Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

Pyroptosis: host cell death and inflammation

Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627

Non-canonical inflammasome activation targets caspase-11

Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Miao, E. A., Leaf, I. A., Treuting, P. M., Mao, D. P., Dors, M., Sarkar, A., Warren, S. E., Wewers, M. D., & Aderem, A. (2010) · Nature Immunology · doi:10.1038/ni.1960 · Cited by 1,336

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Zhao, Y., Yang, J., Shi, J., Gong, Y., Lu, Q., Xu, H., Liu, L., & Shao, F. (2011) · Nature · doi:10.1038/nature10510 · Cited by 1,310

Caspase‐1‐induced pyroptotic cell death

Miao, E. A., Rajan, J. V., & Aderem, A. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01044.x · Cited by 1,162

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Bürckstümmer, T., Baumann, C., Blüml, S., Dixit, E., Dürnberger, G., Jahn, H., Planyavsky, M., Bilban, M., Colinge, J., Bennett, K. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1702 · Cited by 1,091

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

Kofoed, E. M., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10394 · Cited by 894

Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells

Zhao, D., Wu, Y., Zhuang, J., Xu, C. H., & Zhang, F. (2016) · Oncotarget · doi:10.18632/oncotarget.11944 · Cited by 49

The role and mechanisms of macrophage polarization and hepatocyte pyroptosis in acute liver failure

Xie, D., & Ouyang, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1279264 · Cited by 49

Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy

Qi, X., Li, Q., Che, X., Wang, Q., & Wu, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837293 · Cited by 48

Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis

Wree, A., Holtmann, T. M., Inzaugarat, M. E., & Feldstein, A. E. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1685515 · Cited by 48

A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response.

Lin, A. E., Beasley, F. C., Keller, N., Hollands, A., Urbano, R., Troemel, E. R., Hoffman, H. M., & Nizet, V. (2015) · mBio · doi:10.1128/mbio.00133-15 · Cited by 46

Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases

Vong, C. T., Tseng, H. H. L., Yao, P., Yu, H., Wang, S., Zhong, Z., & Wang, Y. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.02.018 · Cited by 47

Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens

Sun, H., Liu, P., Nolan, L. K., & Lamont, S. J. (2015) · BMC Genomics · doi:10.1186/s12864-015-1850-4 · Cited by 45

Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

Lu, Y., Lu, Y., Meng, J., & Wang, Z. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.791848 · Cited by 44

Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients

Lim, J., Kim, M. J., Park, Y., Ahn, J. W., Hwang, S., Moon, J., Cho, K. G., & Kwack, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-44261-9 · Cited by 45

Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism

Jin, H., Xie, W., He, M., Li, H., Xiao, W., & Li, Y. (2022) · Cells · doi:10.3390/cells11071078 · Cited by 43

Overview of Apoptosis, Autophagy, and Inflammatory Processes in Toxoplasma gondii Infected Cells

Ahmadpour, E., Babaie, F., Kazemi, T., Moghaddam, S. M., Moghimi, A., Hosseinzadeh, R., Nissapatorn, V., & Pagheh, A. S. (2023) · Pathogens · doi:10.3390/pathogens12020253 · Cited by 42

Promoting GSDME expression through DNA demethylation to increase chemosensitivity of breast cancer MCF-7 / Taxol cells

Gong, W., Fang, P., Leng, M., & Shi, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282244 · Cited by 42

Cell death in animal development

Ghose, P., & Shaham, S. (2020) · Development · doi:10.1242/dev.191882 · Cited by 42

What role does pyroptosis play in cancer?

Huang, C. L., Li, J., & Zhang, C. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101587 · Cited by 42

A Lipid Perspective on Regulated Pyroptosis

Qiu, Y., Shi, Y., Zhu, N., Zhang, S., Zhang, C., Gu, J. L., He, P., Dai, A., & Li, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81017 · Cited by 44

Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management

Lou, J., Zhou, Y., Feng, Z., Ma, M., Yao, Y., Wang, Y., Deng, Y., & Wu, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.616952 · Cited by 39

Research progress on pyroptosis and its effect on the central nervous system

Hao, W., & Feng, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106333 · Cited by 42

IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome

Guo, M., Yan, R., Yao, H., Duan, L., Sun, M., Xue, Z., & Jia, Y. (2019) · Mediators of Inflammation · doi:10.1155/2019/2917128 · Cited by 39

Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Negative Ehrlichiae

Yang, Q., Stevenson, H. L., Scott, M. J., & Ismail, N. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.10.005 · Cited by 37

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3

Huang, P., Liu, W., Chen, J., Hu, Y., Wang, Y., Sun, J., & Feng, J. (2020) · Cell Biology International · doi:10.1002/cbin.11429 · Cited by 38

