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Bacteriophage genomics

Open access
Hatfull, Graham F·2008·Current Opinion in Microbiology

Abstract

The last three years have seen an escalation in the number of sequenced bacteriophage genomes with more than five hundred now in the NCBI phage database, representing a more than three-fold increase from 2005. These span at least 70 different bacterial hosts, with two-thirds of the sequenced genomes of phages representing only eight bacterial hosts. Three key features emerge from the comparative analysis of these genomes. First, they span a very high degree of genetic diversity, suggesting early evolutionary origins. Secondly, the genome architectures are mosaic, reflecting an unusually high degree of horizontal genetic exchange in their evolution. Thirdly, phage genomes contain a very high proportion of novel genetic sequences of unknown function, and likely represent the largest reservoir of unexplored genes. With an estimated 1031 bacterial and archael viruses in the in the biosphere, our view of the virosphere will draw into sharper focus as further bacteriophage genomes are characterized.

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Metadata

Authors
Hatfull, G. F.
Venue
Current Opinion in Microbiology
Publisher
Elsevier BV
Published
2008-10
Volume
11
Issue
5
Pages
447-453
ISSN
1369-5274 (ISSN-L)
OpenAlex
W4232130854
Cited by
371
References
1
FWCI
1.74
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Bacteriophage genomics. https://app.cochat.ai/papers/10.1016/j.mib.2008.09.004
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Hatfull, G. F. (2008). Bacteriophage genomics. Current Opinion in Microbiology. https://doi.org/10.1016/j.mib.2008.09.004

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