Cited by 297Inflammasome and immune disordersImmune Response and InflammationCell death mechanisms and regulation

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

Open access

Aachoui, Youssef, Sagulenko, Vitaliya, Miao, Edward A, Stacey, Katryn J·2013·Current Opinion in Microbiology

DOI 10.1016/j.mib.2013.04.004PMC PMC3742712

Open this paper in CoChat — free account

Abstract

Cell death is an effective strategy to limit intracellular infections. Canonical inflammasomes, including NLRP3, NLRC4, and AIM2, recruit and activate caspase-1 in response to a range of microbial stimuli and endogenous danger signals. Caspase-1 then promotes the secretion of IL-1β and IL-18 and a rapid form of lytic programmed cell death termed pyroptosis. A second inflammatory caspase, mouse caspase-11, mediates pyroptotic death through an unknown non-canonical inflammasome system in response to cytosolic bacteria. In addition, recent work shows that inflammasomes can also recruit procaspase-8, initiating apoptosis. The induction of multiple pathways of cell death has probably evolved to counteract microbial evasion of cell death pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.mib.2013.04.004

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627
Non-canonical inflammasome activation targets caspase-11
Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Miao, E. A., Leaf, I. A., Treuting, P. M., Mao, D. P., Dors, M., Sarkar, A., Warren, S. E., Wewers, M. D., & Aderem, A. (2010) · Nature Immunology · doi:10.1038/ni.1960 · Cited by 1,336
Self-citation
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
Zhao, Y., Yang, J., Shi, J., Gong, Y., Lu, Q., Xu, H., Liu, L., & Shao, F. (2011) · Nature · doi:10.1038/nature10510 · Cited by 1,310
Caspase‐1‐induced pyroptotic cell death
Miao, E. A., Rajan, J. V., & Aderem, A. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01044.x · Cited by 1,162
Self-citation
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127
Self-citation
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Bürckstümmer, T., Baumann, C., Blüml, S., Dixit, E., Dürnberger, G., Jahn, H., Planyavsky, M., Bilban, M., Colinge, J., Bennett, K. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1702 · Cited by 1,091
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
Kofoed, E. M., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10394 · Cited by 894

