cells in the Neonatal Rat after Treatment with Streptozotocin
Thyssen, S. M., Arany, E. J., & Hill, D. J. (2006) · Endocrinology · doi:10.1210/en.2005-0396 · Cited by 114
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
Xavier, G. D. S., Mondragon, A., Sun, G., Chen, L., McGinty, J., French, P. M. W., & Rutter, G. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2600-7 · Cited by 111
The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway
Miao, X., Gu, Z., Liu, P., Hu, Y., Li, L., Gong, Y., Shu, H., Liu, Y., & Li, C. (2012) · Peptides · doi:10.1016/j.peptides.2012.10.006 · Cited by 107
GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways
Aronis, K. N., Chamberland, J. P., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.010 · Cited by 104
Exendin 4 Up-Regulates Expression of PDX 1 and Hastens Differentiation and Maturation of Human Fetal Pancreatic Cells
Movassat, J., Beattie, G. M., Lopez, A. D., & Hayek, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020137 · Cited by 103
Exenatide inhibits β-cell apoptosis by decreasing thioredoxin-interacting protein
Chen, J., Couto, F. M., Minn, A. H., & Shalev, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.06.027 · Cited by 97
Exendin‐4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX‐1 and HNF3β transcription factors
Zhou, J., Piñeyro, M. A., Wang, X., Doyle, M. E., & Egan, J. M. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10143 · Cited by 97
Glucagon-like Peptide-1 Increases β-Cell Glucose Competence and Proliferation by Translational Induction of Insulin-like Growth Factor-1 Receptor Expression
Cornu, M., Modi, H., Kawamori, D., Kulkarni, R., Joffraud, M., & Thorens, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091116 · Cited by 92
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells
Wang, Y., Egan, J., Raygada, M. J., Nadiv, O., Roth, J., & Montrose‐Rafizadeh, C. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588224 · Cited by 91
Role of the Vagus Nerve in Mediating Proximal Nutrient-Induced Glucagon-Like Peptide-1 Secretion
Rocca, A. S. (1999) · Endocrinology · doi:10.1210/en.140.4.1687 · Cited by 91
Enhanced expression of PDX-1 and Ngn3 by exendin-4 during β cell regeneration in STZ-treated mice
Kodama, S., Toyonaga, T., Kondo, T., Matsumoto, K., Tsuruzoe, K., Kawashima, J., Goto, H., Kume, K., Kume, S., Sakakida, M., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.120 · Cited by 86
A Review of Types 1 and 2 Diabetes Mellitus and Their Treatment with Insulin
Salsali, A., & Nathan, M. (2006) · American Journal of Therapeutics · doi:10.1097/00045391-200607000-00012 · Cited by 85
Anti-proliferative effect of pro-inflammatory cytokines in cultured β cells is associated with extracellular signal-regulated kinase 1/2 pathway inhibition: protective role of glucagon-like peptide -1
Blandino-Rosano, M., Perez-Arana, G., Mellado-Gil, J. M., Segundo, C., & Aguilar-Diosdado, M. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0154 · Cited by 82
Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells
Wang, H., Iezzi, M., Theander, S. S., Antinozzi, P. A., Gauthier, B. R., Halban, P. A., & Wollheim, C. B. (2005) · Diabetologia · doi:10.1007/s00125-005-1692-8 · Cited by 80
A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice
Wideman, R. D., Covey, S. D., Webb, G. C., Drucker, D. J., & Kieffer, T. J. (2007) · Diabetes · doi:10.2337/db07-0563 · Cited by 72
Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans
Meier, J. J., Butler, A. E., Galasso, R., RIZZA, R. A., & Butler, P. C. (2006) · Diabetologia · doi:10.1007/s00125-006-0410-5 · Cited by 71
Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways
Nishizawa, M., Nakabayashi, H., Uehara, K., Nakagawa, A., Uchida, K., & Koya, D. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00565.2012 · Cited by 66
Combination Therapy with Glucagon-Like Peptide-1 and Gastrin Induces β-Cell Neogenesis from Pancreatic Duct Cells in Human Islets Transplanted in Immunodeficient Diabetic Mice
Suarez‐Pinzon, W. L., Lakey, J. R. T., & Rabinovitch, A. (2008) · Cell Transplantation · doi:10.3727/096368908786092775 · Cited by 65
Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth
Nishioka, T., Kim, H., Luo, L.-Y., Huang, Y., Guo, J., & Chen, C. Y. (2011) · Breast Cancer Research · doi:10.1186/bcr3055 · Cited by 65
Human embryonic stem cell differentiation into insulin secreting β‐cells for diabetes
Bose, B., Shenoy, S., Konda, S., & Wangikar, P. (2012) · Cell Biology International · doi:10.1042/cbi20120210 · Cited by 62
Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients
Pugazhenthi, U., Velmurugan, K., Tran, A., Mahaffey, G., & Pugazhenthi, S. (2010) · Diabetologia · doi:10.1007/s00125-010-1849-y · Cited by 61
Exchange protein activated by cAMP 1 (Epac1) ‐deficient mice develop β‐cell dysfunction and metabolic syndrome
Kai, A. K. L., Lam, A. K. M., Chen, Y., Tai, A. C. P., Zhang, X., Lai, A. K. W., Yeung, P. K. K., Tam, S., Wang, J., Lam, K. S. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-230433 · Cited by 58
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Authors: Lee, Y.-S., & Jun, H.-S.
Affiliations: Gachon University (KR)
Corresponding author: Jun, Hee-Sook
ORCID: Lee, Young-Sun
Jun, Hee-Sook
Venue: Metabolism
Publisher: Elsevier BV
Published: 2014-01
Volume: 63
Issue: 1
Pages: 9-19
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2013.09.010
OpenAlex: W2063865446
Cited by: 315
References: 101
Citations by year: 2026: 15 · 2025: 34 · 2024: 34 · 2023: 26 · 2022: 28 · 2021: 35 · 2020: 26 · 2019: 21 · 2018: 27 · 2017: 16 · 2016: 17 · 2015: 19 · 2014: 16
FWCI: 3.11
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: glucagon-like peptide-1, incretins, pancreatic beta cells, insulin secretion, insulin biosynthesis, beta-cell proliferation, beta cell regeneration, beta cell destruction, glucose homeostasis, diabetes treatment, GLP-1 receptor agonists, DPP-4 inhibitors
MeSH terms: Insulin Secretion, Animals, Cell Differentiation, Cell Survival, Humans, Hypoglycemic Agents, Insulin, Signal Transduction, Cell Proliferation, Insulin-Secreting Cells, Glucagon-Like Peptide 1, Incretins

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Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells

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