Physiologically relevant small phosphodonors link metabolism to signal transduction

Wolfe, Alan J

doi:10.1016/j.mib.2010.01.002

Cited by 149Bacterial Genetics and BiotechnologyMicrobial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Physiologically relevant small phosphodonors link metabolism to signal transduction

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Wolfe, Alan J·2010·Current Opinion in Microbiology

DOI 10.1016/j.mib.2010.01.002PMC PMC2847653

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Abstract

Recent reports support the long-standing hypothesis that acetyl phosphate, a physiologically relevant small molecule, can serve as a phosphoryl donor to a subset of two-component response regulators that regulate diverse cellular processes. Since acetyl phosphate is a central metabolite, this ability would link nutritional status to global signaling. This review will first introduce acetyl phosphate and its pathway. It will then summarize the most compelling evidence supporting the hypothesis and list predicted properties of an acetyl phosphate-sensitive pathway. Next, it will describe emerging evidence that acetyl phosphate and/or its pathway can influence diverse cellular processes across a broad spectrum of bacteria. Finally, the review will explore the possibility that other metabolites can function in a capacity similar to acetyl phosphate.

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ATP is universal across lineages but is not the sole energy currency within the metabolism of individual cells.
“However, while ATP is universal across lineages, it is not the sole energy currency within the metabolism of individual cells by any means [80].”
From Early bioenergetic evolution (2013) · cites this paper as [80]
The Introduction says that E. coli cells maintain acetyl phosphate as an energy-storage molecule and that its bond stores more energy than ATP, supporting the point that ATP is not the only cellular energy carrier. The paper does not establish that ATP is universal across lineages; its discussion here concerns bacterial examples. No page number is available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
In many microbes, acetyl-CoA is enzymatically cleaved via phosphorolysis to yield acetyl phosphate.
“In a plethora of microbes, acetyl-CoA is enzymatically cleaved via phosphorolysis to yield acetyl phosphate [79,80], which, with its high free energy of hydrolysis (ΔG°′) of –43 kJ mol−1, can phosphorylate any number of substrates, including ADP to generate ATP, with a free energy of hydrolysis (ΔG°′) of –31 kJ mol−1.”
From Early bioenergetic evolution (2013) · cites this paper as [80]

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Authors: Wolfe, A. J.
Affiliations: Loyola University Chicago (US)
Corresponding author: Wolfe, Alan J
ORCID: Wolfe, Alan J
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2010-04
Volume: 13
Issue: 2
Pages: 204-209
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2010.01.002
PMC: PMC2847653
OpenAlex: W2079720061
Cited by: 149
References: 53
Citations by year: 2026: 7 · 2025: 9 · 2024: 9 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 8
FWCI: 1.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (GM066130, R01GM066130)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: acetyl phosphate, two-component response regulator, signal transduction, bacterial metabolism, metabolite signaling, nutrient sensing
MeSH terms: Bacteria, Bacterial Infections, Bacterial Proteins, Humans, Organophosphates, Phosphorylation, Virulence, Signal Transduction, Gene Expression Regulation, Bacterial

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Physiologically relevant small phosphodonors link metabolism to signal transduction

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