Show all 58 references

Sorted by citations

Items 201–297 of 297

Toll-like Receptors and NOD-like Receptors in Innate Immune Defense during Pathogenic Infection
Jin, H. S., Park, J., & Jo, E. (2014) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2014.44.3.215 · Cited by 11
Spike lavender essential oil attenuates hyperuricemia and induced renal injury by modulating the TLR4/NF-κB/NLRP3 signalling pathway
Zhou, P., Zhang, B., Wang, X., Duan, J., Li, J., Wang, J., Xia, N., Zhang, S., Wang, J., Guo, D., et al. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105897 · Cited by 10
Roles of Pyroptosis in the Progression of Pulpitis and Apical Periodontitis
Gu, F., Huang, D., Li, R., Peng, L., Huan, T., Ye, K., Bian, Z., & Yin, W. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s507198 · Cited by 10
CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice
Li, J., Xue, H., Xu, N., Gong, L., Li, M., Li, S., Huang, D., Zhang, Q., Li, P., Li, Q., et al. (2022) · Engineering · doi:10.1016/j.eng.2022.08.012 · Cited by 10
Flavonoids’ Dual Benefits in Gastrointestinal Cancer and Diabetes: A Potential Treatment on the Horizon?
AL-Ishaq, R. K., Mazuráková, A., Kubatka, P., & Büsselberg, D. (2022) · Cancers · doi:10.3390/cancers14246073 · Cited by 13
Insight into the structure, function and the tumor suppression effect of gasdermin E
Long, Y., Jia, X., & Chu, L. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116348 · Cited by 13
Emerging roles of orphan nuclear receptors in regulation of innate immunity
Jin, H. S., Kim, T. S., & Jo, E. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0841-6 · Cited by 10
Potential Application of Pyroptosis in Kidney Renal Clear Cell Carcinoma Immunotherapy and Targeted Therapy
Qi, X., Che, X., Li, Q., Wang, Q., & Wu, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918647 · Cited by 11
Volume-activated chloride channels contribute to lipopolysaccharide plus nigericin–induced pyroptosis in bone marrow–derived macrophages
Ye, X., Liu, X., Wei, W., Yu, H., Jin, X., Yu, J., Li, C., Xu, B., Guo, X., & Mao, J. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114791 · Cited by 9
Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma
Zhang, J., Deng, J., Ding, R., Yuan, J., Liu, J., Zhao, X., Wu, T., Jia, J., & Cheng, X. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02729-1 · Cited by 9
Burn the house, save the day: pyroptosis in pathogen restriction
Boucher, D., Chen, K. W., & Schroder, K. (2015) · Inflammasome · doi:10.1515/infl-2015-0001 · Cited by 9
Association between interleukin-18 gene polymorphism and Helicobacter pylori infection in the Korean population
Myung, D., Lee, W., Park, Y., Kim, N., Oh, H.-H., Kim, M., Oak, C., Chung, C., Park, H., Kim, J., et al. (2015) · Scientific Reports · doi:10.1038/srep11535 · Cited by 9
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice
Lam, H. Y. P., Chen, T. T.-W., Chen, C.-C., Yang, T.-H., Cheng, P.-C., & Peng, S.-Y. (2020) · Parasitology International · doi:10.1016/j.parint.2020.102119 · Cited by 9
Regulation of gasdermins in pyroptosis and cytokine release
Li, S., Bracey, S., Liu, Z., & Xiao, T. S. (2023) · Advances in immunology · doi:10.1016/bs.ai.2023.03.002 · Cited by 8
Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review
He, W., Xu, C.-L., Mao, D., Zheng, Y., Wang, N., Wang, M., Mao, N., Wang, T., & Li, Y. (2023) · Phytotherapy Research · doi:10.1002/ptr.7989 · Cited by 8
Targeting pyroptosis in atherosclerosis: emerging pharmacologic strategies and natural compound-based therapeutics—a narrative review
Liu, Q., Shi, Y., & Li, Q. (2025) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-025-02065-0 · Cited by 7
Immune-metabolic interactions shape the fibrotic landscape of diabetic kidney disease: emerging mechanisms and therapeutic prospects
Gao, Y., Pang, X., Zhang, H., Li, D., Han, J., Chen, Z., Chen, X., & Li, D. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2025.1736472 · Cited by 8
Pyroptosis in urinary malignancies: a literature review
Wang, S., Liao, X., Xiong, X., Feng, D., Zhu, W., Zheng, B., Li, Y., Yang, L., & Wei, Q. (2023) · Discover Oncology · doi:10.1007/s12672-023-00620-7 · Cited by 7
The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury
Shang, L., Du, Y., Zhao, Y., Zhang, Y., & Liu, C. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04434-9 · Cited by 7
Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications
Li, N., Zhang, L., Wang, X., Zhou, Y., & Gong, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1230646 · Cited by 10
Ion transporter cascade, reactive astrogliosis and cerebrovascular diseases
Rahman, M. S., Islam, R., & Bhuiyan, M. I. H. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1374408 · Cited by 8
A Novel Pathway of Cell Death in Response to Cytosolic DNA in Drosophila Cells
Vitak, N., Johnson, K. N., Sester, D. P., & Stacey, K. J. (2014) · Journal of Innate Immunity · doi:10.1159/000368276 · Cited by 7
Self-citation
The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice
Liu, M., Fu, D., Gao, T., Jiang, H., Yang, P., & Li, X. (2024) · Aging · doi:10.18632/aging.205631 · Cited by 6
Progress in small-molecule inhibitors of gasdermin D
Shua, Y., Wang, Q., Wang, Y., & Cheng, J. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118171 · Cited by 6
α7-nAChR/P300/NLRP3-regulated pyroptosis mediated poor articular cartilage quality induced by prenatal nicotine exposure in female offspring rats
He, H., Chen, J., Hua, Y., Xie, Z., Tu, M., Liu, L., Wang, H., Yang, X., & Chen, L. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111183 · Cited by 6
Modulatory effects of Enteromorpha prolifera powder and its enzymatic hydrolysate on growth performance, antioxidant capacity, and non-specific immunity of Trachinotus ovatus
Zhao, W., Pu, H.-Q., Wang, L., Dai, M.-Q., Wang, P., & Niu, J. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741610 · Cited by 7
The NLRP3 Inflammasome: A Possible Therapeutic Target for Treatment of Stroke
Ishrat, T., & Nasoohi, S. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-66679-2_22 · Cited by 5
The Expression of Pyroptosis-Related Gene May Influence the Occurrence, Development, and Prognosis of Uterine Corpus Endometrial Carcinoma
Huang, X., Li, Y., Li, J., Yang, X., Xiao, J., & Xu, F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.885114 · Cited by 6
Identification of a prognostic index system and tumor immune infiltration characterization for lung adenocarcinoma based on mRNA molecular of pyroptosis
Li, H., Chang, X., Wang, H., Peng, B., Wang, J., Zhang, P., & Zhang, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.934835 · Cited by 5
Pyroptosis-Related Gene Signature Predicts the Prognosis of ccRCC Using TCGA and Single-Cell RNA Seq Database
Gan, Y., Zhang, Z., Wang, X., Li, A., Fan, Y., & Zhang, Q. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/8224618 · Cited by 6
Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection
Hu, M., Zhao, W., Li, H., Gu, J., Yan, Q., Zhou, X., Pan, Z., Cui, G., & Jiao, X. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1404-5 · Cited by 6
Lipid Peroxidation in Cancer Therapy: Molecular Mechanisms Involving Oxidative Stress, Cell Death, and Therapeutic Response
Andryszkiewicz, W., Cichowska, Z., Filipski, M., Szyda, K., Wietrzyk, A., Szpak, P., & Kulbacka, J. (2026) · Molecules · doi:10.3390/molecules31122072 · Cited by 5
Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea
Han, J.-H., Ye, L., & Wang, Y. (2024) · Biomolecules · doi:10.3390/biom14111349 · Cited by 5
Selenoprotein S ablation-mediated pyroptosis contributes to liver damage resulting from selenium deficiency in chickens
Zhang, H., Chen, X., Lu, T., Cao, Q., & Li, X. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105269 · Cited by 6
Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice
Hu, M., Zhao, W., Gao, W., Li, W., Meng, C., Yan, Q., Wang, Y., Zhou, X., Geng, S., Pan, Z., et al. (2017) · BMC Immunology · doi:10.1186/s12865-017-0203-2 · Cited by 5
Therapeutic connections between pyroptosis and paclitaxel in anti-tumor effects: an updated review
Song, S., Wang, J., Ouyang, X., Huang, R., Wang, F., Xie, J., Chen, Q., & Hu, D. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04036-8 · Cited by 4
Pyroptosis of Macrophages Induced by Clostridium perfringens Beta-1 Toxin
Zhang, S., Ma, L., Song, F., Wang, D., Shi, K., Li, Y., Zeng, J., & Wang, Y. (2023) · Toxins · doi:10.3390/toxins15060366 · Cited by 4
Pathological and Therapeutical Implications of Pyroptosis in Psoriasis and Hidradenitis Suppurativa: A Narrative Review
