Glycolysis for Microbiome Generation
Open accessAbstract
For a generation of microbiologists who study pathogenesis in the context of the human microbiome, understanding the diversity of bacterial metabolism is essential. In this chapter, I briefly describe how and why I became, and remain, interested in metabolism. I then will describe and compare some of the strategies used by bacteria to consume sugars as one example of metabolic diversity. I will end with a plea to embrace metabolism in the endeavor to understand pathogenesis.
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The major microbial glycolysis pathways are the Embden-Meyerhof-Parnas and the Entner-Doudoroff pathway, depending on the microorganism.
“The major microbial glycolysis pathways are the Embden-Meyerhof-Parnas (EMP) and the Entner-Doudoroff (ED) pathway, depending on the microorganism [reviewed by Wolfe (2015)].”
From The Enzymatic Conversion of Major Algal and Cyanobacterial Carbohydrates to Bioethanol (2016) · cites this paper as Wolfe, 2015
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Fernie, A. R., Decros, G., Sampathkumar, A., Multhoff, J., Niemeier, J.-O., & Schwarzländer, M. (2026) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2026.09.020
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Doltrário, A. B., Rosenn, E. H., Li, S., Sunchu, B., Padmanarayana, M., Kumari, J., & Soni, V. (2026) · Springer eBooks · doi:10.1007/978-3-032-30306-6_2
An Introduction to Bacterial Metabolism
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The effects of methylglyoxal on the mitochondria
Kalapos, M. P., & Lidia de, B. A. R. I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00004-x
- Authors
- Wolfe, A. J.
- Affiliations
- Loyola University Chicago (US)
- Corresponding author
- Wolfe, Alan J.
- ORCID
- Wolfe, Alan J.
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2015-06-18
- Volume
- 3
- Issue
- 3
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC4507297
- OpenAlex
- W2183686123
- Cited by
- 101
- References
- 110
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology Spectrum (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI108255)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK097435)
- National Institute of Dental and Craniofacial Research (DE-SC0012443)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- bacterial metabolism, glycolysis, sugar consumption, metabolic diversity, human microbiome, bacterial pathogenesis, microbial diversity
- MeSH terms
- Bacteria, Fermentation, Glycolysis, Humans, Pentose Phosphate Pathway, Host-Pathogen Interactions, Microbiota
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