Roles of pyroptosis in atherosclerosis pathogenesis

Liu, X., Luo, P., Zhang, W., Zhang, S., Yang, S., & Hong, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115369 · Cited by 41

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Hu, J., Li, Y., Lian, B., Mao, Y., & Zhao, L. (2025) · 癌症：英文版 · doi:10.1002/cac2.70064 · Cited by 40

Parsing the IL-37-Mediated Suppression of Inflammasome Function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A. S., D’Andrea, L., Ellisdon, A. M., Whisstock, J. C., Berger, P. J., Nold‐Petry, C. A., & Nold, M. F. (2020) · Cells · doi:10.3390/cells9010178 · Cited by 36

The emerging role of pyroptosis-related inflammasome pathway in atherosclerosis

Xu, X., Chen, J., Zhu, L., Xu, S., Jiang, J., & Ren, K. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00594-2 · Cited by 40

NLRP3 inflammasome pathway, the hidden balance in pregnancy: A comprehensive review

Balcı, C. N., & Acar, N. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.104173 · Cited by 39

Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation

Zhang, J., Wang, G., Shi, Y., Liu, X., Liu, S., Chen, W., Ning, Y., Cao, Y., Zhao, Y., & Li, M. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02258-3 · Cited by 34

Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function

Salminen, A., Kauppinen, A., Hiltunen, M. O., & Kaarniranta, K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1524-9 · Cited by 36

Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy

Zheng, T., Zhao, C., Zhao, B., Liu, H., Wang, S., Wang, L., & Liu, P. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00320-z · Cited by 33

Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases

Garg, J. P., & Vucic, D. (2016) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2016.03.003 · Cited by 33

Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and noncanonical caspase-11-mediated pyroptosis pathways.

Yu, Y., Shi, H., Yu, Y. Q., Liu, M., Li, M., Liu, X., Wang, Y., & Chen, R. (2020) · PubMed Central · Cited by 31

New insights into Gasdermin D pore formation

Kappelhoff, S., Margheritis, E. G., & Cosentino, K. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230549 · Cited by 31

Pyroptosis and inflammasomes in obstetrical and gynecological diseases

Yu, S.-Y., & Li, X. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1871893 · Cited by 31

The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis

Deng, Y., Fu, Y., Sheng, L., Hu, Y., Su, L., Luo, J., Yan, C., & Chi, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.669696 · Cited by 31

Neutrophil Inflammasomes Sense the Subcellular Delivery Mechanism of Translocated Bacterial Effectors and Toxins

Oh, C., Li, L., Verma, A., Reuven, A. D., Miao, E. A., Bliska, J. B., & Aachoui, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111688 · Cited by 32

Emerging role of necroptosis, pyroptosis, and ferroptosis in breast cancer: New dawn for overcoming therapy resistance

Fu, B., Lou, Y., Wu, P., Lu, X., & Xu, C. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101017 · Cited by 31

Inflammasome‐mediated pyroptosis in defense against pathogenic bacteria

Oh, C., Spears, T. J., & Aachoui, Y. (2024) · Immunological Reviews · doi:10.1111/imr.13408 · Cited by 31

Pyroptosis: A Developing Foreland of Ovarian Cancer Treatment

Liu, T., Hou, M., Li, M., Qiu, C., Cheng, L. Z., Zhu, T., Qu, J., & Li, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.828303 · Cited by 29

Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus

Beam, J. E., Wagner, N. J., Lu, K., Parsons, J. B., Fowler, V. G., Rowe, S. E., & Conlon, B. P. (2023) · iScience · doi:10.1016/j.isci.2023.107942 · Cited by 29

Pyroptosis and the tumor immune microenvironment: A new battlefield in ovarian cancer treatment

Wang, A., Wang, Y., Du, C., Yang, H., Wang, Z., Jin, C., & Hamblin, M. R. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189058 · Cited by 28

Caspase-11 Non-canonical Inflammasomes in the Lung

Oh, C., Verma, A., & Aachoui, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01895 · Cited by 28

Nlrc3-like is required for microglia maintenance in zebrafish

Wang, T., Yan, B., Lou, L., Lin, X., Yu, T., Wu, S., Lü, Q., Liu, W., Huang, Z., Zhang, M., et al. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.06.002 · Cited by 26

Progress in the Pathogenesis of Diabetic Encephalopathy: The Key Role of Neuroinflammation

Luo, Y., Zhu, J., Hu, Z., Luo, W., Du, X., Hu, H., & Peng, S. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3841 · Cited by 29

Detection of cytosolic bacteria by inflammatory caspases

Hagar, J. A., & Miao, E. A. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.11.008 · Cited by 27

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

Zhou, J., Zhang, F., Lin, H., Quan, M., Yang, Y., Lv, Y., He, Z., & Qian, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.926254 · Cited by 27