Krajewski, P. K., Tsoukas, M. M., & Szepietowski, J. C. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46010043 · Cited by 4
The Senescence‐Related Signature Predicts Prognosis and Characterization of Tumor Microenvironment Infiltration in Pancreatic Cancer
Hua, H., Zheng, C., Fan, J., Li, X., Xie, W., Chen, J., & Yu, C. (2022) · BioMed Research International · doi:10.1155/2022/1916787 · Cited by 4
Identification of pyroptosis‑related genes in neuropathic pain based on bioinformatics analysis
Li, X., Zhang, D., Shi, H., Jing, B., Chen, Z., Zheng, Y., Chang, S., Gao, L., & Zhao, G. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11745 · Cited by 4
Transcriptome modifications in human gingival fibroblasts exposed to 2-hydroxyethyl methacrylate
Nisio, C. D., D’Aurora, M., di Giacomo, V., Stuppia, L., Cataldi, A., & Gatta, V. (2016) · Gene · doi:10.1016/j.gene.2016.01.050 · Cited by 4
Research progress on the role of mesenchymal stem cells in pyroptosis in sepsis
Xu, X., An, J., Yang, T., Li, B., & Dou, Z. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04837-x · Cited by 3
Mechanistic paradigms of cell death - revisited
Rana, S. V. S. (2021) · Journal of Environmental Biology · doi:10.22438/jeb/42/4/mrn-1965 · Cited by 3
The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis
Wang, S., Chen, X., Wang, K., & Yang, S. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01720-7 · Cited by 3
Review Article. Absent in melanoma 2 (AIM2) in the intestine: diverging actions with converging consequences
Vanhove, W., Peeters, P. M., Cleynen, I., Assche, G. V., Ferrante, M., Vermeire, S., & Arijs, I. (2017) · Inflammasome · doi:10.1515/infl-2017-0001 · Cited by 5
Sophora moocroftiana seeds ethanol extract regulates NLRP3 inflammasome activation and pyroptosis via ROS/TXNIP pathway to amelioration of NAFLD in vitro and in vivo
Yuan, R., Gui, M., Huang, S., Ciren, Y., Dongzhi, Z., Yang, G., Zhang, W., Wang, S., & Li, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1622178 · Cited by 2
The NLRP3 inflammasome inhibitor OLT1177 attenuates retinal neovascularization and microglial inflammation with neuroprotective effects
Wu, P., Tang, X., Cui, K., Hu, A., Yang, B., Lu, X., Yang, F., Lin, J., Kong, H., Shanshan, Y., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116066 · Cited by 2
Polyphyllin II Triggers Pyroptosis in Hepatocellular Carcinoma via Modulation of the ROS/NLRP3/Caspase-1/GSDMD Axis
Huang, H., Ni, B., Chen, Q., Wang, W., Guo, Z., Wang, N., Chen, R., Yin, X., Qu, C., Ni, J., et al. (2026) · Antioxidants · doi:10.3390/antiox15010075 · Cited by 2
NLRP3 activation by lipopolysaccharide (LPS) mediates the pyroptosis of human spermatogonial stem cells via GBP4 regulation
Jin, W.-C., Zhang, D., Cui, Y.-H., Du, L., & He, Z. (2026) · Asian Journal of Andrology · doi:10.4103/aja202564 · Cited by 2
Targeting cell death: a promising approach for colorectal cancer therapy
Xiao, C., Oyang, L., Jiang, X., Li, S., & Peng, Q. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04261-y · Cited by 3
The Antimicrobial Functions of Macrophages
Flannagan, R. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_6 · Cited by 2
Programmed cell death and liver diseases
Онищенко, Н. А., Гоникова, З. З., Nikolskaya, A. O., Кирсанова, Л. А., & Sevastianov, V. I. (2022) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2022-1-72-88 · Cited by 3
Inflammasomes and Autoinflammation
Broderick, L. (2019) · Springer eBooks · doi:10.1007/978-3-319-98605-0_5 · Cited by 2
Pathogenesis of CoViD19—Miscellaneous Mechanisms
Mallick, U. (2022) · Springer eBooks · doi:10.1007/978-3-030-90065-6_10 · Cited by 2
Constitutive NLRP3 activation: Too much of a bad thing
Mehal, W. Z. (2013) · Hepatology · doi:10.1002/hep.26674 · Cited by 2
Epigallocatechin-3-gallate alleviates trans, trans-2,4-decadienal-induced endothelial pyroptosis and dysfunction by inhibiting NLRP3 inflammasome activation
Hu, Y., Liu, Z., Tao, X., Li, J., Hou, Z., Guo, X., Zhou, D., Wang, M., & Zhu, B. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105428 · Cited by 1
Mechanism and Application Prospect of Noncoding RNA Regulating Tumor Cell Pyroptosis
Wan, W., Mao, Q., Ye, Z., Huang, D., Zhang, R., Wang, K., Wang, X., Wu, Q., Zhu, L., & Chen, C. (2025) · Oncology · doi:10.1159/000543102 · Cited by 1
Cell Death: Many Causes and Many Effects
