Cited by 297Inflammasome and immune disordersImmune Response and InflammationCell death mechanisms and regulation

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Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

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Aachoui, Youssef, Sagulenko, Vitaliya, Miao, Edward A, Stacey, Katryn J·2013·Current Opinion in Microbiology

DOI 10.1016/j.mib.2013.04.004PMC PMC3742712

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Abstract

Cell death is an effective strategy to limit intracellular infections. Canonical inflammasomes, including NLRP3, NLRC4, and AIM2, recruit and activate caspase-1 in response to a range of microbial stimuli and endogenous danger signals. Caspase-1 then promotes the secretion of IL-1β and IL-18 and a rapid form of lytic programmed cell death termed pyroptosis. A second inflammatory caspase, mouse caspase-11, mediates pyroptotic death through an unknown non-canonical inflammasome system in response to cytosolic bacteria. In addition, recent work shows that inflammasomes can also recruit procaspase-8, initiating apoptosis. The induction of multiple pathways of cell death has probably evolved to counteract microbial evasion of cell death pathways.

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Authors: Aachoui, Y., Sagulenko, V., Miao, E. A., & Stacey, K. J.
Affiliations: University of North Carolina at Chapel Hill (US)
The University of Queensland (AU)
Corresponding author: Miao, Edward A
Stacey, Katryn J
ORCID: Aachoui, Youssef
Sagulenko, Vitaliya
Miao, Edward A
Stacey, Katryn J
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2013-06
Volume: 16
Issue: 3
Pages: 319-326
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2013.04.004
PMC: PMC3742712
OpenAlex: W2077730689
Cited by: 296
References: 58
Citations by year: 2026: 13 · 2025: 16 · 2024: 22 · 2023: 30 · 2022: 39 · 2021: 32 · 2020: 24 · 2019: 29 · 2018: 19 · 2017: 17 · 2016: 14 · 2015: 21 · 2014: 13 · 2013: 7
FWCI: 1.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Australian Research Council Future Fellowship (FT0991576)
National Health and Medical Research Council (631472, 1010887)
National Institute of Health (AI097518, AI057141)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: inflammasome, pyroptosis, apoptosis, caspase-1, caspase-11, NLRP3 inflammasome, NLRC4 inflammasome, AIM2 inflammasome, IL-1β, IL-18, procaspase-8, intracellular infection, host defense against infection
MeSH terms: Animals, Communicable Diseases, Humans, Signal Transduction, Cytokines, Cell Death, Caspases, Mice, Inflammasomes

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Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

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