Cited by 64Antifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control

Clinical efficacy of new antifungal agents

Kauffman, Carol A·2006·Current Opinion in Microbiology

Abstract

Several new options are now available for treating serious fungal infections. All three echinocandin agents currently available have been shown in randomized, blinded clinical trials to be efficacious in treating candidemia and invasive candidiasis. By contrast, the demonstrated efficacy of the echinocandins for the treatment of invasive aspergillosis has been based on historically controlled salvage treatment trials in patients failing or intolerant of other therapies. The new triazole agents, voriconazole and posaconazole, have a broad spectrum of antifungal activity. Voriconazole has become the agent of choice for invasive aspergillosis. On the basis of compassionate treatment data, posaconazole appears to be effective for treatment of zygomycosis. These agents have also been shown to be effective in the treatment of non-Aspergillus mould infections, several of the endemic mycoses and serious Candida infections.

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Crossref · 10.1016/j.mib.2006.08.001

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Authors
Kauffman, C. A.
Affiliations
University of Michigan (US)
Corresponding author
Kauffman, Carol A
Venue
Current Opinion in Microbiology
Publisher
Elsevier BV
Published
2006-10
Volume
9
Issue
5
Pages
483-488
ISSN
1369-5274 (ISSN-L)
OpenAlex
W1994343341
Cited by
64
References
45
Citations by year
2026: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2018: 1 · 2017: 1 · 2015: 5 · 2014: 1 · 2013: 4
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
antifungal agents, echinocandins, triazoles, voriconazole, posaconazole, candidemia, invasive candidiasis, invasive aspergillosis, mucormycosis, endemic mycoses, clinical efficacy
MeSH terms
Antifungal Agents, Aspergillosis, Candidiasis, Clinical Trials as Topic, Diarrhea, Exanthema, Humans, Mycoses, Nausea, Peptides, Cyclic, Triazoles, Vomiting, Zygomycosis

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