Cokkinos, D. V. (2019) · Springer eBooks · doi:10.1007/978-3-319-98186-4_7 · Cited by 1
Differential expression of NLRP3 inflammasome genes in HPV infected cervical cells
Stroe, R., Mambet, C., Curici, A., IVAN, F., ALEXA, L., MORJAN, C., HODIS, N., Matei, L., Dragu, L. D., Lazăr, V., et al. (2020) · ROMANIAN BIOTECHNOLOGICAL LETTERS · doi:10.25083/rbl/26.1/2255.2259 · Cited by 1
Inflammasomes in sepsis
Hurtado‐Navarro, L., García-Palenciano, C., & Pelegrı́n, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91802-2.00014-1 · Cited by 1
In the Midst of Life—Cell Death: What Is It, What Is It Good for, and How to Study ItPreprint
Silke, J., & Johnstone, R. W. (2016) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top070508 · Cited by 1
Understanding the interaction between mycoplasma bovis and bovine respiratory macrophages
Maina, T. (2019) · Cited by 1
Pyroptosis
Lawlor, K. E., Conos, S. A., & Vince, J. E. (2018) · Wiley eBooks · doi:10.1002/9781119432463.ch15 · Cited by 1
Selection of cDNA candidates that induce oligomerization of NLRP3 using a chimeric receptor approach
Honda, S., Nagamune, T., & Kawahara, M. (2015) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.12.021
Necrobiology of Liver Cancer: Autophagy and Cellular Senescence
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_179-1
Using tissue culture to model early events in Francisella tularensis pathogenesis
Burwinkel, J. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
TXNIP and the GAPDH-Siah1 Signalling Pathway in Diabetic Nephropathy
Zhong, H. (2019) · TSpace (University of Toronto)
Structural changes of capsular, vascular, glial and neural elements of the spinal ganglia in acute experimental edema. Light and electron microscopic studies
Gasimov, E. K., & Aliyarbekova, A. A. (2021) · NATIONAL JOURNAL OF NEUROLOGY · doi:10.28942/nnj.v7i1.315
Pathogenesis of age-related macular degeneration
Li, W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822061-0.00002-5
Neutrophil Inflammasomes Sense the Subcellular Delivery Mechanism of Translocated Bacterial Effectors and ToxinsPreprint
Oh, C., Li, L., Verma, A., Reuven, A. D., Miao, E. A., Bliska, J. B., & Aachoui, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4019721
Self-citation
Necrobiology of Liver Cancer: Autophagy and Cellular Senescence
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26956-6_179
Avaliação da via de necroptose em pacientes com sepse e sua correlação com a gravidade e parâmetros clínicos desta enfermidade
Jolvino, D. (2019) · doi:10.31744/pg2019.106812
Disruption of p54nrb's gene regulatory function by caspase-2 exhibits a multifaceted role in tumor cell death susceptibility
Eichler, M. (2023) · doi:10.21248/gups.74656
Shenfu Injection Regulates Pyroptosis through the NLRP3/Caspase-1 Pathway to Improve Chronic Heart FailurePreprint
Xingyu, F. A. N., Liao, X., Huang, S., Li, L., & Hu, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-3325004/v1
Additional file 2 of Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma
Zhang, J., Deng, J., Ding, R., Yuan, J., Liu, J., Zhao, X., Wu, T., Jia, J., & Cheng, X. (2022) · Figshare · doi:10.6084/m9.figshare.21343249
Structural Changes of Membranes, Vascular, Glial and Neural Elements of the Spinal Ganglia in Acute Experimental Edema. Light and Electron-Microscopic Studies
Gasimov, E. K., & Aliyarbayova, A. (2015) · NATIONAL JOURNAL OF NEUROLOGY · doi:10.61788/njn.v1i15.05
Identification and validation of genes involved in pyroptosis of LPS and D-GALN induced acute liver injuryPreprint
Zuo, W. (2024) · Research Square · doi:10.21203/rs.3.rs-4511726/v1
Avaliação da participação de diferentes inflamassomas no reconhecimento e no controle da infecção experimental por Legionella longbeachae
Guerra, R. O. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2024.tde-10062024-092259
Gasdermin-Mediated Pyroptosis in Hidradenitis Suppurativa: Molecular Insights and Therapeutic Implications
Tyczyńska, K. M., Krajewski, P. K., Sójka, A., Nowicka‐Suszko, D., Bednarz‐Misa, I., Fleszar, M. G., Krzystek‐Korpacka, M., & Szepietowski, J. C. (2025) · Biology · doi:10.3390/biology14091258 · Cited by 1
Evaluation of acute nephrotoxicity induced by CuO nanosheet as a nanopesticide through TNF-α and NF-kB up-regulation
