The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections
Abstract
Antibiotic-resistant bacteria threaten life worldwide.Although new antibiotics are scarce, the use of bacteriophages, viruses that infect bacteria, is rarely proposed as a means of offsetting this shortage.Doubt also remains widespread about the efficacy of phage therapy despite recent encouraging results.Using a bioluminescent Pseudomonas aeruginosa strain, we monitored and quantified the efficacy of a bacteriophage treatment in mice during acute lung infection.Bacteriophage treatment not only was effective in saving animals from lethal infection, but also was able to prevent lung infection when given 24 h before bacterial infection, thereby extending the potential use of bacteriophages as therapeutic agents to combat bacterial lung infection.Pulmonary infections are one of the major causes of mortality worldwide.Each year it is estimated that ∼2 million children !5 years old die of acute respiratory infections [1].Furthermore, the number of bacterial infections is probably increasing because of resistance to antibiotics.Opportunistic pathogens are becoming increasingly resistant to multiple antibiotics, which urges us to seek other therapeutic approaches, since new antibacterial compounds are scarce [2].Phage therapy is one of several potential therapeutic approaches and has been considered since the late 1980s [3][4][5][6].Bacteriophages are viruses that target and infect only bacteria.Since the middle of the 20th century, studies of bacteriophages have helped to elucidate fun-
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Cites
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5500 Phages examined in the electron microscope
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Cited by
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy
Malik, D. J., Sokolov, I. J., Vinner, G. K., Mancuso, F., Cinquerrui, S., Vladisavljevic, G. T., Clokie, M. R. J., Garton, N. J., Stapley, A. G. F., & Kirpichnikova, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.05.014 · Cited by 594
Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System
Van Belleghem, J. D., Dąbrowska, K., Vaneechoutte, M., Barr, J. J., & Bollyky, P. L. (2018) · Viruses · doi:10.3390/v11010010 · Cited by 408
Rebuilding the Gut Microbiota Ecosystem
Gagliardi, A., Totino, V., Cacciotti, F., Iebba, V., Neroni, B., Bonfiglio, G., Trancassini, M., Passariello, C., Pantanella, F., & Schippa, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081679 · Cited by 340
Mammalian Host-Versus-Phage immune response determines phage fate in vivo
Hodyra-Stefaniak, K., Miernikiewicz, P., Drapała, J., Drab, M., Jończyk-Matysiak, E., Lecion, D., Kaźmierczak, Z., Beta, W., Majewska, J., Harhala, M., et al. (2015) · Scientific Reports · doi:10.1038/srep14802 · Cited by 302
Barbier, F., Andremont, A., Wolff, M., & Bouadma, L. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32835f27be · Cited by 281
Metadata
- Authors
- Debarbieux, L., Leduc, D., Maura, D., Morello, E., Criscuolo, A., Grossi, O., Balloy, V., & Touqui, L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04
- Volume
- 201
- Issue
- 7
- Pages
- 1096-1104
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2153421727
- Cited by
- 304
- References
- 32
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Debarbieux, L., Leduc, D., Maura, D., Morello, E., Criscuolo, A., Grossi, O., Balloy, V., & Touqui, L. (2010). Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections. The Journal of Infectious Diseases. https://doi.org/10.1086/651135
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