A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis

Gu, H., Cai, X.-W., Zhang, X.-Y., Luo, J., Zhang, X.-Y., Hu, X., Cai, W.-T., & Li, G.-W. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010005 · Cited by 24

Paeonol Interferes With Quorum-Sensing in Pseudomonas aeruginosa and Modulates Inflammatory Responses In Vitro and In Vivo

Tang, H., Yang, D., Zhu, L., Shi, F., Ye, G., Guo, H., Deng, H., Zhao, L., Xu, Z., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896874 · Cited by 26

Progress in the study of molecular mechanisms of cell pyroptosis in tumor therapy

Wang, D., & Wan, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110143 · Cited by 26

Altered gene expression patterns of innate and adaptive immunity pathways in transgenic rainbow trout harboring Cecropin P1 transgene

Lo, J. H., Lin, C., Chen, M. J., & Chen, T. T. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-887 · Cited by 25

Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS/Nrf2/NLRP3 inflammasome pathway

Dhar, R., Zhang, L., Li, Y., Rana, M. N., Hu, Z., Li, Z., Cui, H., & Tang, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116962 · Cited by 25

Synergistically Augmenting Cancer Immunotherapy by Physical Manipulation of Pyroptosis Induction

Zhao, C., Zheng, T., Wang, R., Lin, X., Hu, Z., Zhao, Z., Dai, Z., & Sun, D. (2024) · Phenomics · doi:10.1007/s43657-023-00140-y · Cited by 28

Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis

Liu, B., Xu, J., Lu, L., Gao, L., Zhu, S., Sui, Y., Cao, T., & Yang, T. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05623-4 · Cited by 25

Benzo(a)pyrene-induced a mitochondria-independent apoptosis of liver in juvenile Chinese rare minnows (Gobiocypris rarus)

Zha, J., Hong, X., Rao, H., Yuan, L., Wang, Z., & Satyanarayanan, S. K. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.08.005 · Cited by 24

Protective effects of rapamycin induced autophagy on CLP septic mice

Wang, Z., Li, Y., Yang, X., Zhang, L., Shen, H., Xu, W., & Yuan, C. (2019) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2019.01.009 · Cited by 24

Gasdermin E-mediated programmed cell death: An unpaved path to tumor suppression

Wang, Y., Peng, J., Xie, X., Zhang, Z., Li, M., & Yang, M. W. (2021) · Journal of Cancer · doi:10.7150/jca.48989 · Cited by 23

Pyroptosis in inflammatory bone diseases: Molecular insights and targeting strategies

Zhang, R., Sun, Z., & Zhang, L. (2022) · The FASEB Journal · doi:10.1096/fj.202201229r · Cited by 23

New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Chen, Q., Sun, Y., Wang, S., & Xu, J. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01906-5 · Cited by 23

Nanomaterials evoke pyroptosis boosting cancer immunotherapy

Li, Z., Xi, Z., Fan, C., Xi, X., Zhou, Y., Zhao, M., & Xu, L. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.11.011 · Cited by 23

The role of inflammasome complex in ischemia‐reperfusion injury

Mohamadi, Y., Mousavi, M., Khanbabaei, H., Salarinia, R., Javankiani, S., Hassanzadeh, G., & Momeni, F. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27368 · Cited by 22

Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice

Zhao, M., Dai, Y., Li, P., Wang, J., Ma, T., & Xu, S. (2021) · Food & Function · doi:10.1039/d1fo00876e · Cited by 21

Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma

Yang, B., Zhong, W., Gu, Y., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.832114 · Cited by 21

Antidiarrheal activity of the extracts of Valeriana jatamansi Jones on castor oil-induced diarrhea mouse by regulating multiple signal pathways

Ma, Y., Wu, Z., Liu, X., Lan, J.-E., Zai, W., Jin, X., Xie, H., Mu, Q., & Liu, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115560 · Cited by 21

Leishmania infantum infection reduces the amyloid β42-stimulated NLRP3 inflammasome activation

Saresella, M., Basilico, N., Marventano, I., Perego, F., Rosa, F. L., Piancone, F., Taramelli, D., Banks, H., & Clerici, M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.058 · Cited by 22

Extracellular ATP-mediated purinergic immune signaling in teleost fish: A review

Li, S., Zhang, T., Feng, Y., & Sun, J. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736511 · Cited by 20

Association of the NOD‐like receptor 3 ( NLRP 3) gene variability with recurrent aphthous stomatitis in the Czech population

Slezáková, S., Linhartová, P. B., Masopustová, L., Bártová, J., Petanová, J., Kuklı́nek, P., Fassmann, A., Dušek, L., & Hollá, L. I. (2018) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12694 · Cited by 20