Zaky, M. Y., Abdel-Azeem, A. M., Farghali, A. A., Al-Olayan, E. M., Wang, C., Khidr, F. K., Abdel-Rehiem, E. S., & Abdul‐Hamid, M. (2025) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-025-00848-w
Effects of the addition of Enteromorpha prolifera meal and its derivatives in diets on the growth performance, antioxidant capacity and immune ability of largemouth bass (Micropterus salmoides)
Lin, S., Cui, X., Wang, L., Dai, M.-Q., Wang, P., Pu, H., Chen, A., Guo, Y., Liao, Z., Zhao, W., et al. (2025) · Aquaculture Reports · doi:10.1016/j.aqrep.2025.103266
Additional file 1 of Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma
Zhang, J., Deng, J., Ding, R., Yuan, J., Liu, J., Zhao, X., Wu, T., Jia, J., & Cheng, X. (2022) · Figshare · doi:10.6084/m9.figshare.21343246
Additional file 4 of Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma
Zhang, J., Deng, J., Ding, R., Yuan, J., Liu, J., Zhao, X., Wu, T., Jia, J., & Cheng, X. (2022) · Figshare · doi:10.6084/m9.figshare.21343255
Additional file 1 of Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation
Zhang, J., Wang, G., Shi, Y., Liu, X., Liu, S., Chen, W., Ning, Y., Cao, Y., Zhao, Y., & Li, M. (2024) · Figshare · doi:10.6084/m9.figshare.25770410
Additional file 3 of Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma
Zhang, J., Deng, J., Ding, R., Yuan, J., Liu, J., Zhao, X., Wu, T., Jia, J., & Cheng, X. (2022) · Figshare · doi:10.6084/m9.figshare.21343252
Extracellular vesicles (EVs) carrying hemolysin HlyE variant (HlyE-V) from avian pathogenic Escherichia coli (APEC) induce mitochondria-dependent apoptosis in HD11 macrophages
Mou, Y., Liang, Y., Zhu, D., Wang, M., Liu, Y., Peng, D., Dai, J., Jiang, M., & Zhuge, X. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108441
Molecular and cellular bases of systemic autoinflammatory disorders including Adult-onset Still’s disease
Assrawi, E. (2019) · theses.fr (ABES) · doi:10.70675/82f530d5z0154z474cz9746z470b6a42c9e0
Impact of oxygen and glucose differential availability on human neutrophil viability, metabolism and activation
Injarabian, L. (2020) · theses.fr (ABES) · doi:10.70675/d505f876z0405z4419zbe01z07bf7a8dc156
Physiopathologie des maladies auto-inflammatoires d’expression cutanée : aspects moléculaires et cellulaires
Louvrier, C. (2019) · theses.fr (ABES) · doi:10.70675/ee57af23z15cdz4ec8zafebz9f9ac9f08220
Stem cells and pyroptosis in cancer
Das, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40471-9.00008-2
BMSC-derived exosomal piR-161382 alleviates spinal cord ischemia/reperfusion injury by targeting MCU to inhibit ROS/NLRC4-mediated neuronal pyroptosis
佟湘毅, Ma, Q., An, G., Zhu, X., Jia, P., Ma, H., & Chen, F. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116859
How to recognize if a cell dies from pyroptosis?
Gebuza, M., Bihl, W., Brawańska, K., Tomecka, P., Kulbacki, M., & Kulbacka, J. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12347-z
Lacticaseibacillus paracasei Jlus66 ameliorates hyperuricemia by inhibiting xanthine oxidase activity, modulating uric acid transporter proteins and the gut microbiota
Wang, C., Zhu, L., Shen, X., Xiao, X., Zhang, T., & Ye, H. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-04960-0
Sacubitril/valsartan attenuates renal injury caused by cecal ligation and puncture via TLR4/NFκB/NLRP3 inhibition and reduced oxidative stress and apoptosis in rats
Mohyeldin, R. H., Abdelnaser, M., Rofaeil, R. R., Attya, M. E., Niera, N. M. S., Ayad, M. S., & Sharata, E. E. (2026) · Scientific Reports · doi:10.1038/s41598-026-65493-6
Elucidating the therapeutic potential of natural products in alleviating diabetic cardiomyopathy: contemporary progress and forthcoming opportunities
Fang, D., Cielecka‐Piontek, J., Blundell, R. A., Zhong, Z., & Chen, J. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158707
sDR5-Fc Administered Post-Exposure Alleviates Radiation-Induced Enteric Injury by Inhibiting ROS and NLRP3/Caspase-1/GSDMD-Dependent Pyroptosis and Inflammatory Response
Qiao, X., Guo, S., Tian, Z., Li, L.-T., Yang, Y.-H., Meng, Z., Gan, H., Shu-chen, L., Dou, G., & Gu, R. (2026) · Pharmaceuticals · doi:10.3390/ph19101647
NOVEL COMPOUNDS AS POTENTIAL ALZHEIMER'S DISEASE THERAPEUTICS AND INHIBITORS OF THE NLRP3 INFLAMMASOME
Chojnacki, J. E. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/62wy-9639

