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Bacteriophage genomics
Open accessAbstract
The last three years have seen an escalation in the number of sequenced bacteriophage genomes with more than five hundred now in the NCBI phage database, representing a more than three-fold increase from 2005. These span at least 70 different bacterial hosts, with two-thirds of the sequenced genomes of phages representing only eight bacterial hosts. Three key features emerge from the comparative analysis of these genomes. First, they span a very high degree of genetic diversity, suggesting early evolutionary origins. Secondly, the genome architectures are mosaic, reflecting an unusually high degree of horizontal genetic exchange in their evolution. Thirdly, phage genomes contain a very high proportion of novel genetic sequences of unknown function, and likely represent the largest reservoir of unexplored genes. With an estimated 1031 bacterial and archael viruses in the in the biosphere, our view of the virosphere will draw into sharper focus as further bacteriophage genomes are characterized.
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Cites
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871
Cited by
Phamerator: a bioinformatic tool for comparative bacteriophage genomics
Cresawn, S. G., Bogel, M., Day, N., Jacobs-Sera, D., Hendrix, R. W., & Hatfull, G. F. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-395 · Cited by 462
Self-citationExploring the costs of horizontal gene transfer
Baltrus, D. A. (2013) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2013.04.002 · Cited by 398
Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections
Debarbieux, L., Leduc, D., Maura, D., Morello, E., Criscuolo, A., Grossi, O., Balloy, V., & Touqui, L. (2010) · The Journal of Infectious Diseases · doi:10.1086/651135 · Cited by 304
Hatfull, G. F., Jacobs-Sera, D., Lawrence, J. G., Pope, W. H., Russell, D. A., Ko, C.-C., Weber, R. J., Patel, M. C., Germane, K. L., Edgar, R. H., et al. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.01.011 · Cited by 301
Self-citationPolyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg 2+ , Nucleotides, and RNA
Frankel, E. A., Bevilacqua, P. C., & Keating, C. D. (2016) · Langmuir · doi:10.1021/acs.langmuir.5b04462 · Cited by 159
Metadata
- Authors
- Hatfull, G. F.
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 11
- Issue
- 5
- Pages
- 447-453
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W4232130854
- Cited by
- 371
- References
- 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- green
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