Emerging Roles of Autophagy and Inflammasome in Ehrlichiosis

Tominello, T. R., Oliveira, E., Hussain, S. S., Elfert, A., Wells, J. Z., Golden, B., & Ismail, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01011 · Cited by 22

An overview of disease models for NLRP3 inflammasome over-activation

Zhang, H., Zahid, A., Ismail, H., Tang, Y., Jin, T., & Tao, J. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1844179 · Cited by 20

Anticancer mechanisms on pyroptosis induced by Oridonin: New potential targeted therapeutic strategies

Li, G. Q., Gao, S. X., Wang, F. H., Kang, L., Tang, Z. Y., & Xiao, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115019 · Cited by 20

I Spy in the Developing Fly a Multitude of Ways to Die

Yalonetskaya, A., Mondragon, A. A., Elguero, J., & McCall, K. (2018) · Journal of Developmental Biology · doi:10.3390/jdb6040026 · Cited by 20

Pyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC

Li, Z., Zheng, Q. Y., Xue, X., Shi, X., Zhou, Y., Da, F., Qu, D., Hou, Z., & Luo, X. (2016) · Scientific Reports · doi:10.1038/srep37447 · Cited by 19

Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis

Huang, H., Shi, Z., Li, Y., Zhu, G., Chen, C., Zhang, Z., Shi, R., Su, L., Cao, P., Pan, Z., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.850943 · Cited by 17

Multi‐faceted role of pyroptosis mediated by inflammasome in liver fibrosis

Yang, H., Wang, J., & Liu, Z. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17277 · Cited by 17

Syphilitic infection impairs immunity by inducing both apoptosis and pyroptosis of CD4 + and CD8 + T lymphocytes

Xia, W., Zhao, J., Su, B., Jiao, Y., Weng, W., Zhang, M., Wang, X., Guo, C., Wu, H., Zhang, T., et al. (2020) · Innate Immunity · doi:10.1177/1753425920952840 · Cited by 16

Mesenchymal stromal cells attenuate post-stroke infection by preventing caspase-1-dependent splenic marginal zone B cell death

Huang, Y., Wang, J., Lai, X., Qiu, Y., Cai, J., Ma, Y., Liu, Y., Qiu, W., Lu, Z., & Xiang, A. P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00415-0 · Cited by 17

What type of cell death occurs in chronic cerebral hypoperfusion? A review focusing on pyroptosis and its potential therapeutic implications

He, Y., Chen, X., Wu, M., Hou, X., & Zhou, Z. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1073511 · Cited by 19

The role of lncRNA-mediated pyroptosis in cardiovascular diseases

Hu, B., Chen, W., Zhong, Y., & Tuo, Q. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1217985 · Cited by 17

Immune-associated renal disease found in caspase 3-deficient mice

Suzuki, T., Ichii, O., Nakamura, T., Horino, T., Elewa, Y. H. A., & Kon, Y. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03084-w · Cited by 16

Cytotoxic steroidal glycosides from the rhizomes of Paris polyphylla var. yunnanensis

Liu, Y., Liu, M., Bi, L.-L., Tian, Y.-Y., Qiu, P., Qian, X.-Y., Wang, M., Tang, H., Lu, Y., & Zhang, B. (2022) · Phytochemistry · doi:10.1016/j.phytochem.2022.113577 · Cited by 17

Ferroptosis, necroptosis, and pyroptosis in calcium oxalate crystal-induced kidney injury

Tang, K., Ye, T., He, Y. T., Ba, X., Xia, D., Peng, E., Chen, Z., Ye, Z., & Yang, X. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167791 · Cited by 18

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

Stein, R., Kapplusch, F., Heymann, M. C., Ruß, S., Staroske, W., Hedrich, C. M., Rösen‐Wolff, A., & Hofmann, S. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.718668 · Cited by 15

Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates

Endo, Y., Funayama, H., Yamaguchi, K., Monma, Y., Yu, Z., Deng, X., Oizumi, T., Shikama, Y., Tanaka, Y., Okada, S., et al. (2019) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00125 · Cited by 17

Dec2 inhibits macrophage pyroptosis to promote periodontal homeostasis

He, D., Li, X., Zhang, F., Wang, C., Liu, Y. F., BHAWAL, U. K., & Sun, J. (2021) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2101380069 · Cited by 16

Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes

Li, P., Goodwin, A. J., IV, Cook, J. A., Halushka, P. V., Zhang, X. K., & Fan, H. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.02.003 · Cited by 16

Extracellular vesicles derived from Pinctada martensii mucus regulate skin inflammation via the NF-κB/NLRP3/MAPK pathway

Wu, Z., Ma, L., Lin, P., Dai, Z., Lu, Z., Yan, L., Zhou, C., Qian, Z., Hong, P., & Li, C. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.09.115 · Cited by 15

ALV-J infection induces chicken monocyte death accompanied with the production of IL-1β and IL-18

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