Authors: Aachoui, Y., Sagulenko, V., Miao, E. A., & Stacey, K. J.
Affiliations: University of North Carolina at Chapel Hill (US)
The University of Queensland (AU)
Corresponding author: Miao, Edward A
Stacey, Katryn J
ORCID: Aachoui, Youssef
Sagulenko, Vitaliya
Miao, Edward A
Stacey, Katryn J
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2013-06
Volume: 16
Issue: 3
Pages: 319-326
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2013.04.004
PMC: PMC3742712
OpenAlex: W2077730689
Cited by: 296
References: 58
Citations by year: 2026: 13 · 2025: 16 · 2024: 22 · 2023: 30 · 2022: 39 · 2021: 32 · 2020: 24 · 2019: 29 · 2018: 19 · 2017: 17 · 2016: 14 · 2015: 21 · 2014: 13 · 2013: 7
FWCI: 1.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Australian Research Council Future Fellowship (FT0991576)
National Health and Medical Research Council (631472, 1010887)
National Institute of Health (AI097518, AI057141)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: inflammasome, pyroptosis, apoptosis, caspase-1, caspase-11, NLRP3 inflammasome, NLRC4 inflammasome, AIM2 inflammasome, IL-1β, IL-18, procaspase-8, intracellular infection, host defense against infection
MeSH terms: Animals, Communicable Diseases, Humans, Signal Transduction, Cytokines, Cell Death, Caspases, Mice, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks