Antibiotic resistance in the environment: a link to the clinic?
Abstract
The emergence of resistance to all classes of antibiotics in previously susceptible bacterial pathogens is a major challenge to infectious disease medicine. The origin of the genes associated with resistance has long been a mystery. There is a growing body of evidence that is demonstrating that environmental microbes are highly drug resistant. The genes that make up this environmental resistome have the potential to be transferred to pathogens and indeed there is some evidence that at least some clinically relevant resistance genes have originated in environmental microbes. Understanding the extent of the environmental resistome and its mobilization into pathogenic bacteria is essential for the management and discovery of antibiotics.
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Human antibiotic use has led to an expansion of antibiotic resistance beyond the environment and to clinical bacteria.
“The use of antibiotics by humans has led to an expansion of antibiotic resistance beyond the environment and to clinical bacteria (Wright, 2010).”
From Review of emerging contaminants in green stormwater infrastructure: antibiotic resistance genes, microplastics, tire wear particles, PFAS, and temperature (2024) · cites this paper as Wright, 2010
Cites
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1× · see citing works
“There are 5 10(30) bacteria on the planet [9].”
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Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer
von Wintersdorff, C. J. H., Penders, J., van Niekerk, J. M., Mills, N. D., Majumder, S., van Alphen, L. B., Savelkoul, P. H. M., & Wolffs, P. F. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00173 · Cited by 1,707 · see citing works
Environmental factors influencing the development and spread of antibiotic resistance
Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux053 · Cited by 1,167 · see citing works
The Scourge of Antibiotic Resistance: The Important Role of the Environment
Finley, R. L., Collignon, P., Larsson, D. G. J., McEwen, S. A., Li, X.-Z., Gaze, W. H., Reid-Smith, R., Timinouni, M., Graham, D. W., & Topp, E. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit355 · Cited by 636 · see citing works
The multifaceted roles of antibiotics and antibiotic resistance in nature
Sengupta, S., Chattopadhyay, M. K., & Grossart, H.-P. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00047 · Cited by 629 · see citing works
Karkman, A., Pärnänen, K., & Larsson, D. G. J. (2019) · Nature Communications · doi:10.1038/s41467-018-07992-3 · Cited by 628 · see citing works
Bodus, B., O'Malley, K., Dieter, G., Gunawardana, C., & McDonald, W. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167195 · Cited by 76 · see citing works
- Authors
- Wright, G. D.
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 13
- Issue
- 5
- Pages
- 589-594
- ISSN
- 1369-5274
- Cited by
- 662
- References
- 1
- Language
- en
- Funders
- Canada Research Chair
- Canadian Institutes Health of Research
- Natural Sciences and Engineering Research Council
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